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Aliases for OR1N2 Gene

Aliases for OR1N2 Gene

  • Olfactory Receptor, Family 1, Subfamily N, Member 2 2 3
  • Olfactory Receptor OR9-23 3 4
  • Olfactory Receptor 1N2 3
  • OR9-23 3

External Ids for OR1N2 Gene

Previous GeneCards Identifiers for OR1N2 Gene

  • GC09U990174
  • GC09P120692
  • GC09P122397
  • GC09P124355
  • GC09P125315

Summaries for OR1N2 Gene

Entrez Gene Summary for OR1N2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1N2 Gene

OR1N2 (Olfactory Receptor, Family 1, Subfamily N, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1E2.

UniProtKB/Swiss-Prot for OR1N2 Gene

  • Odorant receptor.

Gene Wiki entry for OR1N2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1N2 Gene

Genomics for OR1N2 Gene

Regulatory Elements for OR1N2 Gene

Genomic Location for OR1N2 Gene

Start:
122,553,112 bp from pter
End:
122,555,173 bp from pter
Size:
2,062 bases
Orientation:
Plus strand

Genomic View for OR1N2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR1N2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1N2 Gene

Proteins for OR1N2 Gene

  • Protein details for OR1N2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGR9-OR1N2_HUMAN
    Recommended name:
    Olfactory receptor 1N2
    Protein Accession:
    Q8NGR9
    Secondary Accessions:
    • A3KFM2
    • B2RNY4
    • Q6IF17
    • Q96RA3

    Protein attributes for OR1N2 Gene

    Size:
    330 amino acids
    Molecular mass:
    36889 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05941.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAM45738.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR1N2 Gene

Proteomics data for OR1N2 Gene at MOPED

Post-translational modifications for OR1N2 Gene

  • Glycosylation at Asn22
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1N2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1N2 Gene

Domains for OR1N2 Gene

Gene Families for OR1N2 Gene

HGNC:
  • OR1 :GPCR / Class A : Olfactory receptors

Protein Domains for OR1N2 Gene

Suggested Antigen Peptide Sequences for OR1N2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGR9

UniProtKB/Swiss-Prot:

OR1N2_HUMAN :
  • Q8NGR9
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1N2: view

Function for OR1N2 Gene

Molecular function for OR1N2 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR1N2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR1N2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR1N2 Gene

Localization for OR1N2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1N2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR1N2 Gene COMPARTMENTS Subcellular localization image for OR1N2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1N2: view

Pathways for OR1N2 Gene

genes like me logo Genes that share pathways with OR1N2: view

Pathways by source for OR1N2 Gene

Interacting Proteins for OR1N2 Gene

Gene Ontology (GO) - Biological Process for OR1N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1N2: view

Transcripts for OR1N2 Gene

mRNA/cDNA for OR1N2 Gene

(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1N2 Gene

Olfactory receptor, family 1, subfamily N, member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR1N2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR1N2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1N2 Gene

No ASD Table

Relevant External Links for OR1N2 Gene

GeneLoc Exon Structure for
OR1N2
ECgene alternative splicing isoforms for
OR1N2

Expression for OR1N2 Gene

mRNA expression in normal human tissues for OR1N2 Gene

SOURCE GeneReport for Unigene cluster for OR1N2 Gene Hs.632682

genes like me logo Genes that share expressions with OR1N2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR1N2 Gene

Orthologs for OR1N2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1N2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473043 35
  • 98.89 (n)
  • 98.48 (a)
OR1N2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC510570 35
  • 88.71 (n)
  • 87.34 (a)
OR1N2 36
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR08C09 36
  • 58 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr354 35
  • 86.08 (n)
  • 88.29 (a)
Olfr354 16
Olfr354 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OPOR49 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OR1N2 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr417 35
  • 85.13 (n)
  • 86.71 (a)
Species with no ortholog for OR1N2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1N2 Gene

ENSEMBL:
Gene Tree for OR1N2 (if available)
TreeFam:
Gene Tree for OR1N2 (if available)

Paralogs for OR1N2 Gene

Selected SIMAP similar genes for OR1N2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1N2: view

Variants for OR1N2 Gene

Sequence variations from dbSNP and Humsavar for OR1N2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1104907 -- 122,551,292(-) GAGAG(A/G)GTGGA upstream-variant-2KB
rs1341042 -- 122,553,754(+) TTCTA(C/T)TGTGA synonymous-codon, reference
rs1341043 -- 122,553,763(+) GATCC(C/T)AGTGC synonymous-codon, reference
rs1341044 - 122,553,900(+) GTTTG(G/T)CATCT missense, reference
rs1411270 -- 122,553,139(+) TATCT(C/G)TAAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1N2 Gene

Variant ID Type Subtype PubMed ID
nsv893822 CNV Gain 21882294
nsv893823 CNV Loss 21882294
nsv893824 CNV Loss 21882294
esv2659552 CNV Deletion 23128226
esv22700 CNV Loss 19812545

Relevant External Links for OR1N2 Gene

HapMap Linkage Disequilibrium report
OR1N2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1N2 Gene

Disorders for OR1N2 Gene

Relevant External Links for OR1N2

Genetic Association Database (GAD)
OR1N2
Human Genome Epidemiology (HuGE) Navigator
OR1N2
genes like me logo Genes that share disorders with OR1N2: view

No data available for UniProtKB/Swiss-Prot for OR1N2 Gene

Publications for OR1N2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A. … Vieira A.R. (Am. J. Med. Genet. A 2010) 3 48
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4

Products for OR1N2 Gene

Sources for OR1N2 Gene

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