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Aliases for OR14I1 Gene

Aliases for OR14I1 Gene

  • Olfactory Receptor Family 14 Subfamily I Member 1 2 3 5
  • Olfactory Receptor 5BU1 3 4
  • OR5BU1P 3 4
  • OR5BU1 3 4
  • Olfactory Receptor, Family 5, Subfamily BU, Member 1 Pseudogene 3
  • Olfactory Receptor, Family 5, Subfamily BU, Member 1 2
  • Olfactory Receptor, Family 14, Subfamily I, Member 1 2
  • Olfactory Receptor 14I1 3

External Ids for OR14I1 Gene

Previous HGNC Symbols for OR14I1 Gene

  • OR5BU1P
  • OR5BU1

Previous GeneCards Identifiers for OR14I1 Gene

  • GC01M246912
  • GC01M248844
  • GC01M248681

Summaries for OR14I1 Gene

Entrez Gene Summary for OR14I1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR14I1 Gene

OR14I1 (Olfactory Receptor Family 14 Subfamily I Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding.

UniProtKB/Swiss-Prot for OR14I1 Gene

  • Odorant receptor.

Additional gene information for OR14I1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR14I1 Gene

Genomics for OR14I1 Gene

Regulatory Elements for OR14I1 Gene

Enhancers for OR14I1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H248471 0.6 FANTOM5 21.2 +227.1 227147 0 HDGF TARDBP MAFG ZNF207 OR14I1 OR2T1 OR2M2 OR2M7 OR2M5 OR2M4 OR2T33 OR2T6 OR2M3 OR2T10
GH01H248731 0.7 ENCODE 11.2 -32.3 -32256 0 ATF1 L3MBTL2 ZBTB2 NRF1 GABPA ZNF592 E2F1 TFDP1 POLR2A IKZF1 OR14I1 LOC101928226 AHCYP8 LYPD8
GH01H248862 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.7 -164.4 -164402 1 TBP ATF1 RB1 ARID4B SIN3A DMAP1 ZSCAN9 RARA YY1 GLIS2 SH3BP5L ZNF692 OR14I1 ZNF672 PGBD2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR14I1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR14I1 Gene

Chromosome:
1
Start:
248,483,422 bp from pter
End:
248,698,899 bp from pter
Size:
215,478 bases
Orientation:
Minus strand

Genomic View for OR14I1 Gene

Genes around OR14I1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR14I1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR14I1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR14I1 Gene

Proteins for OR14I1 Gene

  • Protein details for OR14I1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6ND48-O14I1_HUMAN
    Recommended name:
    Olfactory receptor 14I1
    Protein Accession:
    A6ND48

    Protein attributes for OR14I1 Gene

    Size:
    311 amino acids
    Molecular mass:
    35175 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR14I1 Gene

Post-translational modifications for OR14I1 Gene

  • Glycosylation at posLast=33
  • Modification sites at PhosphoSitePlus

Other Protein References for OR14I1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR14I1 Gene

Domains & Families for OR14I1 Gene

Gene Families for OR14I1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR14I1 Gene

Suggested Antigen Peptide Sequences for OR14I1 Gene

Graphical View of Domain Structure for InterPro Entry

A6ND48

UniProtKB/Swiss-Prot:

O14I1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR14I1: view

Function for OR14I1 Gene

Molecular function for OR14I1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR14I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR14I1: view

Phenotypes for OR14I1 Gene

GenomeRNAi human phenotypes for OR14I1:
genes like me logo Genes that share phenotypes with OR14I1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR14I1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR14I1 Gene

Localization for OR14I1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR14I1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR14I1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR14I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR14I1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR14I1 Gene

Pathways & Interactions for OR14I1 Gene

genes like me logo Genes that share pathways with OR14I1: view

Pathways by source for OR14I1 Gene

Interacting Proteins for OR14I1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000339726%0d%0a9606.ENSP00000248572%0d%0a9606.ENSP00000367869%0d%0a9606.ENSP00000334051%0d%0a9606.ENSP00000371594%0d%0a9606.ENSP00000312262%0d%0a
Selected Interacting proteins: ENSP00000339726 A6ND48-O14I1_HUMAN for OR14I1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR14I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR14I1: view

