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Aliases for OR1D5 Gene

Aliases for OR1D5 Gene

  • Olfactory Receptor Family 1 Subfamily D Member 5 2 3 5
  • Olfactory Receptor, Family 1, Subfamily D, Member 5 2 3
  • Olfactory Receptor 17-31 3 4
  • OR17-31 3 4
  • Olfactory Receptor OR17-2 3
  • OR17-30 3
  • C17orf2 3
  • OR17-2 3
  • OR1D4 3

External Ids for OR1D5 Gene

Previous GeneCards Identifiers for OR1D5 Gene

  • GC17M003280
  • GC17U900018
  • GC17M003173
  • GC17M003174
  • GC17M002912
  • GC17M002965

Summaries for OR1D5 Gene

Entrez Gene Summary for OR1D5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1D5 Gene

OR1D5 (Olfactory Receptor Family 1 Subfamily D Member 5) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1L4.

UniProtKB/Swiss-Prot for OR1D5 Gene

  • Odorant receptor.

Gene Wiki entry for OR1D5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1D5 Gene

Genomics for OR1D5 Gene

Regulatory Elements for OR1D5 Gene

Enhancers for OR1D5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR1D5 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR1D5 Gene

Chromosome:
17
Start:
3,062,669 bp from pter
End:
3,063,607 bp from pter
Size:
939 bases
Orientation:
Minus strand

Genomic View for OR1D5 Gene

Genes around OR1D5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1D5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1D5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1D5 Gene

Proteins for OR1D5 Gene

  • Protein details for OR1D5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58170-OR1D5_HUMAN
    Recommended name:
    Olfactory receptor 1D5
    Protein Accession:
    P58170
    Secondary Accessions:
    • Q96RA6

    Protein attributes for OR1D5 Gene

    Size:
    312 amino acids
    Molecular mass:
    35424 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1D5 Gene

Proteomics data for OR1D5 Gene at MOPED

Post-translational modifications for OR1D5 Gene

No Post-translational modifications

Other Protein References for OR1D5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1D5 Gene

Domains & Families for OR1D5 Gene

Gene Families for OR1D5 Gene

Protein Domains for OR1D5 Gene

Suggested Antigen Peptide Sequences for OR1D5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P58170

UniProtKB/Swiss-Prot:

OR1D5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1D5: view

Function for OR1D5 Gene

Molecular function for OR1D5 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily D,member 5,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR1D5: view
genes like me logo Genes that share phenotypes with OR1D5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1D5 Gene

Localization for OR1D5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1D5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR1D5 Gene COMPARTMENTS Subcellular localization image for OR1D5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR1D5: view

Pathways & Interactions for OR1D5 Gene

genes like me logo Genes that share pathways with OR1D5: view

Pathways by source for OR1D5 Gene

1 KEGG pathway for OR1D5 Gene

Interacting Proteins for OR1D5 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000459028%0d%0a9606.ENSP00000269260%0d%0a9606.ENSP00000317578%0d%0a9606.ENSP00000334051%0d%0a
Selected Interacting proteins: ENSP00000459028 for OR1D5 Gene via STRING

Gene Ontology (GO) - Biological Process for OR1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell TAS 1315913
genes like me logo Genes that share ontologies with OR1D5: view

No data available for SIGNOR curated interactions for OR1D5 Gene

Drugs & Compounds for OR1D5 Gene

No Compound Related Data Available

Transcripts for OR1D5 Gene

mRNA/cDNA for OR1D5 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR1D5 Gene

No ASD Table

Relevant External Links for OR1D5 Gene

GeneLoc Exon Structure for
OR1D5
ECgene alternative splicing isoforms for
OR1D5

Expression for OR1D5 Gene

mRNA expression in normal human tissues for OR1D5 Gene

SOURCE GeneReport for Unigene cluster for OR1D5 Gene Hs.553508

genes like me logo Genes that share expression patterns with OR1D5: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR1D5 Gene

Orthologs for OR1D5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1D5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR1D5 35
  • 84.73 (n)
  • 79.68 (a)
-- 36
  • 75 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia cOR1D8 35
  • 84.84 (n)
  • 79.35 (a)
-- 36
  • 80 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC468150 35
  • 98.72 (n)
  • 97.12 (a)
OR1D5 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr412 36
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
Species with no ortholog for OR1D5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1D5 Gene

ENSEMBL:
Gene Tree for OR1D5 (if available)
TreeFam:
Gene Tree for OR1D5 (if available)

Paralogs for OR1D5 Gene

Paralogs for OR1D5 Gene

(451) SIMAP similar genes for OR1D5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OR1D5 Gene

genes like me logo Genes that share paralogs with OR1D5: view

Variants for OR1D5 Gene

Sequence variations from dbSNP and Humsavar for OR1D5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs703896 -- 3,063,231(-) GGCCA(A/C/G/T)CTGCT reference, missense
rs2014261 -- 3,065,060(-) TAGTA(C/T)GTTTG upstream-variant-2KB
rs2317673 -- 3,063,094(+) CTCTC(A/G)AGGCC reference, stop-gained
rs2676564 -- 3,062,738(+) CTCAG(C/G)CTGTA reference, missense
rs2676565 -- 3,062,879(+) AAATG(C/G/T)GAGGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR1D5 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV Deletion 23128226
nsv7288 OTHER Inversion 18451855
nsv907552 CNV Loss 21882294

Variation tolerance for OR1D5 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.81; 89.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1D5 Gene

HapMap Linkage Disequilibrium report
OR1D5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1D5 Gene

Disorders for OR1D5 Gene

Relevant External Links for OR1D5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR1D5

No disorders were found for OR1D5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1D5 Gene

Publications for OR1D5 Gene

  1. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G. … Lancet D. (Genomics 2000) 2 3 4 67
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Novel G protein-coupled receptors: a gene family of putative human olfactory receptor sequences. (PMID: 1315913) Selbie L.A. … Shine J. (Brain Res. Mol. Brain Res. 1992) 3

Products for OR1D5 Gene

Sources for OR1D5 Gene

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