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OR1J2 Gene

protein-coding   GIFtS: 50
GCID: GC09P125273

Olfactory Receptor, Family 1, Subfamily J, Member 2


(Previous symbols: OR1J3, OR1J5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 1, Subfamily J, Member 21 2     HTPCRX152 3
OR1J31 2 3     OST0442 3
OR1J51 2 3     HG1522
Olfactory Receptor 1J32 3     OR9-192
Olfactory Receptor 1J52 3     Olfactory Receptor 1J22
Olfactory Receptor OR9-192 3     Olfactory Receptor, Family 1, Subfamily J, Member 32
HSA52 3     Olfactory Receptor, Family 1, Subfamily J, Member 52

External Ids:    HGNC: 82091   Entrez Gene: 267402   Ensembl: ENSG000001972337   UniProtKB: Q8NGS23   

Export aliases for OR1J2 gene to outside databases

Previous GC identifers: GC09U990118 GC09P122310 GC09P124312


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR1J2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR1J2 Gene:
OR1J2 (olfactory receptor, family 1, subfamily J, member 2) is a protein-coding gene. Diseases associated with OR1J2 include distal arthrogryposis, and neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1F1.

UniProtKB/Swiss-Prot: OR1J2_HUMAN, Q8NGS2
Function: Odorant receptor (Potential)

Gene Wiki entry for OR1J2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR1J2 gene promoter:
         C/EBPbeta   AML1a   ATF-2   NCX/Ncx   SREBP-1c   C/EBPalpha   FOXL1   SREBP-1b   SREBP-1a   NF-kappaB2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR1J2 promoter sequence
   Search Chromatin IP Primers for OR1J2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR1J2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q33.2

OR1J2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR1J2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P125273:  view genomic region     (about GC identifiers)

Start:
125,273,081 bp from pter      End:
125,274,019 bp from pter
Size:
939 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR1J2_HUMAN, Q8NGS2 (See protein sequence)
Recommended Name: Olfactory receptor 1J2  
Size: 313 amino acids; 35385 Da
Secondary accessions: A3KFL9 Q6IF14 Q96R90 Q9NZP1

Explore the universe of human proteins at neXtProt for OR1J2: NX_Q8NGS2

Explore proteomics data for OR1J2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR1J2

    See OR1J2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_473448.1  
    ENSEMBL proteins: 
     ENSP00000335575  
    Reactome Protein details: Q8NGS2

    OR1J2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for OR1J2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR1: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGS2

    ProtoNet protein and cluster: Q8NGS2

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR1J2_HUMAN, Q8NGS2
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR1J2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR1J2_HUMAN, Q8NGS2
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR1J2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for OR1J2:
     Decreased Hepatitis C virus re  Decreased TP53 protein express  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR1J2
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    miRNA
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    miRTarBase miRNAs that target OR1J2:
    hsa-mir-335-5p (MIRT018330)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR1J2_HUMAN, Q8NGS2: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR1J2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR1J2 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR1J2
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR1J2):
        Olfactory transduction


    OR1J2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR1J2
    Interactions:

        Search GeneGlobe Interaction Network for OR1J2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR1J2 (ENSP000003355754) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10AG1ENSP000003114774STRING: ENSP00000311477
    OR10J5ENSP000003344414STRING: ENSP00000334441
    OR1D2ENSP000003275854STRING: ENSP00000327585
    OR2T1ENSP000003554304STRING: ENSP00000355430
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR1J2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR1J2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR1J2 gene: 
    NM_054107.1  

    Unigene Cluster for OR1J2:

    Olfactory receptor, family 1, subfamily J, member 2
    Hs.460145  [show with all ESTs]
    Unigene Representative Sequence: AK123016
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000335302(uc011lyv.2)
    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR1J2
    Primer
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    OriGene qPCR primer pairs and template standards for OR1J2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OR1J2
      QuantiTect SYBR Green Assays in human, mouse, rat OR1J2
      QuantiFast Probe-based Assays in human, mouse, rat OR1J2

