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Aliases for OR1F1 Gene

Aliases for OR1F1 Gene

  • Olfactory Receptor Family 1 Subfamily F Member 1 2 3 5
  • OR1F10 3 4
  • OR1F4 3 4
  • OR1F5 3 4
  • OR1F6 3 4
  • OR1F7 3 4
  • OR1F8 3 4
  • OR1F9 3 4
  • OLFMF 3 4
  • Olfactory Receptor, Family 1, Subfamily F, Member 13 Pseudogene 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 10 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 1 2
  • Olfactory Receptor, Family 1, Subfamily F, Member 4 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 5 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 6 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 7 3
  • Olfactory Receptor, Family 1, Subfamily F, Member 9 3
  • Olfactory Receptor OR16-4 4
  • Olfactory Receptor 16-35 4
  • Olfactory Receptor 1F10 4
  • Olfactory Receptor 1F1 3
  • Olfactory Receptor 1F4 4
  • Olfactory Receptor 1F5 4
  • Olfactory Receptor 1F6 4
  • Olfactory Receptor 1F7 4
  • Olfactory Receptor 1F8 4
  • Olfactory Receptor 1F9 4
  • OR16-36 3
  • OR16-37 3
  • OR16-88 3
  • OR16-89 3
  • OR16-90 3
  • OR3-145 3
  • ORL1023 3
  • OR1F13P 3
  • OR16-35 4

External Ids for OR1F1 Gene

Previous HGNC Symbols for OR1F1 Gene

  • OR1F4
  • OR1F6
  • OR1F7
  • OR1F8
  • OR1F9
  • OR1F5
  • OR1F10
  • OR1F13P

Previous GeneCards Identifiers for OR1F1 Gene

  • GC16P003274
  • GC16P003255
  • GC16P003256
  • GC16P003195
  • GC16P003257
  • GC16P003260
  • GC16P003269
  • GC16P003218
  • GC16P003249
  • GC16P003288
  • GC16P003326

Summaries for OR1F1 Gene

Entrez Gene Summary for OR1F1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1F1 Gene

OR1F1 (Olfactory Receptor Family 1 Subfamily F Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1C1.

UniProtKB/Swiss-Prot for OR1F1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1F1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1F1 Gene

Genomics for OR1F1 Gene

Regulatory Elements for OR1F1 Gene

Enhancers for OR1F1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F003462 0.9 FANTOM5 9.3 +271.1 271128 0.3 OR1F1 OR2C1 CLUAP1 TIGD7 ENSG00000263212 GC16M003477
GH16F003296 0.3 FANTOM5 7 +104.4 104443 0.2 POLR2A OR2C1 ZNF263 ZNF200 MEFV ZNF174 ZSCAN32 C16orf90 OR1F1 SLX4 CLUAP1
GH16F003105 1.1 FANTOM5 ENCODE 2.4 -84.7 -84729 2.2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF302 ZNF143 FOS KLF13 ZNF205 ZNF213-AS1 CREBBP THOC6 LOC105371055 TRAF7 OR2C1 OR1F1 CLUAP1 PAQR4
GH16F003097 1.5 FANTOM5 Ensembl ENCODE 1.6 -91.0 -91009 6.2 MLX CREB3L1 ZFP64 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF205 CREBBP THOC6 ZNF263 ZNF597 SNHG19 LOC105371055 SNORD60 ZNF213-AS1 ENSG00000200059
GH16F002793 1 FANTOM5 Ensembl ENCODE 1.1 -396.1 -396084 3.6 PKNOX1 GATA2 KLF7 FOS REST SMARCB1 ZNF518A SMARCA4 PBX2 GLIS1 ENSG00000279473 CLUAP1 ZNF213-AS1 RNPS1 ZNF174 MTRNR2L4 ZNF263 MTND1P8 PRSS41 MEFV
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR1F1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR1F1 Gene

Chromosome:
16
Start:
3,191,095 bp from pter
End:
3,205,344 bp from pter
Size:
14,250 bases
Orientation:
Plus strand

Genomic View for OR1F1 Gene

Genes around OR1F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1F1 Gene

Proteins for OR1F1 Gene

  • Protein details for OR1F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43749-OR1F1_HUMAN
    Recommended name:
    Olfactory receptor 1F1
    Protein Accession:
    O43749
    Secondary Accessions:
    • O15246
    • Q6IFL5

    Protein attributes for OR1F1 Gene

    Size:
    312 amino acids
    Molecular mass:
    34866 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1F1 Gene

Post-translational modifications for OR1F1 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1F1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1F1 Gene

