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OR14C36 Gene

protein-coding   GIFtS: 45
GCID: GC01P248512

Olfactory Receptor, Family 14, Subfamily C, Member 36

(Previous names: olfactory receptor, family 5, subfamily BF, member 1)
(Previous symbol: OR5BF1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 14, Subfamily C, Member 361 2
OR5BF11 2 3
Olfactory Receptor, Family 5, Subfamily BF, Member 11 2
Olfactory Receptor 5BF12 3
Olfactory Receptor OR1-592 3
Olfactory Receptor 14C362

External Ids:    HGNC: 150261   Entrez Gene: 1270662   Ensembl: ENSG000001771747   UniProtKB: Q8NHC73   

Export aliases for OR14C36 gene to outside databases

Previous GC identifer: GC01P246579


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR14C36 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR14C36 Gene:
OR14C36 (olfactory receptor, family 14, subfamily C, member 36) is a protein-coding gene. Diseases associated with OR14C36 include central neurocytoma, and neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR14A2.

UniProtKB/Swiss-Prot: O14CZ_HUMAN, Q8NHC7
Function: Odorant receptor (Potential)

Gene Wiki entry for OR14C36 (OR5BF1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR14C36 gene promoter:
         Nkx3-1 v2   Nkx3-1   Nkx3-1 v4   Nkx3-1 v3   Nkx2-5   Nkx3-1 v1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR14C36 promoter sequence
   Search Chromatin IP Primers for OR14C36

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR14C36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

OR14C36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR14C36 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P248512:  view genomic region     (about GC identifiers)

Start:
248,512,077 bp from pter      End:
248,513,012 bp from pter
Size:
936 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: O14CZ_HUMAN, Q8NHC7 (See protein sequence)
Recommended Name: Olfactory receptor 14C36  
Size: 312 amino acids; 34815 Da
Secondary accessions: Q6IEZ6

Explore the universe of human proteins at neXtProt for OR14C36: NX_Q8NHC7

Explore proteomics data for OR14C36 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn3
  • HORDE protein sequence for OR14C36

    See OR14C36 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001001918.1  
    ENSEMBL proteins: 
     ENSP00000324534  
    Reactome Protein details: Q8NHC7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR14: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NHC7

    ProtoNet protein and cluster: Q8NHC7

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O14CZ_HUMAN, Q8NHC7
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR14C36 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O14CZ_HUMAN, Q8NHC7
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR14C36 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O14CZ_HUMAN, Q8NHC7: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR14C36 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR14C36 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR14C36
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR14C36):
        Olfactory transduction


    OR14C36 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR14C36
    Interactions:

        Search GeneGlobe Interaction Network for OR14C36

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR14C36 (ENSP000003245344) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR51B2ENSP000003275404STRING: ENSP00000327540
    OR5AS1ENSP000003241114STRING: ENSP00000324111
    OR5C1ENSP000003627844STRING: ENSP00000362784
    OR5W2ENSP000003424484STRING: ENSP00000342448
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR14C36 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR14C36 (O14CZ)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR14C36 gene: 
    NM_001001918.1  

    Unigene Cluster for OR14C36:

    Olfactory receptor, family 14, subfamily C, member 36
    Hs.553583
    Unigene Representative Sequence: NM_001001918
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000317861(uc010pzl.2)
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    1 AceView cDNA sequence:

    NM_001001918 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR14C36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAGAATTT
    OR14C36 Expression
    About this image

    OR14C36 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR14C36 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553583
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR14C36 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr3011 , 5 olfactory receptor 3011, 5 66.67(n)1
    60.06(a)1
      7 (48.51 cM)5
    2579581  NM_212436.21  NP_997601.11 
     864038495 


    ENSEMBL Gene Tree for OR14C36 (if available)
    TreeFam Gene Tree for OR14C36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR14C36 gene
    OR14A22  OR14A162  OR14J12  OR14I12  OR14K12  
    Selected SIMAP similar genes for OR14C36 using alignment to 1 protein entry:     O14CZ_HUMAN(see all similar genes):
    OR14L1P    OR14I1    OR14J1    OR14A2    OR14A16    OR4E2
    OR14K1    OR2J4P    OR7E86P    OR9Q1    OR10A3    OR1G1
    OR2F1    OR2J1    OR2K2    OR4L1    OR4Q3    OR5A1

    OR14C36 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR14C36 (see all 123)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs284305811,2
    C,F--248510102(+) CAAATT/AATTAT 1 -- us2k1 tfbs38Minor allele frequency- A:0.43NA WA EA 368
    rs1166551941,2
    C,F--248510113(+) TTGGTT/GTGGAA 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1458595611,2
    --248510141(+) ATTTAC/TTAAAT 1 -- us2k10--------
    rs1418920841,2
    C--248510149(+) AATCAA/GCTCAA 1 -- us2k10--------
    rs577498681,2
    C,F--248510286(+) AACTCC/TCGTTC 1 -- us2k13Minor allele frequency- T:0.05WA CSA 122
    rs1152328461,2
    C,F--248510390(+) CTCACA/GTGTTT 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1470299771,2
    --248510538(+) GACTAC/TGTCAC 1 -- us2k10--------
    rs1476727471,2
    --248510539(+) ACTACA/GTCACT 1 -- us2k10--------
    rs283965621,2
    C,F--248510556(+) GCCCAT/CATTGT 1 -- us2k17Minor allele frequency- C:0.45NA EA 250
    rs1896511251,2
    C--248510720(+) CTGAAC/TCTTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR14C36 ( 248512077 - 248513012 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR14C36 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873462CNV Loss21882294
    dgv20n17CNV Loss16327808
    nsv5332CNV Loss18451855
    nsv873459CNV Loss21882294
    dgv17e55CNV Loss17911159
    nsv428357CNV Loss18775914
    nsv873461CNV Gain21882294
    dgv567n71CNV Gain21882294
    esv2750832CNV Gain17911159
    nsv9114CNV Gain18304495

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for OR14C36:    
    About MalaCards
    central neurocytoma    neuronitis


    OR14C36 for disorders           About GeneDecksing


    Export disorders for OR14C36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR14C36 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR14C36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 127066 HGNC: 15026 AceView: OR5BF1 Ensembl:ENSG00000177174 euGenes: HUgn127066
    ECgene: OR14C36 Kegg: 127066 H-InvDB: OR14C36

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR14C36 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR14C36 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR14C36 gene:
    Search GeneIP for patents involving OR14C36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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