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Aliases for OR1E1 Gene

Aliases for OR1E1 Gene

  • Olfactory Receptor Family 1 Subfamily E Member 1 2 3 5
  • Olfactory Receptor-Like Protein HGMP07I 3 4
  • Olfactory Receptor 17-2/17-32 3 4
  • Olfactory Receptor OR17-18 3 4
  • Olfactory Receptor 13-66 3 4
  • Olfactory Receptor 5-85 3 4
  • Olfactory Receptor 1E5 3 4
  • Olfactory Receptor 1E6 3 4
  • OR13-66 3 4
  • OR17-32 3 4
  • OR17-2 3 4
  • OR1E9P 3 4
  • OR5-85 3 4
  • OR1E5 3 4
  • OR1E6 3 4
  • Olfactory Receptor, Family 1, Subfamily E, Member 8 Pseudogene 3
  • Olfactory Receptor, Family 1, Subfamily E, Member 9 Pseudogene 3
  • Olfactory Receptor, Family 1, Subfamily E, Member 1 2
  • Olfactory Receptor, Family 1, Subfamily E, Member 5 3
  • Olfactory Receptor, Family 1, Subfamily E, Member 6 3
  • Olfactory Receptor OR17-4 3
  • Olfactory Receptor 1E1 3
  • HGM071 3
  • OR1E8P 3
  • OST547 3

External Ids for OR1E1 Gene

Previous HGNC Symbols for OR1E1 Gene

  • OR1E9P
  • OR1E5
  • OR1E6

Previous GeneCards Identifiers for OR1E1 Gene

  • GC17M003614
  • GC17M003251
  • GC17M003510
  • GC17M003511
  • GC17M003247
  • GC17M003300

Summaries for OR1E1 Gene

Entrez Gene Summary for OR1E1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1E1 Gene

OR1E1 (Olfactory Receptor Family 1 Subfamily E Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1E2.

UniProtKB/Swiss-Prot for OR1E1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1E1 Gene

Additional gene information for OR1E1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1E1 Gene

Genomics for OR1E1 Gene

Regulatory Elements for OR1E1 Gene

Enhancers for OR1E1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H003518 0.6 dbSUPER 5.8 -120.7 -120698 1 HDGF CTBP1 ZNF366 HDAC2 IKZF1 YBX1 HES1 OR1E2 OR1E1 SPATA22 GC17M003518
GH17H003520 0.2 dbSUPER 5.1 -122.9 -122897 0 OR1E2 OR1E1 SPATA22 GC17M003518
GH17H003503 0.2 dbSUPER 4.7 -105.6 -105552 0 OR1E2 SPATA22 OR1E1 PIR41418 ASPA
GH17H003631 0.3 FANTOM5 2 -233.1 -233121 0 OR1E2 OR1A2 SHPK OR1A1 OR3A2 OR1E1 ENSG00000262304 LOC100422717
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR1E1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR1E1 Gene

3,397,104 bp from pter
3,398,410 bp from pter
1,307 bases
Minus strand

Genomic View for OR1E1 Gene

Genes around OR1E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1E1 Gene

Proteins for OR1E1 Gene

  • Protein details for OR1E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 1E1
    Protein Accession:
    Secondary Accessions:
    • O43884
    • P47882
    • P47885
    • Q6IFA9
    • Q6IFM5
    • Q9UBJ1
    • Q9UM60

    Protein attributes for OR1E1 Gene

    314 amino acids
    Molecular mass:
    35264 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1E1 Gene

Post-translational modifications for OR1E1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1E1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1E1 Gene

Domains & Families for OR1E1 Gene

Gene Families for OR1E1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for OR1E1 Gene

Suggested Antigen Peptide Sequences for OR1E1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1E1: view

Function for OR1E1 Gene

Molecular function for OR1E1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily E,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 1370859
genes like me logo Genes that share ontologies with OR1E1: view
genes like me logo Genes that share phenotypes with OR1E1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR1E1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1E1 Gene

Localization for OR1E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1E1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1E1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1E1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR1E1 Gene

Pathways & Interactions for OR1E1 Gene

genes like me logo Genes that share pathways with OR1E1: view

Pathways by source for OR1E1 Gene

1 KEGG pathway for OR1E1 Gene

Interacting Proteins for OR1E1 Gene

Gene Ontology (GO) - Biological Process for OR1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS 1370859
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR1E1: view

No data available for SIGNOR curated interactions for OR1E1 Gene

Drugs & Compounds for OR1E1 Gene

No Compound Related Data Available

Transcripts for OR1E1 Gene

mRNA/cDNA for OR1E1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1E1 Gene

Olfactory receptor, family 1, subfamily E, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR1E1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR1E1 Gene

No ASD Table

Relevant External Links for OR1E1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR1E1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR1E1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1E1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.1) and Testis (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of OR1E1 Gene:


