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OR1S2 Gene

protein-coding   GIFtS: 45
GCID: GC11M057970

Olfactory Receptor, Family 1, Subfamily S, Member 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 1, Subfamily S, Member 21 2
Olfactory Receptor OR11-2312 3
OR11-2312
Olfactory Receptor 1S22

External Ids:    HGNC: 151411   Entrez Gene: 2199582   Ensembl: ENSG000001978877   UniProtKB: Q8NGQ33   

Export aliases for OR1S2 gene to outside databases

Previous GC identifers: GC11U990572 GC11M057748 GC11M057727


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR1S2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR1S2 Gene:
OR1S2 (olfactory receptor, family 1, subfamily S, member 2) is a protein-coding gene. Diseases associated with OR1S2 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1F1.

UniProtKB/Swiss-Prot: OR1S2_HUMAN, Q8NGQ3
Function: Odorant receptor (Potential)

Gene Wiki entry for OR1S2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR1S2 gene promoter:
         c-Fos   AP-1   FOXJ2 (long isoform)   Sox9   FOXJ2   GATA-1   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OR1S2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR1S2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

OR1S2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR1S2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057970:  view genomic region     (about GC identifiers)

Start:
57,970,679 bp from pter      End:
57,971,614 bp from pter
Size:
936 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OR1S2_HUMAN, Q8NGQ3 (See protein sequence)
Recommended Name: Olfactory receptor 1S2  
Size: 325 amino acids; 36579 Da
Caution: It is uncertain whether Met-1 or Met-14 is the initiator
Sequence caution: Sequence=BAC05957.1; Type=Erroneous initiation;
Secondary accessions: Q6IFG5 Q96R85

Explore the universe of human proteins at neXtProt for OR1S2: NX_Q8NGQ3

Explore proteomics data for OR1S2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn18
  • Modification sites at PhosphoSitePlus
  • HORDE protein sequence for OR1S2

    See OR1S2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004459.1  
    ENSEMBL proteins: 
     ENSP00000305469  
    Reactome Protein details: Q8NGQ3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR1: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGQ3

    ProtoNet protein and cluster: Q8NGQ3

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR1S2_HUMAN, Q8NGQ3
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR1S2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR1S2_HUMAN, Q8NGQ3
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR1S2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OR1S2:
     Synthetic lethal with c-Myc af 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR1S2_HUMAN, Q8NGQ3: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR1S2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR1S2 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR1S2
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR1S2):
        Olfactory transduction


    OR1S2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR1S2
    Interactions:

        Search GeneGlobe Interaction Network for OR1S2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for OR1S2 (ENSP000003054694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRBK2ENSP000003175784STRING: ENSP00000317578
    ARRB2ENSP000002692604STRING: ENSP00000269260
    GNALENSP000003340514STRING: ENSP00000334051
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR1S2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR1S2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR1S2 gene: 
    NM_001004459.1  

    Unigene Cluster for OR1S2:

    Olfactory receptor, family 1, subfamily S, member 2
    Hs.553644
    Unigene Representative Sequence: NM_001004459
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302592(uc010rkb.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR1S2

    1 AceView cDNA sequence:

    NM_001004459 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR1S2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAACCCCT
    OR1S2 Expression
    About this image

    OR1S2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR1S2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553644
        Custom PCR Arrays for OR1S2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    ENSEMBL Gene Tree for OR1S2 (if available)
    TreeFam Gene Tree for OR1S2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR1S2 gene
    OR1F12  OR1I12  OR1N12  OR1J42  OR1E22  OR1N22  OR1S12  OR1J22  
    OR1E12  OR1C12  OR1M12  OR1G12  OR1J12  
    Selected SIMAP similar genes for OR1S2 using alignment to 1 protein entry:     OR1S2_HUMAN(see all similar genes):
    OR1S1    OR1J4    OR1M1    OR7D4    OR1C1    OR1F1
    OR1J1    OR1J2    OR1P1    OR1E1    OR1F12    OR1F2P
    OR1L8    OR1N1    OR1N2    OR7A10    OR7A17    OR7A2P

    OR1S2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OR1S2
    PGOHUM00000240999


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR1S2 (see all 148)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1917228561,2
    --57970212(+) TTAGGA/GGATTA 1 -- ds50010--------
    rs1838928051,2
    --57970481(+) TTGTGA/TCTTAC 1 -- ds50010--------
    rs1882505341,2
    --57970583(+) AGTTCA/GTCAAA 1 -- ds50010--------
    rs1807161001,2
    C--57970598(+) GAACCA/GTCACA 1 -- ds50010--------
    rs1871946511,2
    --57970610(+) CTGTGC/TCATAC 1 -- ds50010--------
    rs1135496621,2
    F--57970616(+) CATACG/ACTCTG 1 -- ds50011Minor allele frequency- A:0.50CSA 4
    rs3741380041,2
    C--57970665(+) GTAGAG/TGTCCA 1 -- ds50010--------
    rs1817929161,2
    --57970679(+) CATCAA/GAGGGA 2 L syn10--------
    rs1505313141,2
    C--57970749(+) TGTAGA/TTGAAG 2 N I mis11Minor allele frequency- T:0.00NA 4552
    rs1500349331,2
    C,F--57970768(+) CATGGG/ATGTCA 2 /P /S mis11Minor allele frequency- A:0.00NA 4552

    HapMap Linkage Disequilibrium report for OR1S2 ( 57970679 - 57971614 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for OR1S2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv222n67CNV Loss20364138
    nsv825916CNV Gain20364138
    nsv832165CNV Gain17160897
    nsv897589CNV Gain21882294
    nsv832166CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR1S2:    
    About MalaCards
    neuronitis


    OR1S2 for disorders           About GeneDecksing


    Export disorders for OR1S2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR1S2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR1S2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    3. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 219958 HGNC: 15141 AceView: OR1S2 Ensembl:ENSG00000197887 euGenes: HUgn219958
    ECgene: OR1S2 Kegg: 219958 H-InvDB: OR1S2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR1S2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR1S2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR1S2 gene:
    Search GeneIP for patents involving OR1S2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Search ThermoFisher Antibodies for OR1S2
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR1S2
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