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Aliases for OR1L4 Gene

Aliases for OR1L4 Gene

  • Olfactory Receptor Family 1 Subfamily L Member 4 2 3 5
  • Olfactory Receptor OR9-29 3 4
  • Olfactory Receptor 1L5 3 4
  • Olfactory Receptor 9-E 3 4
  • OST046 3 4
  • OR1L5 3 4
  • OR9-E 3 4
  • Olfactory Receptor, Family 1, Subfamily L, Member 4 2
  • Olfactory Receptor, Family 1, Subfamily L, Member 5 3
  • Olfactory Receptor 1L4 3
  • OR9-29 3

External Ids for OR1L4 Gene

Previous HGNC Symbols for OR1L4 Gene

  • OR1L5

Previous GeneCards Identifiers for OR1L4 Gene

  • GC09U990114
  • GC09P120863
  • GC09P122565
  • GC09P124526
  • GC09P125486

Summaries for OR1L4 Gene

Entrez Gene Summary for OR1L4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1L4 Gene

OR1L4 (Olfactory Receptor Family 1 Subfamily L Member 4) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1L6.

UniProtKB/Swiss-Prot for OR1L4 Gene

  • Odorant receptor.

Gene Wiki entry for OR1L4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1L4 Gene

Genomics for OR1L4 Gene

Regulatory Elements for OR1L4 Gene

Enhancers for OR1L4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G122355 0.3 FANTOM5 10.9 -368.2 -368236 0.0 OR1Q1 OR1L8 OR1J2 OR1B1 OR1L1 OR1N2 OR1J4 MRRF OR1L4 OR1K1
GH09G123171 0.3 FANTOM5 9 +447.9 447938 0.0 OR1L4 OR1L6 GPR21 PIR44660 GC09M123169 STRBP
GH09G122766 0.3 FANTOM5 5.5 +43.0 43015 0.4 OR1J4 OR1N2 OR1L8 OR1K1 OR5C1 OR1Q1 OR1J2 OR1L1 OR1B1 OR1L4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR1L4 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR1L4 Gene

Chromosome:
9
Start:
122,723,990 bp from pter
End:
122,724,925 bp from pter
Size:
936 bases
Orientation:
Plus strand

Genomic View for OR1L4 Gene

Genes around OR1L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1L4 Gene

Proteins for OR1L4 Gene

  • Protein details for OR1L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGR5-OR1L4_HUMAN
    Recommended name:
    Olfactory receptor 1L4
    Protein Accession:
    Q8NGR5
    Secondary Accessions:
    • Q6IFN0
    • Q96R81

    Protein attributes for OR1L4 Gene

    Size:
    311 amino acids
    Molecular mass:
    35277 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1L4 Gene

Post-translational modifications for OR1L4 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1L4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1L4 Gene

Domains & Families for OR1L4 Gene

Gene Families for OR1L4 Gene

Protein Domains for OR1L4 Gene

Suggested Antigen Peptide Sequences for OR1L4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGR5

UniProtKB/Swiss-Prot:

OR1L4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1L4: view

Function for OR1L4 Gene

Molecular function for OR1L4 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily L,member 4,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR1L4: view
genes like me logo Genes that share phenotypes with OR1L4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1L4 Gene

Localization for OR1L4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1L4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1L4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1L4: view

Pathways & Interactions for OR1L4 Gene

genes like me logo Genes that share pathways with OR1L4: view

Pathways by source for OR1L4 Gene

Interacting Proteins for OR1L4 Gene

Gene Ontology (GO) - Biological Process for OR1L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1L4: view

No data available for SIGNOR curated interactions for OR1L4 Gene

Drugs & Compounds for OR1L4 Gene

No Compound Related Data Available

Transcripts for OR1L4 Gene

mRNA/cDNA for OR1L4 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1L4 Gene

Olfactory receptor, family 1, subfamily L, member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1L4 Gene

No ASD Table

Relevant External Links for OR1L4 Gene

GeneLoc Exon Structure for
OR1L4
ECgene alternative splicing isoforms for
OR1L4

Expression for OR1L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1L4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR1L4 Gene:

OR1L4

SOURCE GeneReport for Unigene cluster for OR1L4 Gene:

Hs.626838
genes like me logo Genes that share expression patterns with OR1L4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1L4 Gene

Orthologs for OR1L4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1L4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473048 34
  • 97.86 (n)
OR1L4 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr364-ps1 35
  • 87 (a)
ManyToMany
Or1l4 55 Olfr365 35
  • 86 (a)
ManyToMany
Or1l4b 55 Olfr364
  • chr2:37,146,118-37,147,134
rat
(Rattus norvegicus)
Mammalia Olr427 34
  • 85.36 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 84 (a)
ManyToMany
-- 35
  • 76 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia OPOR56 35
  • 80 (a)
OneToMany
Species where no ortholog for OR1L4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1L4 Gene

ENSEMBL:
Gene Tree for OR1L4 (if available)
TreeFam:
Gene Tree for OR1L4 (if available)

Paralogs for OR1L4 Gene

(458) SIMAP similar genes for OR1L4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR1L4 Gene

genes like me logo Genes that share paralogs with OR1L4: view

Variants for OR1L4 Gene

Sequence variations from dbSNP and Humsavar for OR1L4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1001085836 -- 122,724,781(+) CCTCT(A/G)TCCAT reference, synonymous-codon
rs1001370041 -- 122,724,220(+) ACAGT(C/T)ATAGT reference, synonymous-codon
rs1002599131 -- 122,723,078(+) ATGTT(C/T)ATGCC upstream-variant-2KB
rs1002935883 -- 122,722,829(+) CTTAC(A/T)CATTC upstream-variant-2KB
rs1003956508 -- 122,723,930(+) TGGTC(A/G)AACTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1L4 Gene

Variant ID Type Subtype PubMed ID
esv2472134 CNV deletion 19546169
esv2739015 CNV deletion 23290073
esv3573379 CNV loss 25503493

Variation tolerance for OR1L4 Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1L4 Gene

Disorders for OR1L4 Gene

Relevant External Links for OR1L4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR1L4

No disorders were found for OR1L4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1L4 Gene

Publications for OR1L4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64

Products for OR1L4 Gene

Sources for OR1L4 Gene

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