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Aliases for OR1K1 Gene

Aliases for OR1K1 Gene

  • Olfactory Receptor Family 1 Subfamily K Member 1 2 3 5
  • Olfactory Receptor, Family 1, Subfamily K, Member 1 2
  • Olfactory Receptor 1K1 3
  • Hg99 3

External Ids for OR1K1 Gene

Previous GeneCards Identifiers for OR1K1 Gene

  • GC09P116667
  • GC09M117253
  • GC09M119065
  • GC09M120987
  • GC09P122642
  • GC09P124602
  • GC09P125563

Summaries for OR1K1 Gene

Entrez Gene Summary for OR1K1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1K1 Gene

OR1K1 (Olfactory Receptor Family 1 Subfamily K Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR1L4.

UniProtKB/Swiss-Prot for OR1K1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1K1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1K1 Gene

Genomics for OR1K1 Gene

Regulatory Elements for OR1K1 Gene

Enhancers for OR1K1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F122374 1.5 FANTOM5 Ensembl ENCODE 9.3 -423.5 -423517 4.2 HDGF ATF1 ARNT ZFP64 ZNF121 ELK1 FOS MCM3 NCOA1 MBD2 OR1K1 PTGS1 DAB2IP OR1L3 ENSG00000269970 ENSG00000233616
GH09F122463 1.2 Ensembl ENCODE 10.9 -335.4 -335359 2.0 PKNOX1 ARID4B BRCA1 ZNF2 RAD21 RFX5 CHAMP1 ZNF143 RCOR1 DEK OR1Q1 OR1K1 OR1N1 OR1J4 PTGS1 OR5C1 RBM18 MRRF TTLL11 ENSG00000231465
GH09F122819 1.1 Ensembl ENCODE 11.2 +20.8 20773 3.6 HDAC1 PKNOX1 TBL1XR1 GATA2 CREM CEBPB ELF1 NR2F2 MEF2D SMARCA4 OR1K1 OR5C1 SNORD90 GC09M122816 PDCL
GH09F122099 1.3 Ensembl ENCODE 9.3 -700.7 -700689 0.7 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 SLC30A9 ZNF766 ZNF143 ENSG00000261094 ZBTB26 MRRF RBM18 OR1K1 TTLL11 MIR4478
GH09F122124 1.1 Ensembl ENCODE 10 -673.7 -673742 2.9 ELF3 PKNOX1 ARID4B DNMT3B ZNF2 RAD21 RFX5 ZNF143 RCOR1 CREM TTLL11 MRRF RBM18 PTGS1 OR1K1 MIR4478 NDUFA8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR1K1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR1K1 Gene

122,800,123 bp from pter
122,801,073 bp from pter
951 bases
Plus strand

Genomic View for OR1K1 Gene

Genes around OR1K1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1K1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1K1 Gene

Proteins for OR1K1 Gene

  • Protein details for OR1K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 1K1
    Protein Accession:
    Secondary Accessions:
    • B9EH41
    • Q4VXB7
    • Q96R23

    Protein attributes for OR1K1 Gene

    316 amino acids
    Molecular mass:
    34268 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1K1 Gene

Post-translational modifications for OR1K1 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1K1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1K1 Gene

Domains & Families for OR1K1 Gene

Gene Families for OR1K1 Gene

Protein Domains for OR1K1 Gene

Suggested Antigen Peptide Sequences for OR1K1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1K1: view

Function for OR1K1 Gene

Molecular function for OR1K1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR1K1: view
genes like me logo Genes that share phenotypes with OR1K1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1K1 Gene

Localization for OR1K1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1K1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1K1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1K1: view

Pathways & Interactions for OR1K1 Gene

genes like me logo Genes that share pathways with OR1K1: view

Pathways by source for OR1K1 Gene

Interacting Proteins for OR1K1 Gene

Gene Ontology (GO) - Biological Process for OR1K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR1K1: view

No data available for SIGNOR curated interactions for OR1K1 Gene

Transcripts for OR1K1 Gene

mRNA/cDNA for OR1K1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1K1 Gene

No ASD Table

Relevant External Links for OR1K1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR1K1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1K1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1K1 Gene

This gene is overexpressed in Testis (x7.2).

NURSA nuclear receptor signaling pathways regulating expression of OR1K1 Gene:


SOURCE GeneReport for Unigene cluster for OR1K1 Gene:

genes like me logo Genes that share expression patterns with OR1K1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR1K1 Gene

Orthologs for OR1K1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1K1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia OR1K1 34 35
  • 89.66 (n)
(Bos Taurus)
Mammalia OR1K1 34 35
  • 88.5 (n)
(Monodelphis domestica)
Mammalia OR1K1 35
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia OR1K1 35
  • 51 (a)
(Mus musculus)
Mammalia Olfr398 35
  • 46 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
-- 35
  • 49 (a)
-- 35
  • 48 (a)
-- 35
  • 47 (a)
Species where no ortholog for OR1K1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1K1 Gene

Gene Tree for OR1K1 (if available)
Gene Tree for OR1K1 (if available)

Paralogs for OR1K1 Gene

(450) SIMAP similar genes for OR1K1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1K1: view

Variants for OR1K1 Gene

Sequence variations from dbSNP and Humsavar for OR1K1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10985781 -- 122,799,154(+) TTTTT(C/T)TCAGA upstream-variant-2KB
rs10985782 -- 122,800,248(+) CTGGG(C/T)AATGG reference, synonymous-codon
rs111275421 -- 122,798,532(+) TTGCC(A/C)AAGAT upstream-variant-2KB
rs112243349 -- 122,799,145(+) TCGAA(A/G)TGCTT upstream-variant-2KB
rs113019251 -- 122,799,761(+) CCAGC(C/T)ACTCG upstream-variant-2KB

Variation tolerance for OR1K1 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1K1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR1K1 Gene

Disorders for OR1K1 Gene

Relevant External Links for OR1K1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR1K1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1K1 Gene

Publications for OR1K1 Gene

  1. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A. … Vieira A.R. (Am. J. Med. Genet. A 2010) 3 46 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR1K1 Gene

Sources for OR1K1 Gene

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