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OR1I1 Gene

protein-coding   GIFtS: 48
GCID: GC19P015197

Olfactory Receptor, Family 1, Subfamily I, Member 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 1, Subfamily I, Member 11 2
Olfactory Receptor 19-202 3
OR19-202 3
OR1I1P2
OR1I1Q2
Olfactory Receptor 1I12

External Ids:    HGNC: 82071   Entrez Gene: 1263702   Ensembl: ENSG000000946617   UniProtKB: O604313   

Export aliases for OR1I1 gene to outside databases

Previous GC identifers: GC19U990225 GC19P015059 GC19P015060


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR1I1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR1I1 Gene:
OR1I1 (olfactory receptor, family 1, subfamily I, member 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1F1.

UniProtKB/Swiss-Prot: OR1I1_HUMAN, O60431
Function: Odorant receptor (Potential)

Gene Wiki entry for OR1I1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR1I1 gene promoter:
         Oct-B1   ER-alpha   oct-B3   oct-B2   NRSF form 1   Nkx2-5   NRSF form 2   POU2F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR1I1 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR1I1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.1

OR1I1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR1I1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P015197:  view genomic region     (about GC identifiers)

Start:
15,197,877 bp from pter      End:
15,198,821 bp from pter
Size:
945 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: OR1I1_HUMAN, O60431 (See protein sequence)
Recommended Name: Olfactory receptor 1I1  
Size: 355 amino acids; 39297 Da
Secondary accessions: Q96R92

Explore the universe of human proteins at neXtProt for OR1I1: NX_O60431

Explore proteomics data for OR1I1 at MOPED

HORDE protein sequence for OR1I1

See OR1I1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001004713.1  
ENSEMBL proteins: 
 ENSP00000209540  
Reactome Protein details: O60431

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
OR1: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry O60431

ProtoNet protein and cluster: O60431

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR1I1_HUMAN, O60431
Similarity: Belongs to the G-protein coupled receptor 1 family


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(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: OR1I1_HUMAN, O60431
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
Find genes that share ontologies with OR1I1           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
OR1I1_HUMAN, O60431: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OR1I1 About    
See pathways by source

SuperPathContained pathways About
1Olfactory Signaling Pathway
Olfactory Signaling Pathway0.82
Olfactory transduction0.82
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90
3Peptide ligand-binding receptors
GPCRs, Class A Rhodopsin-like0.43


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Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for OR1I1
    GPCRs, Class A Rhodopsin-like

1 Reactome Pathway for OR1I1
    Olfactory Signaling Pathway


1 Kegg Pathway  (Kegg details for OR1I1):
    Olfactory transduction

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Interactions:

    Search GeneGlobe Interaction Network for OR1I1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for OR1I1 (ENSP000002095404) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
OR10J1ENSP000003990784STRING: ENSP00000399078
OR1A2ENSP000003713774STRING: ENSP00000371377
OR2AK2ENSP000003554364STRING: ENSP00000355436
OR2B11ENSP000003256824STRING: ENSP00000325682
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for OR1I1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for OR1I1 gene: 
NM_001004713.1  

Unigene Cluster for OR1I1:

Olfactory receptor, family 1, subfamily I, member 1
Hs.631610
Unigene Representative Sequence: BC140930
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000209540(uc010xoe.2)
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Additional mRNA sequence: BC140930.1 

1 AceView cDNA sequence:

NM_001004713 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR1I1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTCCAGGATC
OR1I1 Expression
About this image

OR1I1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OR1I1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.631610
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for OR1I1 gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr13571 , 5 olfactory receptor 13571, 5 80.56(n)1
77.2(a)1
  10 (39.72 cM)5
2578831  NM_001011737.21  NP_001011737.11 
 786116695 


ENSEMBL Gene Tree for OR1I1 (if available)
TreeFam Gene Tree for OR1I1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OR1I1 gene
OR1F12  OR1N12  OR1J42  OR1E22  OR1N22  OR1S12  OR1J22  OR1E12  
OR1C12  OR1M12  OR1G12  OR1J12  OR1S22  
Selected SIMAP similar genes for OR1I1 using alignment to 2 protein entries:     OR1I1_HUMAN (see all proteins) (see all similar genes):
OR1N2    OR1D2    OR1F2P    OR1J4    OR1F1    OR1L6
OR1M1    OR1D5    OR1E1    OR1J2    OR1L1    OR1L4
OR1L8    OR1N1    OR7A10    OR7A2P    OR7C2    OR7D4

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OR1I1 (see all 126)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1147685831,2
F--15195883(+) TGAAGG/ATGGGC 1 -- us2k11Minor allele frequency- A:0.02WA 118
rs1915456661,2
--15195943(+) GACTTA/TTATAT 1 -- us2k10--------
rs104038571,2
C--15196075(+) ctcccG/Aggttc 1 -- us2k11Minor allele frequency- A:0.50NA 2
rs1134060361,2
C,F--15196108(+) TCCCAC/AGTAGC 1 -- us2k11Minor allele frequency- A:0.50WA 2
rs1428526051,2
C--15196135(+) CACCAA/CAACGC 1 -- us2k10--------
rs1122548651,2
C,F--15196139(+) ACAACG/ACCTAG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
rs286934291,2
C,F--15196169(+) AGAGAC/TGGGGC 1 -- us2k13Minor allele frequency- T:0.06CSA NA EA 242
rs104032531,2
C,F--15196174(+) cggggC/Tttcac 1 -- us2k12Minor allele frequency- T:0.25NA WA 4
rs1132372401,2
C,F--15196180(+) TTCACC/TTTGTT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
rs1836889731,2
--15196274(+) CACCAA/CGCCAG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for OR1I1 ( 15197877 - 15198821 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for OR1I1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv525115CNV Loss19592680
dgv1058e1CNV Complex17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OR1I1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with OR1I1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
  2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 126370 HGNC: 8207 AceView: OR1I1 Ensembl:ENSG00000094661 euGenes: HUgn126370
ECgene: OR1I1 Kegg: 126370 H-InvDB: OR1I1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OR1I1 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR1I1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OR1I1 gene:
Search GeneIP for patents involving OR1I1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR1I1
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 Search Addgene for plasmids for OR1I1
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Customized transgenic rodents for:
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 antibodies-online proteins for OR1I1 (2 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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