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Aliases for OR13C5 Gene

Aliases for OR13C5 Gene

  • Olfactory Receptor Family 13 Subfamily C Member 5 2 3 5
  • Olfactory Receptor OR9-11 3 4
  • Olfactory Receptor, Family 13, Subfamily C, Member 5 2
  • Olfactory Receptor 13C5 3
  • OR9-11 3

External Ids for OR13C5 Gene

Previous GeneCards Identifiers for OR13C5 Gene

  • GC09U990184
  • GC09M102741
  • GC09M104440
  • GC09M106400
  • GC09M107360

Summaries for OR13C5 Gene

Entrez Gene Summary for OR13C5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR13C5 Gene

OR13C5 (Olfactory Receptor Family 13 Subfamily C Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR13C2.

UniProtKB/Swiss-Prot for OR13C5 Gene

  • Odorant receptor.

Gene Wiki entry for OR13C5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR13C5 Gene

Genomics for OR13C5 Gene

Regulatory Elements for OR13C5 Gene


Genomic Location for OR13C5 Gene

Chromosome:
9
Start:
104,598,457 bp from pter
End:
104,599,413 bp from pter
Size:
957 bases
Orientation:
Minus strand

Genomic View for OR13C5 Gene

Genes around OR13C5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR13C5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR13C5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR13C5 Gene

Proteins for OR13C5 Gene

  • Protein details for OR13C5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGS8-O13C5_HUMAN
    Recommended name:
    Olfactory receptor 13C5
    Protein Accession:
    Q8NGS8
    Secondary Accessions:
    • B2RNE5
    • B9EGW5
    • Q6IF53

    Protein attributes for OR13C5 Gene

    Size:
    318 amino acids
    Molecular mass:
    35796 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR13C5 Gene

Post-translational modifications for OR13C5 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR13C5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR13C5 Gene

Domains & Families for OR13C5 Gene

Gene Families for OR13C5 Gene

Protein Domains for OR13C5 Gene

Suggested Antigen Peptide Sequences for OR13C5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGS8

UniProtKB/Swiss-Prot:

O13C5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR13C5: view

Function for OR13C5 Gene

Molecular function for OR13C5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR13C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR13C5: view

Phenotypes for OR13C5 Gene

GenomeRNAi human phenotypes for OR13C5:
genes like me logo Genes that share phenotypes with OR13C5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR13C5 Gene

Localization for OR13C5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR13C5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR13C5 Gene COMPARTMENTS Subcellular localization image for OR13C5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR13C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR13C5: view

Pathways & Interactions for OR13C5 Gene

genes like me logo Genes that share pathways with OR13C5: view

Pathways by source for OR13C5 Gene

Gene Ontology (GO) - Biological Process for OR13C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR13C5: view

No data available for SIGNOR curated interactions for OR13C5 Gene

Transcripts for OR13C5 Gene

mRNA/cDNA for OR13C5 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR13C5 Gene

No ASD Table

Relevant External Links for OR13C5 Gene

GeneLoc Exon Structure for
OR13C5
ECgene alternative splicing isoforms for
OR13C5

Expression for OR13C5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR13C5 Gene

mRNA differential expression in normal tissues according to GTEx for OR13C5 Gene

This gene is overexpressed in Pituitary (x13.1), Brain - Hypothalamus (x4.4), Brain - Cortex (x4.1), and Brain - Putamen (basal ganglia) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of OR13C5 Gene:

OR13C5

SOURCE GeneReport for Unigene cluster for OR13C5 Gene:

Hs.553598
genes like me logo Genes that share expression patterns with OR13C5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR13C5 Gene

Orthologs for OR13C5 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for OR13C5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473005 34
  • 98.11 (n)
Species where no ortholog for OR13C5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR13C5 Gene

ENSEMBL:
Gene Tree for OR13C5 (if available)
TreeFam:
Gene Tree for OR13C5 (if available)

Paralogs for OR13C5 Gene

(447) SIMAP similar genes for OR13C5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR13C5: view

Variants for OR13C5 Gene

Sequence variations from dbSNP and Humsavar for OR13C5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10541505 -- 104,599,618(+) GAAGG(-/GAAT)GAATG upstream-variant-2KB
rs10761049 -- 104,598,092(+) CAATC(C/T)TAAAA downstream-variant-500B
rs10761050 -- 104,601,094(+) TTTGT(A/T)AAGTT upstream-variant-2KB
rs10991320 -- 104,600,454(+) AATGC(C/T)TAAAG upstream-variant-2KB
rs10991321 -- 104,600,539(+) GAAAT(A/G)TCAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR13C5 Gene

Variant ID Type Subtype PubMed ID
dgv150n17 CNV loss 16327808
dgv7696n100 CNV gain 25217958
esv22412 CNV loss 19812545
esv2421682 OTHER complex 20811451
esv2546770 CNV deletion 19546169
esv2676803 CNV deletion 23128226
esv2759707 CNV gain+loss 17122850
esv2761260 CNV gain+loss 21179565
esv3891705 CNV loss 25118596
esv3891706 CNV gain 25118596
nsv436624 CNV deletion 17901297
nsv471313 CNV loss 18288195
nsv517609 CNV gain+loss 19592680
nsv825025 CNV loss 20364138
nsv831677 CNV gain 17160897
nsv8556 CNV loss 18304495
nsv972439 CNV duplication 23825009

Variation tolerance for OR13C5 Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 23.94; 99.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR13C5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR13C5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR13C5 Gene

Disorders for OR13C5 Gene

Relevant External Links for OR13C5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR13C5

No disorders were found for OR13C5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR13C5 Gene

Publications for OR13C5 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human. (PMID: 12906860) Hoppe R. … Strotmann J. (Genomics 2003) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR13C5 Gene

Sources for OR13C5 Gene

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