OR1L4 Gene
protein-coding GIFtS: 43
GCID: GC09P125486
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olfactory receptor, family 1, subfamily L, member 4
(Previous symbol: OR1L5)
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Aliases
for OR1L4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 1, Subfamily L, Member 41 2 | | Olfactory Receptor OR9-292 3 | | OR1L51 2 3 | | OST0462 3 | | OR9-E1 2 3 | | OR9-292 | | Olfactory Receptor 1L52 3 | | Olfactory Receptor 1L42 | | Olfactory Receptor 9-E2 3 | | Olfactory Receptor, Family 1, Subfamily L, Member 52 |
Export aliases for OR1L4 gene to outside databasesPrevious GC identifers: GC09U990114 GC09P120863 GC09P122565 GC09P124526 |
Summaries
for OR1L4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR1L4:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: OR1L4_HUMAN, Q8NGR5Function: Odorant receptor (Potential)
Gene Wiki entry for OR1L4
|
Genomic Views
for OR1L4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR1L4 gene promoter:
c-Fos Nkx3-1 Nkx3-1 v4 AP-1 Tal-1 Nkx3-1 v1 E47 GATA-2 Nkx3-1 v2 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR1L4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR1L4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q33.2 Ensembl cytogenetic band: 9q33.2 HGNC chromosome: 9OR1L4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P125486: view genomic region
(about GC identifiers)
Start:
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125,486,269 bp from pter |
End:
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125,487,201 bp from pter |
Size:
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933 bases |
Orientation:
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plus strand |
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Proteins
for OR1L4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OR1L4_HUMAN, Q8NGR5 (See
protein sequence)Recommended Name: Olfactory receptor 1L4 Size: 311 amino acids; 35277 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q6IFN0 Q96R81Explore the universe of human proteins at neXtProt for OR1L4: NX_Q8NGR5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NGR5
HORDE protein sequence for OR1L4
OR1L4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001005235.1
ENSEMBL proteins: ENSP00000259466 Reactome Protein details: Q8NGR5
Human Recombinant Protein Products for OR1L4:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR1L4 for ontologies About GeneDecksing
OR1L4 Antibody Products:
Assay Products for OR1L4: |
Protein
Domains /
Families
for OR1L4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR1L4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NGR5ProtoNet protein and cluster: Q8NGR5 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR1L4_HUMAN, Q8NGR5Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR1L4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: OR1L4_HUMAN, Q8NGR5Function: Odorant receptor (Potential) Genatlas biochemistry entry for OR1L4:olfactory receptor,family 1,subfamily L,member 4,G protein coupled receptor superfamily
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR1L4 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR1L4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR1L4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OR1L4 (NM_001005235) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR1L4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR1L4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR1L4 |
|
Pathways & Interactions
for OR1L4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for OR1L4
1 
Kegg Pathway (Kegg details for OR1L4):
OR1L4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR1L4
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for OR1L4 (ENSP000002594664) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for OR1L4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR1L4
Search CenterWatch for drugs/clinical trials and news about OR1L4
|
Transcripts
for OR1L4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR1L4 gene: NM_001005235.1 Unigene Cluster for OR1L4: Olfactory receptor, family 1, subfamily L, member 4 Hs.626838 Unigene Representative Sequence: NM_0010052351 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000259466(uc004bmu.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR1L4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR1L4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR1L4 (NM_001005235) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR1L4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR1L4 |
1 DOTS entry: DT.121197573
GeneLoc Exon Structure
|
Expression
for OR1L4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR1L4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OR1L4 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.626838
SABiosciences Custom PCR Arrays for OR1L4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR1L4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat OR1L4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR1L4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR1L4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR1L4 |
Orthologs
for OR1L4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OR1L4 gene from 1/5 species (see all 5) About this table
ENSEMBL Gene Tree for OR1L4 (if available)
TreeFam Gene Tree for OR1L4 (if available) |
Paralogs
for OR1L4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR1L4 gene
- OR1Q12 OR1L32 OR1L12 OR1L82 OR1K12 OR1L62 OR1A12 OR1D22
- OR1A22
18/458 SIMAP similar genes for OR1L4 using alignment to 1 protein entry: OR1L4_HUMAN(see all similar genes):OR1L6 OR1L3 OR1L1 OR1L8 OR1F1 OR1F2P
OR1M1 OR1N2 OR5V1 OR8U1 OR8U9 OR6B2
OR6B3 OR12D2 OR16-36 OR16-37 OR16-88 OR16-89
OR1L4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for OR1L4
PGOHUM00000234806
|
Genomic Variants
for OR1L4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR1L4 ( 125486269 - 125487201 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OR1L4
1 CNV: 100776 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR1L4 |
|
Disorders
/ Diseases
for OR1L4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR1L4 for disorders About GeneDecksing
1  disease for OR1L4: About MalaCardsneuronitis
Export disorders for OR1L4 gene to outside databases
|
Publications
for OR1L4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR1L4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR1L4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for OR1L4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OR1L4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR1L4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR1L4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR1L4 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR1L4 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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| | |
About This Section
| Patent Information for OR1L4 gene:
Search GeneIP for patents involving OR1L4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR1L4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR1L4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR1L4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR1L4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR1L4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR1L4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR1L4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OR1L4 | | OriGene Custom Protein Services for OR1L4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR1L4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR1L4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR1L4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR1L4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR1L4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR1L4 |
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 | | | OR1L4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR1L4 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for OR1L4 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR1L4 |
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