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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR1D2 Gene

protein-coding   GIFtS: 54
GCID: GC17M002995

olfactory receptor, family 1, subfamily D, member 2


(Previous symbol: OLFR1)
 Explore 1 disease affiliated with
OR1D2 via our new
 Human Malady Compendium 
Biological research products
for OR1D2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Olfactory Receptor, Family 1, Subfamily D, Member 21 2     Olfactory Receptor OR17-62 3
OLFR11 2 3 5     Olfactory Receptor-Like Protein HGMP07E2 3
OR17-41 2 3     Olfactory Receptor 1D22
Olfactory Receptor 17-42 3     

External Ids:    HGNC: 81831   Entrez Gene: 49912   Ensembl: ENSG000001841667   OMIM: 1643425   UniProtKB: P349823   

Export aliases for OR1D2 gene to outside databases

Previous GC identifers: GC17M003309 GC17M002946 GC17M003201 GC17M002942


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR1D2:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors
(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many
neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of
odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the
olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: OR1D2_HUMAN, P34982
Function: Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm
in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception

Gene Wiki entry for OR1D2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR1D2 gene promoter:
         c-Fos   AML1a   AP-1   FOXO3   C/EBPalpha   GATA-2   FOXO3b   FOXO3a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR1D2 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR1D2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR1D2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

OR1D2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR1D2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M002995:  view genomic region     (about GC identifiers)

Start:
2,995,355 bp from pter      End:
2,996,290 bp from pter
Size:
936 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OR1D2_HUMAN, P34982 (See protein sequence)
Recommended Name: Olfactory receptor 1D2  
Size: 312 amino acids; 35240 Da
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=In spermatazoa is localized in the midpiece and
is translocated to the head region upon receptor stimulation with bourgeonal
Secondary accessions: Q6IFL8 Q96RA4 Q9UM78

Explore the universe of human proteins at neXtProt for OR1D2: NX_P34982

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P34982

  • HORDE protein sequence for OR1D2
    OR1D2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002539.2  
    ENSEMBL proteins: 
     ENSP00000327585  
    Reactome Protein details: P34982
    Human Recombinant Protein Products: 
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    Uscn Proteins for OR1D2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8097991


    OR1D2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    OR1D2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P34982

    ProtoNet protein and cluster: P34982

    1 Blocks protein family: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR1D2_HUMAN, P34982
    Similarity: Belongs to the G-protein coupled receptor 1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: OR1D2_HUMAN, P34982
    Function: Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm
    in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception

         Genatlas biochemistry entry for OR1D2:
    olfactory receptor family 1,subfamily D,member 2,G protein coupled receptor superfamily

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IDA12663925


    OR1D2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for OR1D2:
     Decreased POU5F1-GFP protein e 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by GPCR
    Signaling by GPCR1.00
    Signal Transduction0.56
    GPCR downstream signaling0.89
    2Olfactory transduction
    Olfactory transduction1.00
    Olfactory Signaling Pathway0.77
    3Class A/1 (Rhodopsin-like receptors)
    GPCRs, Class A Rhodopsin-like0.41

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for OR1D2 
        GPCRs, Class A Rhodopsin-like

    4        Reactome Pathways for OR1D2
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for OR1D2):
        Olfactory transduction


    OR1D2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR1D2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/274 Interacting proteins for OR1D2 (P349822, 3 ENSP000003275854) via UniProtKB, MINT, STRING, and/or I2D (see all 274)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPDZO759702, 3, ENSP000003704104MINT-7290191 I2D: score=1 STRING: ENSP00000370410
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10H2ENSP000003060954STRING: ENSP00000306095
    OR10H3ENSP000003071304STRING: ENSP00000307130
    OR10J1ENSP000003990784STRING: ENSP00000399078
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IMP16820410
    GO:0006928cellular component movement TAS1370859
    GO:0006935chemotaxis IEA--
    GO:0007186G-protein coupled receptor signaling pathway IDA16820410
    GO:0007338single fertilization IEA--


    OR1D2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OR1D2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for OR1D2

    Browse Tocris compounds for OR1D2
    Search CenterWatch for drugs/clinical trials and news about OR1D2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OR1D2 gene: 
    NM_002548.2  

    Unigene Cluster for OR1D2:

    Olfactory receptor, family 1, subfamily D, member 2
    Hs.532771  [show with all ESTs]
    Unigene Representative Sequence: NM_002548
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000331459(uc010vrb.2)

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    Additional cDNA sequence: 

