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Aliases for OR1I1 Gene

Aliases for OR1I1 Gene

  • Olfactory Receptor Family 1 Subfamily I Member 1 2 3 5
  • Olfactory Receptor 19-20 3 4
  • OR19-20 3 4
  • Olfactory Receptor, Family 1, Subfamily I, Member 1 2
  • Olfactory Receptor 1I1 3
  • OR1I1P 3
  • OR1I1Q 3

External Ids for OR1I1 Gene

Previous GeneCards Identifiers for OR1I1 Gene

  • GC19U990225
  • GC19P015059
  • GC19P015060
  • GC19P015197

Summaries for OR1I1 Gene

Entrez Gene Summary for OR1I1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1I1 Gene

OR1I1 (Olfactory Receptor Family 1 Subfamily I Member 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR1F1.

UniProtKB/Swiss-Prot for OR1I1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1I1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1I1 Gene

Genomics for OR1I1 Gene

Regulatory Elements for OR1I1 Gene

Enhancers for OR1I1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G015123 1.4 ENCODE dbSUPER 12.2 +38.3 38272 3.7 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B AKAP8 ZNF333 OR1I1 ENSG00000268189 OR7C1 ILVBL ENSG00000268564
GH19G014678 0.4 FANTOM5 9.4 -408.0 -408038 0.3 STAT1 OR7A17 OR1I1 SLC1A6 ZNF333 ENSG00000275432
GH19G015499 1 FANTOM5 ENCODE 1.3 +412.3 412259 0.3 PKNOX1 SP3 SP2 ZIC2 ZFHX2 NFIC IKZF1 GLIS1 CREB1 PRDM10 CYP4F22 PGLYRP2 CYP4F2 CYP4F3 CYP4F11 OR10H4 OR1I1
GH19G014597 0.5 FANTOM5 dbSUPER 2.2 -489.2 -489182 0.3 ADGRE3 ADGRE5 NOTCH3 OR7A17 OR1I1 PRKACA PKN1 ZNF333 RN7SL842P ITGB1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR1I1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR1I1 Gene

Chromosome:
19
Start:
15,086,980 bp from pter
End:
15,088,221 bp from pter
Size:
1,242 bases
Orientation:
Plus strand

Genomic View for OR1I1 Gene

Genes around OR1I1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1I1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1I1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1I1 Gene

Proteins for OR1I1 Gene

  • Protein details for OR1I1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60431-OR1I1_HUMAN
    Recommended name:
    Olfactory receptor 1I1
    Protein Accession:
    O60431
    Secondary Accessions:
    • Q96R92

    Protein attributes for OR1I1 Gene

    Size:
    355 amino acids
    Molecular mass:
    39297 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1I1 Gene

Post-translational modifications for OR1I1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR1I1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1I1 Gene

Domains & Families for OR1I1 Gene

Gene Families for OR1I1 Gene

Protein Domains for OR1I1 Gene

Suggested Antigen Peptide Sequences for OR1I1 Gene

Graphical View of Domain Structure for InterPro Entry

O60431

UniProtKB/Swiss-Prot:

OR1I1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1I1: view

Function for OR1I1 Gene

Molecular function for OR1I1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR1I1: view

Phenotypes for OR1I1 Gene

GenomeRNAi human phenotypes for OR1I1:
genes like me logo Genes that share phenotypes with OR1I1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1I1 Gene

Localization for OR1I1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1I1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1I1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1I1: view

Pathways & Interactions for OR1I1 Gene

genes like me logo Genes that share pathways with OR1I1: view

Pathways by source for OR1I1 Gene

1 KEGG pathway for OR1I1 Gene

Interacting Proteins for OR1I1 Gene

Gene Ontology (GO) - Biological Process for OR1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR1I1: view

No data available for SIGNOR curated interactions for OR1I1 Gene

Drugs & Compounds for OR1I1 Gene

No Compound Related Data Available

Transcripts for OR1I1 Gene

mRNA/cDNA for OR1I1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1I1 Gene

No ASD Table

Relevant External Links for OR1I1 Gene

GeneLoc Exon Structure for
OR1I1
ECgene alternative splicing isoforms for
OR1I1

Expression for OR1I1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1I1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR1I1 Gene:

OR1I1

SOURCE GeneReport for Unigene cluster for OR1I1 Gene:

Hs.631610
genes like me logo Genes that share expression patterns with OR1I1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1I1 Gene

Orthologs for OR1I1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1I1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia OR1I1 34
  • 83.6 (n)
mouse
(Mus musculus)
Mammalia Or1i2 55 Olfr1357 34 16 35
  • 80.56 (n)
rat
(Rattus norvegicus)
Mammalia Olr1087 34
  • 80.35 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 77 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia OR1I1 35
  • 65 (a)
OneToOne
Species where no ortholog for OR1I1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1I1 Gene

ENSEMBL:
Gene Tree for OR1I1 (if available)
TreeFam:
Gene Tree for OR1I1 (if available)

Paralogs for OR1I1 Gene

(444) SIMAP similar genes for OR1I1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR1I1: view

Variants for OR1I1 Gene

Sequence variations from dbSNP and Humsavar for OR1I1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1001503964 -- 15,086,861(+) CTCAG(A/G)CATGA upstream-variant-2KB
rs1002820084 -- 15,086,781(+) CTGAA(A/G)GAAGC upstream-variant-2KB
rs1003630623 -- 15,088,052(+) CTGTT(A/G)GCTGC reference, synonymous-codon
rs1004975971 -- 15,086,240(+) ACCCA(C/G)GAGGC upstream-variant-2KB
rs1006747974 -- 15,086,527(+) CTGCT(C/T)GCTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1I1 Gene

Variant ID Type Subtype PubMed ID
dgv654e214 CNV gain 21293372
esv2758746 CNV gain 17122850
esv3643764 CNV gain 21293372
nsv525115 CNV loss 19592680

Variation tolerance for OR1I1 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.58; 99.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1I1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1I1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1I1 Gene

Disorders for OR1I1 Gene

Relevant External Links for OR1I1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR1I1

No disorders were found for OR1I1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1I1 Gene

Publications for OR1I1 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR1I1 Gene

Sources for OR1I1 Gene

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