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OR1C1 Gene

protein-coding   GIFtS: 50
GCID: GC01M247920

Olfactory Receptor, Family 1, Subfamily C, Member 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 1, Subfamily C, Member 11 2     OR1.5.102
Olfactory Receptor OR1-422 3     ORL2112
Olfactory Receptor TPCR272 3     TPCR272
HSTPCR272     Olfactory Receptor 1C12
OR1-422     

External Ids:    HGNC: 81821   Entrez Gene: 261882   Ensembl: ENSG000002218887   UniProtKB: Q156193   

Export aliases for OR1C1 gene to outside databases

Previous GC identifers: GC01M245778 GC01M243157 GC01M243968 GC01M244819 GC01M244820 GC01M244246 GC01M245987


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR1C1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR1C1 Gene:
OR1C1 (olfactory receptor, family 1, subfamily C, member 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1F1.

UniProtKB/Swiss-Prot: OR1C1_HUMAN, Q15619
Function: Odorant receptor (Potential)

Gene Wiki entry for OR1C1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR1C1 gene promoter:
         c-Fos   ER-alpha   HNF-3beta   C/EBPalpha   CHOP-10   Nkx6-1   FOXO1a   Cart-1   c-Jun   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OR1C1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR1C1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

OR1C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR1C1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M247920:  view genomic region     (about GC identifiers)

Start:
247,920,767 bp from pter      End:
247,921,708 bp from pter
Size:
942 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR1C1_HUMAN, Q15619 (See protein sequence)
Recommended Name: Olfactory receptor 1C1  
Size: 314 amino acids; 35042 Da
Sequence caution: Sequence=DAA04763.1; Type=Erroneous initiation;
Secondary accessions: B9EIR9 Q5VVD2 Q6IF97 Q8NGZ1 Q96R83

Explore the universe of human proteins at neXtProt for OR1C1: NX_Q15619

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • HORDE protein sequence for OR1C1
    REFSEQ proteins: NP_036485.2  
    ENSEMBL proteins: 
     ENSP00000386138  
    Reactome Protein details: Q15619

    OR1C1 Human Recombinant Protein Products:

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    antibodies-online peptides for OR1C1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR1: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q15619

    ProtoNet protein and cluster: Q15619

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR1C1_HUMAN, Q15619
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR1C1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR1C1_HUMAN, Q15619
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity NAS9119360
         
    Find genes that share ontologies with OR1C1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR1C1

    miRNA
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    miRTarBase miRNAs that target OR1C1:
    hsa-mir-335-5p (MIRT017189)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR1C1_HUMAN, Q15619: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane NAS9119360

    Find genes that share ontologies with OR1C1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR1C1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43


    Find genes that share SuperPaths with OR1C1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR1C1
        GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR1C1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR1C1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR1C1
    Interactions:

        Search GeneGlobe Interaction Network for OR1C1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR1C1 (ENSP000003861384) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR14A16ENSP000003502484STRING: ENSP00000350248
    OR2G2ENSP000003263494STRING: ENSP00000326349
    OR2G3ENSP000003263014STRING: ENSP00000326301
    OR2M4ENSP000003066884STRING: ENSP00000306688
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007608sensory perception of smell NAS9119360
    GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS9119360

    Find genes that share ontologies with OR1C1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR1C1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR1C1 gene: 
    NM_012353.2  

    Unigene Cluster for OR1C1:

    Olfactory receptor, family 1, subfamily C, member 1
    Hs.381306
    Unigene Representative Sequence: BC140914
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000408896(uc010pza.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR1C1

    Additional mRNA sequence: 

    BC140914.1 X89674.1 

    1 DOTS entry:

    DT.91954760 

    1 AceView cDNA sequence:

    X89674 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR1C1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTCAATGG
    OR1C1 Expression
    About this image

    OR1C1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.381306
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR1C1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR1C1 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr3745 olfactory receptor 374   --   8 (34.79 cM) 72107040 


