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OR1E1 Gene

protein-coding   GIFtS: 54
GCID: GC17M003300

Olfactory Receptor, Family 1, Subfamily E, Member 1


(Previous symbols: OR1E9P, OR1E5, OR1E6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 1, Subfamily E, Member 11 2     OR17-22 3
OR1E51 2 3     OR17-322 3
OR1E61 2 3     OR5-852 3
OR1E9P1 2 3     HGM0712
Olfactory Receptor 13-662 3     OR1E8P2
Olfactory Receptor 17-2/17-322 3     OST5472
Olfactory Receptor 1E52 3     Olfactory Receptor 1E12
Olfactory Receptor 1E62 3     Olfactory Receptor OR17-42
Olfactory Receptor 5-852 3     Olfactory Receptor, Family 1, Subfamily E, Member 52
Olfactory Receptor OR17-182 3     Olfactory Receptor, Family 1, Subfamily E, Member 62
Olfactory Receptor-Like Protein HGMP07I2 3     Olfactory Receptor, Family 1, Subfamily E, Member 8 Pseudogene2
OR13-662 3     Olfactory Receptor, Family 1, Subfamily E, Member 9 Pseudogene2

External Ids:    HGNC: 81891   Entrez Gene: 83872   Ensembl: ENSG000001800167   UniProtKB: P309533   

Export aliases for OR1E1 gene to outside databases

Previous GC identifers: GC17M003614 GC17M003251 GC17M003510 GC17M003511 GC17M003247


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR1E1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR1E1 Gene:
OR1E1 (olfactory receptor, family 1, subfamily E, member 1) is a protein-coding gene. Diseases associated with OR1E1 include distal arthrogryposis, and neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1F1.

UniProtKB/Swiss-Prot: OR1E1_HUMAN, P30953
Function: Odorant receptor (Potential)

Gene Wiki entry for OR1E1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR1E1 gene promoter:
         TBP   p53   AML1a   CUTL1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   GATA-2   SEF-1 (1)   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR1E1 promoter sequence
   Search Chromatin IP Primers for OR1E1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR1E1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.3

OR1E1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR1E1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M003300:  view genomic region     (about GC identifiers)

Start:
3,300,763 bp from pter      End:
3,301,704 bp from pter
Size:
942 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OR1E1_HUMAN, P30953 (See protein sequence)
Recommended Name: Olfactory receptor 1E1  
Size: 314 amino acids; 35264 Da
Secondary accessions: O43884 P47882 P47885 Q6IFA9 Q6IFM5 Q9UBJ1 Q9UM60

Explore the universe of human proteins at neXtProt for OR1E1: NX_P30953

Explore proteomics data for OR1E1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR1E1

    See OR1E1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003544.2  
    ENSEMBL proteins: 
     ENSP00000313384  
    Reactome Protein details: P30953

    OR1E1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for OR1E1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR1: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P30953

    ProtoNet protein and cluster: P30953

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR1E1_HUMAN, P30953
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR1E1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR1E1_HUMAN, P30953
    Function: Odorant receptor (Potential)

         Genatlas biochemistry entry for OR1E1:
    olfactory receptor,family 1,subfamily E,member 1,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity NAS1370859
         
    OR1E1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OR1E1:
     Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR1E1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR1E1_HUMAN, P30953: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR1E1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR1E1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43
    4GPCRs, Other
    GPCRs, Other

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for OR1E1
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR1E1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR1E1):
        Olfactory transduction


    OR1E1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR1E1
    Interactions:

        Search GeneGlobe Interaction Network for OR1E1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for OR1E1 (ENSP000003133844) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRBK2ENSP000003175784STRING: ENSP00000317578
    ARRB2ENSP000002692604STRING: ENSP00000269260
    GNALENSP000003340514STRING: ENSP00000334051
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007608sensory perception of smell NAS1370859
    GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS1370859

    OR1E1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR1E1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR1E1 gene: 
    NM_003553.2  

    Unigene Cluster for OR1E1:

    Olfactory receptor, family 1, subfamily E, member 1
    Hs.278485  [show with all ESTs]
    Unigene Representative Sequence: NM_003553
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000322608(uc002fvj.1)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR1E1