Domains & Families for OR1F1 Gene

Gene Families for OR1F1 Gene

Protein Domains for OR1F1 Gene

Graphical View of Domain Structure for InterPro Entry

O43749

UniProtKB/Swiss-Prot:

OR1F1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1F1: view

Function for OR1F1 Gene

Molecular function for OR1F1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily F,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA,IBA --
genes like me logo Genes that share ontologies with OR1F1: view
genes like me logo Genes that share phenotypes with OR1F1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1F1 Gene

Localization for OR1F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1F1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR1F1 Gene COMPARTMENTS Subcellular localization image for OR1F1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1F1: view

Pathways & Interactions for OR1F1 Gene

genes like me logo Genes that share pathways with OR1F1: view

Pathways by source for OR1F1 Gene

1 KEGG pathway for OR1F1 Gene

Gene Ontology (GO) - Biological Process for OR1F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,NAS 9500546
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1F1: view

No data available for SIGNOR curated interactions for OR1F1 Gene

Transcripts for OR1F1 Gene

mRNA/cDNA for OR1F1 Gene

(3) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1F1 Gene

No ASD Table

Relevant External Links for OR1F1 Gene

GeneLoc Exon Structure for
OR1F1
ECgene alternative splicing isoforms for
OR1F1

Expression for OR1F1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1F1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1F1 Gene

This gene is overexpressed in Brain - Cerebellum (x11.8) and Brain - Cerebellar Hemisphere (x10.1).

NURSA nuclear receptor signaling pathways regulating expression of OR1F1 Gene:

OR1F1

SOURCE GeneReport for Unigene cluster for OR1F1 Gene:

Hs.664502
genes like me logo Genes that share expression patterns with OR1F1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR1F1 Gene

Orthologs for OR1F1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1F1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC539468 34
  • 86.34 (n)
-- 35
  • 83 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr1378 34
  • 82.64 (n)
mouse
(Mus musculus)
Mammalia Or1f19 55 Olfr161 35
  • 73 (a)
OneToOne
Or1ad1 55 Olfr1377
  • chr11:50,984,703-50,985,623
Or1ad5-ps 55 Olfr1376-ps1
  • chr11:50,991,792-50,992,740
Or1ad6 55 Olfr1378
  • chr11:50,969,020-50,969,964
Or1f20-ps 55 Olfr162-ps1
  • chr16:3,601,922-3,602,862
Or1f21-ps 55 Olfr163-ps1
  • chr16:3,618,089-3,618,869
oppossum
(Monodelphis domestica)
Mammalia OR1F1 35
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR10A11 35
  • 61 (a)
OneToMany
Species where no ortholog for OR1F1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1F1 Gene

ENSEMBL:
Gene Tree for OR1F1 (if available)
TreeFam:
Gene Tree for OR1F1 (if available)

Paralogs for OR1F1 Gene

(455) SIMAP similar genes for OR1F1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR1F1 Gene

genes like me logo Genes that share paralogs with OR1F1: view

Variants for OR1F1 Gene

Sequence variations from dbSNP and Humsavar for OR1F1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10153133 -- 3,186,845(+) TTGGA(A/C)TCTAT upstream-variant-2KB
rs10468342 -- 3,205,712(+) tttca(C/T)ggaca utr-variant-3-prime
rs10468343 -- 3,205,798(+) cgtaa(A/G)ctgac utr-variant-3-prime
rs11077298 -- 3,188,987(+) CATCC(C/T)GGGCA intron-variant, upstream-variant-2KB
rs11077317 -- 3,201,854(+) CAAAC(A/G)TTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR1F1 Gene

Variant ID Type Subtype PubMed ID
esv3581941 CNV loss 25503493
nsv1036149 CNV gain 25217958
nsv1044147 CNV loss 25217958
nsv1713 CNV insertion 18451855
nsv457355 CNV gain 19166990
nsv471074 CNV gain 18288195
nsv524873 CNV loss 19592680
nsv571249 CNV gain 21841781
nsv833127 CNV gain+loss 17160897

Variation tolerance for OR1F1 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.99; 92.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1F1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1F1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1F1 Gene

Disorders for OR1F1 Gene

Relevant External Links for OR1F1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR1F1

No disorders were found for OR1F1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1F1 Gene

Publications for OR1F1 Gene

  1. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S. … Giorgi D. (Nat. Genet. 1998) 2 3 4 64
  2. A candidate gene for familial Mediterranean fever. (PMID: 9288094) Bernot A. … Grateau G. (Nat. Genet. 1997) 2 3 4 64
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64

Products for OR1F1 Gene

Sources for OR1F1 Gene

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