OR1E1 Gene
protein-coding GIFtS: 53
GCID: GC17M003300
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olfactory receptor, family 1, subfamily E, member 1 (Previous symbols: OR1E9P, OR1E5, OR1E6)
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Aliases for OR1E1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 1, Subfamily E, Member 11 2 | | Olfactory Receptor 5-852 3 | | OR13-661 2 3 | | Olfactory Receptor OR17-182 3 | | OR17-21 2 3 | | Olfactory Receptor-Like Protein HGMP07I2 3 | | OR17-321 2 3 | | OR5-852 3 | | OR1E51 2 3 | | OR1E8P2 | | OR1E61 2 3 | | OST5472 | | OR1E9P1 2 3 | | Olfactory Receptor 1E12 | | HGM0711 2 | | Olfactory Receptor OR17-42 | | Olfactory Receptor 13-662 3 | | Olfactory Receptor, Family 1, Subfamily E, Member 52 | | Olfactory Receptor 17-2/17-322 3 | | Olfactory Receptor, Family 1, Subfamily E, Member 62 | | Olfactory Receptor 1E52 3 | | Olfactory Receptor, Family 1, Subfamily E, Member 8 Pseudogene2 | | Olfactory Receptor 1E62 3 | | Olfactory Receptor, Family 1, Subfamily E, Member 9 Pseudogene2 |
Export aliases for OR1E1 gene to outside databasesPrevious GC identifers: GC17M003614 GC17M003251 GC17M003510 GC17M003511 GC17M003247 |
Summaries for OR1E1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for OR1E1: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008) UniProtKB/Swiss-Prot: OR1E1_HUMAN, P30953Function: Odorant receptor (Potential) Gene Wiki entry for OR1E1
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Genomic Views for OR1E1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the OR1E1 gene promoter: TBP p53 AML1a CUTL1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 GATA-2 SEF-1 (1) Chx10 Other transcription factors
Search SABiosciences Chromatin IP Primers for OR1E1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR1E1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.3OR1E1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M003300: view genomic region
(about GC identifiers)
Start:
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3,300,763 bp from pter |
End:
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3,301,704 bp from pter |
Size:
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942 bases |
Orientation:
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minus strand |
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Proteins for OR1E1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: OR1E1_HUMAN, P30953 (See
protein sequence)Recommended Name: Olfactory receptor 1E1 Size: 314 amino acids; 35264 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: O43884 P47882 P47885 Q6IFA9 Q6IFM5 Q9UBJ1 Q9UM60Explore the universe of human proteins at neXtProt for OR1E1: NX_P30953
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P30953 HORDE protein sequence for OR1E1 OR1E1 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_003544.2 ENSEMBL proteins: ENSP00000313384 Reactome Protein details: P30953 Human Recombinant Protein Products for OR1E1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
NAS | -- |
OR1E1 for ontologies About GeneDecksing
OR1E1 Antibody Products: Assay Products for OR1E1: |
Protein
Domains / Families for OR1E1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR1E1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P30953ProtoNet protein and cluster: P30953 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR1E1_HUMAN, P30953Similarity: Belongs to the G-protein coupled receptor 1 family |
Function for OR1E1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: OR1E1_HUMAN, P30953Function: Odorant receptor (Potential) Genatlas biochemistry entry for OR1E1:olfactory receptor,family 1,subfamily E,member 1,G protein coupled receptor superfamily
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
NAS | 1370859 |
OR1E1 for ontologies About GeneDecksing
Phenotypes: 1 GenomeRNAi human phenotype for OR1E1: Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR1E1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR1E1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for OR1E1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR1E1  |
|
Pathways & Interactions for OR1E1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | | | 3 | GPCRs, Other | | | 4 | Class A/1 (Rhodopsin-like receptors) | |
Pathway sources See GeneCards unified pathways Show all pathways
2 BioSystems Pathways for OR1E1 
4
Reactome Pathways for OR1E1
1
Kegg Pathway (Kegg details for OR1E1):
OR1E1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR1E1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
 3 Interacting proteins for OR1E1 (ENSP000003133844) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007608 | sensory perception of smell |
NAS | 1370859 | | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell |
NAS | 1370859 |
OR1E1 for ontologies About GeneDecksing
|
Drugs & Compounds for OR1E1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for OR1E1 Search CenterWatch for drugs/clinical trials and news about OR1E1 
|
Transcripts for OR1E1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for OR1E1 gene: NM_003553.2 Unigene Cluster for OR1E1: Olfactory receptor, family 1, subfamily E, member 1 Hs.278485 [show with all ESTs]Unigene Representative Sequence: NM_0035531 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000322608(uc002fvj.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR1E1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR1E1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OR1E1 (NM_003553) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR1E1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR1E1  |
1 DOTS entry: DT.75128818 6 AceView cDNA sequences: BF477726 NM_003553 AI424858 BF003023 CO249542 CO249498 GeneLoc Exon Structure
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Expression for OR1E1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR1E1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AAGGGAGCCC
 About this image See OR1E1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for OR1E1
SOURCE GeneReport for Unigene cluster: Hs.278485 SABiosciences Custom PCR Arrays for OR1E1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR1E1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR1E1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR1E1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR1E1 |
Orthologs for OR1E1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OR1E1 gene from 1/7 species (see all 7) About this table
ENSEMBL Gene Tree for OR1E1 (if available) TreeFam Gene Tree for OR1E1 (if available)  |
Paralogs for OR1E1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for OR1E1 gene
- OR1F12 OR1I12 OR1N12 OR1E22 OR1J42 OR1N22 OR1S12 OR1J22
- OR1C12 OR1M12 OR1J12 OR1G12 OR1S22
18/458 SIMAP similar genes for OR1E1 using alignment to 1 protein entry: OR1E1_HUMAN(see all similar genes):HSA12 OR1E2 OR1E3 OR1E3P OR1J4 OR1J1 OR1J2 OR1F1 OR1N2 OR1D2 OR1F2P OR1M1 OR7C2 HSA10 OR16-36 OR16-37 OR16-89 OR16-90
OR1E1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for OR1E1 PGOHUM00000237194
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Genomic Variants for OR1E1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 17 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for OR1E1 ( 3300763 - 3301704 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for OR1E1: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR1E1 |
|
Disorders
/ Diseases for OR1E1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR1E1 for disorders About GeneDecksing
1 disease for OR1E1: About MalaCardsneuronitis 1 disease from the University of Copenhagen DISEASES database for OR1E1:Distal arthrogryposis Human Genome Epidemiology (HuGE) Navigator: OR1E1 (1 document) Export disorders for OR1E1 gene to outside databases
|
Publications for OR1E1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR1E1 gene integrated from 9 sources: (articles sorted by number of sources associating them with OR1E1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PubMed id 8004088)1, 2, 3 Ben-Arie N.... North M.A. (1994)
- Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PubMed id 1370859)1, 2, 3 Parmentier M.... Vassart G. (1992)
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
- Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PubMed id 10673334)1, 2 Glusman G.... Lancet D. (2000)
- Distribution of olfactory receptor genes in the human genome. (PubMed id 9500546)1, 2 Rouquier S.... Giorgi D. (1998)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PubMed id 10706615)1 Rouquier S.... Giorgi D. (2000)
|
External Searches for OR1E1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing OR1E1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR1E1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR1E1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for OR1E1 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR1E1 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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About This Section
| Patent Information for OR1E1 gene: Search GeneIP for patents involving OR1E1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for OR1E1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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