    1 DOTS entry:

    DT.75128818 

    6 AceView cDNA sequences:

    BF477726 NM_003553 AI424858 CO249542 BF003023 CO249498 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR1E1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGGAGCCC
    OR1E1 Expression
    About this image

    OR1E1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR1E1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.278485
        Custom PCR Arrays for OR1E1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR1E1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR1E1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr205 olfactory receptor 20   --   11 (45.30 cM) 73350839 


    ENSEMBL Gene Tree for OR1E1 (if available)
    TreeFam Gene Tree for OR1E1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR1E1 gene
    OR1F12  OR1I12  OR1N12  OR1J42  OR1E22  OR1N22  OR1S12  OR1J22  
    OR1C12  OR1M12  OR1G12  OR1J12  OR1S22  
    Selected SIMAP similar genes for OR1E1 using alignment to 1 protein entry:     OR1E1_HUMAN(see all similar genes):
    HSA12    OR1E2    OR1E3    OR1E3P    OR1J4    OR1J1
    OR1J2    OR1F1    OR1N2    OR1D2    OR1F2P    OR1M1
    OR7C2    HSA10    OR16-36    OR16-37    OR16-89    OR16-90

    OR1E1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OR1E1
    PGOHUM00000237194


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR1E1 (see all 137)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1878517271,2
    --3300689(+) ATAATA/TTAGAA 1 -- ds50010--------
    rs2017108691,2
    --3300693(+) TTTAG-/AATAATAT 1 -- ds50010--------
    rs2010276711,2
    C--3300775(+) AAGAAA/GGTTTT 2 T syn10--------
    rs2008548471,2
    F--3300848(+) AGGGGT/GTCAGC 2 /N /T mis11Minor allele frequency- G:0.01EU 561
    rs1442196521,2
    C--3300867(+) CACCAC/GAGTGT 2 L V mis10--------
    rs3798561,2,,4
    F--3300921(-) TATGCC/TCATCA 2 P S mis19Minor allele frequency- T:0.49NA EA MN 304
    rs7694221,2
    C,F--3300934(-) ATTGGT/ACTCTA 2 /G syn1 ese311Minor allele frequency- A:0.09NA NS CSA WA EA EU 6320
    rs586310681,2
    C,F--3300943(+) ATAACG/AGTTCC 2 /T syn12Minor allele frequency- A:0.01WA NA 4554
    rs4049831,2
    C,F--3300946(-) TATGGA/GACCGT 2 G syn1 ese35Minor allele frequency- G:0.02MN NA NS 4774
    rs1931649881,2
    C--3300964(+) GACACA/CACAGA 2 V syn10--------

    HapMap Linkage Disequilibrium report for OR1E1 ( 3300763 - 3301704 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for OR1E1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660206CNV Deletion23128226
    nsv907553CNV Loss21882294
    nsv833341CNV Loss17160897
    nsv521277CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR1E1
    DNA2.0 Custom Variant and Variant Library Synthesis for OR1E1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for OR1E1:    About MalaCards
    distal arthrogryposis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for OR1E1:
    Distal arthrogryposis

    OR1E1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OR1E1
    Human Genome Epidemiology (HuGE) Navigator: OR1E1 (1 document)

    Export disorders for OR1E1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR1E1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR1E1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PubMed id 8004088)1, 2, 3 Ben-Arie N.... North M.A. (Hum. Mol. Genet. 1994)
    2. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PubMed id 1370859)1, 2, 3 Parmentier M.... Vassart G. (Nature 1992)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    5. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    6. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PubMed id 10673334)1, 2 Glusman G.... Lancet D. (Genomics 2000)
    7. Distribution of olfactory receptor genes in the human genome. (PubMed id 9500546)1, 2 Rouquier S.... Giorgi D. (Nat. Genet. 1998)
    8. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)4 Seshadri S....Wolf P.A. (BMC Med. Genet. 2007)
    9. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PubMed id 10706615)1 Rouquier S.... Giorgi D. (Proc. Natl. Acad. Sci. U.S.A. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8387 HGNC: 8189 AceView: OR1E1 Ensembl:ENSG00000180016 euGenes: HUgn8387
    ECgene: OR1E1 Kegg: 8387 H-InvDB: OR1E1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR1E1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR1E1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR1E1 gene:
    Search GeneIP for patents involving OR1E1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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