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Aliases for OR1J2 Gene

Aliases for OR1J2 Gene

  • Olfactory Receptor Family 1 Subfamily J Member 2 2 3 5
  • Olfactory Receptor OR9-19 3 4
  • Olfactory Receptor 1J3 3 4
  • Olfactory Receptor 1J5 3 4
  • HTPCRX15 3 4
  • OST044 3 4
  • OR1J3 3 4
  • OR1J5 3 4
  • HSA5 3 4
  • Olfactory Receptor, Family 1, Subfamily J, Member 2 2
  • Olfactory Receptor, Family 1, Subfamily J, Member 3 3
  • Olfactory Receptor, Family 1, Subfamily J, Member 5 3
  • Olfactory Receptor 1J2 3
  • OR9-19 3
  • HG152 3

External Ids for OR1J2 Gene

Previous HGNC Symbols for OR1J2 Gene

  • OR1J3
  • OR1J5

Previous GeneCards Identifiers for OR1J2 Gene

  • GC09U990118
  • GC09P122310
  • GC09P124312
  • GC09P125273

Summaries for OR1J2 Gene

Entrez Gene Summary for OR1J2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1J2 Gene

OR1J2 (Olfactory Receptor Family 1 Subfamily J Member 2) is a Protein Coding gene. Diseases associated with OR1J2 include Cataract 21, Multiple Types and Cataract 37. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR1J4.

UniProtKB/Swiss-Prot for OR1J2 Gene

  • Odorant receptor.

Gene Wiki entry for OR1J2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1J2 Gene

Genomics for OR1J2 Gene

Regulatory Elements for OR1J2 Gene

Enhancers for OR1J2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G122580 0.8 ENCODE 10 +131.6 131584 0.2 CBX3 TBL1XR1 CHAMP1 FOS JUNB ZEB2 ZNF592 NFIC MAFF SMARCA4 OR1N2 OR1B1 OR1N1 OR1J4 OR1J2 OR1K1 OR1Q1 OR1H1P
GH09G122355 0.3 FANTOM5 20.8 -93.2 -93199 0.0 OR1Q1 OR1L8 OR1J2 OR1B1 OR1L1 OR1N2 OR1J4 MRRF OR1L4 OR1K1
GH09G122766 0.3 FANTOM5 8.6 +318.1 318052 0.4 OR1J4 OR1N2 OR1L8 OR1K1 OR5C1 OR1Q1 OR1J2 OR1L1 OR1B1 OR1L4
GH09G122057 0.6 FANTOM5 dbSUPER 3.5 -391.7 -391669 0.1 ZNF121 TTLL11 OR1N1 OR1N2 OR1J4 MRRF OR1J2 LHX6 DAB2IP TTLL11-IT1
GH09G122453 1 Ensembl ENCODE 0.7 +4.4 4373 0.3 GTF2F1 CTCF SIN3A MAX CEBPG RAD21 RFX5 ZNF143 SMC3 DEK PTGS1 OR1K1 TTLL11 OR5C1 OR1J2 ENSG00000231465
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR1J2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR1J2 Gene

Chromosome:
9
Start:
122,448,953 bp from pter
End:
122,580,751 bp from pter
Size:
131,799 bases
Orientation:
Plus strand

Genomic View for OR1J2 Gene

Genes around OR1J2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1J2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1J2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1J2 Gene

Proteins for OR1J2 Gene

  • Protein details for OR1J2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGS2-OR1J2_HUMAN
    Recommended name:
    Olfactory receptor 1J2
    Protein Accession:
    Q8NGS2
    Secondary Accessions:
    • A3KFL9
    • Q6IF14
    • Q96R90
    • Q9NZP1

    Protein attributes for OR1J2 Gene

    Size:
    313 amino acids
    Molecular mass:
    35385 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1J2 Gene

Post-translational modifications for OR1J2 Gene

Other Protein References for OR1J2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1J2 Gene

Domains & Families for OR1J2 Gene

Gene Families for OR1J2 Gene

Protein Domains for OR1J2 Gene

Suggested Antigen Peptide Sequences for OR1J2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGS2

