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Aliases for OR1L3 Gene

Aliases for OR1L3 Gene

  • Olfactory Receptor Family 1 Subfamily L Member 3 2 3 5
  • Olfactory Receptor OR9-28 3 4
  • Olfactory Receptor 9-D 3 4
  • OR9-D 3 4
  • Olfactory Receptor, Family 1, Subfamily L, Member 3 2
  • Olfactory Receptor 1L3 3
  • OR9-28 3

External Ids for OR1L3 Gene

Previous GeneCards Identifiers for OR1L3 Gene

  • GC09U990115
  • GC09P122516
  • GC09P124477
  • GC09P125438

Summaries for OR1L3 Gene

Entrez Gene Summary for OR1L3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1L3 Gene

OR1L3 (Olfactory Receptor Family 1 Subfamily L Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1L1.

UniProtKB/Swiss-Prot for OR1L3 Gene

  • Odorant receptor.

Gene Wiki entry for OR1L3 Gene

Additional gene information for OR1L3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1L3 Gene

Genomics for OR1L3 Gene

GeneHancer (GH) Regulatory Elements for OR1L3 Gene

Promoters and enhancers for OR1L3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I122374 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 2.7 -298.4 -298430 4.2 HDGF PKNOX1 ATF1 ARNT ZFP64 TCF12 ZNF766 GATA2 ATF7 RUNX3 PTGS1 ZBTB26 RC3H2 OR1K1 DAB2IP OR1L3 ENSG00000269970 ENSG00000233616
GH09I123106 Enhancer 0.3 FANTOM5 4.4 +432.0 431986 0.1 RABGAP1 OR1L3 OR1K1 GPR21 MIR600 LOC100422501
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR1L3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR1L3 gene promoter:

Genomic Locations for OR1L3 Gene

Genomic Locations for OR1L3 Gene
1,118 bases
Plus strand

Genomic View for OR1L3 Gene

Genes around OR1L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1L3 Gene

Proteins for OR1L3 Gene

  • Protein details for OR1L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 1L3
    Protein Accession:
    Secondary Accessions:
    • B2RNF4
    • Q6IFN1

    Protein attributes for OR1L3 Gene

    324 amino acids
    Molecular mass:
    36633 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1L3 Gene

Post-translational modifications for OR1L3 Gene

Other Protein References for OR1L3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1L3 Gene

Domains & Families for OR1L3 Gene

Gene Families for OR1L3 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1L3 Gene

Suggested Antigen Peptide Sequences for OR1L3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1L3: view

Function for OR1L3 Gene

Molecular function for OR1L3 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily L,member 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR1L3: view

Phenotypes for OR1L3 Gene

GenomeRNAi human phenotypes for OR1L3:
genes like me logo Genes that share phenotypes with OR1L3: view

miRNA for OR1L3 Gene

miRTarBase miRNAs that target OR1L3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR1L3 Gene

Localization for OR1L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1L3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1L3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1L3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1L3 Gene

Pathways & Interactions for OR1L3 Gene

genes like me logo Genes that share pathways with OR1L3: view

Pathways by source for OR1L3 Gene

Interacting Proteins for OR1L3 Gene

Gene Ontology (GO) - Biological Process for OR1L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1L3: view

No data available for SIGNOR curated interactions for OR1L3 Gene

Drugs & Compounds for OR1L3 Gene

No Compound Related Data Available

Transcripts for OR1L3 Gene

mRNA/cDNA for OR1L3 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1L3 Gene

No ASD Table

Relevant External Links for OR1L3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR1L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1L3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR1L3 Gene:


SOURCE GeneReport for Unigene cluster for OR1L3 Gene:

genes like me logo Genes that share expression patterns with OR1L3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1L3 Gene

Orthologs for OR1L3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1L3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR1L3 33 34
  • 86.79 (n)
(Monodelphis domestica)
Mammalia OPOR48 34
  • 48 (a)
Species where no ortholog for OR1L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1L3 Gene

Gene Tree for OR1L3 (if available)
Gene Tree for OR1L3 (if available)

Paralogs for OR1L3 Gene

Paralogs for OR1L3 Gene

(453) SIMAP similar genes for OR1L3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1L3: view

Variants for OR1L3 Gene

Sequence variations from dbSNP and Humsavar for OR1L3 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001941077 -- 122,676,040(+) T/A coding_sequence_variant, missense_variant
rs1005002182 -- 122,673,911(+) C/T upstream_transcript_variant
rs1005083352 -- 122,674,146(+) G/A upstream_transcript_variant
rs1007079405 -- 122,674,811(+) C/T upstream_transcript_variant
rs1008189462 -- 122,674,926(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR1L3 Gene

Variant ID Type Subtype PubMed ID
esv6464 OTHER inversion 19470904

Variation tolerance for OR1L3 Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.67; 86.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR1L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1L3 Gene

Disorders for OR1L3 Gene

Additional Disease Information for OR1L3

No disorders were found for OR1L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1L3 Gene

Publications for OR1L3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR1L3 Gene

Sources for OR1L3 Gene

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