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Aliases for OR1L4 Gene

Aliases for OR1L4 Gene

  • Olfactory Receptor, Family 1, Subfamily L, Member 4 2 3
  • Olfactory Receptor OR9-29 3 4
  • Olfactory Receptor 1L5 3 4
  • Olfactory Receptor 9-E 3 4
  • OST046 3 4
  • OR1L5 3 4
  • OR9-E 3 4
  • Olfactory Receptor, Family 1, Subfamily L, Member 5 3
  • Olfactory Receptor 1L4 3
  • OR9-29 3

External Ids for OR1L4 Gene

Previous HGNC Symbols for OR1L4 Gene

  • OR1L5

Previous GeneCards Identifiers for OR1L4 Gene

  • GC09U990114
  • GC09P120863
  • GC09P122565
  • GC09P124526
  • GC09P125486

Summaries for OR1L4 Gene

Entrez Gene Summary for OR1L4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1L4 Gene

OR1L4 (Olfactory Receptor, Family 1, Subfamily L, Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1D5.

UniProtKB/Swiss-Prot for OR1L4 Gene

  • Odorant receptor.

Gene Wiki entry for OR1L4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1L4 Gene

Genomics for OR1L4 Gene

Regulatory Elements for OR1L4 Gene

Genomic Location for OR1L4 Gene

Start:
122,723,990 bp from pter
End:
122,724,925 bp from pter
Size:
936 bases
Orientation:
Plus strand

Genomic View for OR1L4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR1L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1L4 Gene

Proteins for OR1L4 Gene

  • Protein details for OR1L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGR5-OR1L4_HUMAN
    Recommended name:
    Olfactory receptor 1L4
    Protein Accession:
    Q8NGR5
    Secondary Accessions:
    • Q6IFN0
    • Q96R81

    Protein attributes for OR1L4 Gene

    Size:
    311 amino acids
    Molecular mass:
    35277 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1L4 Gene

Proteomics data for OR1L4 Gene at MOPED

Post-translational modifications for OR1L4 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1L4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1L4 Gene

Domains for OR1L4 Gene

Gene Families for OR1L4 Gene

HGNC:
  • OR1 :GPCR / Class A : Olfactory receptors

Protein Domains for OR1L4 Gene

Suggested Antigen Peptide Sequences for OR1L4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGR5

UniProtKB/Swiss-Prot:

OR1L4_HUMAN :
  • Q8NGR5
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1L4: view

Function for OR1L4 Gene

Molecular function for OR1L4 Gene

GENATLAS Biochemistry: olfactory receptor,family 1,subfamily L,member 4,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR1L4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR1L4 Gene

Localization for OR1L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1L4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR1L4 Gene COMPARTMENTS Subcellular localization image for OR1L4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1L4: view

Pathways for OR1L4 Gene

genes like me logo Genes that share pathways with OR1L4: view

Pathways by source for OR1L4 Gene

Interacting Proteins for OR1L4 Gene

Gene Ontology (GO) - Biological Process for OR1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA --
genes like me logo Genes that share ontologies with OR1L4: view

Transcripts for OR1L4 Gene

mRNA/cDNA for OR1L4 Gene

(0) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1L4 Gene

Olfactory receptor, family 1, subfamily L, member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR1L4 Gene

No ASD Table

Relevant External Links for OR1L4 Gene

GeneLoc Exon Structure for
OR1L4
ECgene alternative splicing isoforms for
OR1L4

Expression for OR1L4 Gene

mRNA expression in normal human tissues for OR1L4 Gene

SOURCE GeneReport for Unigene cluster for OR1L4 Gene Hs.626838

genes like me logo Genes that share expressions with OR1L4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR1L4 Gene

Orthologs for OR1L4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1L4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473048 35
  • 97.86 (n)
  • 96.14 (a)
OR1L4 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 84 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr364-ps1 36
  • 87 (a)
ManyToMany
Olfr365 36
  • 86 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia OPOR56 36
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr427 35
  • 85.36 (n)
  • 87.21 (a)
Species with no ortholog for OR1L4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1L4 Gene

ENSEMBL:
Gene Tree for OR1L4 (if available)
TreeFam:
Gene Tree for OR1L4 (if available)

Paralogs for OR1L4 Gene

Paralogs for OR1L4 Gene

Selected SIMAP similar genes for OR1L4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR1L4 Gene

genes like me logo Genes that share paralogs with OR1L4: view

Variants for OR1L4 Gene

Sequence variations from dbSNP and Humsavar for OR1L4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2191695 -- 122,725,331(+) tgtcc(A/G)tgtgt downstream-variant-500B
rs2215530 - 122,724,689(+) CAGCC(A/G)GGAAG missense, reference
rs3049132 -- 122,725,093(+) TATAT(-/AT)GTATA downstream-variant-500B
rs7032935 -- 122,723,469(+) ATTAC(C/T)AAGGA upstream-variant-2KB
rs12341025 - 122,724,917(+) GAATT(C/T)ACTCA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for OR1L4 Gene

Variant ID Type Subtype PubMed ID
esv270569 CNV Insertion 20981092
esv2472134 CNV Deletion 19546169
esv2739015 CNV Deletion 23290073

Relevant External Links for OR1L4 Gene

HapMap Linkage Disequilibrium report
OR1L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1L4 Gene

Disorders for OR1L4 Gene

No disorders were found for OR1L4 Gene.

No data available for UniProtKB/Swiss-Prot for OR1L4 Gene

Publications for OR1L4 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4

Products for OR1L4 Gene

Sources for OR1L4 Gene

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