    ENSEMBL Gene Tree for OR1C1 (if available)
    TreeFam Gene Tree for OR1C1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR1C1 gene
    OR1F12  OR1I12  OR1N12  OR1J42  OR1E22  OR1N22  OR1S12  OR1J22  
    OR1E12  OR1M12  OR1G12  OR1J12  OR1S22  
    Selected SIMAP similar genes for OR1C1 using alignment to 1 protein entry:     OR1C1_HUMAN(see all similar genes):
    OR16-37    OR16-88    OR16-89    OR16-90    OR16-36    OR1F1
    OR1F2P    OR1F12    OR1M1    OR1D2    OR1G1    OR1J1
    OR1J4    OR1K1    OR1S2    OR7D4    OR17-130    OR1A1

    Find genes that share paralogs with OR1C1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR1C1 (see all 112)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs760946391,2
    C,F--247920345(+) AATGTG/ATTCTA 1 -- ds50013Minor allele frequency- A:0.14WA NA EA 358
    rs1508862041,2
    --247920369(+) TTAACA/GTTAGA 1 -- ds50010--------
    rs1499597261,2
    C--247920448(+) TAGCA-/TTTGGG 1 -- ds50010--------
    rs608615351,2
    C--247920510(+) AAACT-/ATTTATC 1 -- ds50011Minor allele frequency- AT:0.00NA 2
    rs801091771,2
    C,F--247920528(+) GGGTTG/TTATGC 1 -- ds50013Minor allele frequency- T:0.08CSA WA NA 240
    rs1808481361,2
    --247920578(+) GAATGC/TTATAT 1 -- ds50010--------
    rs1396949071,2
    C--247920642(+) TAACAC/TGATTT 1 -- ds50010--------
    rs1153340671,2
    F--247920678(+) CAGTTG/CGTTTC 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1852510551,2
    C--247920860(+) AGCATC/TGGAGC 2 P syn10--------
    rs1909728241,2
    C--247920870(+) CCACCA/GTTGAA 2 T M mis10--------

    HapMap Linkage Disequilibrium report for OR1C1 ( 247920767 - 247921708 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for OR1C1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873442CNV Gain21882294
    nsv873440CNV Gain21882294
    esv34503CNV Gain17911159
    nsv515858CNV Gain+Loss19592680
    esv33129CNV Gain+Loss17666407
    dgv204e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR1C1           About GenesLikeMe

    Genetic Association Database (GAD): OR1C1

    Export disorders for OR1C1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR1C1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR1C1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. (PubMed id 9119360)1, 2, 3 Vanderhaeghen P.... Parmentier M. (Genomics 1997)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    5. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)
    6. A probabilistic classifier for olfactory receptor pseudogenes. (PubMed id 16939646)1 Menashe I....Lancet D. (BMC Bioinformatics 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26188 HGNC: 8182 AceView: OR1C1 Ensembl:ENSG00000221888 euGenes: HUgn26188
    ECgene: OR1C1 Kegg: 26188 H-InvDB: OR1C1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR1C1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR1C1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR1C1 gene:
    Search GeneIP for patents involving OR1C1

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OR1C1  
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     OriGene Custom Antibody Services for OR1C1   OriGene Custom Protein Services for OR1C1  

     
     
     Block miRNA regulation of human, mouse, rat OR1C1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OR1C1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR1C1 Predesigned siRNA for gene silencing in human, mouse, rat OR1C1
     QuantiFast Probe-based Assays in human, mouse, rat OR1C1 QuantiTect SYBR Green Assays in human, mouse, rat OR1C1
     Custom PCR Arrays for OR1C1 Search Chromatin IP Primers for OR1C1
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     Browse ESI BIO Cell Lines and PureStem Progenitors for OR1C1
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     Browse compounds at ApexBio
     Search Addgene for plasmids for OR1C1
      Search eBioscience for proteins for OR1C1
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      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for OR1C1
     antibodies-online antibodies for OR1C1 (13 products)
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      Search antibodies-online for proteins for OR1C1
           
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