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Aliases for OR1L6 Gene

Aliases for OR1L6 Gene

  • Olfactory Receptor, Family 1, Subfamily L, Member 6 2 3
  • Olfactory Receptor OR9-30 3 4
  • Olfactory Receptor 1L7 3 4
  • OR1L7 3 4
  • Olfactory Receptor, Family 1, Subfamily L, Member 7 3
  • OR9-30 3
  • HG16 3

External Ids for OR1L6 Gene

Previous HGNC Symbols for OR1L6 Gene

  • OR1L7

Previous GeneCards Identifiers for OR1L6 Gene

  • GC09U990113
  • GC09P120889
  • GC09P122591
  • GC09P124551
  • GC09P125512

Summaries for OR1L6 Gene

Entrez Gene Summary for OR1L6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1L6 Gene

OR1L6 (Olfactory Receptor, Family 1, Subfamily L, Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1D5.

UniProtKB/Swiss-Prot for OR1L6 Gene

  • Odorant receptor.

Gene Wiki entry for OR1L6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1L6 Gene

Genomics for OR1L6 Gene

Regulatory Elements for OR1L6 Gene

Genomic Location for OR1L6 Gene

Chromosome:
9
Start:
122,749,740 bp from pter
End:
122,750,783 bp from pter
Size:
1,044 bases
Orientation:
Plus strand

Genomic View for OR1L6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR1L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1L6 Gene

Proteins for OR1L6 Gene

  • Protein details for OR1L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGR2-OR1L6_HUMAN
    Recommended name:
    Olfactory receptor 1L6
    Protein Accession:
    Q8NGR2
    Secondary Accessions:
    • Q6IFM8
    • Q96R80

    Protein attributes for OR1L6 Gene

    Size:
    347 amino acids
    Molecular mass:
    39515 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05948.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for OR1L6 Gene

Proteomics data for OR1L6 Gene at MOPED

Post-translational modifications for OR1L6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR1L6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1L6 Gene

Domains & Families for OR1L6 Gene

Gene Families for OR1L6 Gene

Protein Domains for OR1L6 Gene

Suggested Antigen Peptide Sequences for OR1L6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGR2

UniProtKB/Swiss-Prot:

OR1L6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1L6: view

Function for OR1L6 Gene

Molecular function for OR1L6 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily L,member 6,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR1L6: view

Phenotypes for OR1L6 Gene

GenomeRNAi human phenotypes for OR1L6:
genes like me logo Genes that share phenotypes with OR1L6: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR1L6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1L6 Gene

Localization for OR1L6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1L6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR1L6 Gene COMPARTMENTS Subcellular localization image for OR1L6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1L6: view

Pathways & Interactions for OR1L6 Gene

genes like me logo Genes that share pathways with OR1L6: view

Pathways by source for OR1L6 Gene

Interacting Proteins for OR1L6 Gene

Gene Ontology (GO) - Biological Process for OR1L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1L6: view

No data available for SIGNOR curated interactions for OR1L6 Gene

Drugs & Compounds for OR1L6 Gene

No Compound Related Data Available

Transcripts for OR1L6 Gene

mRNA/cDNA for OR1L6 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR1L6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1L6 Gene

No ASD Table

Relevant External Links for OR1L6 Gene

GeneLoc Exon Structure for
OR1L6
ECgene alternative splicing isoforms for
OR1L6

Expression for OR1L6 Gene

mRNA expression in normal human tissues for OR1L6 Gene

SOURCE GeneReport for Unigene cluster for OR1L6 Gene Hs.553790

genes like me logo Genes that share expression patterns with OR1L6: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR1L6 Gene

Orthologs for OR1L6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1L6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC504570 35
  • 86.34 (n)
  • 85.16 (a)
-- 36
  • 83 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia OR1L4 35
  • 87.06 (n)
  • 87.38 (a)
-- 36
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr365 35
  • 85.2 (n)
  • 87.83 (a)
Olfr365 16
Olfr364-ps1 36
  • 86 (a)
ManyToMany
Olfr365 36
  • 86 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr428 35
  • 85.27 (n)
  • 87.1 (a)
oppossum
(Monodelphis domestica)
Mammalia OPOR56 36
  • 81 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia OR1L6 36
  • 86 (a)
OneToOne
Species with no ortholog for OR1L6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1L6 Gene

ENSEMBL:
Gene Tree for OR1L6 (if available)
TreeFam:
Gene Tree for OR1L6 (if available)

Paralogs for OR1L6 Gene

Paralogs for OR1L6 Gene

(453) SIMAP similar genes for OR1L6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR1L6 Gene

genes like me logo Genes that share paralogs with OR1L6: view

Variants for OR1L6 Gene

Sequence variations from dbSNP and Humsavar for OR1L6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs4838012 - 122,750,296(+) TTCTT(A/G)CAGCA missense, reference
rs7042027 -- 122,748,490(+) ATTAG(A/G)CCACT upstream-variant-2KB
rs7042402 -- 122,748,897(+) tgaca(C/T)gattt upstream-variant-2KB
rs10120579 -- 122,749,382(+) GATCC(A/G)TGAGC upstream-variant-2KB
rs10732389 -- 122,748,596(+) AGCGG(C/T)CAAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1L6 Gene

Variant ID Type Subtype PubMed ID
esv2472134 CNV Deletion 19546169
esv2739015 CNV Deletion 23290073

Variation tolerance for OR1L6 Gene

Residual Variation Intolerance Score: 91.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1L6 Gene

HapMap Linkage Disequilibrium report
OR1L6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1L6 Gene

Disorders for OR1L6 Gene

Relevant External Links for OR1L6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR1L6
genes like me logo Genes that share disorders with OR1L6: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1L6 Gene

Publications for OR1L6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 67
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 67
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 67

Products for OR1L6 Gene

Sources for OR1L6 Gene

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