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Aliases for OR1S1 Gene

Aliases for OR1S1 Gene

  • Olfactory Receptor Family 1 Subfamily S Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor OR11-232 3 4
  • Olfactory Receptor, Family 1, Subfamily S, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 1, Subfamily S, Member 1 3
  • Olfactory Receptor 1S1 3
  • OR11-232 3
  • OST034 3

External Ids for OR1S1 Gene

Previous GeneCards Identifiers for OR1S1 Gene

  • GC11U990239
  • GC11P057758
  • GC11P057738
  • GC11P057982

Summaries for OR1S1 Gene

Entrez Gene Summary for OR1S1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR1S1 Gene

OR1S1 (Olfactory Receptor Family 1 Subfamily S Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR1S2.

UniProtKB/Swiss-Prot for OR1S1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1S1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1S1 Gene

Genomics for OR1S1 Gene

Regulatory Elements for OR1S1 Gene

Enhancers for OR1S1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G058632 0.3 FANTOM5 11.9 +417.5 417496 0.1 OR5B12 OR1S1 OR5B3 OR10W1 OR10Q1 OR5B2 OR9Q2 OR1S2 ENSG00000280010 ENSG00000197254
GH11G057946 0.4 FANTOM5 6.6 -268.3 -268311 0.0 RFX1 OR10W1 OR10Q1 OR9Q2 OR5B2 OR9Q1 OR5B12 MED19 OR5B3 OR1S1 OR9I1
GH11G058033 0.3 FANTOM5 2.3 -180.8 -180783 0.3 OR6Q1 OR1S1 OR5B12 OR9I1 ENSG00000255146
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR1S1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR1S1 Gene

58,214,745 bp from pter
58,215,723 bp from pter
979 bases
Plus strand

Genomic View for OR1S1 Gene

Genes around OR1S1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1S1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1S1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1S1 Gene

Proteins for OR1S1 Gene

  • Protein details for OR1S1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 1S1
    Protein Accession:
    Secondary Accessions:
    • Q6IFG3

    Protein attributes for OR1S1 Gene

    325 amino acids
    Molecular mass:
    36707 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05745.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR1S1 Gene

Post-translational modifications for OR1S1 Gene

  • Glycosylation at Asn18
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1S1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1S1 Gene

Domains & Families for OR1S1 Gene

Gene Families for OR1S1 Gene

Protein Domains for OR1S1 Gene

Suggested Antigen Peptide Sequences for OR1S1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1S1: view

Function for OR1S1 Gene

Molecular function for OR1S1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR1S1: view
genes like me logo Genes that share phenotypes with OR1S1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1S1 Gene

Localization for OR1S1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1S1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1S1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1S1: view

Pathways & Interactions for OR1S1 Gene

genes like me logo Genes that share pathways with OR1S1: view

Pathways by source for OR1S1 Gene

Interacting Proteins for OR1S1 Gene

Gene Ontology (GO) - Biological Process for OR1S1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR1S1: view

No data available for SIGNOR curated interactions for OR1S1 Gene

Drugs & Compounds for OR1S1 Gene

No Compound Related Data Available

Transcripts for OR1S1 Gene

mRNA/cDNA for OR1S1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1S1 Gene

No ASD Table

Relevant External Links for OR1S1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR1S1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1S1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR1S1 Gene:


SOURCE GeneReport for Unigene cluster for OR1S1 Gene:

genes like me logo Genes that share expression patterns with OR1S1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1S1 Gene

Orthologs for OR1S1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1S1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466598 34
  • 98.87 (n)
(Mus musculus)
Mammalia Olfr1496 34 16
  • 82.96 (n)
Or1ad7-ps 55 Olfr1379-ps1
  • chr11:50,959,027-50,959,930
Or1ad8 55 Olfr51
  • chr11:51,006,974-51,007,894
(Bos Taurus)
Mammalia LOC615941 34
  • 81.82 (n)
(Rattus norvegicus)
Mammalia Olr376 34
  • 81.6 (n)
Species where no ortholog for OR1S1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1S1 Gene

Gene Tree for OR1S1 (if available)
Gene Tree for OR1S1 (if available)

Paralogs for OR1S1 Gene

(453) SIMAP similar genes for OR1S1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1S1: view

Variants for OR1S1 Gene

Sequence variations from dbSNP and Humsavar for OR1S1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1003200946 -- 58,214,292(+) GGTGT(A/T)CACTG upstream-variant-2KB
rs1003724980 -- 58,214,130(+) ACAGA(A/C)GTCTT upstream-variant-2KB
rs1006058750 -- 58,215,001(+) TTCCT(C/T)CATTT reference, missense
rs1007684643 -- 58,214,728(+) TGTTA(G/T)GTTTT upstream-variant-2KB
rs1008945484 -- 58,213,747(+) TGAGA(C/T)CATTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1S1 Gene

Variant ID Type Subtype PubMed ID
dgv222n67 CNV loss 20364138
nsv825916 CNV gain 20364138
nsv832165 CNV gain 17160897
nsv832166 CNV gain+loss 17160897
nsv972033 CNV duplication 23825009

Variation tolerance for OR1S1 Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.07; 92.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1S1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1S1 Gene

Disorders for OR1S1 Gene

Relevant External Links for OR1S1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR1S1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1S1 Gene

Publications for OR1S1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T. … Lancet D. (BMC Genomics 2012) 3 64
  3. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I. … Lancet D. (BMC Bioinformatics 2006) 3 64

Products for OR1S1 Gene

Sources for OR1S1 Gene

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