    BC069552.1 BC106735.1 BC106736.1 

    1 DOTS entry:

    DT.91953095 

    8 AceView cDNA sequences:

    BC069552 CO249806 NM_002548 CO247055 CO250035 CO248551 CO246948 CO247605 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR1D2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    OR1D2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See OR1D2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OR1D2

    SOURCE GeneReport for Unigene cluster: Hs.532771

    UniProtKB/Swiss-Prot: OR1D2_HUMAN, P34982
    Tissue specificity: Expressed in testis. Expressed in spermatozoa (at protein level). Expressed in olfactory epithelium

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    In Situ
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    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for OR1D2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OR1D2 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii BX088524.26
    or109-26
    (see all 23)
    --
    odorant receptor, family D, subfamily 109, member ...
    (see all 23)
    31(a)
    29(a)
    (see all 23)
    many ↔ many
    many ↔ many
    (see all 23)
    10(37401957-37403361)
    10(37419890-37420837)


    ENSEMBL Gene Tree for OR1D2 (if available)
    TreeFam Gene Tree for OR1D2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OR1D2 gene
    OR1Q12  OR1L42  OR1L32  OR1L12  OR1L82  OR1K12  OR1L62  OR1A12  
    OR1A22  
    18/458 SIMAP similar genes for OR1D2 using alignment to 1 protein entry:     OR1D2_HUMAN(see all similar genes):
    OR1D5    OR1D4    LOC441453    OR1F1    OR1N2    OR7G3
    OR1E1    OR1F12    OR1F2P    OR1G1    OR1J4    OR1L1
    OR1L8    OR1M1    OR1N1    OR7A2P    OR7A5    OR7C1

    OR1D2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OR1D2
    PGOHUM00000237196


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/97 NCBI SNPs in OR1D2 are shown (see all 97    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826725851,2
    --2994903(+) CCTGTC/TGAGGT 1 -- ds50010--------
    rs787598231,2
    C,F,--2994918(+) ATCACG/ATGCTG 1 -- ds50011Minor allele frequency- A:0.13WA 118
    rs788252331,2
    --2994925(+) GCTGGA/CTCAGC 1 -- ds50013Minor allele frequency- C:0.10CSA WA 121
    rs1114475401,2
    --2994954(+) TTGCAG/ATCTCT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs2010366041,2
    C--2994962(-) GGTTTG/TAAAGA 1 -- ds50010--------
    rs72136091,2
    C,F,H,--2995018(+) CTGTAC/GTTTGG 1 -- ds50018Minor allele frequency- G:0.05NS EA WA NA 662
    rs746510591,2
    F,--2995098(+) CTGTAG/CTCAAG 1 -- ds50011Minor allele frequency- C:0.09WA 118
    rs1467034091,2
    --2995164(+) TTTACA/GGCCAA 1 -- ds50010--------
    rs1864587661,2
    --2995181(+) TGAGAC/TCTGGG 1 -- ds50010--------
    rs352019921,2
    C,F,--2995227(+) ACATAT/CCTATA 1 -- ds50014Minor allele frequency- C:0.04NA 126

    HapMap Linkage Disequilibrium report for OR1D2 ( 2995355 - 2996290 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for OR1D2: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    OR1D2 for disorders           About GeneDecksing

    OMIM gene information: 164342    OMIM disorders: --

    1 disease for OR1D2:    About MalaCards
    neuronitis


    Export disorders for OR1D2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OR1D2 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with OR1D2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13-->p12 region of the human genome and reveals an MspI restriction fragment length polymorphism. (PubMed id 8097991)1, 2, 9 Schurmans S....Parmentier M. (1993)
    2. Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. (PubMed id 16820410)1, 2 Neuhaus E.M.... Hatt H. (2006)
    3. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification of a testicular odorant receptor mediating human sperm chemotaxis. (PubMed id 12663925)1, 2 Spehr M.... Hatt H. (2003)
    6. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
    7. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PubMed id 10673334)1, 2 Glusman G.... Lancet D. (2000)
    8. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PubMed id 8004088)1, 2 Ben-Arie N.... North M.A. (1994)
    9. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PubMed id 1370859)1, 3 Parmentier M.... Vassart G. (1992)
    10. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. (PubMed id 1840504)1, 3 Buck L. and Axel R. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4991 HGNC: 8183 AceView: OR1D2 Ensembl:ENSG00000184166 euGenes: HUgn4991
    ECgene: OR1D2 Kegg: 4991 H-InvDB: OR1D2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR1D2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR1D2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt115.shtml
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt115.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OR1D2 gene:
    Search GeneIP for patents involving OR1D2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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