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OR2A12 Gene

protein-coding   GIFtS: 44
GCID: GC07P143792

Olfactory Receptor, Family 2, Subfamily A, Member 12

(Previous names: olfactory receptor, family 2, subfamily A, member 12 pseudogene)
(Previous symbol: OR2A12P)
  Search for OR2A12
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 2, Subfamily A, Member 121 2     OR2A16P2
OR2A12P1 2 3     Olfactory Receptor 2A122
Olfactory Receptor, Family 2, Subfamily A, Member 12 Pseudogene1 2     Olfactory Receptor, Family 2, Subfamily A, Member 16 Pseudogene2
Olfactory Receptor OR7-102 3     

External Ids:    HGNC: 150821   Entrez Gene: 3465252   Ensembl: ENSG000002218587   UniProtKB: Q8NGT73   

Export aliases for OR2A12 gene to outside databases

Previous GC identifers: GC07U900036 GC07P143184 GC07P143229 GC07P143423


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR2A12 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR2A12 Gene:
OR2A12 (olfactory receptor, family 2, subfamily A, member 12) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2A25.

UniProtKB/Swiss-Prot: O2A12_HUMAN, Q8NGT7
Function: Odorant receptor (Potential)

Gene Wiki entry for OR2A12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR2A12 gene promoter:
         AREB6   HOXA9   HOXA9B   STAT1   Brachyury   Meis-1a   Meis-1   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR2A12 promoter sequence
   Search Chromatin IP Primers for OR2A12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2A12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q35   HGNC cytogenetic band: 7q35

OR2A12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2A12 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P143792:  view genomic region     (about GC identifiers)

Start:
143,792,201 bp from pter      End:
143,793,130 bp from pter
Size:
930 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 143,130,413-143,131,345     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: O2A12_HUMAN, Q8NGT7 (See protein sequence)
Recommended Name: Olfactory receptor 2A12  
Size: 310 amino acids; 35213 Da
Secondary accessions: Q6IF43

Explore the universe of human proteins at neXtProt for OR2A12: NX_Q8NGT7

Explore proteomics data for OR2A12 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4
  • HORDE protein sequence for OR2A12

    See OR2A12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004135.1  
    ENSEMBL proteins: 
     ENSP00000386174  
    Reactome Protein details: Q8NGT7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR2: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGT7

    ProtoNet protein and cluster: Q8NGT7

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O2A12_HUMAN, Q8NGT7
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR2A12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O2A12_HUMAN, Q8NGT7
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR2A12           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR2A12
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O2A12_HUMAN, Q8NGT7: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR2A12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR2A12 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR2A12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR2A12
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR2A12):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR2A12
    Interactions:

        Search GeneGlobe Interaction Network for OR2A12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR2A12 (ENSP000003861744) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10AD1ENSP000003086894STRING: ENSP00000308689
    OR10P1ENSP000003080824STRING: ENSP00000308082
    OR10W1ENSP000003785164STRING: ENSP00000378516
    OR11G2ENSP000003499304STRING: ENSP00000349930
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR2A12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR2A12 (O2A12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR2A12 gene: 
    NM_001004135.1  

    Unigene Cluster for OR2A12:

    Olfactory receptor, family 2, subfamily A, member 12
    Hs.553708
    Unigene Representative Sequence: BC136902
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000408949(uc011kty.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR2A12

    Additional mRNA sequence: 

    BC136902.1 BC136903.1 

    1 AceView cDNA sequence:

    NM_001004135 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR2A12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR2A12 Expression
    About this image

    OR2A12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR2A12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553708
        Custom PCR Arrays for OR2A12
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR2A12 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr4461 , 5 olfactory receptor 4461, 5 80.89(n)1
    85.67(a)1
      6 (20.97 cM)5
    2582921  NM_146295.11  NP_666407.11 
     429272335 


    ENSEMBL Gene Tree for OR2A12 (if available)
    TreeFam Gene Tree for OR2A12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR2A12 gene
    OR2A252  OR2A42  OR2A422  OR2A12  OR2A52  OR2F22  OR2A22  OR2A72  
    OR2D22  OR2F12  OR2D32  OR2A142  
    Selected SIMAP similar genes for OR2A12 using alignment to 2 protein entries:     O2A12_HUMAN (see all proteins) (see all similar genes):
    OR2A5    OR2A14    OR2A2    OR2A42    OR2A1    OR2A25
    OR2A4    OR2A7    FKSG35    OR2J3    6M1-16    OR2B2
    OR2B8P    OR2F1    OR2J2    OR2J4P    OR2K2    OR2Y1

    Find genes that share paralogs with OR2A12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR2A12 (see all 92)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1890083821,2
    --143790315(+) TCGAAC/TATTTT 1 -- us2k10--------
    rs1820049071,2
    --143790327(+) GGTGAA/CATCTC 1 -- us2k10--------
    rs1412164431,2
    --143790611(+) ACATGC/TGCACA 1 -- us2k10--------
    rs102817151,2
    C,F--143790644(+) tatacG/Atgtgc 1 -- us2k12Minor allele frequency- A:0.33CSA 3
    rs132331881,2
    C,F--143790720(+) cccccA/Cacccc 1 -- us2k12Minor allele frequency- C:0.00NA 4
    rs1124741751,2
    C--143790727(+) CCCCCC/AACCCC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs132323431,2
    C,F,A--143790733(+) accccA/Gcaaca 1 -- us2k13Minor allele frequency- G:0.00NA CSA 5
    rs102261271,2
    C,F,A--143790774(+) gtccaA/Tgtgtt 1 -- us2k15Minor allele frequency- T:0.25NA CSA 8
    rs1848989061,2
    --143791020(+) GTGCCA/GCAATA 1 -- us2k10--------
    rs1382753581,2
    --143791023(+) CCGCAA/GTAAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR2A12 ( 143792201 - 143793130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR2A12 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831174CNV Loss17160897
    nsv831173CNV Gain17160897
    nsv889336CNV Gain21882294
    nsv522225CNV Gain19592680
    dgv7521n71CNV Gain21882294
    esv2752147CNV Gain17911159
    dgv842n27CNV Gain19166990
    dgv7520n71CNV Gain21882294
    nsv428188CNV Gain+Loss18775914
    nsv8227CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR2A12 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR2A12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. Population differences in the human functional olfactory repertoire. (PubMed id 12644552)1 Gilad Y. and Lancet D. (Mol. Biol. Evol. 2003)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (Science 2003)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1 Fuchs T.... Shamir R. (Genomics 2002)
    6. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 346525 HGNC: 15082 AceView: OR2A12 Ensembl:ENSG00000221858 euGenes: HUgn346525
    ECgene: OR2A12 Kegg: 346525 H-InvDB: OR2A12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR2A12 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR2A12 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR2A12 gene:
    Search GeneIP for patents involving OR2A12

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OR2A12  
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     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR2A12 Predesigned siRNA for gene silencing in human, mouse, rat OR2A12
     QuantiFast Probe-based Assays in human, mouse, rat OR2A12 QuantiTect SYBR Green Assays in human, mouse, rat OR2A12
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