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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR14C36 Gene

protein-coding   GIFtS: 45
GCID: GC01P248512

Olfactory Receptor, Family 14, Subfamily C, Member 36

(Previous names: olfactory receptor, family 5, subfamily BF, member 1)
(Previous symbol: OR5BF1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 14, Subfamily C, Member 361 2
OR5BF11 2 3
Olfactory Receptor, Family 5, Subfamily BF, Member 11 2
Olfactory Receptor 5BF12 3
Olfactory Receptor OR1-592 3
Olfactory Receptor 14C362

External Ids:    HGNC: 150261   Entrez Gene: 1270662   Ensembl: ENSG000001771747   UniProtKB: Q8NHC73   

Export aliases for OR14C36 gene to outside databases

Previous GC identifer: GC01P246579


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR14C36 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR14C36 Gene: 
OR14C36 (olfactory receptor, family 14, subfamily C, member 36) is a protein-coding gene. Diseases associated with OR14C36 include central neurocytoma, and neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR14A2.

UniProtKB/Swiss-Prot: O14CZ_HUMAN, Q8NHC7
Function: Odorant receptor (Potential)

Gene Wiki entry for OR14C36 (OR5BF1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR14C36 gene promoter:
         Nkx3-1 v2   Nkx3-1   Nkx3-1 v4   Nkx3-1 v3   Nkx2-5   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR14C36 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR14C36

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR14C36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

OR14C36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR14C36 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P248512:  view genomic region     (about GC identifiers)

Start:
248,512,077 bp from pter      End:
248,513,012 bp from pter
Size:
936 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: O14CZ_HUMAN, Q8NHC7 (See protein sequence)
Recommended Name: Olfactory receptor 14C36  
Size: 312 amino acids; 34815 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q6IEZ6

Explore the universe of human proteins at neXtProt for OR14C36: NX_Q8NHC7

Explore proteomics data for OR14C36 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NHC7

  • HORDE protein sequence for OR14C36
    OR14C36 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OR14C36 Protein Expression
    REFSEQ proteins: NP_001001918.1  
    ENSEMBL proteins: 
     ENSP00000324534  
    Reactome Protein details: Q8NHC7
    Human Recombinant Protein Products for OR14C36: 
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    Cloud-Clone Corp. Proteins for OR14C36 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    OR14C36 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OR14: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NHC7

    ProtoNet protein and cluster: Q8NHC7

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O14CZ_HUMAN, Q8NHC7
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR14C36 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O14CZ_HUMAN, Q8NHC7
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR14C36 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OR14C36 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory transduction
    Olfactory Signaling Pathway0.81
    Olfactory transduction0.81
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for OR14C36
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for OR14C36):
        Olfactory transduction


    OR14C36 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR14C36

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/273 Interacting proteins for OR14C36 (ENSP000003245344) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR5AS1ENSP000003241114STRING: ENSP00000324111
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    OR10A3ENSP000003539884STRING: ENSP00000353988
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR14C36 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OR14C36 (O14CZ)

    Search CenterWatch for drugs/clinical trials and news about OR14C36 / O14CZ

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OR14C36 gene: 
    NM_001001918.1  

    Unigene Cluster for OR14C36:

    Olfactory receptor, family 14, subfamily C, member 36
    Hs.553583
    Unigene Representative Sequence: NM_001001918
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000317861(uc010pzl.2)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR14C36

    1 AceView cDNA sequence:

    NM_001001918 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR14C36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAGAATTT
    OR14C36 Expression
    About this image


    See OR14C36 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.553583
        SABiosciences Custom PCR Arrays for OR14C36
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR14C36

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OR14C36 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr3011 , 5 olfactory receptor 3011, 5 66.67(n)1
    60.06(a)1
      7 (48.51 cM)5
    2579581  NM_212436.21  NP_997601.11 
     864038495 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 12)
    Uncharacterized protein
    (see all 12)
    47(a)
    47(a)
    (see all 12)
    many ↔ many
    possible ortholog
    (see all 12)
    GL343253.1(1048593-1051209)
    GL343253.1(923649-924584)


    ENSEMBL Gene Tree for OR14C36 (if available)
    TreeFam Gene Tree for OR14C36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OR14C36 gene
    OR14A22  OR14A162  OR14J12  OR14I12  OR14K12  
    18/444 SIMAP similar genes for OR14C36 using alignment to 1 protein entry:     O14CZ_HUMAN(see all similar genes):
    OR14L1P    OR14I1    OR14J1    OR14A2    OR14A16    OR4E2
    OR14K1    OR2J4P    OR7E86P    OR9Q1    OR10A3    OR1G1
    OR2F1    OR2J1    OR2K2    OR4L1    OR4Q3    OR5A1

    OR14C36 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/123 SNPs in OR14C36 are shown (see all 123)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs284305811,2
    C,F--248510102(+) CAAATT/AATTAT 1 -- us2k1 tfbs38Minor allele frequency- A:0.43NA WA EA 368
    rs1166551941,2
    C,F--248510113(+) TTGGTT/GTGGAA 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1458595611,2
    --248510141(+) ATTTAC/TTAAAT 1 -- us2k10--------
    rs1418920841,2
    C--248510149(+) AATCAA/GCTCAA 1 -- us2k10--------
    rs577498681,2
    C,F--248510286(+) AACTCC/TCGTTC 1 -- us2k13Minor allele frequency- T:0.05WA CSA 122
    rs1152328461,2
    C,F--248510390(+) CTCACA/GTGTTT 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1470299771,2
    --248510538(+) GACTAC/TGTCAC 1 -- us2k10--------
    rs1476727471,2
    --248510539(+) ACTACA/GTCACT 1 -- us2k10--------
    rs283965621,2
    C,F--248510556(+) GCCCAT/CATTGT 1 -- us2k17Minor allele frequency- C:0.45NA EA 250
    rs1896511251,2
    C--248510720(+) CTGAAC/TCTTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR14C36 ( 248512077 - 248513012 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for OR14C36 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv873462CNV Loss21882294
    dgv20n17CNV Loss16327808
    nsv5332CNV Loss18451855
    nsv873459CNV Loss21882294
    dgv17e55CNV Loss17911159
    nsv428357CNV Loss18775914
    nsv873461CNV Gain21882294
    dgv567n71CNV Gain21882294
    esv2750832CNV Gain17911159
    nsv9114CNV Gain18304495

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for OR14C36:    About MalaCards
    central neurocytoma    neuronitis


    OR14C36 for disorders           About GeneDecksing


    Export disorders for OR14C36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OR14C36 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OR14C36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
    3. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 127066 HGNC: 15026 AceView: OR5BF1 Ensembl:ENSG00000177174 euGenes: HUgn127066
    ECgene: OR14C36 Kegg: 127066 H-InvDB: OR14C36

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR14C36 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR14C36 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OR14C36 gene:
    Search GeneIP for patents involving OR14C36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for OR14C36
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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