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Aliases for OR1D2 Gene

Aliases for OR1D2 Gene

  • Olfactory Receptor, Family 1, Subfamily D, Member 2 2 3
  • OLFR1 3 4 6
  • Olfactory Receptor-Like Protein HGMP07E 3 4
  • Olfactory Receptor OR17-6 3 4
  • Olfactory Receptor 17-4 3 4
  • OR17-4 3 4
  • Olfactory Receptor 1D2 3

External Ids for OR1D2 Gene

Previous HGNC Symbols for OR1D2 Gene

  • OLFR1

Previous GeneCards Identifiers for OR1D2 Gene

  • GC17M003309
  • GC17M002946
  • GC17M003201
  • GC17M002942
  • GC17M002995

Summaries for OR1D2 Gene

Entrez Gene Summary for OR1D2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1D2 Gene

OR1D2 (Olfactory Receptor, Family 1, Subfamily D, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1D5.

UniProtKB/Swiss-Prot for OR1D2 Gene

  • Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception.

Gene Wiki entry for OR1D2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1D2 Gene

Genomics for OR1D2 Gene

Regulatory Elements for OR1D2 Gene

Genomic Location for OR1D2 Gene

Start:
3,092,058 bp from pter
End:
3,092,996 bp from pter
Size:
939 bases
Orientation:
Minus strand

Genomic View for OR1D2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR1D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1D2 Gene

Proteins for OR1D2 Gene

  • Protein details for OR1D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34982-OR1D2_HUMAN
    Recommended name:
    Olfactory receptor 1D2
    Protein Accession:
    P34982
    Secondary Accessions:
    • Q6IFL8
    • Q96RA4
    • Q9UM78

    Protein attributes for OR1D2 Gene

    Size:
    312 amino acids
    Molecular mass:
    35240 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1D2 Gene

Proteomics data for OR1D2 Gene at MOPED

Post-translational modifications for OR1D2 Gene

  • Glycosylation at Asn5 and Asn195
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1D2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1D2 Gene

Domains for OR1D2 Gene

Gene Families for OR1D2 Gene

HGNC:
  • OR1 :GPCR / Class A : Olfactory receptors

Protein Domains for OR1D2 Gene

Suggested Antigen Peptide Sequences for OR1D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P34982

UniProtKB/Swiss-Prot:

OR1D2_HUMAN :
  • P34982
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1D2: view

Function for OR1D2 Gene

Molecular function for OR1D2 Gene

GENATLAS Biochemistry: olfactory receptor family 1,subfamily D,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception.

Gene Ontology (GO) - Molecular Function for OR1D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IDA 12663925
genes like me logo Genes that share ontologies with OR1D2: view

Phenotypes for OR1D2 Gene

GenomeRNAi human phenotypes for OR1D2:
genes like me logo Genes that share phenotypes with OR1D2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR1D2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR1D2 Gene

Localization for OR1D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1D2 Gene

Cell membrane; Multi-pass membrane protein. Note=In spermatazoa is localized in the midpiece and is translocated to the head region upon receptor stimulation with bourgeonal.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR1D2 Gene COMPARTMENTS Subcellular localization image for OR1D2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8097991
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1D2: view

Pathways for OR1D2 Gene

genes like me logo Genes that share pathways with OR1D2: view

Pathways by source for OR1D2 Gene

1 KEGG pathway for OR1D2 Gene

Gene Ontology (GO) - Biological Process for OR1D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IMP 16820410
GO:0006928 movement of cell or subcellular component TAS 1370859
GO:0006935 chemotaxis IEA --
GO:0007186 G-protein coupled receptor signaling pathway IDA 16820410
GO:0007338 single fertilization IEA --
genes like me logo Genes that share ontologies with OR1D2: view

Compounds for OR1D2 Gene

No Compound Related Data Available

Transcripts for OR1D2 Gene

mRNA/cDNA for OR1D2 Gene

(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1D2 Gene

Olfactory receptor, family 1, subfamily D, member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR1D2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR1D2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1D2 Gene

No ASD Table

Relevant External Links for OR1D2 Gene

GeneLoc Exon Structure for
OR1D2
ECgene alternative splicing isoforms for
OR1D2

Expression for OR1D2 Gene

mRNA expression in normal human tissues for OR1D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR1D2 Gene

This gene is overexpressed in Testis (28.7).

SOURCE GeneReport for Unigene cluster for OR1D2 Gene Hs.532771

mRNA Expression by UniProt/SwissProt for OR1D2 Gene

P34982-OR1D2_HUMAN
Tissue specificity: Expressed in testis. Expressed in spermatozoa (at protein level). Expressed in olfactory epithelium.
genes like me logo Genes that share expressions with OR1D2: view

In Situ Assay Products

No data available for Protein expression for OR1D2 Gene

Orthologs for OR1D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1D2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR1D2 35
  • 99.25 (n)
  • 98.4 (a)
OR1D2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 75 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 87 (a)
OneToMany
LOC611352 35
  • 88.25 (n)
  • 87.5 (a)
mouse
(Mus musculus)
Mammalia Olfr412 35
  • 85.47 (n)
  • 86.86 (a)
Olfr412 16
Olfr54 36
  • 51 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1520 35
  • 85.21 (n)
  • 85.53 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
Species with no ortholog for OR1D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1D2 Gene

ENSEMBL:
Gene Tree for OR1D2 (if available)
TreeFam:
Gene Tree for OR1D2 (if available)

Paralogs for OR1D2 Gene

Paralogs for OR1D2 Gene

Selected SIMAP similar genes for OR1D2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR1D2 Gene

genes like me logo Genes that share paralogs with OR1D2: view

Variants for OR1D2 Gene

Sequence variations from dbSNP and Humsavar for OR1D2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs769423 - 3,092,923(-) GCAGC(A/G)GATCC missense, reference
rs769424 -- 3,092,700(-) CTGAC(A/G)CAGCT reference, synonymous-codon
rs4300683 - 3,092,278(+) CACAG(A/G)TGGAG reference, missense
rs5818889 -- 3,094,420(+) ATGTA(-/GTA)TATAT upstream-variant-2KB
rs7213609 -- 3,091,724(+) CTGTA(C/G)TTTGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR1D2 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV Deletion 23128226
nsv7288 OTHER Inversion 18451855
nsv907552 CNV Loss 21882294
dgv3n29 CNV Complex 16826518

Relevant External Links for OR1D2 Gene

HapMap Linkage Disequilibrium report
OR1D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1D2 Gene

Disorders for OR1D2 Gene

No disorders were found for OR1D2 Gene.

No data available for UniProtKB/Swiss-Prot for OR1D2 Gene

Publications for OR1D2 Gene

  1. The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13-->p12 region of the human genome and reveals an MspI restriction fragment length polymorphism. (PMID: 8097991) Schurmans S. … Parmentier M. (Cytogenet. Cell Genet. 1993) 3 4 23
  2. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M. … Vassart G. (Nature 1992) 2 3
  3. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. (PMID: 1840504) Buck L. … Axel R. (Cell 1991) 2 3
  4. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PMID: 8004088) Ben-Arie N. … North M.A. (Hum. Mol. Genet. 1994) 3 4
  5. Identification of a testicular odorant receptor mediating human sperm chemotaxis. (PMID: 12663925) Spehr M. … Hatt H. (Science 2003) 3 4

Products for OR1D2 Gene

Sources for OR1D2 Gene

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