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OR1G1 Gene

protein-coding   GIFtS: 51
GCID: GC17M003029

Olfactory Receptor, Family 1, Subfamily G, Member 1


(Previous symbol: OR1G2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 1, Subfamily G, Member 11 2     OR17-2092 3
OR1G21 2 3     OR17-1302
Olfactory Receptor 17-2092 3     Olfactory Receptor 1G12
Olfactory Receptor 1G22 3     Olfactory Receptor, Family 1, Subfamily G, Member 22
Olfactory Receptor OR17-82 3     

External Ids:    HGNC: 82041   Entrez Gene: 83902   Ensembl: ENSG000001830247   UniProtKB: P478903   

Export aliases for OR1G1 gene to outside databases

Previous GC identifers: GC17M003344 GC17M003371 GC17M002980 GC17M003236 GC17M002976


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR1G1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR1G1 Gene:
OR1G1 (olfactory receptor, family 1, subfamily G, member 1) is a protein-coding gene. Diseases associated with OR1G1 include endometriosis, and neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1F1.

UniProtKB/Swiss-Prot: OR1G1_HUMAN, P47890
Function: Odorant receptor (Potential)

Gene Wiki entry for OR1G1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR1G1 gene promoter:
         ER-alpha   AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR1G1 promoter sequence
   Search Chromatin IP Primers for OR1G1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR1G1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

OR1G1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR1G1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M003029:  view genomic region     (about GC identifiers)

Start:
3,029,907 bp from pter      End:
3,030,845 bp from pter
Size:
939 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR1G1_HUMAN, P47890 (See protein sequence)
Recommended Name: Olfactory receptor 1G1  
Size: 313 amino acids; 34924 Da
Sequence caution: Sequence=DAA04641.1; Type=Erroneous initiation;
Secondary accessions: Q4VBM1 Q6IFL9 Q9UM76

Explore the universe of human proteins at neXtProt for OR1G1: NX_P47890

Explore proteomics data for OR1G1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR1G1

    See OR1G1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003546.1  
    ENSEMBL proteins: 
     ENSP00000331545  
    Reactome Protein details: P47890

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR1: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P47890

    ProtoNet protein and cluster: P47890

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR1G1_HUMAN, P47890
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR1G1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR1G1_HUMAN, P47890
    Function: Odorant receptor (Potential)

         Genatlas biochemistry entry for OR1G1:
    olfactory receptor,family 1,subfamily G,member 1,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR1G1 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR1G1_HUMAN, P47890: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR1G1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR1G1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43
    4GPCRs, Other
    GPCRs, Other

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for OR1G1
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR1G1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR1G1):
        Olfactory transduction


    OR1G1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR1G1
    Interactions:

        Search GeneGlobe Interaction Network for OR1G1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR1G1 (P478903 ENSP000003315454) via UniProtKB, MINT, STRING, and/or I2D (see all 274)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OBP2AQ9NY563, ENSP000003608414I2D: score=1 STRING: ENSP00000360841
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10H2ENSP000003060954STRING: ENSP00000306095
    OR10J1ENSP000003990784STRING: ENSP00000399078
    OR1A1ENSP000003052074STRING: ENSP00000305207
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS8004088
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR1G1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR1G1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR1G1 gene: 
    NM_003555.1  

    Unigene Cluster for OR1G1:

    Olfactory receptor, family 1, subfamily G, member 1
    Hs.248183  [show with all ESTs]
    Unigene Representative Sequence: BC095520
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000328890(uc002fvc.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat OR1G1
      QuantiFast Probe-based Assays in human, mouse, rat OR1G1

    Additional mRNA sequence: 

    BC069379.1 BC095520.1 

    1 DOTS entry:

    DT.91889894 

    9 AceView cDNA sequences:

    CO247817 NM_003555 BC069379 CO246519 CF147773 CO247941 CO246957 CO246968 
    CO247701 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR1G1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATCCCACA
    OR1G1 Expression
    About this image

    OR1G1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR1G1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248183
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR1G1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr13775 olfactory receptor 1377   --   11 (30.96 cM) 50984703 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017319921 olfactory receptor 5V1-like 55.59(n)
    50.83(a)
      101731992  XM_004911375.1  XP_004911432.1 


