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Aliases for OR1E2 Gene

Aliases for OR1E2 Gene

  • Olfactory Receptor, Family 1, Subfamily E, Member 2 2 3
  • Olfactory Receptor 17-93/17-135/17-136 3 4
  • Olfactory Receptor 1E4 3 4
  • OR17-135 3 4
  • OR17-136 3 4
  • OR17-93 3 4
  • OR1E4 3 4
  • Olfactory Receptor, Family 1, Subfamily E, Member 4 3
  • Olfactory Receptor, Family 1, Subfamily E, Member 7 3
  • Olfactory Receptor OR17-17 3
  • Olfactory Receptor OR17-3 3
  • Olfactory Receptor 1E2 3
  • OST529 3
  • OR1E7 3

External Ids for OR1E2 Gene

Previous HGNC Symbols for OR1E2 Gene

  • OR1E4

Previous GeneCards Identifiers for OR1E2 Gene

  • GC17M003650
  • GC17M003286
  • GC17M003542
  • GC17M003282
  • GC17M003336

Summaries for OR1E2 Gene

Entrez Gene Summary for OR1E2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1E2 Gene

OR1E2 (Olfactory Receptor, Family 1, Subfamily E, Member 2) is a Protein Coding gene. Diseases associated with OR1E2 include colorectal cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and receptor activity. An important paralog of this gene is OR1J4.

UniProtKB/Swiss-Prot for OR1E2 Gene

  • Odorant receptor.

Gene Wiki entry for OR1E2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1E2 Gene

Genomics for OR1E2 Gene

Regulatory Elements for OR1E2 Gene

Genomic Location for OR1E2 Gene

3,432,870 bp from pter
3,433,841 bp from pter
972 bases
Minus strand

Genomic View for OR1E2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR1E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1E2 Gene

Proteins for OR1E2 Gene

  • Protein details for OR1E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 1E2
    Protein Accession:
    Secondary Accessions:
    • O43877
    • O95632
    • Q0VAD5
    • Q0VAD6
    • Q9UL13

    Protein attributes for OR1E2 Gene

    323 amino acids
    Molecular mass:
    36391 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1E2 Gene

Proteomics data for OR1E2 Gene at MOPED

Post-translational modifications for OR1E2 Gene

  • Glycosylation at Asn5 and Asn274
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1E2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1E2 Gene

Domains for OR1E2 Gene

Gene Families for OR1E2 Gene

Protein Domains for OR1E2 Gene

Suggested Antigen Peptide Sequences for OR1E2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1E2: view

Function for OR1E2 Gene

Molecular function for OR1E2 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily E,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 8004088
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR1E2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR1E2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1E2 Gene

Localization for OR1E2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1E2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR1E2 Gene COMPARTMENTS Subcellular localization image for OR1E2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8004088
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1E2: view

Pathways for OR1E2 Gene

genes like me logo Genes that share pathways with OR1E2: view

Pathways by source for OR1E2 Gene

1 KEGG pathway for OR1E2 Gene

Interacting Proteins for OR1E2 Gene

Gene Ontology (GO) - Biological Process for OR1E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8004088
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007606 sensory perception of chemical stimulus TAS 8004088
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA --
genes like me logo Genes that share ontologies with OR1E2: view

Transcripts for OR1E2 Gene

mRNA/cDNA for OR1E2 Gene

(13) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1E2 Gene

Olfactory receptor, family 1, subfamily E, member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR1E2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1E2 Gene

No ASD Table

Relevant External Links for OR1E2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR1E2 Gene

mRNA expression in normal human tissues for OR1E2 Gene

SOURCE GeneReport for Unigene cluster for OR1E2 Gene Hs.533931

genes like me logo Genes that share expressions with OR1E2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for OR1E2 Gene

Orthologs for OR1E2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1E2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OR1E1 35
  • 83.06 (n)
  • 80.66 (a)
-- 36
  • 82 (a)
-- 36
  • 82 (a)
-- 36
  • 83 (a)
-- 36
  • 81 (a)
-- 36
  • 82 (a)
-- 36
  • 82 (a)
-- 36
  • 82 (a)
(Mus musculus)
Mammalia Olfr20 35
  • 84.47 (n)
  • 84.14 (a)
Olfr376 16
Olfr1 36
  • 81 (a)
Olfr20 36
  • 83 (a)
Olfr23 36
  • 73 (a)
Olfr376 36
  • 82 (a)
Olfr378 36
  • 77 (a)
Olfr380 36
  • 71 (a)
Olfr381 36
  • 71 (a)
Olfr382 36
  • 71 (a)
Olfr384 36
  • 74 (a)
Olfr385 36
  • 72 (a)
Olfr389 36
  • 76 (a)
Olfr390 36
  • 77 (a)
Olfr392 36
  • 75 (a)
Olfr393 36
  • 74 (a)
Olfr394 36
  • 74 (a)
Olfr395 36
  • 75 (a)
(Pan troglodytes)
Mammalia PTOR1E2 35
  • 98.51 (n)
  • 97.45 (a)
PTR203 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Olr1466 35
  • 84.79 (n)
  • 84.14 (a)
(Canis familiaris)
Mammalia DTMT 36
  • 83 (a)
OR1E2 36
  • 84 (a)
(Monodelphis domestica)
Mammalia OPOR52 36
  • 75 (a)
Species with no ortholog for OR1E2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1E2 Gene

Gene Tree for OR1E2 (if available)
Gene Tree for OR1E2 (if available)

Paralogs for OR1E2 Gene

(454) SIMAP similar genes for OR1E2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1E2: view

Variants for OR1E2 Gene

Sequence variations from dbSNP and Humsavar for OR1E2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs189013 -- 3,435,273(+) aattt(C/T)ttgcc upstream-variant-2KB
rs394644 -- 3,435,398(-) cctgc(A/C)ctcca upstream-variant-2KB
rs436972 -- 3,433,080(+) ACAGA(C/G)AGGTG reference, synonymous-codon
rs769431 - 3,433,763(-) ACCTG(C/T)GCTAT missense, reference
rs7215705 -- 3,435,385(+) cagcc(A/G)tccag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1E2 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV Deletion 23128226
nsv907553 CNV Loss 21882294
nsv833341 CNV Loss 17160897
nsv521277 CNV Gain 19592680

Relevant External Links for OR1E2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1E2 Gene

Disorders for OR1E2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for OR1E2 Gene in MalaCards »

(1) Disease for OR1E2 Gene

Relevant External Links for OR1E2

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with OR1E2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for OR1E2 Gene

Publications for OR1E2 Gene

  1. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PMID: 8004088) Ben-Arie N. … North M.A. (Hum. Mol. Genet. 1994) 2 3 4
  2. Distribution of olfactory receptor genes in the human genome. (PMID: 9500546) Rouquier S. … Giorgi D. (Nat. Genet. 1998) 2 3 4
  3. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G. … Lancet D. (Genomics 2000) 3 4
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for OR1E2 Gene

Sources for OR1E2 Gene

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