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Aliases for OR1C1 Gene

Aliases for OR1C1 Gene

  • Olfactory Receptor, Family 1, Subfamily C, Member 1 2 3
  • Olfactory Receptor OR1-42 3 4
  • Olfactory Receptor TPCR27 3 4
  • Olfactory Receptor 1C1 3
  • HSTPCR27 3
  • OR1.5.10 3
  • OR1-42 3
  • ORL211 3
  • TPCR27 3

External Ids for OR1C1 Gene

Summaries for OR1C1 Gene

Entrez Gene Summary for OR1C1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1C1 Gene

OR1C1 (Olfactory Receptor, Family 1, Subfamily C, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1E2.

UniProtKB/Swiss-Prot for OR1C1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1C1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1C1 Gene

Genomics for OR1C1 Gene

Genomic Location for OR1C1 Gene

Start:
247,757,462 bp from pter
End:
247,758,406 bp from pter
Size:
945 bases
Orientation:
Minus strand

Genomic View for OR1C1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR1C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1C1 Gene

Regulatory Elements for OR1C1 Gene

Proteins for OR1C1 Gene

  • Protein details for OR1C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15619-OR1C1_HUMAN
    Recommended name:
    Olfactory receptor 1C1
    Protein Accession:
    Q15619
    Secondary Accessions:
    • B9EIR9
    • Q5VVD2
    • Q6IF97
    • Q8NGZ1
    • Q96R83

    Protein attributes for OR1C1 Gene

    Size:
    314 amino acids
    Molecular mass:
    35042 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04763.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR1C1 Gene

Proteomics data for OR1C1 Gene at MOPED

Post-translational modifications for OR1C1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR1C1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR1C1 Gene

Domains for OR1C1 Gene

Gene Families for OR1C1 Gene

HGNC:
  • OR1 :GPCR / Class A : Olfactory receptors

Protein Domains for OR1C1 Gene

UniProtKB/Swiss-Prot:

OR1C1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q15619
genes like me logo Genes that share domains with OR1C1: view

Function for OR1C1 Gene

Molecular function for OR1C1 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9119360
genes like me logo Genes that share ontologies with OR1C1: view

miRNA for OR1C1 Gene

miRTarBase miRNAs that target OR1C1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OR1C1 Gene

Localization for OR1C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1C1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR1C1 Gene COMPARTMENTS Subcellular localization image for OR1C1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane NAS 9119360
genes like me logo Genes that share ontologies with OR1C1: view

Pathways for OR1C1 Gene

genes like me logo Genes that share pathways with OR1C1: view

Pathways by source for OR1C1 Gene

1 KEGG pathway for OR1C1 Gene

Interacting Proteins for OR1C1 Gene

Gene Ontology (GO) - Biological Process for OR1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS 9119360
GO:0050911 detection of chemical stimulus involved in sensory perception of smell NAS 9119360
genes like me logo Genes that share ontologies with OR1C1: view

Transcripts for OR1C1 Gene

mRNA/cDNA for OR1C1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR1C1 Gene

No ASD Table

Relevant External Links for OR1C1 Gene

GeneLoc Exon Structure for
OR1C1
ECgene alternative splicing isoforms for
OR1C1

Expression for OR1C1 Gene

mRNA expression in normal human tissues for OR1C1 Gene

mRNA differential expression in normal tissues according to GTEx for OR1C1 Gene

This gene is overexpressed in Testis (45.7).

SOURCE GeneReport for Unigene cluster for OR1C1 Gene Hs.381306

genes like me logo Genes that share expressions with OR1C1: view

Orthologs for OR1C1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR1C1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 37
  • 50 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia OR08C09 36
  • 63.6 (n)
  • 58.22 (a)
mouse
(Mus musculus)
Mammalia Olfr1366 37
  • 51 (a)
ManyToMany
Olfr374 16
oppossum
(Monodelphis domestica)
Mammalia OPOR44 37
  • 58 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 52 (a)
ManyToMany
Species with no ortholog for OR1C1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1C1 Gene

ENSEMBL:
Gene Tree for OR1C1 (if available)
TreeFam:
Gene Tree for OR1C1 (if available)

Paralogs for OR1C1 Gene

Selected SIMAP similar genes for OR1C1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1C1: view

Variants for OR1C1 Gene

Sequence variations from dbSNP and Humsavar for OR1C1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs965975 -- 247,758,586(+) GTGTT(C/T)ATGAT upstream-variant-2KB
rs1552812 -- 247,757,798(+) AGACC(G/T)CCTAC reference, synonymous-codon
rs1552813 -- 247,758,050(+) TCATA(C/T)GCCAT synonymous-codon, reference
rs10749655 -- 247,759,264(+) AGCAA(A/G)CATAC upstream-variant-2KB
rs10888359 -- 247,758,415(+) CCCAA(A/C)AAATC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR1C1 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV Gain+Loss 17666407
nsv873440 CNV Gain 21882294
dgv204e1 CNV Complex 17122850
esv34503 CNV Gain 17911159
nsv515858 CNV Gain+Loss 19592680
nsv873442 CNV Gain 21882294

Relevant External Links for OR1C1 Gene

HapMap Linkage Disequilibrium report
OR1C1

Disorders for OR1C1 Gene

Relevant External Links for OR1C1

Genetic Association Database (GAD)
OR1C1
genes like me logo Genes that share disorders with OR1C1: view

No data available for UniProtKB/Swiss-Prot for OR1C1 Gene

Publications for OR1C1 Gene

  1. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PMID: 9119360) Vanderhaeghen P. … Parmentier M. (Genomics 1997) 2 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I. … Lancet D. (BMC Bioinformatics 2006) 3

Products for OR1C1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate OR1C1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for OR1C1
    • Block miRNA regulation of OR1C1 using miScript Target Protectors

    Sources for OR1C1 Gene

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