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Aliases for OR1L1 Gene

Aliases for OR1L1 Gene

  • Olfactory Receptor Family 1 Subfamily L Member 1 2 3 5
  • Olfactory Receptor OR9-27 3 4
  • Olfactory Receptor 1L2 3 4
  • Olfactory Receptor 9-C 3 4
  • OR1L2 3 4
  • OR9-C 3 4
  • Olfactory Receptor, Family 1, Subfamily L, Member 1 2
  • Olfactory Receptor, Family 1, Subfamily L, Member 2 3
  • Olfactory Receptor 1L1 3
  • OR9-27 3
  • HG23 3

External Ids for OR1L1 Gene

Previous HGNC Symbols for OR1L1 Gene

  • OR1L2

Previous GeneCards Identifiers for OR1L1 Gene

  • GC09U990116
  • GC09P122503
  • GC09P124463
  • GC09P125423

Summaries for OR1L1 Gene

Entrez Gene Summary for OR1L1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1L1 Gene

OR1L1 (Olfactory Receptor Family 1 Subfamily L Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1L3.

UniProtKB/Swiss-Prot for OR1L1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1L1 Gene

Additional gene information for OR1L1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1L1 Gene

Genomics for OR1L1 Gene

Regulatory Elements for OR1L1 Gene

Enhancers for OR1L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H122355 0.3 FANTOM5 18.5 -305.8 -305812 0 OR1Q1 OR1L8 OR1J2 OR1B1 OR1L1 OR1N2 OR1J4 MRRF OR1L4 OR1K1
GH09H122766 0.3 FANTOM5 7.6 +105.4 105439 0 OR1J4 OR1N2 OR1L8 OR1K1 OR5C1 OR1Q1 OR1J2 OR1L1 OR1B1 OR1L4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR1L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR1L1 Gene

Chromosome:
9
Start:
122,661,566 bp from pter
End:
122,662,648 bp from pter
Size:
1,083 bases
Orientation:
Plus strand

Genomic View for OR1L1 Gene

Genes around OR1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1L1 Gene

Proteins for OR1L1 Gene

  • Protein details for OR1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH94-OR1L1_HUMAN
    Recommended name:
    Olfactory receptor 1L1
    Protein Accession:
    Q8NH94
    Secondary Accessions:
    • Q5T7Z3
    • Q6IFN2

    Protein attributes for OR1L1 Gene

    Size:
    360 amino acids
    Molecular mass:
    41046 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05743.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW87540.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for OR1L1 Gene

Post-translational modifications for OR1L1 Gene

  • Glycosylation at Asn55 and Asn315
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1L1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1L1 Gene

Domains & Families for OR1L1 Gene

Gene Families for OR1L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR1L1 Gene

Suggested Antigen Peptide Sequences for OR1L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH94

UniProtKB/Swiss-Prot:

OR1L1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1L1: view

Function for OR1L1 Gene

Molecular function for OR1L1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily L,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR1L1: view
genes like me logo Genes that share phenotypes with OR1L1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR1L1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1L1 Gene

Localization for OR1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1L1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1L1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1L1 Gene

Pathways & Interactions for OR1L1 Gene

genes like me logo Genes that share pathways with OR1L1: view

Pathways by source for OR1L1 Gene

Interacting Proteins for OR1L1 Gene

Gene Ontology (GO) - Biological Process for OR1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1L1: view

No data available for SIGNOR curated interactions for OR1L1 Gene

Drugs & Compounds for OR1L1 Gene

No Compound Related Data Available

Transcripts for OR1L1 Gene

mRNA/cDNA for OR1L1 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR1L1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR1L1 Gene

No ASD Table

Relevant External Links for OR1L1 Gene

GeneLoc Exon Structure for
OR1L1
ECgene alternative splicing isoforms for
OR1L1

Expression for OR1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR1L1 Gene:

OR1L1

SOURCE GeneReport for Unigene cluster for OR1L1 Gene:

Hs.567736
genes like me logo Genes that share expression patterns with OR1L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1L1 Gene

Orthologs for OR1L1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473046 33
  • 99.03 (n)
OR1L1 34
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC785392 33
  • 86.77 (n)
OR1L1 34
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr366 34
  • 62 (a)
ManyToMany
Or12k5 52 Olfr358
  • chr2:37,004,623-37,005,612
Or12k6-ps 52 Olfr359-ps1
  • chr2:37,019,242-37,020,202
Or12k7 52 Olfr360
  • chr2:37,068,307-37,069,257
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
ManyToMany
Species where no ortholog for OR1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1L1 Gene

ENSEMBL:
Gene Tree for OR1L1 (if available)
TreeFam:
Gene Tree for OR1L1 (if available)

Paralogs for OR1L1 Gene

(460) SIMAP similar genes for OR1L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1L1: view

Variants for OR1L1 Gene

Sequence variations from dbSNP and Humsavar for OR1L1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000157774 -- 122,660,437(+) TTCTT(A/G)GCTTG upstream-variant-2KB
rs1000435348 -- 122,662,946(+) GTGTG(A/C)GTGCG downstream-variant-500B
rs1003603201 -- 122,659,855(+) ACAGG(C/T)GTGAG upstream-variant-2KB
rs1003686256 -- 122,663,069(+) TCCTT(A/C)CTCTG downstream-variant-500B
rs1003770909 -- 122,660,024(+) TCATA(C/T)ATAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1L1 Gene

Variant ID Type Subtype PubMed ID
nsv1054800 CNV loss 25217958

Variation tolerance for OR1L1 Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.73; 66.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1L1 Gene

Disorders for OR1L1 Gene

Relevant External Links for OR1L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR1L1

No disorders were found for OR1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1L1 Gene

Publications for OR1L1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 60

Products for OR1L1 Gene

Sources for OR1L1 Gene

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