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Aliases for OR1N1 Gene

Aliases for OR1N1 Gene

  • Olfactory Receptor Family 1 Subfamily N Member 1 2 3 5
  • Olfactory Receptor OR9-22 3 4
  • Olfactory Receptor 1-26 3 4
  • Olfactory Receptor 1N3 3 4
  • OR1-26 3 4
  • OR1N3 3 4
  • Olfactory Receptor, Family 1, Subfamily N, Member 1 2
  • Olfactory Receptor, Family 1, Subfamily N, Member 3 3
  • Olfactory Receptor 1N1 3
  • OR9-22 3

External Ids for OR1N1 Gene

Previous HGNC Symbols for OR1N1 Gene

  • OR1N3

Previous GeneCards Identifiers for OR1N1 Gene

  • GC01U990262
  • GC09M120664
  • GC09M122368
  • GC09M124328
  • GC09M125288

Summaries for OR1N1 Gene

Entrez Gene Summary for OR1N1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1N1 Gene

OR1N1 (Olfactory Receptor Family 1 Subfamily N Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and taste receptor activity. An important paralog of this gene is OR1N2.

UniProtKB/Swiss-Prot for OR1N1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1N1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1N1 Gene

Genomics for OR1N1 Gene

Regulatory Elements for OR1N1 Gene

Enhancers for OR1N1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F122499 0.2 ENCODE 10.8 +28.2 28220 0.1 HDGF ATF1 PKNOX1 ARNT ZNF766 ZNF143 ZNF207 NCOA1 TBX21 ZNF518A OR1J4 OR1N1 ENSG00000231465 OR1N2 OR5C1 PIR39690 OR1J1
GH09F122463 0.7 Ensembl ENCODE 10.6 +62.5 62532 2.0 PKNOX1 ARID4B BRCA1 ZNF2 RAD21 RFX5 CHAMP1 ZNF143 RCOR1 DEK OR1Q1 OR1K1 OR1N1 OR1J4 PTGS1 OR5C1 RBM18 MRRF TTLL11 ENSG00000231465
GH09F122580 0.6 ENCODE 10.4 -53.2 -53241 0.2 CBX3 TBL1XR1 JUN BACH1 CHAMP1 ZNF316 FOXK2 NCOR1 NFE2 TRIM24 OR1N2 OR1B1 OR1N1 OR1J4 OR1J2 OR1K1 OR1Q1 OR1H1P
GH09F122355 0.7 FANTOM5 4.7 +171.5 171542 0.0 OR1Q1 OR1L8 OR1J2 OR1B1 OR1L1 OR1N2 OR1J4 MRRF OR1L4 OR1K1
GH09F122057 0.3 FANTOM5 4.7 +470.0 470012 0.1 ZNF121 TTLL11 OR1N1 OR1N2 OR1J4 MRRF OR1J2 LHX6 DAB2IP TTLL11-IT1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR1N1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR1N1 Gene

Chromosome:
9
Start:
122,526,358 bp from pter
End:
122,527,296 bp from pter
Size:
939 bases
Orientation:
Minus strand

Genomic View for OR1N1 Gene

Genes around OR1N1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1N1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1N1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1N1 Gene

Proteins for OR1N1 Gene

  • Protein details for OR1N1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGS0-OR1N1_HUMAN
    Recommended name:
    Olfactory receptor 1N1
    Protein Accession:
    Q8NGS0
    Secondary Accessions:
    • A3KFM1
    • O43870
    • Q6IF16
    • Q96R93

    Protein attributes for OR1N1 Gene

    Size:
    311 amino acids
    Molecular mass:
    34650 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1N1 Gene

Post-translational modifications for OR1N1 Gene

Other Protein References for OR1N1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1N1 Gene

Domains & Families for OR1N1 Gene

Gene Families for OR1N1 Gene

Protein Domains for OR1N1 Gene

Suggested Antigen Peptide Sequences for OR1N1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGS0

UniProtKB/Swiss-Prot:

OR1N1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1N1: view

Function for OR1N1 Gene

Molecular function for OR1N1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily N,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR1N1: view

Phenotypes for OR1N1 Gene

GenomeRNAi human phenotypes for OR1N1:
genes like me logo Genes that share phenotypes with OR1N1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1N1 Gene

Localization for OR1N1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1N1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR1N1 Gene COMPARTMENTS Subcellular localization image for OR1N1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR1N1: view

Pathways & Interactions for OR1N1 Gene

genes like me logo Genes that share pathways with OR1N1: view

Pathways by source for OR1N1 Gene

1 BioSystems pathway for OR1N1 Gene
1 KEGG pathway for OR1N1 Gene

Gene Ontology (GO) - Biological Process for OR1N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR1N1: view

No data available for SIGNOR curated interactions for OR1N1 Gene

Transcripts for OR1N1 Gene

mRNA/cDNA for OR1N1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1N1 Gene

No ASD Table

Relevant External Links for OR1N1 Gene

GeneLoc Exon Structure for
OR1N1
ECgene alternative splicing isoforms for
OR1N1

Expression for OR1N1 Gene

mRNA expression in normal human tissues for OR1N1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1N1 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x6.9) and Testis (x6.0).

Protein differential expression in normal tissues from HIPED for OR1N1 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR1N1 Gene



Protein tissue co-expression partners for OR1N1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR1N1 Gene:

OR1N1

SOURCE GeneReport for Unigene cluster for OR1N1 Gene:

Hs.553604
genes like me logo Genes that share expression patterns with OR1N1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR1N1 Gene

Orthologs for OR1N1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1N1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473042 34
  • 99.46 (n)
OR1N1 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR1N1 34 35
  • 85.85 (n)
rat
(Rattus norvegicus)
Mammalia Olr414 34
  • 82.21 (n)
mouse
(Mus musculus)
Mammalia Or1n1 55 Olfr351 34 16 35
  • 81.72 (n)
Or1n1b 55 Olfr353 35
  • 79 (a)
OneToMany
Or1ah3 55 Olfr367
  • chr2:37,270,545-37,271,384
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 66 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OR1P2 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 54 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
Species where no ortholog for OR1N1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1N1 Gene

ENSEMBL:
Gene Tree for OR1N1 (if available)
TreeFam:
Gene Tree for OR1N1 (if available)

Paralogs for OR1N1 Gene

(451) SIMAP similar genes for OR1N1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR1N1 Gene

genes like me logo Genes that share paralogs with OR1N1: view

Variants for OR1N1 Gene

Sequence variations from dbSNP and Humsavar for OR1N1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_036208 A breast cancer sample
rs201161748 Uncertain significance 122,526,441(+) AAAGG(A/G/T)GTTCA reference, missense
rs10760228 -- 122,528,118(+) ATTTA(A/G)TCCCT upstream-variant-2KB
rs10760229 -- 122,528,458(+) CCGGG(C/T)GTGGT upstream-variant-2KB
rs10760230 -- 122,528,487(+) CAGCT(A/G)CTTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1N1 Gene

Variant ID Type Subtype PubMed ID
esv3891726 CNV loss 25118596

Variation tolerance for OR1N1 Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.65; 82.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1N1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1N1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1N1 Gene

Disorders for OR1N1 Gene

Relevant External Links for OR1N1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR1N1

No disorders were found for OR1N1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1N1 Gene

Publications for OR1N1 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S. … Giorgi D. (Nat. Genet. 1998) 2 3 4 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  4. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 4 64
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64

Products for OR1N1 Gene

Sources for OR1N1 Gene

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