UniProtKB/Swiss-Prot:

OR1J2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1J2: view

Function for OR1J2 Gene

Molecular function for OR1J2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR1J2: view
genes like me logo Genes that share phenotypes with OR1J2: view

Animal Model Products

CRISPR Products

miRNA for OR1J2 Gene

miRTarBase miRNAs that target OR1J2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR1J2 Gene

Localization for OR1J2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1J2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1J2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1J2: view

Pathways & Interactions for OR1J2 Gene

genes like me logo Genes that share pathways with OR1J2: view

Pathways by source for OR1J2 Gene

Interacting Proteins for OR1J2 Gene

Gene Ontology (GO) - Biological Process for OR1J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1J2: view

No data available for SIGNOR curated interactions for OR1J2 Gene

Drugs & Compounds for OR1J2 Gene

No Compound Related Data Available

Transcripts for OR1J2 Gene

mRNA/cDNA for OR1J2 Gene

(2) REFSEQ mRNAs :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1J2 Gene

No ASD Table

Relevant External Links for OR1J2 Gene

GeneLoc Exon Structure for
OR1J2
ECgene alternative splicing isoforms for
OR1J2

Expression for OR1J2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1J2 Gene

mRNA differential expression in normal tissues according to GTEx for OR1J2 Gene

This gene is overexpressed in Testis (x11.3).

Protein differential expression in normal tissues from HIPED for OR1J2 Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR1J2 Gene



Protein tissue co-expression partners for OR1J2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR1J2 Gene:

OR1J2

SOURCE GeneReport for Unigene cluster for OR1J2 Gene:

Hs.460145
genes like me logo Genes that share expression patterns with OR1J2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1J2 Gene

Orthologs for OR1J2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1J2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PTR212 35
  • 100 (a)
OneToOne
LOC473040 34
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia OR1J2 34 35
  • 86.28 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr348 34 16
  • 73.7 (n)
Or1j17 55 Olfr346 35
  • 71 (a)
ManyToMany
Or1j11 55 Olfr339
  • chr2:36,421,400-36,422,326
Or1j20 55 Olfr352
  • chr2:36,869,568-36,870,512
Or1j9-ps 55 Olfr336-ps1
  • chr2:36,323,324-36,324,286
Or1u1-ps 55 Olfr334-ps1
  • chr2:36,285,037-36,285,882
Or1v1-ps 55 Olfr349-ps1
  • chr2:36,844,548-36,845,114
rat
(Rattus norvegicus)
Mammalia Olr409 34
  • 73.68 (n)
Species where no ortholog for OR1J2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1J2 Gene

ENSEMBL:
Gene Tree for OR1J2 (if available)
TreeFam:
Gene Tree for OR1J2 (if available)

Paralogs for OR1J2 Gene

Paralogs for OR1J2 Gene

(456) SIMAP similar genes for OR1J2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1J2: view

Variants for OR1J2 Gene

Sequence variations from dbSNP and Humsavar for OR1J2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000045065 -- 122,475,650(+) CTTCA(C/T)TTTGT intron-variant
rs1000094498 -- 122,443,305(+) GAATA(A/C)CTGGG intron-variant
rs1000126539 -- 122,464,299(+) GGTGC(C/T)CCCCC intron-variant
rs1000160263 -- 122,439,512(+) ATAAA(A/G)TCATT intron-variant
rs1000240164 -- 122,420,899(+) GTGCT(C/T)CTACC intron-variant

Variation tolerance for OR1J2 Gene

Residual Variation Intolerance Score: 68.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1J2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1J2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR1J2 Gene

Disorders for OR1J2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OR1J2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cataract 21, multiple types
  • cataract 21 multiple types
cataract 37
  • cca5
- elite association - COSMIC cancer census association via MalaCards
Search OR1J2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OR1J2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR1J2
genes like me logo Genes that share disorders with OR1J2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR1J2 Gene

Publications for OR1J2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PMID: 10706615) Rouquier S. … Giorgi D. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64
  4. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M. … Vassart G. (Nature 1992) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64

Products for OR1J2 Gene

Sources for OR1J2 Gene

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