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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR1A2 Gene

protein-coding   GIFtS: 49
GCID: GC17P003100

Olfactory Receptor, Family 1, Subfamily A, Member 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 1, Subfamily A, Member 21 2
Olfactory Receptor 17-62 3
Olfactory Receptor OR17-102 3
OR17-62 3
Olfactory Receptor 1A22

External Ids:    HGNC: 81801   Entrez Gene: 261892   Ensembl: ENSG000001721507   UniProtKB: Q9Y5853   

Export aliases for OR1A2 gene to outside databases

Previous GC identifers: GC17P003415 GC17P003051 GC17P003307 GC17P003047


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR1A2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR1A2 Gene: 
OR1A2 (olfactory receptor, family 1, subfamily A, member 2) is a protein-coding gene. Diseases associated with OR1A2 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1Q1.

UniProtKB/Swiss-Prot: OR1A2_HUMAN, Q9Y585
Function: Odorant receptor (Potential)

Gene Wiki entry for OR1A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR1A2 gene promoter:
         LHX3b/Lhx3b   GATA-3   C/EBPalpha   HEN1   FOXJ2 (long isoform)   SEF-1 (1)   LHX3a/Lhx3a   FOXJ2   MRF-2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR1A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR1A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR1A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

OR1A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR1A2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P003100:  view genomic region     (about GC identifiers)

Start:
3,100,813 bp from pter      End:
3,101,739 bp from pter
Size:
927 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OR1A2_HUMAN, Q9Y585 (See protein sequence)
Recommended Name: Olfactory receptor 1A2  
Size: 309 amino acids; 34396 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q3KPH3 Q6IFM0 Q6NTD8 Q96R86

Explore the universe of human proteins at neXtProt for OR1A2: NX_Q9Y585

Explore proteomics data for OR1A2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y585

  • HORDE protein sequence for OR1A2
    OR1A2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OR1A2 Protein Expression
    REFSEQ proteins: NP_036484.1  
    ENSEMBL proteins: 
     ENSP00000371377  
    Reactome Protein details: Q9Y585
    Human Recombinant Protein Products for OR1A2: 
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    Novus Biologicals OR1A2 Protein
    Novus Biologicals OR1A2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OR1A2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane NAS--

    OR1A2 for ontologies           About GeneDecksing



    OR1A2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for OR1A2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OR1: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9Y585

    ProtoNet protein and cluster: Q9Y585

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR1A2_HUMAN, Q9Y585
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR1A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR1A2_HUMAN, Q9Y585
    Function: Odorant receptor (Potential)

         Genatlas biochemistry entry for OR1A2:
    olfactory receptor,family 1,subfamily A,member 2,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity NAS--
         
    OR1A2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OR1A2:
     Decreased viability with cispl 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for OR1A2 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR1A2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OR1A2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory transduction
    Olfactory Signaling Pathway0.81
    Olfactory transduction0.81
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Class A/1 (Rhodopsin-like receptors)
    GPCRs, Class A Rhodopsin-like0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR1A2
        GPCRs, Class A Rhodopsin-like

    4        Reactome Pathways for OR1A2
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for OR1A2):
        Olfactory transduction


    OR1A2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR1A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/273 Interacting proteins for OR1A2 (ENSP000003713774) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10G3ENSP000003024374STRING: ENSP00000302437
    OR10H2ENSP000003060954STRING: ENSP00000306095
    OR10J1ENSP000003990784STRING: ENSP00000399078
    OR1A1ENSP000003052074STRING: ENSP00000305207
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007608sensory perception of smell NAS--
    GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS--

    OR1A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OR1A2

    Search CenterWatch for drugs/clinical trials and news about OR1A2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OR1A2 gene: 
    NM_012352.1  

    Unigene Cluster for OR1A2:

    Olfactory receptor, family 1, subfamily A, member 2
    Hs.532660  [show with all ESTs]
    Unigene Representative Sequence: BC069092
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000381951(uc002fvd.1)
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OR1A2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR1A2
    Clone
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    OriGene clones in human, mouse for OR1A2 (see all 5)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR1A2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR1A2

    Additional mRNA sequence: 

    BC069092.1 BC106733.1 BC106734.1 

    1 DOTS entry:

    DT.91736923 

    7 AceView cDNA sequences:

    CO246760 CO246717 NM_012352 BC069092 CO247942 CO247893 CO246654 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR1A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR1A2 Expression
    About this image


    See OR1A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OR1A2

    SOURCE GeneReport for Unigene cluster: Hs.532660
        SABiosciences Custom PCR Arrays for OR1A2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR1A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for OR1A2 (if available)
    TreeFam Gene Tree for OR1A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OR1A2 gene
    OR1Q12  OR1L42  OR1L32  OR1L12  OR1L82  OR1K12  OR1L62  OR1A12  
    OR1D22  OR1D52  
    18/455 SIMAP similar genes for OR1A2 using alignment to 1 protein entry:     OR1A2_HUMAN(see all similar genes):
    OR1A1    OR16-37    OR16-36    OR16-88    OR16-89    OR16-90
    OR1F1    OR1F2P    OR1J4    OR1D2    OR1L3    OR1L4
    OR1L6    HSA10    OR1L1    OR1M1    OR1P1    OR1S2

    OR1A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/123 SNPs in OR1A2 are shown (see all 123)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1418167321,2
    Cuntested13101025(+) GACATC/TATCTT 2 I syn10--------
    rs1382971081,2
    C--3098871(+) TTTCTG/TTGAGA 1 -- us2k10--------
    rs600151681,2
    C,F--3099068(+) GTGGGC/TAGGTC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1451802781,2
    --3099070(+) GGGCAC/GGTCAC 1 -- us2k10--------
    rs561488911,2
    C,F--3099162(+) TGGCGC/TGTGCC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs568426391,2
    C,F--3099271(+) TGGGCG/AACAGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs2009462681,2
    C--3099316(-) TGTTTC/TTTTTC 1 -- us2k10--------
    rs126016851,2
    C,F,H--3099416(+) GAAATC/GGAGAC 1 -- us2k1 tfbs312Minor allele frequency- G:0.11NS EA NA WA 804
    rs733047441,2
    C,F--3099465(+) AATCCA/GCTGTG 1 -- us2k13Minor allele frequency- G:0.13WA 122
    rs744809351,2
    C,F--3099556(+) CATGTT/CGAAAT 1 -- us2k12Minor allele frequency- C:0.14WA 120

    HapMap Linkage Disequilibrium report for OR1A2 ( 3100813 - 3101739 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for OR1A2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660206CNV Deletion23128226
    nsv457637CNV Loss19166990
    nsv907555CNV Loss21882294
    nsv907553CNV Loss21882294
    nsv907554CNV Loss21882294
    nsv469609CNV Loss16826518
    nsv907556CNV Gain21882294
    nsv526486CNV Gain19592680
    dgv3n29CNV Complex16826518
    nsv7288OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for OR1A2:    About MalaCards
    neuronitis    


    OR1A2 for disorders           About GeneDecksing


    Export disorders for OR1A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OR1A2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OR1A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PubMed id 10673334)1, 2, 3 Glusman G.... Lancet D. (2000)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
    5. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. (PubMed id 17601748)1 Schmiedeberg K....Krautwurst D. (2007)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26189 HGNC: 8180 AceView: OR1A2 Ensembl:ENSG00000172150 euGenes: HUgn26189
    ECgene: OR1A2 Kegg: 26189 H-InvDB: OR1A2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR1A2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR1A2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OR1A2 gene:
    Search GeneIP for patents involving OR1A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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