OR1A2 Gene
protein-coding GIFtS: 48
GCID: GC17P003100
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olfactory receptor, family 1, subfamily A, member 2
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Aliases
for OR1A2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 1, Subfamily A, Member 21 2 | | OR17-61 2 3 | | Olfactory Receptor 17-62 3 | | Olfactory Receptor OR17-102 3 | | Olfactory Receptor 1A22 |
Export aliases for OR1A2 gene to outside databasesPrevious GC identifers: GC17P003415 GC17P003051 GC17P003307 GC17P003047 |
Summaries
for OR1A2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR1A2:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: OR1A2_HUMAN, Q9Y585Function: Odorant receptor (Potential)
Gene Wiki entry for OR1A2
|
Genomic Views
for OR1A2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR1A2 gene promoter:
LHX3b/Lhx3b GATA-3 C/EBPalpha HEN1 FOXJ2 (long isoform) SEF-1 (1) LHX3a/Lhx3a FOXJ2 MRF-2 LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR1A2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR1A2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13.3OR1A2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P003100: view genomic region
(about GC identifiers)
Start:
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3,100,813 bp from pter |
End:
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3,101,739 bp from pter |
Size:
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927 bases |
Orientation:
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plus strand |
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Proteins
for OR1A2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OR1A2_HUMAN, Q9Y585 (See
protein sequence)Recommended Name: Olfactory receptor 1A2 Size: 309 amino acids; 34396 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q3KPH3 Q6IFM0 Q6NTD8 Q96R86Explore the universe of human proteins at neXtProt for OR1A2: NX_Q9Y585
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y585
HORDE protein sequence for OR1A2
OR1A2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036484.1
ENSEMBL proteins: ENSP00000371377 Reactome Protein details: Q9Y585
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
NAS | -- |
OR1A2 for ontologies About GeneDecksing
OR1A2 Antibody Products:
Assay Products for OR1A2: |
Protein
Domains /
Families
for OR1A2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR1A2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y585ProtoNet protein and cluster: Q9Y585 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR1A2_HUMAN, Q9Y585Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR1A2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OR1A2_HUMAN, Q9Y585Function: Odorant receptor (Potential) Genatlas biochemistry entry for OR1A2:olfactory receptor,family 1,subfamily A,member 2,G protein coupled receptor superfamily
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR1A2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR1A2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for OR1A2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR1A2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
NAS | -- |
OR1A2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for OR1A2:
|
Pathways & Interactions
for OR1A2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | | | 3 | Class A/1 (Rhodopsin-like receptors) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for OR1A2
4 
Reactome Pathways for OR1A2
1 
Kegg Pathway (Kegg details for OR1A2):
OR1A2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR1A2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/273 Interacting proteins for OR1A2 (ENSP000003713774) via UniProtKB, MINT, STRING, and/or I2D (see all 273)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007608 | sensory perception of smell |
NAS | -- | | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell |
NAS | -- |
OR1A2 for ontologies About GeneDecksing
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Drugs & Compounds
for OR1A2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR1A2
Search CenterWatch for drugs/clinical trials and news about OR1A2
|
Transcripts
for OR1A2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR1A2 gene: NM_012352.1 Unigene Cluster for OR1A2: Olfactory receptor, family 1, subfamily A, member 2 Hs.532660 [show with all ESTs]Unigene Representative Sequence: BC0690921 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000381951(uc002fvd.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR1A2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR1A2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR1A2 (NM_012352) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR1A2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR1A2 |
Additional cDNA sequence: BC069092.1 BC106733.1 BC106734.1 1 DOTS entry: DT.91736923 7 AceView cDNA sequences: BC069092 CO246717 NM_012352 CO246760 CO247942 CO246654 CO247893
GeneLoc Exon Structure
|
Expression
for OR1A2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR1A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OR1A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR1A2
SOURCE GeneReport for Unigene cluster: Hs.532660
SABiosciences Custom PCR Arrays for OR1A2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR1A2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat OR1A2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR1A2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR1A2 |
Orthologs
for OR1A2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OR1A2 gene from 1/3 species (see all 3) About this table
ENSEMBL Gene Tree for OR1A2 (if available)
TreeFam Gene Tree for OR1A2 (if available) |
Paralogs
for OR1A2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR1A2 gene
- OR1Q12 OR1L42 OR1L32 OR1L12 OR1L82 OR1K12 OR1L62 OR1A12
- OR1D22
18/455 SIMAP similar genes for OR1A2 using alignment to 1 protein entry: OR1A2_HUMAN(see all similar genes):OR1A1 OR16-37 OR16-36 OR16-88 OR16-89 OR16-90
OR1F1 OR1F2P OR1J4 OR1D2 OR1L3 OR1L4
OR1L6 HSA10 OR1L1 OR1M1 OR1P1 OR1S2
OR1A2 for paralogs About GeneDecksing
|
Genomic Variants
for OR1A2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR1A2 ( 3100813 - 3101739 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OR1A2
1 CNV: 2217 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR1A2 |
|
Disorders
/ Diseases
for OR1A2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR1A2 for disorders About GeneDecksing
1  disease for OR1A2: About MalaCardsneuronitis
Export disorders for OR1A2 gene to outside databases
|
Publications
for OR1A2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR1A2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR1A2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PubMed id 10673334)1, 2, 3 Glusman G.... Lancet D. (2000)
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
- Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. (PubMed id 17601748)1 Schmiedeberg K....Krautwurst D. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for OR1A2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing OR1A2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR1A2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR1A2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR1A2 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR1A2 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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About This Section
| Patent Information for OR1A2 gene:
Search GeneIP for patents involving OR1A2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR1A2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | OR1A2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for OR1A2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR1A2 |
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