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OR1D2 Gene

protein-coding   GIFtS: 57
GCID: GC17M002995

Olfactory Receptor, Family 1, Subfamily D, Member 2


(Previous symbol: OLFR1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 1, Subfamily D, Member 21 2     Olfactory Receptor-Like Protein HGMP07E2 3
OLFR11 2 3 5     OR17-42 3
Olfactory Receptor 17-42 3     Olfactory Receptor 1D22
Olfactory Receptor OR17-62 3     

External Ids:    HGNC: 81831   Entrez Gene: 49912   Ensembl: ENSG000001841667   OMIM: 1643425   UniProtKB: P349823   

Export aliases for OR1D2 gene to outside databases

Previous GC identifers: GC17M003309 GC17M002946 GC17M003201 GC17M002942


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR1D2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR1D2 Gene:
OR1D2 (olfactory receptor, family 1, subfamily D, member 2) is a protein-coding gene. Diseases associated with OR1D2 include endometriosis, and neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1Q1.

UniProtKB/Swiss-Prot: OR1D2_HUMAN, P34982
Function: Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for
sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception

Gene Wiki entry for OR1D2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR1D2 gene promoter:
         c-Fos   AML1a   AP-1   FOXO3   C/EBPalpha   GATA-2   FOXO3b   FOXO3a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR1D2 promoter sequence
   Search Chromatin IP Primers for OR1D2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR1D2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

OR1D2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR1D2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M002995:  view genomic region     (about GC identifiers)

Start:
2,995,355 bp from pter      End:
2,996,290 bp from pter
Size:
936 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR1D2_HUMAN, P34982 (See protein sequence)
Recommended Name: Olfactory receptor 1D2  
Size: 312 amino acids; 35240 Da
Secondary accessions: Q6IFL8 Q96RA4 Q9UM78

Explore the universe of human proteins at neXtProt for OR1D2: NX_P34982

Explore proteomics data for OR1D2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn195
  • Modification sites at PhosphoSitePlus
  • HORDE protein sequence for OR1D2

    See OR1D2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002539.2  
    ENSEMBL proteins: 
     ENSP00000327585  
    Reactome Protein details: P34982

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR1: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P34982

    ProtoNet protein and cluster: P34982

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR1D2_HUMAN, P34982
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR1D2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR1D2_HUMAN, P34982
    Function: Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for
    sperm in vitro and is shown to be a strong agonist for OR1D2 in vitro. May also function in olfactory reception

         Genatlas biochemistry entry for OR1D2:
    olfactory receptor family 1,subfamily D,member 2,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IDA12663925
         
    OR1D2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OR1D2:
     Decreased POU5F1-GFP protein e 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR1D2_HUMAN, P34982: Cell membrane; Multi-pass membrane protein. Note=In spermatazoa is localized in the midpiece
    and is translocated to the head region upon receptor stimulation with bourgeonal
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8097991
    GO:0016021integral component of membrane ----

    OR1D2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR1D2 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR1D2
        GPCRs, Class A Rhodopsin-like


    1 Reactome Pathway for OR1D2
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR1D2):
        Olfactory transduction


    OR1D2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR1D2
    Interactions:

        Search GeneGlobe Interaction Network for OR1D2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR1D2 (P349822, 3 ENSP000003275854) via UniProtKB, MINT, STRING, and/or I2D (see all 274)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPDZO759702, 3, ENSP000003704104MINT-7290191 I2D: score=1 STRING: ENSP00000370410
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    GNALENSP000003340514STRING: ENSP00000334051
    OR10H2ENSP000003060954STRING: ENSP00000306095
    OR10H3ENSP000003071304STRING: ENSP00000307130
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    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000060protein import into nucleus, translocation IMP16820410
    GO:0006928cellular component movement TAS1370859
    GO:0006935chemotaxis IEA--
    GO:0007186G-protein coupled receptor signaling pathway IDA16820410
    GO:0007338single fertilization IEA--

    OR1D2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for OR1D2
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    Browse Tocris compounds for OR1D2



    OR1D2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR1D2 gene: 
    NM_002548.2  

    Unigene Cluster for OR1D2:

    Olfactory receptor, family 1, subfamily D, member 2
    Hs.532771  [show with all ESTs]
    Unigene Representative Sequence: NM_002548
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000331459(uc010vrb.2)
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      QuantiFast Probe-based Assays in human, mouse, rat OR1D2

    Additional mRNA sequence: 

    BC069552.1 BC106735.1 BC106736.1 

    1 DOTS entry:

    DT.91953095 

    8 AceView cDNA sequences:

    BC069552 NM_002548 CO247055 CO248551 CO249806 CO250035 CO246948 CO247605 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR1D2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR1D2 Expression
    About this image


