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Aliases for OR1L8 Gene

Aliases for OR1L8 Gene

  • Olfactory Receptor, Family 1, Subfamily L, Member 8 2 3
  • Olfactory Receptor OR9-24 3 4
  • Olfactory Receptor 1L8 3
  • OR9-24 3

External Ids for OR1L8 Gene

Summaries for OR1L8 Gene

Entrez Gene Summary for OR1L8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1L8 Gene

OR1L8 (Olfactory Receptor, Family 1, Subfamily L, Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1D5.

UniProtKB/Swiss-Prot for OR1L8 Gene

  • Odorant receptor.

Gene Wiki entry for OR1L8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1L8 Gene

Genomics for OR1L8 Gene

Genomic Location for OR1L8 Gene

Start:
122,567,548 bp from pter
End:
122,568,477 bp from pter
Size:
930 bases
Orientation:
Minus strand

Genomic View for OR1L8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR1L8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1L8 Gene

Regulatory Elements for OR1L8 Gene

Proteins for OR1L8 Gene

  • Protein details for OR1L8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGR8-OR1L8_HUMAN
    Recommended name:
    Olfactory receptor 1L8
    Protein Accession:
    Q8NGR8
    Secondary Accessions:
    • A3KFM3
    • B9EIR6
    • Q6IF15
    • Q96R79

    Protein attributes for OR1L8 Gene

    Size:
    309 amino acids
    Molecular mass:
    35083 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1L8 Gene

Proteomics data for OR1L8 Gene at MOPED

Post-translational modifications for OR1L8 Gene

Other Protein References for OR1L8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR1L8 Gene

Domains for OR1L8 Gene

Gene Families for OR1L8 Gene

HGNC:
  • OR1 :GPCR / Class A : Olfactory receptors

Protein Domains for OR1L8 Gene

UniProtKB/Swiss-Prot:

OR1L8_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGR8
genes like me logo Genes that share domains with OR1L8: view

Function for OR1L8 Gene

Molecular function for OR1L8 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR1L8: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR1L8 Gene

Localization for OR1L8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1L8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR1L8 Gene COMPARTMENTS Subcellular localization image for OR1L8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1L8: view

Pathways for OR1L8 Gene

genes like me logo Genes that share pathways with OR1L8: view

Pathways by source for OR1L8 Gene

Interacting Proteins for OR1L8 Gene

Gene Ontology (GO) - Biological Process for OR1L8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA --
genes like me logo Genes that share ontologies with OR1L8: view

Transcripts for OR1L8 Gene

mRNA/cDNA for OR1L8 Gene

(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR1L8 Gene

No ASD Table

Relevant External Links for OR1L8 Gene

GeneLoc Exon Structure for
OR1L8
ECgene alternative splicing isoforms for
OR1L8

Expression for OR1L8 Gene

mRNA expression in normal human tissues for OR1L8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR1L8 Gene

SOURCE GeneReport for Unigene cluster for OR1L8 Gene Hs.632695

genes like me logo Genes that share expressions with OR1L8: view

Orthologs for OR1L8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1L8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473044 36
  • 97.95 (n)
  • 95.47 (a)
OR1L8 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 78 (a)
OneToMany
-- 37
  • 79 (a)
OneToMany
-- 37
  • 80 (a)
OneToMany
-- 37
  • 74 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
-- 37
  • 72 (a)
OneToMany
-- 37
  • 73 (a)
OneToMany
LOC787415 36
  • 87.4 (n)
  • 84.04 (a)
dog
(Canis familiaris)
Mammalia LOC100687372 36
  • 86.06 (n)
  • 80.72 (a)
OR1L8 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr355 36
  • 83.23 (n)
  • 85.06 (a)
Olfr355 16
Olfr355 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr418 36
  • 83.33 (n)
  • 84.09 (a)
Species with no ortholog for OR1L8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1L8 Gene

ENSEMBL:
Gene Tree for OR1L8 (if available)
TreeFam:
Gene Tree for OR1L8 (if available)

Paralogs for OR1L8 Gene

Paralogs for OR1L8 Gene

Selected SIMAP similar genes for OR1L8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1L8: view

Variants for OR1L8 Gene

Sequence variations from dbSNP and Humsavar for OR1L8 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1411265 -- 122,568,926(+) TAAAA(C/T)AGTAT upstream-variant-2KB
rs1831365 -- 122,568,678(+) GGGCA(A/T)TATAT upstream-variant-2KB
rs1831366 -- 122,568,705(+) AGAGG(A/G)AGAGT upstream-variant-2KB
rs1831367 -- 122,568,768(+) CCTAT(C/T)CTGTG upstream-variant-2KB
rs1934924 -- 122,569,107(-) CAACA(G/T)TCGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1L8 Gene

Variant ID Type Subtype PubMed ID
nsv893822 CNV Gain 21882294
nsv893823 CNV Loss 21882294
esv2659552 CNV Deletion 23128226

Relevant External Links for OR1L8 Gene

HapMap Linkage Disequilibrium report
OR1L8

Disorders for OR1L8 Gene

Relevant External Links for OR1L8

Genetic Association Database (GAD)
OR1L8
genes like me logo Genes that share disorders with OR1L8: view

No data available for UniProtKB/Swiss-Prot for OR1L8 Gene

Publications for OR1L8 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. (PMID: 17434096) MatarA-n M. … Meschia J.F. (Lancet Neurol 2007) 49
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4

Products for OR1L8 Gene

Sources for OR1L8 Gene

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