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Aliases for OR1S1 Gene

Aliases for OR1S1 Gene

  • Olfactory Receptor, Family 1, Subfamily S, Member 1 (Gene/Pseudogene) 2 3
  • Olfactory Receptor OR11-232 3 4
  • Olfactory Receptor 1S1 3
  • OR11-232 3
  • OST034 3

External Ids for OR1S1 Gene

Previous GeneCards Identifiers for OR1S1 Gene

  • GC11U990239
  • GC11P057758
  • GC11P057738
  • GC11P057982

Summaries for OR1S1 Gene

Entrez Gene Summary for OR1S1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1S1 Gene

OR1S1 (Olfactory Receptor, Family 1, Subfamily S, Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1E2.

UniProtKB/Swiss-Prot for OR1S1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1S1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1S1 Gene

Genomics for OR1S1 Gene

Regulatory Elements for OR1S1 Gene

Genomic Location for OR1S1 Gene

Start:
58,214,745 bp from pter
End:
58,215,722 bp from pter
Size:
978 bases
Orientation:
Plus strand

Genomic View for OR1S1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR1S1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1S1 Gene

Proteins for OR1S1 Gene

  • Protein details for OR1S1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH92-OR1S1_HUMAN
    Recommended name:
    Olfactory receptor 1S1
    Protein Accession:
    Q8NH92
    Secondary Accessions:
    • Q6IFG3

    Protein attributes for OR1S1 Gene

    Size:
    325 amino acids
    Molecular mass:
    36707 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05745.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR1S1 Gene

Proteomics data for OR1S1 Gene at MOPED

Post-translational modifications for OR1S1 Gene

  • Glycosylation at Asn18
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1S1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1S1 Gene

Domains for OR1S1 Gene

Gene Families for OR1S1 Gene

HGNC:
  • OR1 :GPCR / Class A : Olfactory receptors

Protein Domains for OR1S1 Gene

Suggested Antigen Peptide Sequences for OR1S1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH92

UniProtKB/Swiss-Prot:

OR1S1_HUMAN :
  • Q8NH92
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1S1: view

Function for OR1S1 Gene

Molecular function for OR1S1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR1S1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR1S1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR1S1 Gene

Localization for OR1S1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1S1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR1S1 Gene COMPARTMENTS Subcellular localization image for OR1S1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1S1: view

Pathways for OR1S1 Gene

genes like me logo Genes that share pathways with OR1S1: view

Pathways by source for OR1S1 Gene

Interacting Proteins for OR1S1 Gene

Gene Ontology (GO) - Biological Process for OR1S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1S1: view

Transcripts for OR1S1 Gene

mRNA/cDNA for OR1S1 Gene

(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR1S1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1S1 Gene

No ASD Table

Relevant External Links for OR1S1 Gene

GeneLoc Exon Structure for
OR1S1
ECgene alternative splicing isoforms for
OR1S1

Expression for OR1S1 Gene

mRNA expression in normal human tissues for OR1S1 Gene

SOURCE GeneReport for Unigene cluster for OR1S1 Gene Hs.553645

genes like me logo Genes that share expressions with OR1S1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for OR1S1 Gene

Orthologs for OR1S1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1S1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC615941 35
  • 81.82 (n)
  • 75 (a)
-- 36
  • 74 (a)
ManyToMany
-- 36
  • 74 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr1496 35
  • 82.96 (n)
  • 80.58 (a)
Olfr1496 16
Olfr1496 36
  • 79 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC466598 35
  • 98.87 (n)
  • 97.54 (a)
OR1S1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr376 35
  • 81.6 (n)
  • 77.92 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 51 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
OneToMany
Species with no ortholog for OR1S1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1S1 Gene

ENSEMBL:
Gene Tree for OR1S1 (if available)
TreeFam:
Gene Tree for OR1S1 (if available)

Paralogs for OR1S1 Gene

Selected SIMAP similar genes for OR1S1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1S1: view

Variants for OR1S1 Gene

Sequence variations from dbSNP and Humsavar for OR1S1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1817072 -- 58,214,562(-) AAAAA(C/G)TGTTT upstream-variant-2KB
rs1966834 - 58,215,148(-) CAAAG(C/T)GGTCA reference, missense
rs1966835 - 58,215,112(-) TGTCA(A/G)TGACG missense, reference
rs1966836 - 58,214,757(-) GGAAC(C/T)AAAAG reference, missense
rs1966837 -- 58,214,534(-) CTGAA(G/T)GTGAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1S1 Gene

Variant ID Type Subtype PubMed ID
nsv897589 CNV Gain 21882294
nsv832165 CNV Gain 17160897
nsv832166 CNV Gain+Loss 17160897
nsv825916 CNV Gain 20364138
dgv222n67 CNV Loss 20364138

Relevant External Links for OR1S1 Gene

HapMap Linkage Disequilibrium report
OR1S1
Human Gene Mutation Database (HGMD)
OR1S1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1S1 Gene

Disorders for OR1S1 Gene

No disorders were found for OR1S1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR1S1 Gene

Publications for OR1S1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4

Products for OR1S1 Gene

Sources for OR1S1 Gene

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