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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR1J2 Gene

protein-coding   GIFtS: 48
GCID: GC09P125273

Olfactory Receptor, Family 1, Subfamily J, Member 2


(Previous symbols: OR1J3, OR1J5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 1, Subfamily J, Member 21 2     HTPCRX152 3
OR1J31 2 3     OST0442 3
OR1J51 2 3     HG1522
Olfactory Receptor 1J32 3     OR9-192
Olfactory Receptor 1J52 3     Olfactory Receptor 1J22
Olfactory Receptor OR9-192 3     Olfactory Receptor, Family 1, Subfamily J, Member 32
HSA52 3     Olfactory Receptor, Family 1, Subfamily J, Member 52

External Ids:    HGNC: 82091   Entrez Gene: 267402   Ensembl: ENSG000001972337   UniProtKB: Q8NGS23   

Export aliases for OR1J2 gene to outside databases

Previous GC identifers: GC09U990118 GC09P122310 GC09P124312


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR1J2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR1J2 Gene: 
OR1J2 (olfactory receptor, family 1, subfamily J, member 2) is a protein-coding gene. Diseases associated with OR1J2 include distal arthrogryposis, and neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1F1.

UniProtKB/Swiss-Prot: OR1J2_HUMAN, Q8NGS2
Function: Odorant receptor (Potential)

Gene Wiki entry for OR1J2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR1J2 gene promoter:
         C/EBPbeta   AML1a   ATF-2   NCX/Ncx   SREBP-1c   C/EBPalpha   FOXL1   SREBP-1b   SREBP-1a   NF-kappaB2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR1J2 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR1J2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR1J2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q33.2

OR1J2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR1J2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P125273:  view genomic region     (about GC identifiers)

Start:
125,273,081 bp from pter      End:
125,274,019 bp from pter
Size:
939 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OR1J2_HUMAN, Q8NGS2 (See protein sequence)
Recommended Name: Olfactory receptor 1J2  
Size: 313 amino acids; 35385 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A3KFL9 Q6IF14 Q96R90 Q9NZP1

Explore the universe of human proteins at neXtProt for OR1J2: NX_Q8NGS2

Explore proteomics data for OR1J2 at MOPED 

HORDE protein sequence for OR1J2
OR1J2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

OR1J2 Protein Expression

REFSEQ proteins: NP_473448.1  
ENSEMBL proteins: 
 ENSP00000335575  
Reactome Protein details: Q8NGS2
Human Recombinant Protein Products for OR1J2: 
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Cloud-Clone Corp. Proteins for OR1J2 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

OR1J2 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for OR1J2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
OR1: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGS2

ProtoNet protein and cluster: Q8NGS2

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR1J2_HUMAN, Q8NGS2
Similarity: Belongs to the G-protein coupled receptor 1 family


OR1J2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: OR1J2_HUMAN, Q8NGS2
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
OR1J2 for ontologies           About GeneDecksing


Phenotypes:
     3 GenomeRNAi human phenotypes for OR1J2:
 Decreased Hepatitis C virus re  Decreased TP53 protein express  Increased gamma-H2AX phosphory 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for OR1J2 
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miRNA
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Gene Editing
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OR1J2 About                                                                                                See pathways by source

SuperPathContained pathways About
1Olfactory transduction
Olfactory Signaling Pathway0.81
Olfactory transduction0.81
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


4        Reactome Pathways for OR1J2
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR


1         Kegg Pathway  (Kegg details for OR1J2):
    Olfactory transduction


OR1J2 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR1J2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/273 Interacting proteins for OR1J2 (ENSP000003355754) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
OR10J5ENSP000003344414STRING: ENSP00000334441
OR1D2ENSP000003275854STRING: ENSP00000327585
OR2T1ENSP000003554304STRING: ENSP00000355430
OR4Q3ENSP000003300494STRING: ENSP00000330049
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

OR1J2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR1J2

Search CenterWatch for drugs/clinical trials and news about OR1J2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OR1J2 gene: 
NM_054107.1  

Unigene Clusters for OR1J2:

Olfactory receptor, family 1, subfamily J, member 2
Hs.460145  [show with all ESTs], Hs.745497
Unigene Representative Sequences: AK123016, NM_054107
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000335302(uc011lyv.2)
miRNA
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Products:
     
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                     Customized lentivirus expression plasmids for stable overexpression of OR1J2 
Primer
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OriGene qPCR primer pairs and template standards for OR1J2
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR1J2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR1J2

