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Aliases for OR1K1 Gene

Aliases for OR1K1 Gene

  • Olfactory Receptor Family 1 Subfamily K Member 1 2 3 5
  • Olfactory Receptor, Family 1, Subfamily K, Member 1 2
  • Olfactory Receptor 1K1 3
  • Hg99 3

External Ids for OR1K1 Gene

Previous GeneCards Identifiers for OR1K1 Gene

  • GC09P116667
  • GC09M117253
  • GC09M119065
  • GC09M120987
  • GC09P122642
  • GC09P124602
  • GC09P125563

Summaries for OR1K1 Gene

Entrez Gene Summary for OR1K1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1K1 Gene

OR1K1 (Olfactory Receptor Family 1 Subfamily K Member 1) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR1L6.

UniProtKB/Swiss-Prot for OR1K1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1K1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1K1 Gene

Genomics for OR1K1 Gene

Regulatory Elements for OR1K1 Gene

Enhancers for OR1K1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G122819 1.4 Ensembl ENCODE dbSUPER 11.2 +20.8 20773 3.6 HDAC1 PKNOX1 FOXA2 TBL1XR1 TCF12 ZNF766 GATA2 FOS RELB CREM OR1K1 OR5C1 SNORD90 GC09M122816 PDCL
GH09G122374 1.5 FANTOM5 Ensembl ENCODE 9.3 -423.5 -423517 4.2 HDGF PKNOX1 ATF1 ARNT ZFP64 TCF12 ZNF121 ZNF766 GATA2 ELK1 OR1K1 PTGS1 DAB2IP OR1L3 ENSG00000269970 ENSG00000233616
GH09G122463 1.2 Ensembl ENCODE 10.9 -335.3 -335317 1.9 PKNOX1 ARID4B BRCA1 ZNF2 ZNF143 DEK JUNB REST MIER2 TBX21 OR1Q1 OR1K1 OR1N1 OR1J4 PTGS1 OR5C1 RBM18 MRRF TTLL11 ENSG00000231465
GH09G122099 1.4 Ensembl ENCODE 9.3 -700.7 -700689 0.7 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 MRRF RBM18 OR1K1 TTLL11 MIR4478
GH09G122125 1.2 Ensembl ENCODE 10 -673.7 -673659 2.8 ELF3 HDGF ATF1 PKNOX1 RB1 ARID4B SIN3A DNMT3B ZNF2 RAD21 TTLL11 MRRF RBM18 PTGS1 OR1K1 MIR4478 NDUFA8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR1K1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR1K1 Gene

Chromosome:
9
Start:
122,800,123 bp from pter
End:
122,801,073 bp from pter
Size:
951 bases
Orientation:
Plus strand

Genomic View for OR1K1 Gene

Genes around OR1K1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1K1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1K1 Gene

Proteins for OR1K1 Gene

  • Protein details for OR1K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGR3-OR1K1_HUMAN
    Recommended name:
    Olfactory receptor 1K1
    Protein Accession:
    Q8NGR3
    Secondary Accessions:
    • B9EH41
    • Q4VXB7
    • Q96R23

    Protein attributes for OR1K1 Gene

    Size:
    316 amino acids
    Molecular mass:
    34268 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1K1 Gene

Post-translational modifications for OR1K1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1K1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1K1 Gene

Domains & Families for OR1K1 Gene

Gene Families for OR1K1 Gene

Protein Domains for OR1K1 Gene

Suggested Antigen Peptide Sequences for OR1K1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGR3

UniProtKB/Swiss-Prot:

OR1K1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1K1: view

Function for OR1K1 Gene

Molecular function for OR1K1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR1K1: view
genes like me logo Genes that share phenotypes with OR1K1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1K1 Gene

Localization for OR1K1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1K1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1K1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1K1: view

Pathways & Interactions for OR1K1 Gene

genes like me logo Genes that share pathways with OR1K1: view

Pathways by source for OR1K1 Gene

Interacting Proteins for OR1K1 Gene

Gene Ontology (GO) - Biological Process for OR1K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR1K1: view

No data available for SIGNOR curated interactions for OR1K1 Gene

Drugs & Compounds for OR1K1 Gene

No Compound Related Data Available

Transcripts for OR1K1 Gene

mRNA/cDNA for OR1K1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1K1 Gene

No ASD Table

Relevant External Links for OR1K1 Gene

GeneLoc Exon Structure for
OR1K1
ECgene alternative splicing isoforms for
OR1K1

Expression for OR1K1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1K1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1K1 Gene

This gene is overexpressed in Testis (x7.2).

NURSA nuclear receptor signaling pathways regulating expression of OR1K1 Gene:

OR1K1

SOURCE GeneReport for Unigene cluster for OR1K1 Gene:

Hs.632681
genes like me logo Genes that share expression patterns with OR1K1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1K1 Gene

Orthologs for OR1K1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1K1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia OR1K1 34 35
  • 89.66 (n)
cow
(Bos Taurus)
Mammalia OR1K1 34 35
  • 88.5 (n)
oppossum
(Monodelphis domestica)
Mammalia OR1K1 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OR1K1 35
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr398 35
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
Species where no ortholog for OR1K1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1K1 Gene

ENSEMBL:
Gene Tree for OR1K1 (if available)
TreeFam:
Gene Tree for OR1K1 (if available)

Paralogs for OR1K1 Gene

(450) SIMAP similar genes for OR1K1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1K1: view

Variants for OR1K1 Gene

Sequence variations from dbSNP and Humsavar for OR1K1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000363825 -- 122,799,608(+) TGAGT(A/T)ACTTC upstream-variant-2KB
rs1000803420 -- 122,798,886(+) GCTGG(C/G)ATTAC upstream-variant-2KB
rs1001197051 -- 122,799,185(+) TTCTA(G/T)AATCT upstream-variant-2KB
rs1001419980 -- 122,800,846(+) CCACC(C/T)GTGGC reference, missense
rs1001669438 -- 122,799,502(+) TTTTC(C/T)TTCAT upstream-variant-2KB

Variation tolerance for OR1K1 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1K1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1K1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR1K1 Gene

Disorders for OR1K1 Gene

Relevant External Links for OR1K1

Genetic Association Database (GAD)
OR1K1
Human Genome Epidemiology (HuGE) Navigator
OR1K1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR1K1

No disorders were found for OR1K1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1K1 Gene

Publications for OR1K1 Gene

  1. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A. … Vieira A.R. (Am. J. Med. Genet. A 2010) 3 46 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR1K1 Gene

Sources for OR1K1 Gene

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