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OR1F2P Gene

pseudogene   GIFtS: 36
GCID: GC16P003271

Olfactory Receptor, Family 1, Subfamily F, Member 2


(Previous symbols: OR1F3P, OR1F2)
  Search for OR1F2P
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 1, Subfamily F, Member 21 2     OR16-32
OR1F21 2 3     OR1F112
OR1F3P1 2     hg912
OLFMF22     OLFmf23

External Ids:    HGNC: 81961   Entrez Gene: 261842   Ensembl: ENSG000002035817   UniProtKB: Q96R843   

Export aliases for OR1F2P gene to outside databases

Previous GC identifers: GC16P003266 GC16P003207 GC16P003267


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR1F2P Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR1F2P Gene:
OR1F2P (olfactory receptor, family 1, subfamily F, member 2) is a pseudogene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot: OR1F2_HUMAN, Q96R84
Function: Odorant receptor (Potential)

Gene Wiki entry for OR1F2P (OR1F2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR1F2P gene promoter:
         Nkx3-1   HOXA9   HOXA9B   Nkx3-1 v1   HNF-4alpha1   Nkx3-1 v2   Nkx3-1 v3   Meis-1a   Meis-1   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR1F2P


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

OR1F2P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR1F2P gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P003271:  view genomic region     (about GC identifiers)

Start:
3,265,566 bp from pter      End:
3,266,546 bp from pter
Size:
981 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
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UniProtKB/Swiss-Prot: OR1F2_HUMAN, Q96R84 (See protein sequence)
Recommended Name: Putative olfactory receptor 1F2  
Size: 312 amino acids; 34944 Da
Caution: Could be the product of a pseudogene
Sequence caution: Sequence=AJ003145; Type=Frameshift; Positions=1;

Explore the universe of human proteins at neXtProt for OR1F2P: NX_Q96R84

HORDE protein sequence for OR1F2P
Reactome Protein details: Q96R84

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
OR1: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q96R84

ProtoNet protein and cluster: Q96R84

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR1F2_HUMAN, Q96R84
Similarity: Belongs to the G-protein coupled receptor 1 family


Find genes that share domains with OR1F2P           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: OR1F2_HUMAN, Q96R84
Function: Odorant receptor (Potential)

     Genatlas biochemistry entry for OR1F2P:
olfactory receptor,family 1,subfamily F,member 2,likely a pseudogene,G protein coupled receptor superfamily

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
Find genes that share ontologies with OR1F2P           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
OR1F2_HUMAN, Q96R84: Cell membrane; Multi-pass membrane protein

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with OR1F2P           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OR1F2P About    
See pathways by source

SuperPathContained pathways About
1Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90
2Olfactory Signaling Pathway
Olfactory Signaling Pathway0.82


Find genes that share SuperPaths with OR1F2P           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for OR1F2P
    Olfactory Signaling Pathway


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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for OR1F2P (OR1F2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Unigene Cluster for OR1F2P:

Olfactory receptor, family 1, subfamily F, member 2
Hs.651203
Unigene Representative Sequence: AJ003145
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000570470(uc010uwv.2) ENST00000366390
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Additional mRNA sequence: 

AJ003145.1 NR_002169.1 X64987.1 

1 DOTS entry:

DT.92046460 

3 AceView cDNA sequences:

X64987 BG193339 AJ003145 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR1F2P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGTGGTTGCC
OR1F2P Expression
About this image

OR1F2P Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.651203
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for OR1F2P (if available)
TreeFam Gene Tree for OR1F2P (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OR1F2P gene
Selected SIMAP similar genes for OR1F2P using alignment to 1 protein entry:     OR1F2_HUMAN(see all similar genes):
OR1F1    OR16-36    OR16-37    OR16-88    OR16-89    OR16-90
OR1C1    OR1F12    OR1J4    HSA10    OR1A1    OR1D2
OR1E1    OR1J1    OR1J2    OR1K1    OR1L3    OR1N1

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OR1F2P (see all 84)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs129272421,2
C--3263564(+) caggaA/Gaatct 1 -- us2k10--------
rs1439847391,2
C--3263569(+) GAATCA/TCTTGA 1 -- us2k10--------
rs129350781,2
C--3263572(+) tctctC/Tgaacc 1 -- us2k10--------
rs560722041,2
C--3263638(+) ACAGAG/CTGAAA 1 -- us2k13Minor allele frequency- C:0.45NA EA 242
rs355513441,2
C--3263675(+) AAAAAAA/-GAGAA 1 -- us2k11Minor allele frequency- -:0.00NA 2
rs1441709191,2
--3263783(+) TATGGC/TGAAGG 1 -- us2k10--------
rs1399028591,2
--3263816(+) CTGGGG/TCTCCA 1 -- us2k10--------
rs1433914101,2
C--3263886(+) GTTGCA/TGGGAC 1 -- us2k10--------
rs775497141,2
--3263898(+) TCCCCA/TAAGAT 1 -- us2k10--------
rs127092371,2
C,F,A,H--3263937(+) ATCACG/AGCATC 1 -- us2k123Minor allele frequency- A:0.47NS EA NA WA CSA 2350

HapMap Linkage Disequilibrium report for OR1F2P ( 3265566 - 3266546 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for OR1F2P:    About this table    
Variant IDTypeSubtypePubMed ID
nsv509592CNV Insertion20534489
nsv905208CNV Loss21882294
nsv905209CNV Gain21882294
nsv471074CNV Gain18288195
nsv516280CNV Gain19592680
nsv457355CNV Gain19166990
nsv833127CNV Gain+Loss17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OR1F2P gene integrated from 10 sources:
(articles sorted by number of sources associating them with OR1F2P)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A transcriptional map of the FMF region. (PubMed id 9653642)1, 2, 3 Bernot A.... Weissenbach J. (Genomics 1998)
  2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
  3. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  4. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PubMed id 1370859)1 Parmentier M.... Vassart G. (Nature 1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26184 HGNC: 8196 AceView: OR1F2 Ensembl:ENSG00000203581 euGenes: HUgn26184
ECgene: OR1F2P H-InvDB: OR1F2P

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OR1F2P Pharmacogenomics, SNPs, Pathways
HORDE entry for OR1F2P The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OR1F2P gene:
Search GeneIP for patents involving OR1F2P

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR1F2P
 Browse SwitchGear 3'UTR luciferase reporter plasmids for OR1F2P
 Browse SwitchGear Promoter luciferase reporter plasmids for OR1F2P
 Search ThermoFisher Antibodies for OR1F2P
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR1F2P
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR1F2P
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OR1F2P
 Search LSBio for Antibodies for OR1F2P
Customized transgenic rodents for:
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 Browse compounds at ApexBio
 Search Addgene for plasmids for OR1F2P
  Search eBioscience for proteins for OR1F2P
  Search eBioscience for elisas for OR1F2P
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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