Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR2A1 Gene

Aliases for OR2A1 Gene

  • Olfactory Receptor, Family 2, Subfamily A, Member 1 2 3
  • Olfactory Receptor OR7-16 4
  • Olfactory Receptor OR7-19 4
  • OR2A1 OR2A42 4

External Ids for OR2A1 Gene

Summaries for OR2A1 Gene

Entrez Gene Summary for OR2A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2A1 Gene

OR2A1 (Olfactory Receptor, Family 2, Subfamily A, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. An important paralog of this gene is OR2A42.

UniProtKB/Swiss-Prot for OR2A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR2A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2A1 Gene

Genomics for OR2A1 Gene

Genomic Location for OR2A1 Gene

Start:
144,311,946 bp from pter
End:
144,320,465 bp from pter
Size:
8,520 bases
Orientation:
Plus strand

Genomic View for OR2A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR2A1 Gene

Regulatory Elements for OR2A1 Gene

Proteins for OR2A1 Gene

  • Protein details for OR2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGT9-OR2A1_HUMAN
    Recommended name:
    Olfactory receptor 2A1/2A42
    Protein Accession:
    Q8NGT9
    Secondary Accessions:
    • Q6IF44
    • Q96R46

    Protein attributes for OR2A1 Gene

    Size:
    310 amino acids
    Molecular mass:
    34714 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05915.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR2A1 Gene

Proteomics data for OR2A1 Gene at MOPED

Post-translational modifications for OR2A1 Gene

Other Protein References for OR2A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR2A1 Gene

Domains for OR2A1 Gene

Gene Families for OR2A1 Gene

HGNC:
  • OR2 :GPCR / Class A : Olfactory receptors

Protein Domains for OR2A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NGT9

UniProtKB/Swiss-Prot:

OR2A1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGT9
genes like me logo Genes that share domains with OR2A1: view

No data available for Suggested Antigen Peptide Sequences for OR2A1 Gene

Function for OR2A1 Gene

Molecular function for OR2A1 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2A1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR2A1 Gene

Localization for OR2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR2A1 Gene COMPARTMENTS Subcellular localization image for OR2A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2A1: view

Pathways for OR2A1 Gene

genes like me logo Genes that share pathways with OR2A1: view

Pathways by source for OR2A1 Gene

Interacting Proteins for OR2A1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000386175%0d%0a9606.ENSP00000334051%0d%0a9606.ENSP00000269260%0d%0a9606.ENSP00000317578%0d%0a
Selected Interacting proteins: ENSP00000386175 for OR2A1 Gene via STRING

Gene Ontology (GO) - Biological Process for OR2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2A1: view

Transcripts for OR2A1 Gene

mRNA/cDNA for OR2A1 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR2A1 Gene

Olfactory receptor, family 2, subfamily A, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR2A1 Gene

No ASD Table

Relevant External Links for OR2A1 Gene

GeneLoc Exon Structure for
OR2A1
ECgene alternative splicing isoforms for
OR2A1

Expression for OR2A1 Gene

mRNA expression in normal human tissues for OR2A1 Gene

mRNA differential expression in normal tissues according to GTEx for OR2A1 Gene

This gene is overexpressed in Thyroid (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR2A1 Gene

SOURCE GeneReport for Unigene cluster for OR2A1 Gene Hs.528398

genes like me logo Genes that share expressions with OR2A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR2A1 Gene

Orthologs for OR2A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
LOC744895 35
  • 98.28 (n)
  • 97.1 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 47 (a)
ManyToMany
LOC504233 35
  • 84.25 (n)
  • 77.35 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 80 (a)
ManyToMany
OR08A11 35
  • 85.59 (n)
  • 83.55 (a)
OR08A11 36
  • 83 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr434 36
  • 77 (a)
ManyToMany
Olfr435 35
  • 79.46 (n)
  • 77.74 (a)
Olfr435 36
  • 77 (a)
ManyToMany
Olfr47 36
  • 76 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr819 35
  • 77.63 (n)
  • 75.81 (a)
Species with no ortholog for OR2A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2A1 Gene

ENSEMBL:
Gene Tree for OR2A1 (if available)
TreeFam:
Gene Tree for OR2A1 (if available)

Paralogs for OR2A1 Gene

Selected SIMAP similar genes for OR2A1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with OR2A1: view

Variants for OR2A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR2A1 Gene

Variant ID Type Subtype PubMed ID
nsv428188 CNV Gain+Loss 18775914
dgv2148e1 CNV Complex 17122850
nsv8227 CNV Gain+Loss 18304495
esv1682998 OTHER Inversion 17803354
dgv7520n71 CNV Gain 21882294
dgv2149e1 CNV Complex 17122850
dgv2150e1 CNV Complex 17122850
essv3984 CNV CNV 17122850
nsv7411 OTHER Inversion 18451855
dgv7522n71 CNV Gain 21882294
dgv7523n71 CNV Gain 21882294
dgv7524n71 CNV Gain+Loss 21882294
esv1003295 OTHER Inversion 20482838
dgv7525n71 CNV Loss 21882294
nsv821609 CNV Duplication 20802225
nsv824360 CNV Gain 20364138
dgv24n31 CNV Duplication 19718026
nsv819701 CNV Insertion 19587683
esv24292 CNV Gain+Loss 19812545
nsv831175 CNV Loss 17160897
esv33253 CNV Gain 17666407
nsv515040 CNV Complex 21397061
nsv433394 CNV Gain 18776910
nsv508489 CNV Loss 20534489
nsv469769 CNV Complex 16826518
nsv471646 CNV Gain+Loss 15918152
dgv7526n71 CNV Gain 21882294
dgv7527n71 CNV Loss 21882294
nsv889373 CNV Loss 21882294
nsv471455 CNV Duplication 19718026

Relevant External Links for OR2A1 Gene

HapMap Linkage Disequilibrium report
OR2A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for OR2A1 Gene

Disorders for OR2A1 Gene

No disorders were found for OR2A1 Gene.

No data available for UniProtKB/Swiss-Prot for OR2A1 Gene

Publications for OR2A1 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3

Products for OR2A1 Gene

Sources for OR2A1 Gene

Back to Top

Content