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Aliases for OR1D2 Gene

Aliases for OR1D2 Gene

  • Olfactory Receptor Family 1 Subfamily D Member 2 2 3 5
  • Olfactory Receptor-Like Protein HGMP07E 3 4
  • Olfactory Receptor OR17-6 3 4
  • Olfactory Receptor 17-4 3 4
  • OR17-4 3 4
  • OLFR1 3 4
  • Olfactory Receptor, Family 1, Subfamily D, Member 2 2
  • Olfactory Receptor 1D2 3

External Ids for OR1D2 Gene

Previous HGNC Symbols for OR1D2 Gene

  • OLFR1

Previous GeneCards Identifiers for OR1D2 Gene

  • GC17M003309
  • GC17M002946
  • GC17M003201
  • GC17M002942
  • GC17M002995

Summaries for OR1D2 Gene

Entrez Gene Summary for OR1D2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1D2 Gene

OR1D2 (Olfactory Receptor Family 1 Subfamily D Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1D5.

UniProtKB/Swiss-Prot for OR1D2 Gene

  • Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception.

Gene Wiki entry for OR1D2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1D2 Gene

Genomics for OR1D2 Gene

Regulatory Elements for OR1D2 Gene

Enhancers for OR1D2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F002390 1.6 FANTOM5 ENCODE 16.2 +694.0 693985 18.6 CREB3L1 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 METTL16 SMYD4 ENSG00000263345 SMG6 MNT EIF4A1P9 SAMD11P1 ENSG00000262869 OR1E3 OR1D2
GH17F002847 1.5 FANTOM5 Ensembl ENCODE 16.2 +244.5 244503 2.6 ELF3 ZFP64 INSM2 KLF17 SIN3A ZNF48 ZNF2 RAD21 ZEB1 GLIS2 HNRNPA1P16 METTL16 ENSG00000263345 LOC105371492 OR1D5 SAMD11P1 OR1D2 OR1E3 EIF4A1P9 OR1D3P
GH17F003885 1.5 FANTOM5 ENCODE 16.2 -797.5 -797541 10.9 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF302 ZNF416 P2RX1 OR1E2 OR3A4P OR1D2 OR1E3 OR1D3P OR1D5 CAMKK1 SHPK NCBP3
GH17F003988 1.3 Ensembl ENCODE 16.2 -896.0 -896039 1.1 ATF1 PKNOX1 SIN3A GLI4 ZNF2 ZNF121 GLIS2 ZNF416 KLF7 ZNF548 OR1E2 OR3A4P OR1E3 OR1D3P OR1D2 OR1D5 SHPK LOC101927979 CYB5D2 ZZEF1
GH17F003001 1.2 Ensembl ENCODE 16.3 +89.4 89401 4.8 WRNIP1 SIN3A BRCA1 ZNF2 YY1 GLIS2 ZHX2 REST TBX21 MBD2 OR1D5 OR1D2 OR1E3 OR1D3P OR3A4P SAMD11P1 EIF4A1P9 OR1E2 ENSG00000262869 RAP1GAP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR1D2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR1D2 Gene

Chromosome:
17
Start:
3,092,058 bp from pter
End:
3,092,996 bp from pter
Size:
939 bases
Orientation:
Minus strand

Genomic View for OR1D2 Gene

Genes around OR1D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1D2 Gene

Proteins for OR1D2 Gene

  • Protein details for OR1D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34982-OR1D2_HUMAN
    Recommended name:
    Olfactory receptor 1D2
    Protein Accession:
    P34982
    Secondary Accessions:
    • Q6IFL8
    • Q96RA4
    • Q9UM78

    Protein attributes for OR1D2 Gene

    Size:
    312 amino acids
    Molecular mass:
    35240 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1D2 Gene

Post-translational modifications for OR1D2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR1D2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1D2 Gene

Domains & Families for OR1D2 Gene

Gene Families for OR1D2 Gene

Protein Domains for OR1D2 Gene

Suggested Antigen Peptide Sequences for OR1D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P34982

UniProtKB/Swiss-Prot:

OR1D2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1D2: view

Function for OR1D2 Gene

Molecular function for OR1D2 Gene

GENATLAS Biochemistry:
olfactory receptor family 1,subfamily D,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception.

