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Aliases for OR1N1 Gene

Aliases for OR1N1 Gene

  • Olfactory Receptor Family 1 Subfamily N Member 1 2 3 5
  • Olfactory Receptor OR9-22 3 4
  • Olfactory Receptor 1-26 3 4
  • Olfactory Receptor 1N3 3 4
  • OR1-26 3 4
  • OR1N3 3 4
  • Olfactory Receptor, Family 1, Subfamily N, Member 1 2
  • Olfactory Receptor, Family 1, Subfamily N, Member 3 3
  • Olfactory Receptor 1N1 3
  • OR9-22 3

External Ids for OR1N1 Gene

Previous HGNC Symbols for OR1N1 Gene

  • OR1N3

Previous GeneCards Identifiers for OR1N1 Gene

  • GC01U990262
  • GC09M120664
  • GC09M122368
  • GC09M124328
  • GC09M125288

Summaries for OR1N1 Gene

Entrez Gene Summary for OR1N1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1N1 Gene

OR1N1 (Olfactory Receptor Family 1 Subfamily N Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is OR1N2.

UniProtKB/Swiss-Prot for OR1N1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1N1 Gene

Additional gene information for OR1N1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1N1 Gene

Genomics for OR1N1 Gene

Regulatory Elements for OR1N1 Gene

Enhancers for OR1N1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H122463 1.2 Ensembl ENCODE 10.6 +62.5 62490 1.9 PKNOX1 ARID4B BRCA1 ZNF2 ZNF143 ATF7 DEK JUNB REST MIER2 OR1Q1 OR1K1 OR1N1 OR1J4 PTGS1 OR5C1 RBM18 MRRF TTLL11 ENSG00000231465
GH09H122580 0.8 ENCODE 10.5 -53.2 -53241 0.2 TBL1XR1 JUN BACH1 CHAMP1 FOSL1 ZNF316 FOXK2 NCOR1 NFE2 FOS OR1N2 OR1B1 OR1N1 OR1J4 OR1J2 OR1K1 OR1Q1 OR1H1P
GH09H122499 0.7 ENCODE 10.8 +28.2 28220 0.1 CTCF TFAP4 ZNF654 PKNOX1 TRIM22 MAX REST RAD21 FOXA1 ZNF217 OR1J4 OR1N1 ENSG00000231465 OR1N2 OR5C1 PIR39690 OR1J1
GH09H122057 0.5 FANTOM5 dbSUPER 4.8 +470.0 470012 0.1 TTLL11 OR1N1 OR1N2 OR1J4 MRRF OR1J2 LHX6 DAB2IP TTLL11-IT1
GH09H122355 0.3 FANTOM5 4.8 +171.5 171542 0 OR1Q1 OR1L8 OR1J2 OR1B1 OR1L1 OR1N2 OR1J4 MRRF OR1L4 OR1K1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR1N1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OR1N1 Gene

Genomic Locations for OR1N1 Gene
939 bases
Minus strand

Genomic View for OR1N1 Gene

Genes around OR1N1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1N1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1N1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1N1 Gene

Proteins for OR1N1 Gene

  • Protein details for OR1N1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 1N1
    Protein Accession:
    Secondary Accessions:
    • A3KFM1
    • O43870
    • Q6IF16
    • Q96R93

    Protein attributes for OR1N1 Gene

    311 amino acids
    Molecular mass:
    34650 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1N1 Gene

Post-translational modifications for OR1N1 Gene

Other Protein References for OR1N1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1N1 Gene

Domains & Families for OR1N1 Gene

Gene Families for OR1N1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1N1 Gene

Suggested Antigen Peptide Sequences for OR1N1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1N1: view

Function for OR1N1 Gene

Molecular function for OR1N1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily N,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR1N1: view

Phenotypes for OR1N1 Gene

GenomeRNAi human phenotypes for OR1N1:
genes like me logo Genes that share phenotypes with OR1N1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1N1 Gene

Localization for OR1N1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1N1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1N1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with OR1N1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1N1 Gene

Pathways & Interactions for OR1N1 Gene

genes like me logo Genes that share pathways with OR1N1: view

Pathways by source for OR1N1 Gene

1 BioSystems pathway for OR1N1 Gene
1 KEGG pathway for OR1N1 Gene

Interacting Proteins for OR1N1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
Selected Interacting proteins: Q8NGS0-OR1N1_HUMAN ENSP00000306974 for OR1N1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for OR1N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA,IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR1N1: view

No data available for SIGNOR curated interactions for OR1N1 Gene

Drugs & Compounds for OR1N1 Gene

No Compound Related Data Available

Transcripts for OR1N1 Gene

mRNA/cDNA for OR1N1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1N1 Gene

No ASD Table

Relevant External Links for OR1N1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR1N1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1N1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1N1 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x6.9) and Testis (x6.0).

Protein differential expression in normal tissues from HIPED for OR1N1 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR1N1 Gene

Protein tissue co-expression partners for OR1N1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR1N1 Gene:


SOURCE GeneReport for Unigene cluster for OR1N1 Gene:

genes like me logo Genes that share expression patterns with OR1N1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1N1 Gene

Orthologs for OR1N1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1N1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC473042 33
  • 99.46 (n)
OR1N1 34
  • 99 (a)
(Bos Taurus)
Mammalia OR1N1 33 34
  • 85.85 (n)
(Rattus norvegicus)
Mammalia Olr414 33
  • 82.21 (n)
(Mus musculus)
Mammalia Or1n1 52 Olfr351 33 16 34
  • 81.72 (n)
Or1n1b 52 Olfr353 34
  • 79 (a)
Or1ah3 52 Olfr367
  • chr2:37,270,545-37,271,384
(Monodelphis domestica)
Mammalia -- 34
  • 66 (a)
-- 34
  • 64 (a)
(Canis familiaris)
Mammalia OR1P2 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 54 (a)
-- 34
  • 51 (a)
-- 34
  • 51 (a)
Species where no ortholog for OR1N1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1N1 Gene

Gene Tree for OR1N1 (if available)
Gene Tree for OR1N1 (if available)

Paralogs for OR1N1 Gene

(451) SIMAP similar genes for OR1N1 Gene using alignment to 1 proteins: Pseudogenes for OR1N1 Gene

genes like me logo Genes that share paralogs with OR1N1: view

Variants for OR1N1 Gene

Sequence variations from dbSNP and Humsavar for OR1N1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_036208 A breast cancer sample
rs201161748 Uncertain significance 122,526,441(+) AAAGG(A/G/T)GTTCA reference, missense
rs1000117179 -- 122,529,292(+) AAGAA(A/G)GGCTA upstream-variant-2KB
rs1001177590 -- 122,526,046(+) GAAAA(G/T)ATTTT downstream-variant-500B
rs1002191338 -- 122,528,200(+) ACAAC(A/G)AAATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1N1 Gene

Variant ID Type Subtype PubMed ID
esv3891726 CNV loss 25118596

Variation tolerance for OR1N1 Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.65; 82.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1N1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1N1 Gene

Disorders for OR1N1 Gene

Relevant External Links for OR1N1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR1N1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1N1 Gene

Publications for OR1N1 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S … Giorgi D (Nature genetics 1998) 2 3 4 60
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 60
  4. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 60
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 60

Products for OR1N1 Gene

Sources for OR1N1 Gene

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