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Aliases for OR1A1 Gene

Aliases for OR1A1 Gene

  • Olfactory Receptor, Family 1, Subfamily A, Member 1 2 3
  • Olfactory Receptor OR17-11 3 4
  • Olfactory Receptor 17-7 3 4
  • OR17-7 3 4
  • Olfactory Receptor 1A1 3

External Ids for OR1A1 Gene

Previous GeneCards Identifiers for OR1A1 Gene

  • GC17P003433
  • GC17P003069
  • GC17P003325
  • GC17P003065
  • GC17P003118

Summaries for OR1A1 Gene

Entrez Gene Summary for OR1A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR1A1 Gene

OR1A1 (Olfactory Receptor, Family 1, Subfamily A, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR1D5.

UniProtKB/Swiss-Prot for OR1A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR1A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR1A1 Gene

Genomics for OR1A1 Gene

Regulatory Elements for OR1A1 Gene

Genomic Location for OR1A1 Gene

3,215,621 bp from pter
3,216,550 bp from pter
930 bases
Plus strand

Genomic View for OR1A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR1A1 Gene

Proteins for OR1A1 Gene

  • Protein details for OR1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 1A1
    Protein Accession:
    Secondary Accessions:
    • A5D914
    • Q6IFM1
    • Q6NTA9
    • Q96R87

    Protein attributes for OR1A1 Gene

    309 amino acids
    Molecular mass:
    34565 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR1A1 Gene

Proteomics data for OR1A1 Gene at MOPED

Post-translational modifications for OR1A1 Gene

  • Glycosylation at Asn5 and Asn264
  • Modification sites at PhosphoSitePlus

Other Protein References for OR1A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR1A1 Gene

Domains for OR1A1 Gene

Gene Families for OR1A1 Gene

Protein Domains for OR1A1 Gene

Suggested Antigen Peptide Sequences for OR1A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR1A1: view

Function for OR1A1 Gene

Molecular function for OR1A1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 1,subfamily A,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR1A1: view

Phenotypes for OR1A1 Gene

GenomeRNAi human phenotypes for OR1A1:
genes like me logo Genes that share phenotypes with OR1A1: view

Animal Model Products

CRISPR Products

miRNA for OR1A1 Gene

miRTarBase miRNAs that target OR1A1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR1A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for OR1A1 Gene

Localization for OR1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR1A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR1A1 Gene COMPARTMENTS Subcellular localization image for OR1A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR1A1: view

Pathways for OR1A1 Gene

genes like me logo Genes that share pathways with OR1A1: view

Pathways by source for OR1A1 Gene

1 KEGG pathway for OR1A1 Gene

Interacting Proteins for OR1A1 Gene

Gene Ontology (GO) - Biological Process for OR1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IBA --
genes like me logo Genes that share ontologies with OR1A1: view

Transcripts for OR1A1 Gene

mRNA/cDNA for OR1A1 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR1A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR1A1 Gene

No ASD Table

Relevant External Links for OR1A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR1A1 Gene

mRNA expression in normal human tissues for OR1A1 Gene

Protein differential expression in normal tissues for OR1A1 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR1A1 Gene

SOURCE GeneReport for Unigene cluster for OR1A1 Gene Hs.532688

genes like me logo Genes that share expressions with OR1A1: view

Expression partners for OR1A1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR1A1 Gene

Orthologs for OR1A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR1A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC540082 35
  • 88.24 (n)
  • 89 (a)
-- 36
  • 88 (a)
-- 36
  • 85 (a)
(Canis familiaris)
Mammalia COR1A3 35
  • 87.66 (n)
  • 87.01 (a)
-- 36
  • 50 (a)
(Mus musculus)
Mammalia Olfr403 35
  • 82.42 (n)
  • 84.14 (a)
Olfr43 16
Olfr403 36
  • 83 (a)
Olfr43 36
  • 83 (a)
(Pan troglodytes)
Mammalia OR1A1 35
  • 99.24 (n)
  • 99.03 (a)
OR1A1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Olr1514 35
  • 82.57 (n)
  • 82.89 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
-- 36
  • 43 (a)
-- 36
  • 47 (a)
-- 36
  • 46 (a)
Species with no ortholog for OR1A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR1A1 Gene

Gene Tree for OR1A1 (if available)
Gene Tree for OR1A1 (if available)

Paralogs for OR1A1 Gene

Paralogs for OR1A1 Gene

(457) SIMAP similar genes for OR1A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR1A1: view

Variants for OR1A1 Gene

Sequence variations from dbSNP and Humsavar for OR1A1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs769425 -- 3,216,103(+) ACTCT(G/T)CTCAC reference, synonymous-codon
rs769426 -- 3,216,379(+) GGTAC(A/G)GTCAT reference, synonymous-codon
rs769427 - 3,216,473(+) TAAAT(C/T)CTTTC reference, missense
rs4325604 -- 3,215,714(+) TCTTC(C/T)TGTTC synonymous-codon, reference
rs4374201 -- 3,215,755(+) CTCAT(C/T)GTCCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR1A1 Gene

Variant ID Type Subtype PubMed ID
esv2660206 CNV Deletion 23128226
nsv7288 OTHER Inversion 18451855
dgv3n29 CNV Complex 16826518
nsv907553 CNV Loss 21882294
nsv469609 CNV Loss 16826518
nsv907554 CNV Loss 21882294
nsv526486 CNV Gain 19592680
nsv907555 CNV Loss 21882294
nsv907556 CNV Gain 21882294
nsv457637 CNV Loss 19166990
nsv907557 CNV Loss 21882294

Relevant External Links for OR1A1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR1A1 Gene

Disorders for OR1A1 Gene

No disorders were found for OR1A1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR1A1 Gene

Publications for OR1A1 Gene

  1. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. (PMID: 10673334) Glusman G. … Lancet D. (Genomics 2000) 2 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. (PMID: 17601748) Schmiedeberg K. … Krautwurst D. (J. Struct. Biol. 2007) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for OR1A1 Gene

  • Addgene plasmids for OR1A1

Sources for OR1A1 Gene

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