    OR1D2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
    OR1D2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR1D2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532771

    UniProtKB/Swiss-Prot: OR1D2_HUMAN, P34982
    Tissue specificity: Expressed in testis. Expressed in spermatozoa (at protein level). Expressed in olfactory
    epithelium

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR1D2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr4121 , 5 olfactory receptor 4121, 5 85.47(n)1
    86.86(a)1
      11 (45.76 cM)5
    2581531  NM_001011851.11  NP_001011851.11 
     743646715 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    49(a)
    46(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343252.1(223169-224982)
    GL343252.1(213816-214766)


    ENSEMBL Gene Tree for OR1D2 (if available)
    TreeFam Gene Tree for OR1D2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR1D2 gene
    OR1Q12  OR1L42  OR1L32  OR1L12  OR1L82  OR1L62  OR1K12  OR1A12  
    OR1A22  OR1D52  
    Selected SIMAP similar genes for OR1D2 using alignment to 1 protein entry:     OR1D2_HUMAN(see all similar genes):
    OR1D5    OR1D4    LOC441453    OR1F1    OR1N2    OR7G3
    OR1E1    OR1F12    OR1F2P    OR1G1    OR1J4    OR1L1
    OR1L8    OR1M1    OR1N1    OR7A2P    OR7A5    OR7C1

    OR1D2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OR1D2
    PGOHUM00000237196


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR1D2 (see all 134)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826725851,2
    --2994903(+) CCTGTC/TGAGGT 1 -- ds50010--------
    rs787598231,2
    C,F--2994918(+) ATCACG/ATGCTG 1 -- ds50011Minor allele frequency- A:0.13WA 118
    rs788252331,2
    C,F--2994925(+) GCTGGA/CTCAGC 1 -- ds50013Minor allele frequency- C:0.10CSA WA 121
    rs1114475401,2
    F--2994954(+) TTGCAG/ATCTCT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs2010366041,2
    C--2994962(-) GGTTTG/TAAAGA 1 -- ds50010--------
    rs72136091,2
    C,F,H--2995018(+) CTGTAC/GTTTGG 1 -- ds50018Minor allele frequency- G:0.05NS EA WA NA 662
    rs746510591,2
    C,F--2995098(+) CTGTAG/CTCAAG 1 -- ds50011Minor allele frequency- C:0.09WA 118
    rs1467034091,2
    --2995164(+) TTTACA/GGCCAA 1 -- ds50010--------
    rs1864587661,2
    --2995181(+) TGAGAC/TCTGGG 1 -- ds50010--------
    rs352019921,2
    C,F--2995227(+) ACATAT/CCTATA 1 -- ds50014Minor allele frequency- C:0.04NA 126

    HapMap Linkage Disequilibrium report for OR1D2 ( 2995355 - 2996290 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for OR1D2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660206CNV Deletion23128226
    nsv907552CNV Loss21882294
    dgv3n29CNV Complex16826518
    nsv7288OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164342    OMIM disorders: --

    2 diseases for OR1D2:    
    About MalaCards
    endometriosis    neuronitis


    OR1D2 for disorders           About GeneDecksing


    Export disorders for OR1D2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR1D2 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with OR1D2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13-->p12 region of the human genome and reveals an MspI restriction fragment length polymorphism. (PubMed id 8097991)1, 2, 9 Schurmans S....Parmentier M. (Cytogenet. Cell Genet. 1993)
    2. Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. (PubMed id 16820410)1, 2 Neuhaus E.M.... Hatt H. (J. Cell Sci. 2006)
    3. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Identification of a testicular odorant receptor mediating human sperm chemotaxis. (PubMed id 12663925)1, 2 Spehr M.... Hatt H. (Science 2003)
    6. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    7. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PubMed id 10673334)1, 2 Glusman G.... Lancet D. (Genomics 2000)
    8. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. (PubMed id 8004088)1, 2 Ben-Arie N.... North M.A. (Hum. Mol. Genet. 1994)
    9. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PubMed id 1370859)1, 3 Parmentier M.... Vassart G. (Nature 1992)
    10. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. (PubMed id 1840504)1, 3 Buck L. and Axel R. (Cell 1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4991 HGNC: 8183 AceView: OR1D2 Ensembl:ENSG00000184166 euGenes: HUgn4991
    ECgene: OR1D2 Kegg: 4991 H-InvDB: OR1D2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR1D2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR1D2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/115
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/115

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR1D2 gene:
    Search GeneIP for patents involving OR1D2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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