Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR14A16 Gene

Aliases for OR14A16 Gene

  • Olfactory Receptor Family 14 Subfamily A Member 16 2 3 5
  • Olfactory Receptor, Family 5, Subfamily AT, Member 1 2 3
  • Olfactory Receptor OR1-45 3 4
  • Olfactory Receptor 5AT1 3 4
  • OR5AT1 3 4
  • Olfactory Receptor, Family 14, Subfamily A, Member 16 2
  • Olfactory Receptor 14A16 3

External Ids for OR14A16 Gene

Previous HGNC Symbols for OR14A16 Gene

  • OR5AT1

Previous GeneCards Identifiers for OR14A16 Gene

  • GC01M246045
  • GC01M247978

Summaries for OR14A16 Gene

Entrez Gene Summary for OR14A16 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR14A16 Gene

OR14A16 (Olfactory Receptor Family 14 Subfamily A Member 16) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR14A2.

UniProtKB/Swiss-Prot for OR14A16 Gene

  • Odorant receptor.

Gene Wiki entry for OR14A16 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR14A16 Gene

Genomics for OR14A16 Gene

Regulatory Elements for OR14A16 Gene

Enhancers for OR14A16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G247741 0.5 ENCODE 9.9 +92.9 92917 1.3 ZSCAN4 ZNF512 KDM1A IRF1 OR13G1 OR14A16 ENSG00000235749 OR14K1 LOC105373274
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR14A16 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR14A16 Gene

Chromosome:
1
Start:
247,814,800 bp from pter
End:
247,834,858 bp from pter
Size:
20,059 bases
Orientation:
Minus strand

Genomic View for OR14A16 Gene

Genes around OR14A16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR14A16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR14A16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR14A16 Gene

Proteins for OR14A16 Gene

  • Protein details for OR14A16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHC5-O14AG_HUMAN
    Recommended name:
    Olfactory receptor 14A16
    Protein Accession:
    Q8NHC5
    Secondary Accessions:
    • Q6IF96

    Protein attributes for OR14A16 Gene

    Size:
    309 amino acids
    Molecular mass:
    34307 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04764.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR14A16 Gene

Post-translational modifications for OR14A16 Gene

  • Glycosylation at posLast=33 and posLast=8787
  • Modification sites at PhosphoSitePlus

Other Protein References for OR14A16 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR14A16 Gene

Domains & Families for OR14A16 Gene

Gene Families for OR14A16 Gene

Protein Domains for OR14A16 Gene

Suggested Antigen Peptide Sequences for OR14A16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHC5

UniProtKB/Swiss-Prot:

O14AG_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR14A16: view

Function for OR14A16 Gene

Molecular function for OR14A16 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR14A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR14A16: view
genes like me logo Genes that share phenotypes with OR14A16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR14A16 Gene

Localization for OR14A16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR14A16 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR14A16 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR14A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR14A16: view

Pathways & Interactions for OR14A16 Gene

genes like me logo Genes that share pathways with OR14A16: view

Pathways by source for OR14A16 Gene

1 KEGG pathway for OR14A16 Gene

Interacting Proteins for OR14A16 Gene

Gene Ontology (GO) - Biological Process for OR14A16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR14A16: view

No data available for SIGNOR curated interactions for OR14A16 Gene

Drugs & Compounds for OR14A16 Gene

No Compound Related Data Available

Transcripts for OR14A16 Gene

mRNA/cDNA for OR14A16 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR14A16 Gene

No ASD Table

Relevant External Links for OR14A16 Gene

GeneLoc Exon Structure for
OR14A16
ECgene alternative splicing isoforms for
OR14A16

Expression for OR14A16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR14A16 Gene

mRNA differential expression in normal tissues according to GTEx for OR14A16 Gene

This gene is overexpressed in Testis (x39.8) and Thyroid (x13.2).

Protein differential expression in normal tissues from HIPED for OR14A16 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR14A16 Gene



Protein tissue co-expression partners for OR14A16 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR14A16 Gene:

OR14A16

SOURCE GeneReport for Unigene cluster for OR14A16 Gene:

Hs.626620
genes like me logo Genes that share expression patterns with OR14A16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR14A16 Gene

Orthologs for OR14A16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR14A16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC740188 34
  • 98.27 (n)
OR14A16 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC101904415 34
  • 60.84 (n)
OR14A16 35
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1653 34
  • 59.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 48 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 53 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr761 35
  • 47 (a)
ManyToMany
Species where no ortholog for OR14A16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR14A16 Gene

ENSEMBL:
Gene Tree for OR14A16 (if available)
TreeFam:
Gene Tree for OR14A16 (if available)

Paralogs for OR14A16 Gene

Paralogs for OR14A16 Gene

(440) SIMAP similar genes for OR14A16 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR14A16 Gene

genes like me logo Genes that share paralogs with OR14A16: view

Variants for OR14A16 Gene

Sequence variations from dbSNP and Humsavar for OR14A16 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs193920961 Uncertain significance 247,815,389(-) CCTCA(C/T)GGTGA reference, missense
rs1000237171 -- 247,815,907(+) GTTCT(C/T)TTTTA upstream-variant-2KB
rs1000437330 -- 247,816,460(+) GGTGG(C/T)TCACG upstream-variant-2KB
rs1001396493 -- 247,816,506(+) TGGAT(C/T)GCCTG upstream-variant-2KB
rs1002086000 -- 247,814,928(+) AGCAT(C/T)CAAAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR14A16 Gene

Variant ID Type Subtype PubMed ID
dgv604n100 CNV gain 25217958
dgv605n100 CNV gain 25217958
dgv606n100 CNV gain 25217958
dgv900n54 CNV loss 21841781
esv2759014 CNV gain+loss 17122850
esv2762235 CNV gain 21179565
esv33129 CNV gain+loss 17666407
esv34503 CNV gain 17911159
esv3589522 CNV gain 21293372
nsv1013273 CNV gain 25217958
nsv515858 CNV gain+loss 19592680
nsv549597 CNV gain 21841781
nsv549601 CNV loss 21841781
nsv549602 CNV loss 21841781

Variation tolerance for OR14A16 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR14A16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR14A16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR14A16 Gene

Disorders for OR14A16 Gene

Relevant External Links for OR14A16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR14A16

No disorders were found for OR14A16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR14A16 Gene

Publications for OR14A16 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64

Products for OR14A16 Gene

Sources for OR14A16 Gene

Content
Loading form....