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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR1F12 Gene

pseudogene   GIFtS: 28
GCID: GC06P028044

olfactory receptor, family 1, subfamily F, member 12

(Previous names: olfactory receptor, family 1, subfamily F, member 12 pseudogene...)
(Previous symbol: OR1F12P)
 Explore 1 disease affiliated with
OR1F12 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for OR1F12    

Aliases
for OR1F12 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Olfactory Receptor, Family 1, Subfamily F, Member 121 2     Olfactory Receptor, Family 1, Subfamily F, Member 12 Pseudogene1
OR1F12P1 2 3     OR6-122
OR1F12Q1 2     Hs6M1-35P3
Hs6M1-35P3     

External Ids:    HGNC: 139641   Entrez Gene: 4421792   Ensembl: ENSG000002207217   UniProtKB: Q8NHA83   

Export aliases for OR1F12 gene to outside databases

Previous GC identifers: GC00U990906 GC06P028148


Summaries
for OR1F12 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for OR1F12:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors
(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many
neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of
odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the
olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: OR1FC_HUMAN, Q8NHA8
Function: Odorant receptor (Potential)




Genomic Views
for OR1F12 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for OR1F12
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR1F12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

OR1F12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR1F12 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P028044:  view genomic region     (about GC identifiers)

Start:
 28,041,094 bp from pter      End:
 28,042,014 bp from pter
Size:
 921 bases      Orientation:
 plus strand

Proteins
for OR1F12 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OR1FC_HUMAN, Q8NHA8 (See protein sequence)
Recommended Name: Olfactory receptor 1F12  
Size: 337 amino acids; 36933 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for OR1F12: NX_Q8NHA8

HORDE protein sequence for OR1F12
OR1F12 Protein expression data from MOPED and PaxDb: --
Reactome Protein details: Q8NHA8
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Uscn Proteins for OR1F12

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--


OR1F12 for ontologies           About GeneDecksing



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Protein Domains /
Families
for OR1F12 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
OR1F12 for domains           About GeneDecksing

3 InterPro domains/families:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NHA8

ProtoNet protein and cluster: Q8NHA8

1 Blocks protein family: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR1FC_HUMAN, Q8NHA8
Similarity: Belongs to the G-protein coupled receptor 1 family


Function
for OR1F12 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: OR1FC_HUMAN, Q8NHA8
Function: Odorant receptor (Potential)

miRNA
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Cell Line
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In Situ Assay
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--


OR1F12 for ontologies           About GeneDecksing



Pathways & Interactions
for OR1F12 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Signaling by GPCR
Signaling by GPCR1.00
Signal Transduction0.56
GPCR downstream signaling0.89
2Olfactory transduction
Olfactory Signaling Pathway0.77

Pathway sources
See GeneCards unified pathways
Show all pathways


4        Reactome Pathways for OR1F12
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR



OR1F12 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR1F12

Drugs & Compounds
for OR1F12 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for OR1F12
Search CenterWatch for drugs/clinical trials and news about OR1F12 

Transcripts
for OR1F12 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000402365

miRNA
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Inhib. RNA
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Clone
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Primer
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24/26 AceView cDNA sequences (see all 26):

BX104338 NM_003447 AY366500 AI798474 AY083664 X84801 BF980027 BC026092 
BG771463 BE613722 BC037779 BF979736 U78722 BM829284 W31899 AI559497 
W39262 BE614607 BE000513 AI581244 BI465337 C05700 AI254486 AI792510 

GeneLoc Exon Structure


Expression
for OR1F12 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR1F12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image    SABiosciences Custom PCR Arrays for OR1F12
Primer
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In Situ
Assay Products: 
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Orthologs
for OR1F12 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of human and mouse.

Orthologs for OR1F12 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Olfr13665 olfactory receptor 1366   --   13 (7.85 cM) 21536974 


ENSEMBL Gene Tree for OR1F12 (if available)
TreeFam Gene Tree for OR1F12 (if available) 

Paralogs
for OR1F12 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for OR1F12 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR1F12
DNA2.0 Custom Variant and Variant Library Synthesis for OR1F12

Disorders / Diseases
for OR1F12 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OR1F12 for disorders           About GeneDecksing

1 disease for OR1F12:    About MalaCards
neuronitis


Export disorders for OR1F12 gene to outside databases

Publications
for OR1F12 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed article for OR1F12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR1F12)		    Utopia: connect your pdf to the dynamic
world of online information

  1. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (2004)

External Searches for OR1F12 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing OR1F12 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 442179 HGNC: 13964 AceView: ZNF165 Ensembl:ENSG00000220721 euGenes: HUgn442179
ECgene: OR1F12 H-InvDB: OR1F12

Other Databases showing OR1F12 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing OR1F12 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR1F12 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR1F12 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property
for OR1F12 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR1F12 gene:
Search GeneIP for patents involving OR1F12

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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About This Section

 
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