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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR1D5 Gene

protein-coding   GIFtS: 47
GCID: GC17M002965

Olfactory Receptor, Family 1, Subfamily D, Member 5

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 1, Subfamily D, Member 51 2     OR17-22
Olfactory Receptor 17-312 3     OR17-302
OR17-312 3     Olfactory Receptor 1D52
C17orf22     Olfactory Receptor OR17-22

External Ids:    HGNC: 81861   Entrez Gene: 83862   Ensembl: ENSG000002626287   UniProtKB: P581703   

Export aliases for OR1D5 gene to outside databases

Previous GC identifers: GC17M003280 GC17U900018 GC17M003173 GC17M003174 GC17M002912


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR1D5 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR1D5 Gene: 
OR1D5 (olfactory receptor, family 1, subfamily D, member 5) is a protein-coding gene. Diseases associated with OR1D5 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1Q1.

UniProtKB/Swiss-Prot: OR1D5_HUMAN, P58170
Function: Odorant receptor (Potential)

Gene Wiki entry for OR1D5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR1D5 gene promoter:
         c-Fos   AML1a   AP-1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   C/EBPalpha   AREB6   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR1D5 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR1D5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR1D5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

OR1D5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR1D5 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M002965:  view genomic region     (about GC identifiers)

Start:
2,965,966 bp from pter      End:
2,966,901 bp from pter
Size:
936 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OR1D5_HUMAN, P58170 (See protein sequence)
Recommended Name: Olfactory receptor 1D5  
Size: 312 amino acids; 35424 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q96RA6

Explore the universe of human proteins at neXtProt for OR1D5: NX_P58170

HORDE protein sequence for OR1D5
OR1D5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_055381.1  
ENSEMBL proteins: 
 ENSP00000459028  
Reactome Protein details: P58170
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016021integral to membrane IEA--

OR1D5 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
OR1: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P58170

ProtoNet protein and cluster: P58170

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR1D5_HUMAN, P58170
Similarity: Belongs to the G-protein coupled receptor 1 family


OR1D5 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: OR1D5_HUMAN, P58170
Function: Odorant receptor (Potential)

     Genatlas biochemistry entry for OR1D5:
olfactory receptor,family 1,subfamily D,member 5,G protein coupled receptor superfamily

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
OR1D5 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for OR1D5:
 Increased gamma-H2AX phosphory 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OR1D5 About                                                                                                See pathways by source

SuperPathContained pathways About
1Olfactory transduction
Olfactory Signaling Pathway0.81
Olfactory transduction0.81
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
3Class A/1 (Rhodopsin-like receptors)
GPCRs, Class A Rhodopsin-like0.41

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for OR1D5
    GPCRs, Class A Rhodopsin-like

4        Reactome Pathways for OR1D5
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR


1         Kegg Pathway  (Kegg details for OR1D5):
    Olfactory transduction


OR1D5 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR1D5

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway TAS1315913
GO:0007608sensory perception of smell TAS1315913
GO:0050911detection of chemical stimulus involved in sensory perception of smell TAS1315913

OR1D5 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR1D5

Search CenterWatch for drugs/clinical trials and news about OR1D5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OR1D5 gene: 
NM_014566.1  

Unigene Cluster for OR1D5:

Olfactory receptor, family 1, subfamily D, member 5
Hs.553508
Unigene Representative Sequence: NM_014566
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000575751(uc021tns.1)
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR1D5

Additional mRNA sequence: BC106876.2 

1 DOTS entry:

DT.91652162 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR1D5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGGCTCCGGG
OR1D5 Expression
About this image


Genevestigator expression for OR1D5

SOURCE GeneReport for Unigene cluster: Hs.553508
    SABiosciences Custom PCR Arrays for OR1D5
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for OR1D5 gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 4)
Uncharacterized protein
(see all 4)
42(a)
42(a)
(see all 4)
possible ortholog
possible ortholog
(see all 4)
GL343253.1(1104105-1105037)
GL343253.1(1113268-1114679)
        Species with no ortholog for OR1D5

ENSEMBL Gene Tree for OR1D5 (if available)
TreeFam Gene Tree for OR1D5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OR1D5 gene
OR1Q12  OR1L42  OR1L32  OR1L12  OR1L82  OR1K12  OR1L62  OR1A12  
OR1D22  OR1A22  
18/453 SIMAP similar genes for OR1D5 using alignment to 2 protein entries:     OR1D5_HUMAN (see all proteins) (see all similar genes):
OR1D4    OR1D2    DAPL1    LOC441453    OR1F1    OR1N2
OR1F2P    OR7A2P    OR1N1    OR7C1    OR7D4    OR7G3
OR1F12    OR1G1    OR1L8    OR7A10    OR7C2    OR7A5

OR1D5 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for OR1D5
PGOHUM00000259201


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/61 SNPs in OR1D5 are shown (see all 61)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs3752079431,2
C--2965855(+) CTCATC/TCTGAG 1 -- ds50010--------
rs1457624441,2
--2965860(+) CCTGAG/TCTGGA 1 -- ds50010--------
rs3691188201,2
C--2965915(+) TGTGGA/TGAAGG 1 -- ds50010--------
rs2013582211,2
C,F--2965929(+) TTTCCG/AGTCTC 1 -- ds50011Minor allele frequency- A:0.25EU 331
rs1824425611,2
C--2965945(+) CAATCC/TCCTTT 1 -- ds50010--------
rs2020490821,2
C--2966032(+) CTCAGC/GCTGTA 2 S R mis10--------
rs2001969181,2
C,F--2966064(+) TGTCAG/CCACAG 2 /L /V mis11Minor allele frequency- C:0.04EU 523
rs1474853401,2
C--2966140(+) GCAAGC/TGTCCC 2 T syn10--------
rs1452561551,2
C,F--2966154(+) AAAGAG/AGGAGA 2 /L /F mis11Minor allele frequency- A:0.05EU 539
rs617521931,2
C,F--2966173(+) AAATGC/GGAGGC 2 S syn12Minor allele frequency- G:0.16NS NA 80

HapMap Linkage Disequilibrium report for OR1D5 ( 2965966 - 2966901 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for OR1D5:    About this table     
Variant IDTypeSubtypePubMed ID
esv2660206CNV Deletion23128226
nsv907552CNV Loss21882294
nsv7288OTHER Inversion18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for OR1D5:    About MalaCards
neuronitis    


OR1D5 for disorders           About GeneDecksing


Export disorders for OR1D5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OR1D5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR1D5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PubMed id 10673334)1, 2, 3 Glusman G.... Lancet D. (2000)
  2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
  3. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  5. Novel G protein-coupled receptors: a gene family of putative human olfactory receptor sequences. (PubMed id 1315913)1 Selbie L.A.... Shine J. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 8386 HGNC: 8186 Ensembl:ENSG00000262628 euGenes: HUgn8386 ECgene: OR1D5 Kegg: 8386
H-InvDB: OR1D5

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR1D5 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR1D5 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR1D5 gene:
Search GeneIP for patents involving OR1D5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Proteins for OR1D5
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 inGenious Targeting Laboratory - Custom generated mouse model solutions for OR1D5
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Customized:
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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