SOURCE GeneReport for Unigene cluster for OR1E1 Gene:

genes like me logo Genes that share expression patterns with OR1E1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR1E1 Gene

Orthologs for OR1E1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1E1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OR1E1 34
  • 98 (a)
(Canis familiaris)
Mammalia LOC100683843 33
  • 87.03 (n)
OR1E2 34
  • 84 (a)
  • 83 (a)
(Bos Taurus)
Mammalia LOC615901 33
  • 86.41 (n)
-- 34
  • 83 (a)
-- 34
  • 83 (a)
-- 34
  • 83 (a)
-- 34
  • 82 (a)
-- 34
  • 82 (a)
-- 34
  • 82 (a)
-- 34
  • 81 (a)
(Mus musculus)
Mammalia Or1e1 52 Olfr20 34
  • 84 (a)
Or1e1c 52 Olfr376 34
  • 81 (a)
Or1e16 52 Olfr1 34
  • 80 (a)
Or1e30 52 Olfr390 34
  • 77 (a)
Or1e29 52 Olfr389 34
  • 76 (a)
Or1e32 52 Olfr392 34
  • 76 (a)
Or1e35 52 Olfr395 34
  • 76 (a)
Or1e19 52 Olfr378 34
  • 75 (a)
Or1e34 52 Olfr394 34
  • 75 (a)
Or1e33 52 Olfr393 34
  • 74 (a)
Or1e17 52 Olfr23 34
  • 73 (a)
Or1e25 52 Olfr384 34
  • 73 (a)
Or1e21 52 Olfr380 34
  • 72 (a)
Or1e22 52 Olfr381 34
  • 72 (a)
Or1e23 52 Olfr382 34
  • 72 (a)
Or1e26 52 Olfr385 34
  • 71 (a)
Or1e12 52 Olfr397
  • chr11:73,964,553-73,965,554
Or1e18-ps 52 Olfr377-ps1
  • chr11:73,388,084-73,389,024
Or1e1b-ps 52 Olfr22-ps1
  • chr11:73,954,692-73,955,625
Or1e1d-ps 52 Olfr396-ps1
  • chr11:73,928,007-73,928,942
Or1e20-ps 52 Olfr379-ps1
  • chr11:73,433,294-73,434,224
Or1e24-ps 52 Olfr383-ps1
  • chr11:73,540,422-73,541,353
Or1e27-ps 52 Olfr387-ps1
  • chr11:73,664,611-73,665,539
Or1e28-ps 52 Olfr388-ps1
  • chr11:73,724,085-73,725,022
Or1e31 52 Olfr391
  • chr11:73,798,820-73,799,755
Or1e36-ps 52 Olfr75-ps1
  • chr11:73,405,445-73,406,379
(Rattus norvegicus)
Mammalia Olr1468 33
  • 82.8 (n)
(Monodelphis domestica)
Mammalia OPOR52 34
  • 75 (a)
Species where no ortholog for OR1E1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1E1 Gene

Gene Tree for OR1E1 (if available)
Gene Tree for OR1E1 (if available)

Paralogs for OR1E1 Gene

Paralogs for OR1E1 Gene

(458) SIMAP similar genes for OR1E1 Gene using alignment to 1 proteins: Pseudogenes for OR1E1 Gene

genes like me logo Genes that share paralogs with OR1E1: view

Variants for OR1E1 Gene

Sequence variations from dbSNP and Humsavar for OR1E1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000216059 -- 3,399,142(+) CAGAG(C/T)AAGAC upstream-variant-2KB
rs1000714874 -- 3,399,467(+) CTTGA(A/C)AGATC upstream-variant-2KB
rs1001166215 -- 3,397,729(+) AGGGA(A/C)CTTGA reference, missense
rs1004558881 -- 3,400,084(+) TCATC(C/T)GGCTC upstream-variant-2KB
rs1006363112 -- 3,397,029(+) GCCAC(A/G)ATTGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR1E1 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV deletion 23128226
esv3892950 CNV loss 25118596
nsv1055740 CNV gain 25217958
nsv1059413 CNV loss 25217958
nsv1065489 CNV gain 25217958
nsv521277 CNV gain 19592680
nsv574232 CNV gain 21841781
nsv574236 CNV gain 21841781
nsv833341 CNV loss 17160897
nsv962248 CNV duplication 23825009

Variation tolerance for OR1E1 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1E1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1E1 Gene

Disorders for OR1E1 Gene

Relevant External Links for OR1E1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR1E1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1E1 Gene

Publications for OR1E1 Gene

  1. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PMID: 8004088) Ben-Arie N … Lehrach H (Human molecular genetics 1994) 2 3 4 60
  2. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M … Perret J (Nature 1992) 2 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 60

Products for OR1E1 Gene

Sources for OR1E1 Gene

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