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Aliases for OR1D2 Gene

Aliases for OR1D2 Gene

  • Olfactory Receptor Family 1 Subfamily D Member 2 2 3 5
  • Olfactory Receptor, Family 1, Subfamily D, Member 2 2 3
  • Olfactory Receptor-Like Protein HGMP07E 3 4
  • Olfactory Receptor OR17-6 3 4
  • Olfactory Receptor 17-4 3 4
  • OR17-4 3 4
  • OLFR1 3 4

External Ids for OR1D2 Gene

Previous HGNC Symbols for OR1D2 Gene

  • OLFR1

Previous GeneCards Identifiers for OR1D2 Gene

  • GC17M003309
  • GC17M002946
  • GC17M003201
  • GC17M002942
  • GC17M002995

Summaries for OR1D2 Gene

Entrez Gene Summary for OR1D2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1D2 Gene

OR1D2 (Olfactory Receptor Family 1 Subfamily D Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1D5.

UniProtKB/Swiss-Prot for OR1D2 Gene

  • Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception.

Gene Wiki entry for OR1D2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1D2 Gene

Genomics for OR1D2 Gene

Regulatory Elements for OR1D2 Gene

Genomic Location for OR1D2 Gene

3,092,058 bp from pter
3,092,996 bp from pter
939 bases
Minus strand

Genomic View for OR1D2 Gene

Genes around OR1D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR1D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR1D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1D2 Gene

Proteins for OR1D2 Gene

  • Protein details for OR1D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 1D2
    Protein Accession:
    Secondary Accessions:
    • Q6IFL8
    • Q96RA4
    • Q9UM78

    Protein attributes for OR1D2 Gene

    312 amino acids
    Molecular mass:
    35240 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1D2 Gene

Proteomics data for OR1D2 Gene at MOPED

Post-translational modifications for OR1D2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR1D2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

  • Abcam antibodies for OR1D2
  • Santa Cruz Biotechnology (SCBT) Antibodies for OR1D2

No data available for DME Specific Peptides for OR1D2 Gene

Domains & Families for OR1D2 Gene

Gene Families for OR1D2 Gene

Protein Domains for OR1D2 Gene

Suggested Antigen Peptide Sequences for OR1D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1D2: view

Function for OR1D2 Gene

Molecular function for OR1D2 Gene

GENATLAS Biochemistry:
olfactory receptor family 1,subfamily D,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception.
genes like me logo Genes that share phenotypes with OR1D2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR1D2 Gene

Localization for OR1D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1D2 Gene

Cell membrane; Multi-pass membrane protein. Note=In spermatazoa is localized in the midpiece and is translocated to the head region upon receptor stimulation with bourgeonal.

Subcellular locations from

Jensen Localization Image for OR1D2 Gene COMPARTMENTS Subcellular localization image for OR1D2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8097991
genes like me logo Genes that share ontologies with OR1D2: view

Pathways & Interactions for OR1D2 Gene

genes like me logo Genes that share pathways with OR1D2: view

Pathways by source for OR1D2 Gene

1 KEGG pathway for OR1D2 Gene

Gene Ontology (GO) - Biological Process for OR1D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IDA 16820410
GO:0007338 single fertilization IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR1D2: view

No data available for SIGNOR curated interactions for OR1D2 Gene

Drugs & Compounds for OR1D2 Gene

No Compound Related Data Available

Transcripts for OR1D2 Gene

mRNA/cDNA for OR1D2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1D2 Gene

Olfactory receptor, family 1, subfamily D, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR1D2 Gene

No ASD Table

Relevant External Links for OR1D2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR1D2 Gene

mRNA expression in normal human tissues for OR1D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR1D2 Gene

This gene is overexpressed in Testis (x28.7).

SOURCE GeneReport for Unigene cluster for OR1D2 Gene Hs.532771

mRNA Expression by UniProt/SwissProt for OR1D2 Gene

Tissue specificity: Expressed in testis. Expressed in spermatozoa (at protein level). Expressed in olfactory epithelium.
genes like me logo Genes that share expression patterns with OR1D2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for OR1D2 Gene

Orthologs for OR1D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1D2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC611352 35
  • 88.25 (n)
  • 87.5 (a)
-- 36
  • 87 (a)
(Mus musculus)
Mammalia Olfr412 35
  • 85.47 (n)
  • 86.86 (a)
Olfr412 16
Olfr54 36
  • 51 (a)
(Pan troglodytes)
Mammalia OR1D2 35
  • 99.25 (n)
  • 98.4 (a)
OR1D2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Olr1520 35
  • 85.21 (n)
  • 85.53 (a)
(Bos Taurus)
Mammalia -- 36
  • 75 (a)
-- 36
  • 82 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 41 (a)
-- 36
  • 45 (a)
-- 36
  • 46 (a)
-- 36
  • 49 (a)
Species with no ortholog for OR1D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1D2 Gene

Gene Tree for OR1D2 (if available)
Gene Tree for OR1D2 (if available)

Paralogs for OR1D2 Gene

Paralogs for OR1D2 Gene

(458) SIMAP similar genes for OR1D2 Gene using alignment to 1 proteins: Pseudogenes for OR1D2 Gene

genes like me logo Genes that share paralogs with OR1D2: view

Variants for OR1D2 Gene

Sequence variations from dbSNP and Humsavar for OR1D2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs769423 - 3,092,923(-) GCAGC(A/G)GATCC reference, missense
rs9916628 - 3,092,905(+) ACAGG(A/T)ACATC reference, missense
rs4300683 - 3,092,278(+) CACAG(A/G)TGGAG reference, missense
rs55803944 - 3,092,357(+) GATCA(C/T)GAATC reference, missense
rs769424 -- 3,092,700(-) CTGAC(A/G)CAGCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR1D2 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV Deletion 23128226
nsv7288 OTHER Inversion 18451855
nsv907552 CNV Loss 21882294
dgv3n29 CNV Complex 16826518

Variation tolerance for OR1D2 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.41; 85.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR1D2 Gene

Disorders for OR1D2 Gene

Relevant External Links for OR1D2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR1D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR1D2 Gene

Publications for OR1D2 Gene

  1. The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13-->p12 region of the human genome and reveals an MspI restriction fragment length polymorphism. (PMID: 8097991) Schurmans S. … Parmentier M. (Cytogenet. Cell Genet. 1993) 3 4 23 67
  2. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M. … Vassart G. (Nature 1992) 2 3
  3. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. (PMID: 1840504) Buck L. … Axel R. (Cell 1991) 2 3
  4. Genome-wide association study link novel loci to endometriosis. (PMID: 23472165) Albertsen H.M. … Ward K. (PLoS ONE 2013) 3
  5. Human olfactory sensitivity for bourgeonal and male infertility: a preliminary investigation. (PMID: 23525651) Ottaviano G. … Foresta C. (Eur Arch Otorhinolaryngol 2013) 3

Products for OR1D2 Gene

Sources for OR1D2 Gene