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Aliases for OR1N1 Gene

Aliases for OR1N1 Gene

  • Olfactory Receptor, Family 1, Subfamily N, Member 1 2 3
  • Olfactory Receptor OR9-22 3 4
  • Olfactory Receptor 1-26 3 4
  • Olfactory Receptor 1N3 3 4
  • OR1-26 3 4
  • OR1N3 3 4
  • Olfactory Receptor, Family 1, Subfamily N, Member 3 3
  • Olfactory Receptor 1N1 3
  • OR9-22 3

External Ids for OR1N1 Gene

Previous HGNC Symbols for OR1N1 Gene

  • OR1N3

Previous GeneCards Identifiers for OR1N1 Gene

  • GC01U990262
  • GC09M120664
  • GC09M122368
  • GC09M124328
  • GC09M125288

Summaries for OR1N1 Gene

Entrez Gene Summary for OR1N1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1N1 Gene

OR1N1 (Olfactory Receptor, Family 1, Subfamily N, Member 1) is a Protein Coding gene. Diseases associated with OR1N1 include colorectal cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1E2.

UniProtKB/Swiss-Prot for OR1N1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1N1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1N1 Gene

Genomics for OR1N1 Gene

Regulatory Elements for OR1N1 Gene

Genomic Location for OR1N1 Gene

Start:
122,526,358 bp from pter
End:
122,527,296 bp from pter
Size:
939 bases
Orientation:
Minus strand

Genomic View for OR1N1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR1N1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1N1 Gene

Proteins for OR1N1 Gene

  • Protein details for OR1N1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGS0-OR1N1_HUMAN
    Recommended name:
    Olfactory receptor 1N1
    Protein Accession:
    Q8NGS0
    Secondary Accessions:
    • A3KFM1
    • O43870
    • Q6IF16
    • Q96R93

    Protein attributes for OR1N1 Gene

    Size:
    311 amino acids
    Molecular mass:
    34650 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1N1 Gene

Proteomics data for OR1N1 Gene at MOPED

Post-translational modifications for OR1N1 Gene

Other Protein References for OR1N1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1N1 Gene

Domains for OR1N1 Gene

Gene Families for OR1N1 Gene

HGNC:
  • OR1 :GPCR / Class A : Olfactory receptors

Protein Domains for OR1N1 Gene

Suggested Antigen Peptide Sequences for OR1N1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGS0

UniProtKB/Swiss-Prot:

OR1N1_HUMAN :
  • Q8NGS0
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1N1: view

Function for OR1N1 Gene

Molecular function for OR1N1 Gene

GENATLAS Biochemistry: olfactory receptor,family 1,subfamily N,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004984 olfactory receptor activity IEA --
GO:0008527 taste receptor activity IBA --
genes like me logo Genes that share ontologies with OR1N1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR1N1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR1N1 Gene

Localization for OR1N1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1N1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR1N1 Gene COMPARTMENTS Subcellular localization image for OR1N1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1N1: view

Pathways for OR1N1 Gene

genes like me logo Genes that share pathways with OR1N1: view

Pathways by source for OR1N1 Gene

1 BioSystems pathway for OR1N1 Gene
1 KEGG pathway for OR1N1 Gene

Interacting Proteins for OR1N1 Gene

Gene Ontology (GO) - Biological Process for OR1N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
GO:0050912 detection of chemical stimulus involved in sensory perception of taste IBA --
genes like me logo Genes that share ontologies with OR1N1: view

Transcripts for OR1N1 Gene

mRNA/cDNA for OR1N1 Gene

(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR1N1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR1N1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1N1 Gene

No ASD Table

Relevant External Links for OR1N1 Gene

GeneLoc Exon Structure for
OR1N1
ECgene alternative splicing isoforms for
OR1N1

Expression for OR1N1 Gene

mRNA expression in normal human tissues for OR1N1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1N1 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (6.9) and Testis (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR1N1 Gene

SOURCE GeneReport for Unigene cluster for OR1N1 Gene Hs.553604

genes like me logo Genes that share expressions with OR1N1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR1N1 Gene

Orthologs for OR1N1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1N1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473042 35
  • 99.46 (n)
  • 98.71 (a)
OR1N1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR1N1 35
  • 85.85 (n)
  • 84.57 (a)
OR1N1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR1P2 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr351 35
  • 81.72 (n)
  • 85.16 (a)
Olfr351 16
Olfr351 36
  • 85 (a)
OneToMany
Olfr353 36
  • 79 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
-- 36
  • 51 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr414 35
  • 82.21 (n)
  • 85.21 (a)
Species with no ortholog for OR1N1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1N1 Gene

ENSEMBL:
Gene Tree for OR1N1 (if available)
TreeFam:
Gene Tree for OR1N1 (if available)

Paralogs for OR1N1 Gene

Selected SIMAP similar genes for OR1N1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR1N1 Gene

genes like me logo Genes that share paralogs with OR1N1: view

Variants for OR1N1 Gene

Sequence variations from dbSNP and Humsavar for OR1N1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs7025073 -- 122,526,146(+) TACTG(A/G)ATGCA downstream-variant-500B
rs7038514 -- 122,529,152(+) GATCT(A/G)AGGCT upstream-variant-2KB
rs10760228 -- 122,528,118(+) ATTTA(A/G)TCCCT upstream-variant-2KB
rs10760229 -- 122,528,458(+) CCGGG(C/T)GTGGT upstream-variant-2KB
rs10760230 -- 122,528,487(+) CAGCT(A/G)CTTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1N1 Gene

Variant ID Type Subtype PubMed ID
nsv893822 CNV Gain 21882294
nsv893823 CNV Loss 21882294
nsv893824 CNV Loss 21882294

Relevant External Links for OR1N1 Gene

HapMap Linkage Disequilibrium report
OR1N1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1N1 Gene

Disorders for OR1N1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for OR1N1 Gene including...

Search for OR1N1 Gene in MalaCards »
genes like me logo Genes that share disorders with OR1N1: view

No data available for UniProtKB/Swiss-Prot for OR1N1 Gene

Publications for OR1N1 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S. … Giorgi D. (Nat. Genet. 1998) 2 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 4

Products for OR1N1 Gene

Sources for OR1N1 Gene

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