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Aliases for OR1G1 Gene

Aliases for OR1G1 Gene

  • Olfactory Receptor Family 1 Subfamily G Member 1 2 3 5
  • Olfactory Receptor, Family 1, Subfamily G, Member 1 2 3
  • Olfactory Receptor 17-209 3 4
  • Olfactory Receptor OR17-8 3 4
  • Olfactory Receptor 1G2 3 4
  • OR17-209 3 4
  • OR1G2 3 4
  • Olfactory Receptor, Family 1, Subfamily G, Member 2 3
  • OR17-130 3

External Ids for OR1G1 Gene

Previous HGNC Symbols for OR1G1 Gene

  • OR1G2

Previous GeneCards Identifiers for OR1G1 Gene

  • GC17M003344
  • GC17M003371
  • GC17M002980
  • GC17M003236
  • GC17M002976
  • GC17M003029

Summaries for OR1G1 Gene

Entrez Gene Summary for OR1G1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1G1 Gene

OR1G1 (Olfactory Receptor Family 1 Subfamily G Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR1E2.

UniProtKB/Swiss-Prot for OR1G1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1G1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1G1 Gene

Genomics for OR1G1 Gene

Regulatory Elements for OR1G1 Gene

Transcription factor binding sites by QIAGEN in the OR1G1 gene promoter:

Genomic Location for OR1G1 Gene

Chromosome:
17
Start:
3,126,505 bp from pter
End:
3,128,253 bp from pter
Size:
1,749 bases
Orientation:
Minus strand

Genomic View for OR1G1 Gene

Genes around OR1G1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1G1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1G1 Gene

Proteins for OR1G1 Gene

  • Protein details for OR1G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47890-OR1G1_HUMAN
    Recommended name:
    Olfactory receptor 1G1
    Protein Accession:
    P47890
    Secondary Accessions:
    • Q4VBM1
    • Q6IFL9
    • Q9UM76

    Protein attributes for OR1G1 Gene

    Size:
    313 amino acids
    Molecular mass:
    34924 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04641.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR1G1 Gene

Proteomics data for OR1G1 Gene at MOPED

Post-translational modifications for OR1G1 Gene

Other Protein References for OR1G1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1G1 Gene

Domains & Families for OR1G1 Gene

Gene Families for OR1G1 Gene

Protein Domains for OR1G1 Gene

Suggested Antigen Peptide Sequences for OR1G1 Gene

Graphical View of Domain Structure for InterPro Entry

P47890

UniProtKB/Swiss-Prot:

OR1G1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1G1: view

Function for OR1G1 Gene

Molecular function for OR1G1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily G,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR1G1: view
genes like me logo Genes that share phenotypes with OR1G1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1G1 Gene

Localization for OR1G1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1G1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR1G1 Gene COMPARTMENTS Subcellular localization image for OR1G1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR1G1: view

Pathways & Interactions for OR1G1 Gene

genes like me logo Genes that share pathways with OR1G1: view

Pathways by source for OR1G1 Gene

1 KEGG pathway for OR1G1 Gene

Gene Ontology (GO) - Biological Process for OR1G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1G1: view

No data available for SIGNOR curated interactions for OR1G1 Gene

Drugs & Compounds for OR1G1 Gene

No Compound Related Data Available

Transcripts for OR1G1 Gene

mRNA/cDNA for OR1G1 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1G1 Gene

Olfactory receptor, family 1, subfamily G, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR1G1 Gene

No ASD Table

Relevant External Links for OR1G1 Gene

GeneLoc Exon Structure for
OR1G1
ECgene alternative splicing isoforms for
OR1G1

Expression for OR1G1 Gene

mRNA expression in normal human tissues for OR1G1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1G1 Gene

This gene is overexpressed in Testis (x9.7) and Bladder (x8.0).

SOURCE GeneReport for Unigene cluster for OR1G1 Gene Hs.248183

genes like me logo Genes that share expression patterns with OR1G1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR1G1 Gene

Orthologs for OR1G1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1G1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR1G1 35
  • 98.3 (n)
  • 96.46 (a)
OR1G1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR1G1 35
  • 83.44 (n)
  • 78.53 (a)
OR1G1 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1324 36
  • 49 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 65 (a)
OneToMany
OPOR43 36
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1406 35
  • 64 (n)
  • 55.33 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731992 35
  • 55.59 (n)
  • 50.83 (a)
Species with no ortholog for OR1G1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1G1 Gene

ENSEMBL:
Gene Tree for OR1G1 (if available)
TreeFam:
Gene Tree for OR1G1 (if available)

Paralogs for OR1G1 Gene

(454) SIMAP similar genes for OR1G1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1G1: view

Variants for OR1G1 Gene

Sequence variations from dbSNP and Humsavar for OR1G1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs9892491 - 3,127,288(+) TGACT(C/G)TGGAT reference, missense
rs7217631 -- 3,129,900(+) GTGCC(C/T)GGCCT upstream-variant-2KB
rs7222865 -- 3,129,491(+) GAGTT(C/T)AATAT upstream-variant-2KB
rs6502697 -- 3,126,126(+) GGAGC(A/G)TCACA downstream-variant-500B
rs16952650 -- 3,127,907(+) ATTTA(C/T)ACAAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1G1 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV Deletion 23128226
nsv7288 OTHER Inversion 18451855
dgv3n29 CNV Complex 16826518
nsv907553 CNV Loss 21882294
nsv469609 CNV Loss 16826518

Variation tolerance for OR1G1 Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.04; 68.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1G1 Gene

HapMap Linkage Disequilibrium report
OR1G1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1G1 Gene

Disorders for OR1G1 Gene

Relevant External Links for OR1G1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR1G1

No disorders were found for OR1G1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1G1 Gene

Publications for OR1G1 Gene

  1. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PMID: 8004088) Ben-Arie N. … North M.A. (Hum. Mol. Genet. 1994) 2 3 4 67
  2. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S. … Giorgi D. (Nat. Genet. 1998) 2 3
  3. Genome-wide association study link novel loci to endometriosis. (PMID: 23472165) Albertsen H.M. … Ward K. (PLoS ONE 2013) 3
  4. How broadly tuned olfactory receptors equally recognize their agonists. Human OR1G1 as a test case. (PMID: 22926438) Charlier L. … Golebiowski J. (Cell. Mol. Life Sci. 2012) 3
  5. Relationships between molecular structure and perceived odor quality of ligands for a human olfactory receptor. (PMID: 18603653) Sanz G. … Tromelin A. (Chem. Senses 2008) 3

Products for OR1G1 Gene

Sources for OR1G1 Gene

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