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Aliases for OR1L8 Gene

Aliases for OR1L8 Gene

  • Olfactory Receptor Family 1 Subfamily L Member 8 2 3 5
  • Olfactory Receptor, Family 1, Subfamily L, Member 8 2 3
  • Olfactory Receptor OR9-24 3 4
  • OR9-24 3

External Ids for OR1L8 Gene

Previous GeneCards Identifiers for OR1L8 Gene

  • GC09U990175
  • GC09M120706
  • GC09M122409
  • GC09M124369
  • GC09M125329

Summaries for OR1L8 Gene

Entrez Gene Summary for OR1L8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1L8 Gene

OR1L8 (Olfactory Receptor Family 1 Subfamily L Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1D5.

UniProtKB/Swiss-Prot for OR1L8 Gene

  • Odorant receptor.

Gene Wiki entry for OR1L8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1L8 Gene

Genomics for OR1L8 Gene

Regulatory Elements for OR1L8 Gene

Enhancers for OR1L8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR1L8 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR1L8 Gene

122,546,236 bp from pter
122,693,914 bp from pter
147,679 bases
Minus strand

Genomic View for OR1L8 Gene

Genes around OR1L8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1L8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1L8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1L8 Gene

Proteins for OR1L8 Gene

  • Protein details for OR1L8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 1L8
    Protein Accession:
    Secondary Accessions:
    • A3KFM3
    • B9EIR6
    • Q6IF15
    • Q96R79

    Protein attributes for OR1L8 Gene

    309 amino acids
    Molecular mass:
    35083 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1L8 Gene

Proteomics data for OR1L8 Gene at MOPED

Post-translational modifications for OR1L8 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1L8 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1L8 Gene

Domains & Families for OR1L8 Gene

Gene Families for OR1L8 Gene

Protein Domains for OR1L8 Gene

Suggested Antigen Peptide Sequences for OR1L8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1L8: view

Function for OR1L8 Gene

Molecular function for OR1L8 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR1L8: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR1L8 Gene

Localization for OR1L8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1L8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR1L8 Gene COMPARTMENTS Subcellular localization image for OR1L8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR1L8: view

Pathways & Interactions for OR1L8 Gene

genes like me logo Genes that share pathways with OR1L8: view

Pathways by source for OR1L8 Gene

Interacting Proteins for OR1L8 Gene

Gene Ontology (GO) - Biological Process for OR1L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1L8: view

No data available for SIGNOR curated interactions for OR1L8 Gene

Drugs & Compounds for OR1L8 Gene

No Compound Related Data Available

Transcripts for OR1L8 Gene

mRNA/cDNA for OR1L8 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR1L8 Gene

No ASD Table

Relevant External Links for OR1L8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR1L8 Gene

mRNA expression in normal human tissues for OR1L8 Gene

Protein differential expression in normal tissues from HIPED for OR1L8 Gene

This gene is overexpressed in Breast (37.3), Ovary (12.7), Adipocyte (12.5), and Salivary gland (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR1L8 Gene

SOURCE GeneReport for Unigene cluster for OR1L8 Gene Hs.632695

genes like me logo Genes that share expression patterns with OR1L8: view

Protein tissue co-expression partners for OR1L8 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR1L8 Gene

Orthologs for OR1L8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1L8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC787415 35
  • 87.4 (n)
  • 84.04 (a)
-- 36
  • 78 (a)
-- 36
  • 79 (a)
-- 36
  • 80 (a)
-- 36
  • 74 (a)
-- 36
  • 83 (a)
-- 36
  • 72 (a)
-- 36
  • 73 (a)
(Canis familiaris)
Mammalia LOC100687372 35
  • 86.06 (n)
  • 80.72 (a)
OR1L8 36
  • 80 (a)
(Mus musculus)
Mammalia Olfr355 35
  • 83.23 (n)
  • 85.06 (a)
Olfr355 16
Olfr355 36
  • 85 (a)
(Pan troglodytes)
Mammalia LOC473044 35
  • 97.95 (n)
  • 95.47 (a)
OR1L8 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Olr418 35
  • 83.33 (n)
  • 84.09 (a)
Species with no ortholog for OR1L8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1L8 Gene

Gene Tree for OR1L8 (if available)
Gene Tree for OR1L8 (if available)

Paralogs for OR1L8 Gene

Paralogs for OR1L8 Gene

(451) SIMAP similar genes for OR1L8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1L8: view

Variants for OR1L8 Gene

Sequence variations from dbSNP and Humsavar for OR1L8 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_024087 -
VAR_024088 -
rs721225 -- 122,644,788(+) GCTCA(A/G)GTCCC intron-variant
rs723258 -- 122,624,904(-) AATAA(G/T)TTACT intron-variant
rs1029886 -- 122,695,462(+) atatc(G/T)atata upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1L8 Gene

Variant ID Type Subtype PubMed ID
nsv893822 CNV Gain 21882294
nsv893823 CNV Loss 21882294
esv2659552 CNV Deletion 23128226

Variation tolerance for OR1L8 Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR1L8 Gene

Disorders for OR1L8 Gene

Relevant External Links for OR1L8

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR1L8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1L8 Gene

Publications for OR1L8 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR1L8 Gene

Sources for OR1L8 Gene