    Additional mRNA sequence: AK123016.1 

    2 DOTS entries:

    DT.101970692  DT.75154872 

    9 AceView cDNA sequences:

    CB216532 CR621498 X64989 BX394234 BX954673 AK123016 BX394235 BF212737 
    AA375549 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR1J2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAGGCCC
    OR1J2 Expression
    About this image

    OR1J2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR1J2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.460145
        Custom PCR Arrays for OR1J2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR1J2 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr3481 , 5 olfactory receptor 3481, 5 73.7(n)1
    71.1(a)1
      2 (24.19 cM)5
    2589461  NM_146944.11  NP_667155.11 
     367842765 


    ENSEMBL Gene Tree for OR1J2 (if available)
    TreeFam Gene Tree for OR1J2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR1J2 gene
    OR1F12  OR1I12  OR1N12  OR1J42  OR1E22  OR1N22  OR1S12  OR1E12  
    OR1C12  OR1M12  OR1G12  OR1J12  OR1S22  
    Selected SIMAP similar genes for OR1J2 using alignment to 1 protein entry:     OR1J2_HUMAN(see all similar genes):
    HSA10    OR1J4    OR1J1    OR1E1    OR1E2    HSA12
    OR1F1    OR1E3    OR1F2P    OR1M1    OR1N1    OR16-89
    OR16-90    OR1A1    OR1D2    OR1L8    OR1N2    OR1S1

    OR1J2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR1J2 (see all 134)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs109856611,2
    C--125271119(+) tctggA/Gggtca 1 -- us2k13Minor allele frequency- G:0.07NA WA 240
    rs1443760681,2
    C--125271287(+) ACATAA/GCATCT 1 -- us2k10--------
    rs1918451251,2
    --125271344(+) TAAGGC/TACTCA 1 -- us2k10--------
    rs680777861,2
    C,F--125271393(+) TCCCCA/GTTTTA 1 -- us2k13Minor allele frequency- G:0.13WA NA 240
    rs1512017371,2
    --125271411(+) CTGATC/TAGCAA 1 -- us2k10--------
    rs1403821201,2
    --125271674(+) CCTAGA/GGAGGA 1 -- us2k10--------
    rs1841136641,2
    --125271683(+) GAAAGA/GGAGAC 1 -- us2k10--------
    rs1891878701,2
    --125271756(+) CTGCTC/TTGTGT 1 -- us2k10--------
    rs1499669331,2
    --125271781(+) AAAGCA/GTAAAT 1 -- us2k10--------
    rs70195451,2
    C,A,H--125271800(+) CTAAAA/GTATTT 1 -- us2k1 tfbs311Minor allele frequency- G:0.46NA WA CSA EA 372

    HapMap Linkage Disequilibrium report for OR1J2 ( 125273081 - 125274019 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OR1J2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893823CNV Loss21882294
    nsv893822CNV Gain21882294

    1 Site Specific Mutation Identification with PCR Assay for OR1J2:
    Cosmic IdAA Change
    141897p.D109N
    SeqTarget long-range PCR primers for resequencing OR1J2
    DNA2.0 Custom Variant and Variant Library Synthesis for OR1J2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for OR1J2:    
    About MalaCards
    distal arthrogryposis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for OR1J2:
    Distal arthrogryposis

    OR1J2 for disorders           About GeneDecksing


    Export disorders for OR1J2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR1J2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR1J2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    3. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PubMed id 10706615)1, 2 Rouquier S.... Giorgi D. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    4. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PubMed id 1370859)1, 2 Parmentier M.... Vassart G. (Nature 1992)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (Nature 2004)
    7. Natural selection on the olfactory receptor gene family in humans and chimpanzees. (PubMed id 12908129)1 Gilad Y.... Paabo S. (Am. J. Hum. Genet. 2003)
    8. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26740 HGNC: 8209 AceView: OR1J2 Ensembl:ENSG00000197233 euGenes: HUgn26740
    ECgene: OR1J2 Kegg: 26740 H-InvDB: OR1J2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR1J2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR1J2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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