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Aliases for OR1F1 Gene

Aliases for OR1F1 Gene

  • Olfactory Receptor, Family 1, Subfamily F, Member 1 2 3
  • OLFMF 3 4 6
  • OR1F10 3 4
  • OR1F4 3 4
  • OR1F5 3 4
  • OR1F6 3 4
  • OR1F7 3 4
  • OR1F8 3 4
  • OR1F9 3 4
  • Olfactory Receptor, Family 1, Subfamily F, Member 13 Pseudogene 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 10 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 4 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 5 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 6 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 7 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 9 3
  • Olfactory Receptor OR16-4 4
  • Olfactory Receptor 16-35 4
  • Olfactory Receptor 1F10 4
  • Olfactory Receptor 1F1 3
  • Olfactory Receptor 1F4 4
  • Olfactory Receptor 1F5 4
  • Olfactory Receptor 1F6 4
  • Olfactory Receptor 1F7 4
  • Olfactory Receptor 1F8 4
  • Olfactory Receptor 1F9 4
  • OR16-36 3
  • OR16-37 3
  • OR16-88 3
  • OR16-89 3
  • OR16-90 3
  • OR3-145 3
  • ORL1023 3
  • OR1F13P 3
  • OR16-35 4

External Ids for OR1F1 Gene

Previous Symbols for OR1F1 Gene

  • OR1F4
  • OR1F6
  • OR1F7
  • OR1F8
  • OR1F9
  • OR1F5
  • OR1F10
  • OR1F13P

Summaries for OR1F1 Gene

Entrez Gene Summary for OR1F1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1F1 Gene

OR1F1 (Olfactory Receptor, Family 1, Subfamily F, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1E2.

UniProtKB/Swiss-Prot for OR1F1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1F1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1F1 Gene

Genomics for OR1F1 Gene

Genomic Location for OR1F1 Gene

Start:
3,204,247 bp from pter
End:
3,205,188 bp from pter
Size:
942 bases
Orientation:
Plus strand

Genomic View for OR1F1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR1F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1F1 Gene

Proteins for OR1F1 Gene

  • Protein details for OR1F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43749-OR1F1_HUMAN
    Recommended name:
    Olfactory receptor 1F1
    Protein Accession:
    O43749
    Secondary Accessions:
    • O15246
    • Q6IFL5

    Protein attributes for OR1F1 Gene

    Size:
    312 amino acids
    Molecular mass:
    34866 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1F1 Gene

Proteomics data for OR1F1 Gene at MOPED

Post-translational modifications for OR1F1 Gene

Other Protein References for OR1F1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR1F1 Gene

Domains for OR1F1 Gene

Gene Families for OR1F1 Gene

HGNC:
  • OR1 :GPCR / Class A : Olfactory receptors

Protein Domains for OR1F1 Gene

Suggested Antigen Peptide Sequences for OR1F1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43749

UniProtKB/Swiss-Prot:

OR1F1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • O43749
genes like me logo Genes that share domains with OR1F1: view

Function for OR1F1 Gene

Molecular function for OR1F1 Gene

GENATLAS Biochemistry: olfactory receptor,family 1,subfamily F,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR1F1: view

Phenotypes for OR1F1 Gene

genes like me logo Genes that share phenotypes with OR1F1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR1F1 Gene

Localization for OR1F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1F1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR1F1 Gene COMPARTMENTS Subcellular localization image for OR1F1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1F1: view

Pathways for OR1F1 Gene

genes like me logo Genes that share pathways with OR1F1: view

Pathways by source for OR1F1 Gene

1 KEGG pathway for OR1F1 Gene

Interacting Proteins for OR1F1 Gene

Gene Ontology (GO) - Biological Process for OR1F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 9500546
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA --
genes like me logo Genes that share ontologies with OR1F1: view

Transcripts for OR1F1 Gene

mRNA/cDNA for OR1F1 Gene

(5) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR1F1 Gene

No ASD Table

Relevant External Links for OR1F1 Gene

GeneLoc Exon Structure for
OR1F1
ECgene alternative splicing isoforms for
OR1F1

Expression for OR1F1 Gene

mRNA expression in normal human tissues for OR1F1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1F1 Gene

This gene is overexpressed in Brain - Cerebellum (11.8) and Brain - Cerebellar Hemisphere (10.1).

SOURCE GeneReport for Unigene cluster for OR1F1 Gene Hs.664502

genes like me logo Genes that share expressions with OR1F1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for OR1F1 Gene

Orthologs for OR1F1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1F1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
LOC539468 35
  • 86.34 (n)
  • 84.26 (a)
dog
(Canis familiaris)
Mammalia OR10A11 36
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr161 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR1F1 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1378 35
  • 82.64 (n)
  • 80.06 (a)
Species with no ortholog for OR1F1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1F1 Gene

ENSEMBL:
Gene Tree for OR1F1 (if available)
TreeFam:
Gene Tree for OR1F1 (if available)

Paralogs for OR1F1 Gene

Selected SIMAP similar genes for OR1F1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR1F1 Gene

genes like me logo Genes that share paralogs with OR1F1: view

Variants for OR1F1 Gene

Sequence variations from dbSNP and Humsavar for OR1F1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs224176 -- 3,203,133(-) ATACA(C/T)AATTC upstream-variant-2KB
rs885744 -- 3,202,334(+) GTTAT(C/T)ATTCA upstream-variant-2KB
rs885745 -- 3,202,341(+) TTCAG(A/C)TCCCT upstream-variant-2KB
rs1834026 - 3,204,470(-) TGGTG(A/G)AGGAG missense, reference
rs2075851 -- 3,204,972(+) TGTGG(C/T)TCTCA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for OR1F1 Gene

Variant ID Type Subtype PubMed ID
nsv457355 CNV Gain 19166990
nsv905208 CNV Loss 21882294
nsv833127 CNV Gain+Loss 17160897
nsv471074 CNV Gain 18288195
nsv1713 CNV Insertion 18451855
nsv524873 CNV Loss 19592680
nsv905209 CNV Gain 21882294

Relevant External Links for OR1F1 Gene

HapMap Linkage Disequilibrium report
OR1F1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1F1 Gene

Disorders for OR1F1 Gene

No disorders were found for OR1F1 Gene.

No data available for UniProtKB/Swiss-Prot for OR1F1 Gene

Publications for OR1F1 Gene

  1. A candidate gene for familial Mediterranean fever. (PMID: 9288094) Bernot A. … Grateau G. (Nat. Genet. 1997) 2 3 4
  2. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S. … Giorgi D. (Nat. Genet. 1998) 2 3 4
  3. A transcriptional map of the FMF region. (PMID: 9653642) Bernot A. … Weissenbach J. (Genomics 1998) 3 4
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  5. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4

Products for OR1F1 Gene

Sources for OR1F1 Gene

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