OR1E2 Gene
protein-coding GIFtS: 46
GCID: GC17M003336
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olfactory receptor, family 1, subfamily E, member 2
(Previous symbol: OR1E4)
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Aliases
for OR1E2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 1, Subfamily E, Member 21 2 | | OR1E72 | | OR17-1351 2 3 | | OST5292 | | OR17-931 2 3 | | Olfactory Receptor 1E22 | | OR1E41 2 3 | | Olfactory Receptor OR17-172 | | Olfactory Receptor 17-93/17-135/17-1362 3 | | Olfactory Receptor OR17-32 | | Olfactory Receptor 1E42 3 | | Olfactory Receptor, Family 1, Subfamily E, Member 42 | | OR17-1362 3 | | Olfactory Receptor, Family 1, Subfamily E, Member 72 |
Export aliases for OR1E2 gene to outside databasesPrevious GC identifers: GC17M003650 GC17M003286 GC17M003542 GC17M003282 |
Summaries
for OR1E2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR1E2:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: OR1E2_HUMAN, P47887Function: Odorant receptor (Potential)
Gene Wiki entry for OR1E2
|
Genomic Views
for OR1E2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR1E2 gene promoter:
SRF AML1a SRF (504 AA) GCNF RORalpha2 GATA-2 PPAR-gamma1 GCNF-1 PPAR-gamma2 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR1E2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR1E2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.3OR1E2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M003336: view genomic region
(about GC identifiers)
Start:
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3,336,167 bp from pter |
End:
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3,337,135 bp from pter |
Size:
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969 bases |
Orientation:
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minus strand |
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Proteins
for OR1E2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OR1E2_HUMAN, P47887 (See
protein sequence)Recommended Name: Olfactory receptor 1E2 Size: 323 amino acids; 36391 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: O43877 O95632 Q0VAD5 Q0VAD6 Q9UL13Explore the universe of human proteins at neXtProt for OR1E2: NX_P47887
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P47887
HORDE protein sequence for OR1E2
OR1E2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003545.1
ENSEMBL proteins: ENSP00000248384 Reactome Protein details: P47887
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
OR1E2 for ontologies About GeneDecksing
OR1E2 Antibody Products:
Assay Products for OR1E2: |
Protein
Domains /
Families
for OR1E2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR1E2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P47887ProtoNet protein and cluster: P47887 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR1E2_HUMAN, P47887Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR1E2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OR1E2_HUMAN, P47887Function: Odorant receptor (Potential) Genatlas biochemistry entry for OR1E2:olfactory receptor,family 1,subfamily E,member 2,G protein coupled receptor superfamily
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR1E2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR1E2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for OR1E2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR1E2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
OR1E2 for ontologies About GeneDecksing
|
Pathways & Interactions
for OR1E2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | | | 3 | Class A/1 (Rhodopsin-like receptors) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for OR1E2
4 
Reactome Pathways for OR1E2
1 
Kegg Pathway (Kegg details for OR1E2):
OR1E2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR1E2
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for OR1E2 (ENSP000002483844) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
OR1E2 for ontologies About GeneDecksing
|
Drugs & Compounds
for OR1E2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR1E2
Search CenterWatch for drugs/clinical trials and news about OR1E2
|
Transcripts
for OR1E2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR1E2 gene: NM_003554.1 Unigene Cluster for OR1E2: Olfactory receptor, family 1, subfamily E, member 2 Hs.533931 [show with all ESTs]Unigene Representative Sequence: BC1211061 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000248384(uc010vre.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR1E2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR1E2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR1E2 (NM_003554) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR1E2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR1E2 |
Additional cDNA sequence: BC121105.1 BC121106.1 1 DOTS entry: DT.92036496 13 AceView cDNA sequences: CO245994 CO250244 NM_003554 CO245351 CO245352 CO250015 CO245307 CO245397 CO245341 CO246023 CO249986 CO250143 CO250236
GeneLoc Exon Structure
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Expression
for OR1E2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR1E2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OR1E2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR1E2
SOURCE GeneReport for Unigene cluster: Hs.533931
SABiosciences Custom PCR Arrays for OR1E2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR1E2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR1E2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR1E2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR1E2 |
Orthologs
for OR1E2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OR1E2 gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for OR1E2 (if available)
TreeFam Gene Tree for OR1E2 (if available) |
Paralogs
for OR1E2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR1E2 gene
- OR1F12 OR1I12 OR1N12 OR1J42 OR1N22 OR1S12 OR1J22 OR1E12
- OR1C12 OR1M12 OR1G12 OR1J12 OR1S22
18/455 SIMAP similar genes for OR1E2 using alignment to 1 protein entry: OR1E2_HUMAN(see all similar genes):HSA12 OR1E1 OR1E3 OR1E3P OR1J4 OR1J1
OR1J2 HSA10 OR1F1 OR1F2P OR1M1 OR1N2
OR1D2 OR1N1 OR7C2 OR16-37 OR16-89 OR16-90
OR1E2 for paralogs About GeneDecksing
|
Genomic Variants
for OR1E2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR1E2 ( 3336167 - 3337135 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR1E2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR1E2 |
|
Disorders
/ Diseases
for OR1E2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR1E2 for disorders About GeneDecksing
1  disease for OR1E2: About MalaCardsneuronitis
Export disorders for OR1E2 gene to outside databases
|
Publications
for OR1E2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR1E2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR1E2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Distribution of olfactory receptor genes in the human genome. (PubMed id 9500546)1, 2, 3 Rouquier S.... Giorgi D. (1998)
- Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PubMed id 8004088)1, 2, 3 Ben-Arie N.... North M.A. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
- Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PubMed id 10673334)1, 2 Glusman G.... Lancet D. (2000)
- A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Development of polysaccharide vaccines for the prevention of meningococcal diseases. (PubMed id 804088)1 Gotschlich E.C. (1975)
|
External Searches for OR1E2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing OR1E2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR1E2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR1E2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR1E2 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR1E2 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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| | |
About This Section
| Patent Information for OR1E2 gene:
Search GeneIP for patents involving OR1E2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR1E2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR1E2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR1E2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR1E2 | | | OriGene Protein Over-expression Lysate for OR1E2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR1E2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR1E2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR1E2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OR1E2 | | OriGene Custom Protein Services for OR1E2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR1E2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR1E2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR1E2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR1E2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR1E2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR1E2 |
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 | | | OR1E2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for OR1E2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR1E2 |
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