No data available for SIGNOR curated interactions for OR14I1 Gene

Drugs & Compounds for OR14I1 Gene

No Compound Related Data Available

Transcripts for OR14I1 Gene

mRNA/cDNA for OR14I1 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR14I1 Gene

Olfactory receptor, family 14, subfamily I, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR14I1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR14I1 Gene

No ASD Table

Relevant External Links for OR14I1 Gene

GeneLoc Exon Structure for
OR14I1
ECgene alternative splicing isoforms for
OR14I1

Expression for OR14I1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR14I1 Gene

mRNA differential expression in normal tissues according to GTEx for OR14I1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x14.1), Brain - Anterior cingulate cortex (BA24) (x11.3), and Brain - Cortex (x10.1).

NURSA nuclear receptor signaling pathways regulating expression of OR14I1 Gene:

OR14I1

SOURCE GeneReport for Unigene cluster for OR14I1 Gene:

Hs.449973
genes like me logo Genes that share expression patterns with OR14I1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR14I1 Gene

Orthologs for OR14I1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR14I1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469772 33
  • 98.71 (n)
OR14I1 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100686790 33
  • 83.01 (n)
OR14I1 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 55 (a)
OneToMany
-- 34
  • 55 (a)
OneToMany
-- 34
  • 55 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
-- 34
  • 53 (a)
OneToMany
-- 34
  • 53 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
-- 34
  • 51 (a)
OneToMany
chicken
(Gallus gallus)
Aves OR14I1 34
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
OneToMany
-- 34
  • 47 (a)
OneToMany
-- 34
  • 47 (a)
OneToMany
-- 34
  • 47 (a)
OneToMany
-- 34
  • 46 (a)
OneToMany
-- 34
  • 46 (a)
OneToMany
-- 34
  • 46 (a)
OneToMany
-- 34
  • 45 (a)
OneToMany
-- 34
  • 43 (a)
OneToMany
-- 34
  • 43 (a)
OneToMany
-- 34
  • 42 (a)
OneToMany
-- 34
  • 42 (a)
OneToMany
Species where no ortholog for OR14I1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR14I1 Gene

ENSEMBL:
Gene Tree for OR14I1 (if available)
TreeFam:
Gene Tree for OR14I1 (if available)

Paralogs for OR14I1 Gene

(443) SIMAP similar genes for OR14I1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR14I1: view

No data available for Paralogs for OR14I1 Gene

Variants for OR14I1 Gene

Sequence variations from dbSNP and Humsavar for OR14I1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000611870 -- 248,682,737(+) GTTTG(A/T)AGTTT intron-variant, upstream-variant-2KB
rs1000925921 -- 248,684,890(+) TTATA(C/T)CTGTA intron-variant
rs1000940034 -- 248,683,039(+) ATTCA(C/T)AATTG intron-variant, upstream-variant-2KB
rs1002218219 -- 248,684,471(+) TTCTC(A/T)CAAAT intron-variant
rs1002367216 -- 248,685,529(+) TTCTA(C/T)AAAAC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for OR14I1 Gene

Variant ID Type Subtype PubMed ID
dgv20n17 CNV loss 16327808
dgv631n100 CNV gain 25217958
dgv637n100 CNV loss 25217958
dgv638n100 CNV gain 25217958
dgv642n100 CNV gain 25217958
dgv643n100 CNV gain 25217958
dgv906n54 CNV gain 21841781
esv2750832 CNV gain 17911159
esv2750835 CNV gain 17911159
esv2759015 CNV gain+loss 17122850
esv32631 CNV loss 17666407
esv3589562 CNV gain 21293372
esv3891415 CNV gain 25118596
nsv1003091 CNV gain 25217958
nsv1003605 CNV gain 25217958
nsv1004790 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv428357 CNV loss 18775914
nsv469750 CNV loss 16826518
nsv515858 CNV gain+loss 19592680
nsv5387 CNV deletion 18451855
nsv549740 CNV loss 21841781

Variation tolerance for OR14I1 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.88; 83.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR14I1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR14I1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR14I1 Gene

Disorders for OR14I1 Gene

Relevant External Links for OR14I1

Genetic Association Database (GAD)
OR14I1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR14I1

No disorders were found for OR14I1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR14I1 Gene

Publications for OR14I1 Gene

  1. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for OR14I1 Gene

Sources for OR14I1 Gene

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