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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OR1D4 Gene

pseudogene GIFtS: 34
GCID: GC17P003144

olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene)

(Previous names: olfactory receptor, family 1, subfamily D, member 4 )

Explore 1 disease affiliated with
OR1D4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Olfactory Receptor, Family 1, Subfamily D, Member 4 (Gene/Pseudogene)¹ ²
OR17-30¹ ² ³
Olfactory Receptor, Family 1, Subfamily D, Member 4¹
Olfactory Receptor 1D4²
Olfactory Receptor 17-30³

External Ids:	HGNC: 8185¹	Entrez Gene: 653166²	Ensembl: ENSG00000255095⁷	UniProtKB: P47884³

ORGUL members:
	NONCODE:n409396

Export aliases for OR1D4 gene to outside databases

Previous GC identifers: GC17P003458 GC17M003307 GC17M002916 GC17M003172 GC17P003350 GC17M002913 GC17P003090 GC17P003036

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR1D4:

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the

perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors

(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many

neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of

odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the

olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul

2010)

UniProtKB/Swiss-Prot: OR1D4_HUMAN, P47884

Function: Odorant receptor (Potential)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OR1D4 gene promoter:
c-Fos AML1a AP-1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 C/EBPalpha AREB6 c-Jun
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR1D4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13.3

OR1D4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR1D4 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P003144: view genomic region (about GC identifiers)

Start:	3,143,970 bp from pter	End:	3,144,905 bp from pter
Size:	936 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OR1D4_HUMAN, P47884 (See protein sequence)

Recommended Name: Olfactory receptor 1D4

Size: 311 amino acids; 35227 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q96RA5 Q9UM75

Explore the universe of human proteins at neXtProt for OR1D4: NX_P47884

HORDE protein sequence for OR1D4
OR1D4 Protein expression data from MOPED and PaxDb: --
Reactome Protein details: P47884
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	8004088

OR1D4 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OR1D4 for domains About GeneDecksing

3 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR000725 Olfact_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P47884

ProtoNet protein and cluster: P47884

1 Blocks protein family: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR1D4_HUMAN, P47884

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: OR1D4_HUMAN, P47884

Function: Odorant receptor (Potential)

Genatlas biochemistry entry for OR1D4:

olfactory receptor,family 1,subfamily D,member 4,G protein coupled receptor superfamily

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004984	olfactory receptor activity	IEA	--

OR1D4 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for OR1D4:

Cell cycle / mitosis defect

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Olfactory transduction

Olfactory Signaling Pathway

0.77

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for OR1D4

	GPCR downstream signaling
	Olfactory Signaling Pathway
	Signal Transduction
	Signaling by GPCR

OR1D4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OR1D4

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor signaling pathway	TAS	8004088
GO:0007606	sensory perception of chemical stimulus	TAS	8004088

OR1D4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about OR1D4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for OR1D4 gene:

NM_003552.2

Unigene Cluster for OR1D4:

Olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene)

Hs.653087

Unigene Representative Sequence: BC118668

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000531680(uc002fvf.3) ENST00000525719

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Additional cDNA sequence:

BC118668.1 BC122528.1 NR_033795.1

1 DOTS entry:

DT.120948494

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR1D4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
Genevestigator expression for OR1D4

SOURCE GeneReport for Unigene cluster: Hs.653087
SABiosciences Custom PCR Arrays for OR1D4

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for OR1D4 (if available)
TreeFam Gene Tree for OR1D4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200226157^1,2		--	3142644(+)	`GAACT-/GTGGCT`	1	--	us2k¹		0	--	--	--	--
rs200675059^1,2		--	3142894(+)	`TCATC-/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs2676571^1,2	C,F,H	--	3142992(-)	`TTAAGA/GTATTA`	1	--	us2k¹		8		NS EA NA CSA WA	542
rs143031059^1,2		--	3143255(+)	`GTTCGA/GGATCA`	1	--	us2k¹		0	--	--	--	--
rs57425169^1,2	F	--	3143324(+)	`CCCCCA/GAATCT`	1	--	us2k¹		2		NA	8
rs60672117^1,2	F	--	3143371(+)	`CACAGG/AACGGT`	1	--	us2k¹		1		WA	118
rs200686480^1,2	F	--	3143983(+)	`AGATAA/GCCAGA`	1	--	nc-transcript-variant		1		EU	565
rs201853411^1,2		--	3144023(+)	`ATCTC-/AGAGAGT`	1	--	nc-transcript-variant		0	--	--	--	--
rs186524730^1,2		--	3144346(+)	`GGCCAC/TCTGCT`	1	--	nc-transcript-variant		0	--	--	--	--
rs200957745^1,2	F	--	3144482(+)	`GGGCCT/CTGAGA`	1	--	nc-transcript-variant		1		EU	439

