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Aliases for OR14C36 Gene

Aliases for OR14C36 Gene

  • Olfactory Receptor, Family 14, Subfamily C, Member 36 2 3
  • Olfactory Receptor, Family 5, Subfamily BF, Member 1 2 3
  • Olfactory Receptor OR1-59 3 4
  • Olfactory Receptor 5BF1 3 4
  • OR5BF1 3 4

External Ids for OR14C36 Gene

Previous HGNC Symbols for OR14C36 Gene

  • OR5BF1

Previous GeneCards Identifiers for OR14C36 Gene

  • GC01P246579
  • GC01P248512

Summaries for OR14C36 Gene

Entrez Gene Summary for OR14C36 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR14C36 Gene

OR14C36 (Olfactory Receptor, Family 14, Subfamily C, Member 36) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR14K1.

UniProtKB/Swiss-Prot for OR14C36 Gene

  • Odorant receptor.

Gene Wiki entry for OR14C36 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR14C36 Gene

Genomics for OR14C36 Gene

Regulatory Elements for OR14C36 Gene

Genomic Location for OR14C36 Gene

Chromosome:
1
Start:
248,348,775 bp from pter
End:
248,349,713 bp from pter
Size:
939 bases
Orientation:
Plus strand

Genomic View for OR14C36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR14C36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR14C36 Gene

Proteins for OR14C36 Gene

  • Protein details for OR14C36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHC7-O14CZ_HUMAN
    Recommended name:
    Olfactory receptor 14C36
    Protein Accession:
    Q8NHC7
    Secondary Accessions:
    • Q6IEZ6

    Protein attributes for OR14C36 Gene

    Size:
    312 amino acids
    Molecular mass:
    34815 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR14C36 Gene

Proteomics data for OR14C36 Gene at MOPED

Post-translational modifications for OR14C36 Gene

  • Glycosylation at Asn 3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR14C36 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR14C36 Gene

Domains & Families for OR14C36 Gene

Gene Families for OR14C36 Gene

Protein Domains for OR14C36 Gene

Suggested Antigen Peptide Sequences for OR14C36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHC7

UniProtKB/Swiss-Prot:

O14CZ_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR14C36: view

Function for OR14C36 Gene

Molecular function for OR14C36 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR14C36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR14C36: view

Phenotypes for OR14C36 Gene

GenomeRNAi human phenotypes for OR14C36:
genes like me logo Genes that share phenotypes with OR14C36: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR14C36

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR14C36 Gene

Localization for OR14C36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR14C36 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR14C36 Gene COMPARTMENTS Subcellular localization image for OR14C36 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR14C36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR14C36: view

Pathways & Interactions for OR14C36 Gene

genes like me logo Genes that share pathways with OR14C36: view

Pathways by source for OR14C36 Gene

1 KEGG pathway for OR14C36 Gene

Interacting Proteins for OR14C36 Gene

Gene Ontology (GO) - Biological Process for OR14C36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR14C36: view

No data available for SIGNOR curated interactions for OR14C36 Gene

Drugs & Compounds for OR14C36 Gene

No Compound Related Data Available

Transcripts for OR14C36 Gene

mRNA/cDNA for OR14C36 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR14C36

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR14C36 Gene

No ASD Table

Relevant External Links for OR14C36 Gene

GeneLoc Exon Structure for
OR14C36
ECgene alternative splicing isoforms for
OR14C36

Expression for OR14C36 Gene

mRNA expression in normal human tissues for OR14C36 Gene

Protein differential expression in normal tissues from HIPED for OR14C36 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (62.2) and Platelet (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR14C36 Gene



SOURCE GeneReport for Unigene cluster for OR14C36 Gene Hs.553583

genes like me logo Genes that share expression patterns with OR14C36: view

Protein tissue co-expression partners for OR14C36 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR14C36 Gene

Orthologs for OR14C36 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR14C36 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Olfr301 35
  • 66.67 (n)
  • 60.06 (a)
Olfr301 16
Olfr292 36
  • 60 (a)
OneToMany
Olfr293 36
  • 55 (a)
OneToMany
Olfr295 36
  • 58 (a)
OneToMany
Olfr297 36
  • 57 (a)
OneToMany
Olfr299 36
  • 55 (a)
OneToMany
Olfr301 36
  • 59 (a)
OneToMany
Olfr310 36
  • 54 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC469768 35
  • 98.61 (n)
  • 96.47 (a)
OR14C36 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR14C36 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR14C36 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
Species with no ortholog for OR14C36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR14C36 Gene

ENSEMBL:
Gene Tree for OR14C36 (if available)
TreeFam:
Gene Tree for OR14C36 (if available)

Paralogs for OR14C36 Gene

Paralogs for OR14C36 Gene

(442) SIMAP similar genes for OR14C36 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR14C36: view

Variants for OR14C36 Gene

Sequence variations from dbSNP and Humsavar for OR14C36 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1339988 -- 248,348,372(-) TCACC(C/T)ACATC upstream-variant-2KB
rs1339989 -- 248,348,322(-) CAAAT(C/G)TATGT upstream-variant-2KB
rs2039824 -- 248,349,335(-) TCAGA(A/G)CAAGA reference, synonymous-codon
rs2039825 -- 248,347,396(-) CTGTA(A/G)AAGAG upstream-variant-2KB
rs7537913 -- 248,350,111(+) TATTA(C/T)AGAAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR14C36 Gene

Variant ID Type Subtype PubMed ID
nsv515858 CNV Gain+Loss 19592680
esv2750832 CNV Gain 17911159
dgv17e55 CNV Loss 17911159
dgv566n71 CNV Gain 21882294
dgv567n71 CNV Gain 21882294
nsv873459 CNV Loss 21882294
nsv873461 CNV Gain 21882294
nsv873462 CNV Loss 21882294
dgv20n17 CNV Loss 16327808
essv15752 CNV CNV 17122850
dgv206e1 CNV Complex 17122850
nsv428357 CNV Loss 18775914
nsv5332 CNV Loss 18451855
nsv9114 CNV Gain 18304495

Variation tolerance for OR14C36 Gene

Residual Variation Intolerance Score: 75.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.80; 97.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR14C36 Gene

HapMap Linkage Disequilibrium report
OR14C36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR14C36 Gene

Disorders for OR14C36 Gene

Relevant External Links for OR14C36

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR14C36
genes like me logo Genes that share disorders with OR14C36: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR14C36 Gene

Publications for OR14C36 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 67
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 67

Products for OR14C36 Gene

Sources for OR14C36 Gene

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