    ENSEMBL Gene Tree for OR1G1 (if available)
    TreeFam Gene Tree for OR1G1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR1G1 gene
    OR1F12  OR1I12  OR1N12  OR1J42  OR1E22  OR1N22  OR1S12  OR1J22  
    OR1E12  OR1C12  OR1M12  OR1J12  OR1S22  
    Selected SIMAP similar genes for OR1G1 using alignment to 1 protein entry:     OR1G1_HUMAN(see all similar genes):
    OR17-130    OR7D4    OR7A10    OR7A2P    OR7G3    OR1D2
    OR7A17    OR7C2    OR7D2    OR1C1    OR1F2P    OR1J1
    OR1M1    OR1P1    OR7A5    OR7E86P    OR7G1    OR7G2

    OR1G1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR1G1 (see all 105)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1488343441,2
    --3029406(+) CATCAA/CTGAGC 1 -- ds50010--------
    rs65026971,2
    C,F,A,H--3029420(+) GGAGCA/GTCACA 1 -- ds500124Minor allele frequency- G:0.30NA NS EA WA CSA 2366
    rs1924030251,2
    --3029430(+) AGATAC/TGGGCA 1 -- ds50010--------
    rs733027391,2
    C,F--3029454(+) AAACAC/TTGTGG 1 -- ds50013Minor allele frequency- T:0.06WA 122
    rs124494651,2
    C,F,H--3029554(+) CCAGAT/CATTCC 1 -- ds500127Minor allele frequency- C:0.19NS EA NA WA 3128
    rs1845908481,2
    C--3029640(+) TAACTA/GTAGTA 1 -- ds50010--------
    rs788417781,2
    C,F--3029657(+) ATAAGG/CCATGA 1 -- ds50011Minor allele frequency- C:0.06WA 118
    rs1169818421,2
    F--3029679(+) ACATCT/AGGATG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1425003041,2
    --3029792(+) AGATCA/GTAGGT 1 -- ds50010--------
    rs99136641,2
    C,F,H--3029858(+) GGTGAA/TCGCAG 1 -- ds50015Minor allele frequency- T:0.02NS EA WA 536

    HapMap Linkage Disequilibrium report for OR1G1 ( 3029907 - 3030845 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for OR1G1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660206CNV Deletion23128226
    nsv907553CNV Loss21882294
    nsv469609CNV Loss16826518
    dgv3n29CNV Complex16826518
    nsv7288OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for OR1G1:    
    About MalaCards
    endometriosis    neuronitis


    OR1G1 for disorders           About GeneDecksing


    Export disorders for OR1G1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR1G1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR1G1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PubMed id 8004088)1, 2, 3 Ben-Arie N.... North M.A. (Hum. Mol. Genet. 1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PubMed id 10673334)1, 2 Glusman G.... Lancet D. (Genomics 2000)
    5. Distribution of olfactory receptor genes in the human genome. (PubMed id 9500546)1, 3 Rouquier S.... Giorgi D. (Nat. Genet. 1998)
    6. Genome-wide association study link novel loci to endometriosis. (PubMed id 23472165)1 Albertsen H.M....Ward K. (PLoS ONE 2013)
    7. How broadly tuned olfactory receptors equally recognize their agonists. Human OR1G1 as a test case. (PubMed id 22926438)1 Charlier L....Golebiowski J. (Cell. Mol. Life Sci. 2012)
    8. Relationships between molecular structure and perceived odor quality of ligands for a human olfactory receptor. (PubMed id 18603653)1 Sanz G....Tromelin A. (Chem. Senses 2008)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Porcine odorant-binding protein selectively binds to a human olfactory receptor. (PubMed id 12379593)1 Matarazzo V....Ronin C. (Chem. Senses 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8390 HGNC: 8204 AceView: OR1G1 Ensembl:ENSG00000183024 euGenes: HUgn8390
    ECgene: OR1G1 Kegg: 8390 H-InvDB: OR1G1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR1G1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR1G1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR1G1 gene:
    Search GeneIP for patents involving OR1G1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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