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Aliases for OR1D5 Gene

Aliases for OR1D5 Gene

  • Olfactory Receptor Family 1 Subfamily D Member 5 2 3 5
  • Olfactory Receptor 17-31 3 4
  • OR17-31 3 4
  • Olfactory Receptor, Family 1, Subfamily D, Member 5 2
  • Olfactory Receptor OR17-2 3
  • Olfactory Receptor 1D5 3
  • OR17-30 3
  • C17orf2 3
  • OR17-2 3
  • OR1D4 3

External Ids for OR1D5 Gene

Previous GeneCards Identifiers for OR1D5 Gene

  • GC17M003280
  • GC17U900018
  • GC17M003173
  • GC17M003174
  • GC17M002912
  • GC17M002965

Summaries for OR1D5 Gene

Entrez Gene Summary for OR1D5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1D5 Gene

OR1D5 (Olfactory Receptor Family 1 Subfamily D Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1D2.

UniProtKB/Swiss-Prot for OR1D5 Gene

  • Odorant receptor.

Gene Wiki entry for OR1D5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1D5 Gene

Genomics for OR1D5 Gene

Regulatory Elements for OR1D5 Gene

Enhancers for OR1D5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F003001 1 Ensembl ENCODE 16.3 +60.0 60012 4.8 WRNIP1 SIN3A BRCA1 ZNF2 YY1 GLIS2 ZHX2 REST TBX21 MBD2 OR1D5 OR1D2 OR1E3 OR1D3P OR3A4P SAMD11P1 EIF4A1P9 OR1E2 ENSG00000262869 RAP1GAP2
GH17F002847 1.1 FANTOM5 Ensembl ENCODE 16.2 +215.1 215114 2.6 ELF3 ZFP64 INSM2 KLF17 SIN3A ZNF48 ZNF2 RAD21 ZEB1 GLIS2 HNRNPA1P16 METTL16 ENSG00000263345 LOC105371492 OR1D5 SAMD11P1 OR1D2 OR1E3 EIF4A1P9 OR1D3P
GH17F002924 1.2 Ensembl ENCODE 16.2 +138.1 138090 2.6 INSM2 ZNF76 SIN3A KLF17 GLI4 ZNF2 RAD21 ZNF366 ZNF143 ZNF391 OR1D5 OR1D2 OR1E3 SAMD11P1 EIF4A1P9 OR1D3P OR3A4P OR1E2 ENSG00000262869 LOC105371492
GH17F002489 1 ENCODE 16.2 +573.9 573929 0.8 HDGF CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 KLF13 SP3 EIF4A1P9 SAMD11P1 ENSG00000262869 OR1D5 OR1D2 OR1E3 OR1D3P OR1E2 OR3A4P METTL16
GH17F002485 0.8 Ensembl ENCODE 16.2 +577.0 577007 2.0 SOX13 CTCF KLF1 CEBPG CHD7 ZNF121 GATA3 ZFHX2 THAP11 EGR2 EIF4A1P9 SAMD11P1 ENSG00000262869 OR1D5 OR1D2 OR1E3 OR1D3P OR1E2 OR3A4P METTL16
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR1D5 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR1D5 Gene

Chromosome:
17
Start:
3,062,669 bp from pter
End:
3,063,607 bp from pter
Size:
939 bases
Orientation:
Minus strand

Genomic View for OR1D5 Gene

Genes around OR1D5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1D5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1D5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1D5 Gene

Proteins for OR1D5 Gene

  • Protein details for OR1D5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58170-OR1D5_HUMAN
    Recommended name:
    Olfactory receptor 1D5
    Protein Accession:
    P58170
    Secondary Accessions:
    • Q96RA6

    Protein attributes for OR1D5 Gene

    Size:
    312 amino acids
    Molecular mass:
    35424 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1D5 Gene

Post-translational modifications for OR1D5 Gene

No Post-translational modifications

Other Protein References for OR1D5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1D5 Gene

Domains & Families for OR1D5 Gene

Gene Families for OR1D5 Gene

Protein Domains for OR1D5 Gene

Suggested Antigen Peptide Sequences for OR1D5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P58170