Additional mRNA sequence: X64989.1 

2 DOTS entries:

DT.101970692  DT.75154872 

9 AceView cDNA sequences:

CR621498 CB216532 X64989 BX394234 BX394235 BX954673 AK123016 BF212737 
AA375549 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR1J2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAAGAGGCCC
OR1J2 Expression
About this image


See OR1J2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR1J2

SOURCE GeneReport for Unigene clusters: Hs.460145 Hs.745497
    SABiosciences Custom PCR Arrays for OR1J2
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR1J2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR1J2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for OR1J2 gene from 2/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr3481 , 5 olfactory receptor 3481, 5 73.7(n)1
71.1(a)1
  2 (24.19 cM)5
2589461  NM_146944.11  NP_667155.11 
 367842765 
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 3)
Uncharacterized protein
(see all 3)
49(a)
46(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
GL343252.1(213816-214766)
GL343252.1(172662-175625)


ENSEMBL Gene Tree for OR1J2 (if available)
TreeFam Gene Tree for OR1J2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OR1J2 gene
OR1F12  OR1I12  OR1N12  OR1J42  OR1E22  OR1N22  OR1S12  OR1E12  
OR1C12  OR1M12  OR1G12  OR1J12  OR1S22  
18/456 SIMAP similar genes for OR1J2 using alignment to 1 protein entry:     OR1J2_HUMAN(see all similar genes):
HSA10    OR1J4    OR1J1    OR1E1    OR1E2    HSA12
OR1F1    OR1E3    OR1F2P    OR1M1    OR1N1    OR16-89
OR16-90    OR1A1    OR1D2    OR1L8    OR1N2    OR1S1

OR1J2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/134 SNPs in OR1J2 are shown (see all 134)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs109856611,2
C--125271119(+) tctggA/Gggtca 1 -- us2k13Minor allele frequency- G:0.07NA WA 240
rs1443760681,2
C--125271287(+) ACATAA/GCATCT 1 -- us2k10--------
rs1918451251,2
--125271344(+) TAAGGC/TACTCA 1 -- us2k10--------
rs680777861,2
C,F--125271393(+) TCCCCA/GTTTTA 1 -- us2k13Minor allele frequency- G:0.13WA NA 240
rs1512017371,2
--125271411(+) CTGATC/TAGCAA 1 -- us2k10--------
rs1403821201,2
--125271674(+) CCTAGA/GGAGGA 1 -- us2k10--------
rs1841136641,2
--125271683(+) GAAAGA/GGAGAC 1 -- us2k10--------
rs1891878701,2
--125271756(+) CTGCTC/TTGTGT 1 -- us2k10--------
rs1499669331,2
--125271781(+) AAAGCA/GTAAAT 1 -- us2k10--------
rs70195451,2
C,A,H--125271800(+) CTAAAA/GTATTT 1 -- us2k1 tfbs311Minor allele frequency- G:0.46NA WA CSA EA 372

HapMap Linkage Disequilibrium report for OR1J2 ( 125273081 - 125274019 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for OR1J2:    About this table     
Variant IDTypeSubtypePubMed ID
nsv893823CNV Loss21882294
nsv893822CNV Gain21882294

1 SABiosciences Cancer Mutation PCR Assay for OR1J2:
Cosmic IdAA Change
141897p.D109N
SeqTarget long-range PCR primers for resequencing OR1J2
DNA2.0 Custom Variant and Variant Library Synthesis for OR1J2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for OR1J2:    About MalaCards
distal arthrogryposis    neuronitis

1 disease from the University of Copenhagen DISEASES database for OR1J2:
Distal arthrogryposis

OR1J2 for disorders           About GeneDecksing


Export disorders for OR1J2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OR1J2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR1J2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
  2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
  3. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PubMed id 10706615)1, 2 Rouquier S.... Giorgi D. (2000)
  4. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PubMed id 1370859)1, 2 Parmentier M.... Vassart G. (1992)
  5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  7. Natural selection on the olfactory receptor gene family in humans and chimpanzees. (PubMed id 12908129)1 Gilad Y....Paabo S. (2003)
  8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 26740 HGNC: 8209 AceView: OR1J2 Ensembl:ENSG00000197233 euGenes: HUgn26740
ECgene: OR1J2 Kegg: 26740 H-InvDB: OR1J2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR1J2 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR1J2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR1J2 gene:
Search GeneIP for patents involving OR1J2

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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