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OR1Q1 Gene

protein-coding   GIFtS: 46
GCID: GC09P125376

Olfactory Receptor, Family 1, Subfamily Q, Member 1


(Previous symbols: OR1Q2, OR1Q3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 1, Subfamily Q, Member 11 2     OST2262 3
OR1Q21 2 3     HSTPCR1062
OR1Q31 2 3     OR9-252
Olfactory Receptor 1Q22 3     OST226OR9-A2
Olfactory Receptor 1Q32 3     TPCR1062
Olfactory Receptor 9-A2 3     Olfactory Receptor 1Q12
Olfactory Receptor OR9-252 3     Olfactory Receptor, Family 1, Subfamily Q, Member 22
Olfactory Receptor TPCR1062 3     Olfactory Receptor, Family 1, Subfamily Q, Member 32
OR9-A2 3     

External Ids:    HGNC: 82231   Entrez Gene: 1581312   Ensembl: ENSG000001652027   UniProtKB: Q156123   

Export aliases for OR1Q1 gene to outside databases

Previous GC identifers: GC09U990112 GC09M117023 GC09P118830 GC09P120753 GC09P120749 GC09P122456 GC09P124416


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR1Q1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR1Q1 Gene:
OR1Q1 (olfactory receptor, family 1, subfamily Q, member 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1L4.

UniProtKB/Swiss-Prot: OR1Q1_HUMAN, Q15612
Function: Odorant receptor (Potential)

Gene Wiki entry for OR1Q1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the OR1Q1 gene promoter:
         HOXA9B   HOXA9   Tal-1   AML1a   E47   CREB   COMP1   deltaCREB   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR1Q1 promoter sequence
   Search Chromatin IP Primers for OR1Q1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR1Q1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.2   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q33.2

OR1Q1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR1Q1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P125376:  view genomic region     (about GC identifiers)

Start:
125,377,017 bp from pter      End:
125,377,958 bp from pter
Size:
942 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR1Q1_HUMAN, Q15612 (See protein sequence)
Recommended Name: Olfactory receptor 1Q1  
Size: 314 amino acids; 35598 Da
Secondary accessions: Q6IFN4 Q8NGR7 Q96R82

Explore the universe of human proteins at neXtProt for OR1Q1: NX_Q15612

Explore proteomics data for OR1Q1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR1Q1

    See OR1Q1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036496.1  
    ENSEMBL proteins: 
     ENSP00000297913  
    Reactome Protein details: Q15612

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR1: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q15612

    ProtoNet protein and cluster: Q15612

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR1Q1_HUMAN, Q15612
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR1Q1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR1Q1_HUMAN, Q15612
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity NAS9119360
         
    Find genes that share ontologies with OR1Q1           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR1Q1_HUMAN, Q15612: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane NAS9119360

    Find genes that share ontologies with OR1Q1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR1Q1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43


    Find genes that share SuperPaths with OR1Q1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR1Q1
        GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR1Q1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR1Q1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR1Q1
    Interactions:

        Search GeneGlobe Interaction Network for OR1Q1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR1Q1 (ENSP000002979134) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR1B1ENSP000003031514STRING: ENSP00000303151
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    OR10A3ENSP000003539884STRING: ENSP00000353988
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007608sensory perception of smell NAS9119360
    GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS9119360

    Find genes that share ontologies with OR1Q1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR1Q1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR1Q1 gene: 
    NM_012364.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000297913(uc011lyy.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR1Q1

    5 AceView cDNA sequences:

    NM_012364 AI827216 X89667 AI470655 BI830485 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR1Q1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR1Q1 Expression
    About this image

    OR1Q1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR1Q1 Protein Expression
        Custom PCR Arrays for OR1Q1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR1Q1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr3571 , 5 olfactory receptor 3571, 5 82.25(n)1
    81.49(a)1
      2 (24.19 cM)5
    2586161  NM_146623.11  NP_666834.11 
     369968125 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    49(a)
    47(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343252.1(223169-224982)
    GL343252.1(213816-214766)


    ENSEMBL Gene Tree for OR1Q1 (if available)
    TreeFam Gene Tree for OR1Q1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR1Q1 gene
    OR1L42  OR1L32  OR1L12  OR1L82  OR1K12  OR1L62  OR1A12  OR1D22  
    OR1A22  OR1D52  
    Selected SIMAP similar genes for OR1Q1 using alignment to 2 protein entries:     OR1Q1_HUMAN (see all proteins) (see all similar genes):
    OR16-36    OR16-37    OR16-88    OR16-89    OR16-90    OR1L3
    OR1D2    OR1F1    OR1L8    HSA12    OR1D4    OR1F12
    OR1L1    OR1L4    OR1L6    OR5M3    FKSG35    OR1A1

    Find genes that share paralogs with OR1Q1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR1Q1 (see all 116)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1834228541,2
    --125375034(+) TCACAA/GTAGAG 1 -- us2k10--------
    rs1877895411,2
    --125375035(+) CACAGC/TAGAGA 1 -- us2k10--------
    rs1907074851,2
    --125375067(+) GAGACA/GCTATG 1 -- us2k10--------
    rs1379569871,2
    --125375225(+) GCTGGG/TCTTTT 1 -- us2k10--------
    rs1434239541,2
    --125375318(+) AGGACC/TAACCT 1 -- us2k10--------
    rs1169151301,2
    C,F--125375321(+) ACCAAC/TCTCAT 1 -- us2k11Minor allele frequency- T:0.05EA 120
    rs108187301,2
    A--125375328(+) TCATTC/TTGCGA 1 -- us2k10--------
    rs766508081,2
    --125375331(+) TTCTGC/TGAGAC 1 -- us2k10--------
    rs665832601,2
    C--125375373(+) CTGTA-/A/AAAA
            
    AAAAA
    1 -- us2k11NA 2
    rs48369011,2
    C,F,A,H--125375428(+) AAAGCA/GTTCAA 1 -- us2k133Minor allele frequency- G:0.32NS EA NA WA CSA 2979

    HapMap Linkage Disequilibrium report for OR1Q1 ( 125377017 - 125377958 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OR1Q1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893823CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for OR1Q1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR1Q1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR1Q1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    3. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PubMed id 9119360)1, 2 Vanderhaeghen P.... Parmentier M. (Genomics 1997)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 158131 HGNC: 8223 AceView: OR1Q1 Ensembl:ENSG00000165202 euGenes: HUgn158131
    ECgene: OR1Q1 Kegg: 158131 H-InvDB: OR1Q1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR1Q1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR1Q1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR1Q1 gene:
    Search GeneIP for patents involving OR1Q1

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OR1Q1  
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     QuantiFast Probe-based Assays in human, mouse, rat OR1Q1 QuantiTect SYBR Green Assays in human, mouse, rat OR1Q1
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     Browse ESI BIO Cell Lines and PureStem Progenitors for OR1Q1
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     Search Addgene for plasmids for OR1Q1
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      eBioscience FlowRNA Probe Sets
           
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