Gene Ontology (GO) - Molecular Function for OR1D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA,TAS --
GO:0004984 olfactory receptor activity IDA 12663925
genes like me logo Genes that share ontologies with OR1D2: view
genes like me logo Genes that share phenotypes with OR1D2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1D2 Gene

Localization for OR1D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1D2 Gene

Cell membrane; Multi-pass membrane protein. Note=In spermatazoa is localized in the midpiece and is translocated to the head region upon receptor stimulation with bourgeonal.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR1D2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8097991
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR1D2: view

Pathways & Interactions for OR1D2 Gene

genes like me logo Genes that share pathways with OR1D2: view

Pathways by source for OR1D2 Gene

1 KEGG pathway for OR1D2 Gene

Gene Ontology (GO) - Biological Process for OR1D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IMP 16820410
GO:0006928 movement of cell or subcellular component TAS 1370859
GO:0006935 chemotaxis IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IDA 16820410
genes like me logo Genes that share ontologies with OR1D2: view

No data available for SIGNOR curated interactions for OR1D2 Gene

Drugs & Compounds for OR1D2 Gene

No Compound Related Data Available

Transcripts for OR1D2 Gene

mRNA/cDNA for OR1D2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1D2 Gene

Olfactory receptor, family 1, subfamily D, member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1D2 Gene

No ASD Table

Relevant External Links for OR1D2 Gene

GeneLoc Exon Structure for
OR1D2
ECgene alternative splicing isoforms for
OR1D2

Expression for OR1D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR1D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR1D2 Gene

This gene is overexpressed in Testis (x28.7).

NURSA nuclear receptor signaling pathways regulating expression of OR1D2 Gene:

OR1D2

SOURCE GeneReport for Unigene cluster for OR1D2 Gene:

Hs.532771

mRNA Expression by UniProt/SwissProt for OR1D2 Gene:

P34982-OR1D2_HUMAN
Tissue specificity: Expressed in testis. Expressed in spermatozoa (at protein level). Expressed in olfactory epithelium.
genes like me logo Genes that share expression patterns with OR1D2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for OR1D2 Gene

Orthologs for OR1D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1D2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR1D2 34 35
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia LOC611352 34
  • 88.25 (n)
-- 35
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Or1d2 55 Olfr412 34 16
  • 85.47 (n)
Olfr54 35
  • 51 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1520 34
  • 85.21 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 82 (a)
ManyToMany
-- 35
  • 75 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 43 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
Species where no ortholog for OR1D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1D2 Gene

ENSEMBL:
Gene Tree for OR1D2 (if available)
TreeFam:
Gene Tree for OR1D2 (if available)

Paralogs for OR1D2 Gene

(458) SIMAP similar genes for OR1D2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR1D2 Gene

genes like me logo Genes that share paralogs with OR1D2: view

Variants for OR1D2 Gene

Sequence variations from dbSNP and Humsavar for OR1D2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11078437 -- 3,093,362(+) GAAAA(C/T)AAAAG upstream-variant-2KB
rs111447540 -- 3,091,660(+) TTGCA(A/G)TCTCT downstream-variant-500B
rs111706594 -- 3,093,582(+) GCGAA(A/T)CATGA upstream-variant-2KB
rs112341631 -- 3,092,540(+) GAGGA(C/T)GGATA reference, missense
rs112503311 -- 3,093,033(+) CAAAT(A/G)TTTAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1D2 Gene

Variant ID Type Subtype PubMed ID
nsv978349 CNV duplication 23825009
nsv7288 OTHER inversion 18451855
nsv1065489 CNV gain 25217958
esv2660206 CNV deletion 23128226
dgv4n29 CNV loss 16826518
dgv3084n100 CNV loss 25217958

Variation tolerance for OR1D2 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.41; 85.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR1D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR1D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1D2 Gene

Disorders for OR1D2 Gene

Relevant External Links for OR1D2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR1D2

No disorders were found for OR1D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1D2 Gene

Publications for OR1D2 Gene

  1. The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13-->p12 region of the human genome and reveals an MspI restriction fragment length polymorphism. (PMID: 8097991) Schurmans S. … Parmentier M. (Cytogenet. Cell Genet. 1993) 3 4 22 64
  2. Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. (PMID: 16820410) Neuhaus E.M. … Hatt H. (J. Cell Sci. 2006) 3 4 64
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification of a testicular odorant receptor mediating human sperm chemotaxis. (PMID: 12663925) Spehr M. … Hatt H. (Science 2003) 3 4 64

Products for OR1D2 Gene

Sources for OR1D2 Gene

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