HapMap Linkage Disequilibrium report for OR1D4 ( 3143970 - 3144905 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR1D4: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OR1D4 for disorders About GeneDecksing

1 disease for OR1D4: About MalaCards

neuronitis

Export disorders for OR1D4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OR1D4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR1D4)

Utopia: connect your pdf to the dynamic
world of online information

Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PubMed id 10673334)^{1, 2, 3} Glusman G.... Lancet D. (2000)
Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PubMed id 8004088)^{1, 2, 3} Ben-Arie N.... North M.A. (1994)
DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)^{1, 2} Fuchs T.... Shamir R. (2002)
The human olfactory receptor gene family. (PubMed id 14983052)¹ Malnic B.... Buck L.B. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 653166	HGNC: 8185	Ensembl:ENSG00000255095	euGenes: HUgn653166	ECgene: OR1D4
H-InvDB: OR1D4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OR1D4	Pharmacogenomics, SNPs, Pathways
HORDE entry for OR1D4	The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property for OR1D4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for OR1D4 gene:
Search GeneIP for patents involving OR1D4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

OR1D4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for OR1D4

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for OR1D4

	Browse SwitchGear 3'UTR luciferase reporter plasmids for OR1D4
	Browse SwitchGear Promoter luciferase reporter plasmids for OR1D4

Search ThermoFisher Antibodies for OR1D4

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR1D4

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for OR1D4

Sirion Biotech Customized:

	stable knockdown cell line services for OR1D4
	inducible knockdown cell line services for OR1D4
	design and validation of potent shRNA sequences against OR1D4
	adenovirus for potent knockdown of OR1D4
	adenovirus for overexpression of OR1D4
	stable overexpressing cell line services for OR1D4
	inducible overexpressing cell line services for OR1D4

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes OR1D4 gene at Home site.

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OR1D4 Gene

olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene)

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OR1D4 Gene

olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene)

Aliasesfor OR1D4 gene

Summariesfor OR1D4 gene

Genomic Viewsfor OR1D4 gene

Proteinsfor OR1D4 gene

Protein Domains /Familiesfor OR1D4 gene

Functionfor OR1D4 gene

Pathways & Interactionsfor OR1D4 gene

Drugs & Compoundsfor OR1D4 gene

Transcriptsfor OR1D4 gene

Expression for OR1D4 gene

Orthologsfor OR1D4 gene

Paralogsfor OR1D4 gene

Genomic Variantsfor OR1D4 gene

Disorders / Diseasesfor OR1D4 gene

Publicationsfor OR1D4 gene

External Searches for OR1D4 gene

Genome Databases showing OR1D4 gene

Other Databases showing OR1D4 gene

Specialized Databases showing OR1D4 gene

Intellectual Propertyfor OR1D4 gene

Productsfor OR1D4 gene

View Random Gene

Aliases
for OR1D4 gene

Summaries
for OR1D4 gene

Genomic Views
for OR1D4 gene

Proteins
for OR1D4 gene

Protein Domains /
Families
for OR1D4 gene

Function
for OR1D4 gene

Pathways & Interactions
for OR1D4 gene

Drugs & Compounds
for OR1D4 gene

Transcripts
for OR1D4 gene

Expression
for OR1D4 gene

Orthologs
for OR1D4 gene

Paralogs
for OR1D4 gene

Genomic Variants
for OR1D4 gene

Disorders / Diseases
for OR1D4 gene

Publications
for OR1D4 gene

Intellectual Property
for OR1D4 gene

Products
for OR1D4 gene