Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR2A12 Gene

Aliases for OR2A12 Gene

  • Olfactory Receptor Family 2 Subfamily A Member 12 2 3 5
  • Olfactory Receptor, Family 2, Subfamily A, Member 12 Pseudogene 2 3
  • Olfactory Receptor OR7-10 3 4
  • OR2A12P 3 4
  • Olfactory Receptor, Family 2, Subfamily A, Member 16 Pseudogene 3
  • Olfactory Receptor, Family 2, Subfamily A, Member 12 2
  • Olfactory Receptor 2A12 3
  • OR2A16P 3

External Ids for OR2A12 Gene

Previous HGNC Symbols for OR2A12 Gene

  • OR2A12P

Previous GeneCards Identifiers for OR2A12 Gene

  • GC07U900036
  • GC07P143184
  • GC07P143229
  • GC07P143423
  • GC07P143792

Summaries for OR2A12 Gene

Entrez Gene Summary for OR2A12 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2A12 Gene

OR2A12 (Olfactory Receptor Family 2 Subfamily A Member 12) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2A5.

UniProtKB/Swiss-Prot for OR2A12 Gene

  • Odorant receptor.

Gene Wiki entry for OR2A12 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2A12 Gene

Genomics for OR2A12 Gene

Regulatory Elements for OR2A12 Gene

Enhancers for OR2A12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G143898 1.7 FANTOM5 Ensembl ENCODE 4.2 -191.9 -191892 9.0 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A FEZF1 ARHGEF35 OR2A13P TCAF1 OR2A25 OR2A12 ARHGEF34P OR2A2 OR2F1
GH07G143893 0.8 FANTOM5 4.5 -202.5 -202514 0.0 HDAC1 ZNF362 ATF1 ZNF175 DPF2 ELF1 CHAMP1 FOSL1 FOXM1 JUND OR2A2 OR2A25 OR2A12 TCAF1 OR2F1 TAS2R60 LOC105375549
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2A12 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2A12 Gene

Chromosome:
7
Start:
144,095,048 bp from pter
End:
144,096,093 bp from pter
Size:
1,046 bases
Orientation:
Plus strand

Genomic View for OR2A12 Gene

Genes around OR2A12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2A12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2A12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2A12 Gene

Proteins for OR2A12 Gene

  • Protein details for OR2A12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGT7-O2A12_HUMAN
    Recommended name:
    Olfactory receptor 2A12
    Protein Accession:
    Q8NGT7
    Secondary Accessions:
    • Q6IF43

    Protein attributes for OR2A12 Gene

    Size:
    310 amino acids
    Molecular mass:
    35213 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2A12 Gene

Post-translational modifications for OR2A12 Gene

  • Glycosylation at posLast=44
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2A12 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2A12 Gene

Domains & Families for OR2A12 Gene

Gene Families for OR2A12 Gene

Protein Domains for OR2A12 Gene

Suggested Antigen Peptide Sequences for OR2A12 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NGT7

UniProtKB/Swiss-Prot:

O2A12_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2A12: view

Function for OR2A12 Gene

Molecular function for OR2A12 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2A12: view

Phenotypes for OR2A12 Gene

genes like me logo Genes that share phenotypes with OR2A12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2A12 Gene

Localization for OR2A12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2A12 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2A12 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2A12: view

Pathways & Interactions for OR2A12 Gene

genes like me logo Genes that share pathways with OR2A12: view

Pathways by source for OR2A12 Gene

Interacting Proteins for OR2A12 Gene

Gene Ontology (GO) - Biological Process for OR2A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2A12: view

No data available for SIGNOR curated interactions for OR2A12 Gene

Drugs & Compounds for OR2A12 Gene

No Compound Related Data Available

Transcripts for OR2A12 Gene

mRNA/cDNA for OR2A12 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR2A12 Gene

No ASD Table

Relevant External Links for OR2A12 Gene

GeneLoc Exon Structure for
OR2A12
ECgene alternative splicing isoforms for
OR2A12

Expression for OR2A12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2A12 Gene

Protein differential expression in normal tissues from HIPED for OR2A12 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2A12 Gene



Protein tissue co-expression partners for OR2A12 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2A12 Gene:

OR2A12

SOURCE GeneReport for Unigene cluster for OR2A12 Gene:

Hs.553708
genes like me logo Genes that share expression patterns with OR2A12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2A12 Gene

Orthologs for OR2A12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2A12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC472574 34
  • 99.14 (n)
OR2A12 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or2a55-ps 55 Olfr443-ps1 35
  • 88 (a)
OneToMany
Or2a12 55 Olfr446 34 16 35
  • 80.89 (n)
Or2a53-ps 55 Olfr440-ps1
  • chr6:43,122,350-43,123,263
dog
(Canis familiaris)
Mammalia OR2A12 34 35
  • 83.6 (n)
cow
(Bos Taurus)
Mammalia OR2A12 34 35
  • 83.01 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 55 (a)
OneToMany
Species where no ortholog for OR2A12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2A12 Gene

ENSEMBL:
Gene Tree for OR2A12 (if available)
TreeFam:
Gene Tree for OR2A12 (if available)

Paralogs for OR2A12 Gene

Paralogs for OR2A12 Gene

(456) SIMAP similar genes for OR2A12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR2A12: view

Variants for OR2A12 Gene

Sequence variations from dbSNP and Humsavar for OR2A12 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000002715 -- 144,096,262(+) CCAGC(C/T)TAACC downstream-variant-500B
rs1000059104 -- 144,093,939(+) ACATA(C/T)GTGTG upstream-variant-2KB
rs1001020989 -- 144,094,748(+) CAGTG(A/G)TAAAT upstream-variant-2KB
rs1001072910 -- 144,094,330(+) GAAAG(C/G/T)CACTT upstream-variant-2KB
rs1001566843 -- 144,094,376(+) TCATG(A/G)CCCCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR2A12 Gene

Variant ID Type Subtype PubMed ID
dgv11664n54 CNV gain 21841781
dgv6725n100 CNV gain 25217958
dgv842n27 CNV gain 19166990
esv1682998 OTHER inversion 17803354
esv2752147 CNV gain 17911159
esv2759570 CNV gain+loss 17122850
esv3615317 CNV loss 21293372
esv3891223 CNV loss 25118596
esv3891224 CNV loss 25118596
nsv1016831 CNV gain 25217958
nsv1032320 CNV gain 25217958
nsv428188 CNV gain+loss 18775914
nsv522225 CNV gain 19592680
nsv608682 CNV gain 21841781
nsv608699 CNV gain 21841781
nsv8227 CNV gain+loss 18304495
nsv831173 CNV gain 17160897
nsv831174 CNV loss 17160897

Variation tolerance for OR2A12 Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2A12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2A12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2A12 Gene

Disorders for OR2A12 Gene

Relevant External Links for OR2A12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2A12

No disorders were found for OR2A12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2A12 Gene

Publications for OR2A12 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. Population differences in the human functional olfactory repertoire. (PMID: 12644552) Gilad Y. … Lancet D. (Mol. Biol. Evol. 2003) 3 64
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 64
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR2A12 Gene

Sources for OR2A12 Gene

Content
Loading form....