OR14I1 Gene
protein-coding GIFtS: 44
GCID: GC01M248844
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olfactory receptor, family 14, subfamily I, member 1(Previous names: olfactory receptor, family 5, subfamily BU, member 1 )
(Previous symbols: OR5BU1P, OR5BU1)
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Aliases
for OR14I1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 14, Subfamily I, Member 11 2 | | Olfactory Receptor, Family 5, Subfamily BU, Member 11 | | OR5BU11 2 3 | | Olfactory Receptor 14I12 | | OR5BU1P1 2 3 | | Olfactory Receptor, Family 5, Subfamily BU, Member 1 Pseudogene2 | | Olfactory Receptor 5BU12 3 | | |
Export aliases for OR14I1 gene to outside databasesPrevious GC identifer: GC01M246912 |
Summaries
for OR14I1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR14I1:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: O14I1_HUMAN, A6ND48Function: Odorant receptor (Potential)
|
Genomic Views
for OR14I1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR14I1 gene promoter:
SRF SRF (504 AA) Sox9 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) NF-Y Pax-4a POU3F2 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR14I1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR14I1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44OR14I1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M248844: view genomic region
(about GC identifiers)
Start:
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248,844,673 bp from pter |
End:
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248,845,605 bp from pter |
Size:
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933 bases |
Orientation:
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minus strand |
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Proteins
for OR14I1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: O14I1_HUMAN, A6ND48 (See
protein sequence)Recommended Name: Olfactory receptor 14I1 Size: 311 amino acids; 35175 Da
Subcellular location: Cell membrane; Multi-pass membrane proteinExplore the universe of human proteins at neXtProt for OR14I1: NX_A6ND48
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6ND48
HORDE protein sequence for OR14I1
OR14I1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001004734.1
ENSEMBL proteins: ENSP00000339726 Reactome Protein details: A6ND48
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR14I1 for ontologies About GeneDecksing
OR14I1 Antibody Products:
Assay Products for OR14I1: |
Protein
Domains /
Families
for OR14I1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR14I1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6ND48ProtoNet protein and cluster: A6ND48 UniProtKB/Swiss-Prot: O14I1_HUMAN, A6ND48Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR14I1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: O14I1_HUMAN, A6ND48Function: Odorant receptor (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR14I1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR14I1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OR14I1 (NM_001004734) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR14I1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR14I1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR14I1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR14I1 for ontologies About GeneDecksing
|
Pathways & Interactions
for OR14I1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for OR14I1
1 
Kegg Pathway (Kegg details for OR14I1):
OR14I1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR14I1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/274 Interacting proteins for OR14I1 (ENSP000003397264) via UniProtKB, MINT, STRING, and/or I2D (see all 274)About this table
|
Drugs & Compounds
for OR14I1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR14I1
Search CenterWatch for drugs/clinical trials and news about OR14I1 / O14I1
|
Transcripts
for OR14I1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR14I1 gene: NM_001004734.1 Unigene Cluster for OR14I1: Olfactory receptor, family 14, subfamily I, member 1 Hs.449973 Unigene Representative Sequence: BC1371881 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000342623(uc001ieu.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR14I1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR14I1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR14I1 (NM_001004734) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR14I1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR14I1 |
Additional cDNA sequence: BC137188.1 BC137189.1 1 DOTS entry: DT.75132662 2 AceView cDNA sequences: NM_001004734 AI911102
GeneLoc Exon Structure
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Expression
for OR14I1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR14I1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGAGACTCT
About this image
See OR14I1 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.449973
SABiosciences Custom PCR Arrays for OR14I1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR14I1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR14I1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR14I1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR14I1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR14I1 |
Orthologs
for OR14I1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OR14I1 gene from 2/5 species (see all 5) About this table
ENSEMBL Gene Tree for OR14I1 (if available)
TreeFam Gene Tree for OR14I1 (if available) |
Paralogs
for OR14I1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR14I1 gene
- OR14A22 OR14J12 OR14A162 OR14C362 OR14K12
18/446 SIMAP similar genes for OR14I1 using alignment to 2 protein entries: O14I1_HUMAN (see all proteins)
(see all similar genes):OR14L1P LOC441453 OR14A2 OR14A16 OR14J1 OR14C36
OR14K1 OR2J4P OR4D1 OR4D10 OR4D2 OR52K3P
OR5AN1 OR10A4 OR10AG1 OR13A1 OR4D11 OR4D9
OR14I1 for paralogs About GeneDecksing
|
Genomic Variants
for OR14I1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR14I1 ( 248844673 - 248845605 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for OR14I1
7 CNVs: 2056 0017 6819 8355 34798 3340 8354 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR14I1 |
|
Disorders
/ Diseases
for OR14I1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR14I1 for disorders About GeneDecksing
1  disease for OR14I1: About MalaCardsneuronitis
Export disorders for OR14I1 gene to outside databases
|
Publications
for OR14I1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR14I1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR14I1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for OR14I1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing OR14I1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR14I1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR14I1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR14I1 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR14I1 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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| | |
About This Section
| Patent Information for OR14I1 gene:
Search GeneIP for patents involving OR14I1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR14I1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR14I1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR14I1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR14I1 | | | OriGene Protein Over-expression Lysate for OR14I1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR14I1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR14I1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR14I1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OR14I1 | | OriGene Custom Protein Services for OR14I1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR14I1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR14I1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR14I1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR14I1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR14I1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR14I1 |
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 | | | OR14I1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR14I1 |
|  |  |  | | | | Search ThermoFisher Antibodies for OR14I1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR14I1 |
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