Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR1A2 Gene

Aliases for OR1A2 Gene

  • Olfactory Receptor, Family 1, Subfamily A, Member 2 2 3
  • Olfactory Receptor OR17-10 3 4
  • Olfactory Receptor 17-6 3 4
  • OR17-6 3 4
  • Olfactory Receptor 1A2 3

External Ids for OR1A2 Gene

Summaries for OR1A2 Gene

Entrez Gene Summary for OR1A2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1A2 Gene

OR1A2 (Olfactory Receptor, Family 1, Subfamily A, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1D5.

UniProtKB/Swiss-Prot for OR1A2 Gene

  • Odorant receptor.

Gene Wiki entry for OR1A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1A2 Gene

Genomics for OR1A2 Gene

Genomic Location for OR1A2 Gene

Start:
3,197,519 bp from pter
End:
3,198,448 bp from pter
Size:
930 bases
Orientation:
Plus strand

Genomic View for OR1A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1A2 Gene

Proteins for OR1A2 Gene

  • Protein details for OR1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y585-OR1A2_HUMAN
    Recommended name:
    Olfactory receptor 1A2
    Protein Accession:
    Q9Y585
    Secondary Accessions:
    • Q3KPH3
    • Q6IFM0
    • Q6NTD8
    • Q96R86

    Protein attributes for OR1A2 Gene

    Size:
    309 amino acids
    Molecular mass:
    34396 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1A2 Gene

Proteomics data for OR1A2 Gene at MOPED

Post-translational modifications for OR1A2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn5

Other Protein References for OR1A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR1A2 Gene

Domains for OR1A2 Gene

Gene Families for OR1A2 Gene

HGNC:
  • OR1 :GPCR / Class A : Olfactory receptors

Protein Domains for OR1A2 Gene

UniProtKB/Swiss-Prot:

OR1A2_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9Y585
genes like me logo Genes that share domains with OR1A2: view

Function for OR1A2 Gene

Molecular function for OR1A2 Gene

GENATLAS Biochemistry: olfactory receptor,family 1,subfamily A,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR1A2: view

Phenotypes for OR1A2 Gene

GenomeRNAi human phenotypes for OR1A2:
genes like me logo Genes that share phenotypes with OR1A2: view

miRNA for OR1A2 Gene

miRTarBase miRNAs that target OR1A2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OR1A2 Gene

Localization for OR1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR1A2 Gene COMPARTMENTS Subcellular localization image for OR1A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1A2: view

Pathways for OR1A2 Gene

genes like me logo Genes that share pathways with OR1A2: view

Pathways by source for OR1A2 Gene

1 KEGG pathway for OR1A2 Gene

Interacting Proteins for OR1A2 Gene

Gene Ontology (GO) - Biological Process for OR1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0032467 positive regulation of cytokinesis IMP 22888021
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA --
genes like me logo Genes that share ontologies with OR1A2: view

Transcripts for OR1A2 Gene

mRNA/cDNA for OR1A2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR1A2 Gene

Olfactory receptor, family 1, subfamily A, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR1A2 Gene

No ASD Table

Relevant External Links for OR1A2 Gene

GeneLoc Exon Structure for
OR1A2
ECgene alternative splicing isoforms for
OR1A2

Expression for OR1A2 Gene

mRNA expression in normal human tissues for OR1A2 Gene

SOURCE GeneReport for Unigene cluster for OR1A2 Gene Hs.532660

genes like me logo Genes that share expressions with OR1A2: view

Orthologs for OR1A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 37
  • 80 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia OR1A2 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 42 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 43 (a)
ManyToMany
-- 37
  • 40 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
-- 37
  • 44 (a)
ManyToMany
Species with no ortholog for OR1A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1A2 Gene

ENSEMBL:
Gene Tree for OR1A2 (if available)
TreeFam:
Gene Tree for OR1A2 (if available)

Paralogs for OR1A2 Gene

Paralogs for OR1A2 Gene

Selected SIMAP similar genes for OR1A2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1A2: view

Variants for OR1A2 Gene

Sequence variations from dbSNP and Humsavar for OR1A2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2241091 - 3,198,284(-) CATGC(A/C)CATCG reference, missense
rs2241093 -- 3,197,533(-) GATTG(A/G)TTTTC synonymous-codon, reference
rs2241094 -- 3,197,508(-) CTTCA(G/T)CATGA upstream-variant-2KB
rs2459552 -- 3,197,265(+) TTCTT(A/T)GACAT upstream-variant-2KB
rs2459553 -- 3,198,816(+) AGGCT(A/G)CAAAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR1A2 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV Deletion 23128226
nsv7288 OTHER Inversion 18451855
dgv3n29 CNV Complex 16826518
nsv907553 CNV Loss 21882294
nsv469609 CNV Loss 16826518
nsv907554 CNV Loss 21882294
nsv526486 CNV Gain 19592680
nsv907555 CNV Loss 21882294
nsv907556 CNV Gain 21882294
nsv457637 CNV Loss 19166990

Relevant External Links for OR1A2 Gene

HapMap Linkage Disequilibrium report
OR1A2

Disorders for OR1A2 Gene

No disorders were found for OR1A2 Gene.

No data available for UniProtKB/Swiss-Prot for OR1A2 Gene

Publications for OR1A2 Gene

  1. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G. … Lancet D. (Genomics 2000) 2 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. (PMID: 17601748) Schmiedeberg K. … Krautwurst D. (J. Struct. Biol. 2007) 3

Products for OR1A2 Gene

Sources for OR1A2 Gene

Back to Top

Content