UniProtKB/Swiss-Prot:

OR1D5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1D5: view

Function for OR1D5 Gene

Molecular function for OR1D5 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily D,member 5,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA,TAS --
GO:0004984 olfactory receptor activity IEA,TAS --
genes like me logo Genes that share ontologies with OR1D5: view
genes like me logo Genes that share phenotypes with OR1D5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1D5 Gene

Localization for OR1D5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1D5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR1D5 Gene COMPARTMENTS Subcellular localization image for OR1D5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1D5: view

Pathways & Interactions for OR1D5 Gene

genes like me logo Genes that share pathways with OR1D5: view

Pathways by source for OR1D5 Gene

1 KEGG pathway for OR1D5 Gene

Interacting Proteins for OR1D5 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000459028%0d%0a9606.ENSP00000334051%0d%0a9606.ENSP00000269260%0d%0a9606.ENSP00000317578%0d%0a
Selected Interacting proteins: ENSP00000459028 P58170-OR1D5_HUMAN for OR1D5 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
GO:0007608 sensory perception of smell TAS 1315913
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1D5: view

No data available for SIGNOR curated interactions for OR1D5 Gene

Transcripts for OR1D5 Gene

mRNA/cDNA for OR1D5 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1D5 Gene

No ASD Table

Relevant External Links for OR1D5 Gene

GeneLoc Exon Structure for
OR1D5
ECgene alternative splicing isoforms for
OR1D5

Expression for OR1D5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1D5 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR1D5 Gene:

OR1D5

SOURCE GeneReport for Unigene cluster for OR1D5 Gene:

Hs.553508
genes like me logo Genes that share expression patterns with OR1D5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR1D5 Gene

Orthologs for OR1D5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1D5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC468150 34
  • 98.72 (n)
OR1D5 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cOR1D8 34
  • 84.84 (n)
-- 35
  • 80 (a)
OneToMany
cow
(Bos Taurus)
Mammalia OR1D5 34
  • 84.73 (n)
-- 35
  • 76 (a)
ManyToMany
-- 35
  • 75 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr412 35
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 41 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 47 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
Species where no ortholog for OR1D5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1D5 Gene

ENSEMBL:
Gene Tree for OR1D5 (if available)
TreeFam:
Gene Tree for OR1D5 (if available)

Paralogs for OR1D5 Gene

(451) SIMAP similar genes for OR1D5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OR1D5 Gene

genes like me logo Genes that share paralogs with OR1D5: view

Variants for OR1D5 Gene

Sequence variations from dbSNP and Humsavar for OR1D5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10544457 -- 3,064,219(+) AACTC(-/TTTTTT)TTTTT upstream-variant-2KB
rs142753580 -- 3,063,250(+) ATCAT(-/A)CGCCA reference, frameshift-variant
rs145762444 -- 3,062,566(+) CCTGA(G/T)CTGGA downstream-variant-500B
rs146458727 -- 3,063,109(+) GAAGG(C/T)CACCC reference, missense
rs147485340 -- 3,062,846(+) GCAAG(C/T)GTCCC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR1D5 Gene

Variant ID Type Subtype PubMed ID
dgv3084n100 CNV loss 25217958
esv2660206 CNV deletion 23128226
nsv1065489 CNV gain 25217958
nsv7288 OTHER inversion 18451855
nsv962245 CNV duplication 23825009

Variation tolerance for OR1D5 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.81; 89.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1D5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1D5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1D5 Gene

Disorders for OR1D5 Gene

Relevant External Links for OR1D5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR1D5

No disorders were found for OR1D5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1D5 Gene

Publications for OR1D5 Gene

  1. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G. … Lancet D. (Genomics 2000) 2 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. Novel G protein-coupled receptors: a gene family of putative human olfactory receptor sequences. (PMID: 1315913) Selbie L.A. … Shine J. (Brain Res. Mol. Brain Res. 1992) 3 64

Products for OR1D5 Gene

Sources for OR1D5 Gene

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