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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR13C2 Gene

protein-coding   GIFtS: 41
GCID: GC09M107366

Olfactory Receptor, Family 13, Subfamily C, Member 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 13, Subfamily C, Member 21 2
Olfactory Receptor OR9-122 3
OR37K2
Olfactory Receptor 13C22

External Ids:    HGNC: 147011   Entrez Gene: 3923762   Ensembl: ENSG000002570197   UniProtKB: Q8NGS93   

Export aliases for OR13C2 gene to outside databases

Previous GC identifers: GC09U990157 GC09M102747 GC09M104446 GC09M106406


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR13C2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR13C2 Gene: 
OR13C2 (olfactory receptor, family 13, subfamily C, member 2) is a protein-coding gene. Diseases associated with OR13C2 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR13C8.

UniProtKB/Swiss-Prot: O13C2_HUMAN, Q8NGS9
Function: Odorant receptor (Potential)

Gene Wiki entry for OR13C2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR13C2 gene promoter:
         AhR   TBP   YY1   Arnt   MEF-2A   POU2F1   CP2   TFIID   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR13C2 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR13C2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR13C2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.1   Ensembl cytogenetic band:  9q31.1   HGNC cytogenetic band: 9q31.1

OR13C2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR13C2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M107366:  view genomic region     (about GC identifiers)

Start:
107,366,955 bp from pter      End:
107,367,908 bp from pter
Size:
954 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: O13C2_HUMAN, Q8NGS9 (See protein sequence)
Recommended Name: Olfactory receptor 13C2  
Size: 318 amino acids; 35694 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B9EGV8 Q6IF54

Explore the universe of human proteins at neXtProt for OR13C2: NX_Q8NGS9

HORDE protein sequence for OR13C2
OR13C2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_001004481.1  
ENSEMBL proteins: 
 ENSP00000438815  
Reactome Protein details: Q8NGS9
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

OR13C2 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
OR13: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGS9

ProtoNet protein and cluster: Q8NGS9

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O13C2_HUMAN, Q8NGS9
Similarity: Belongs to the G-protein coupled receptor 1 family


OR13C2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: O13C2_HUMAN, Q8NGS9
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
OR13C2 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OR13C2 About                                                                                                See pathways by source

SuperPathContained pathways About
1Olfactory transduction
Olfactory Signaling Pathway0.81
Olfactory transduction0.81
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


4        Reactome Pathways for OR13C2
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR


1         Kegg Pathway  (Kegg details for OR13C2):
    Olfactory transduction


OR13C2 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR13C2

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

OR13C2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR13C2 (O13C2)

Search CenterWatch for drugs/clinical trials and news about OR13C2 / O13C2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OR13C2 gene: 
NM_001004481.1  

Unigene Cluster for OR13C2:

Olfactory receptor, family 13, subfamily C, member 2
Hs.553789
Unigene Representative Sequence: BC136824
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000542196(uc011lvq.2)
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Additional mRNA sequence: 

BC136824.1 BC136826.1 

1 AceView cDNA sequence:

NM_001004481 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR13C2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
OR13C2 Expression
About this image


SOURCE GeneReport for Unigene cluster: Hs.553789
    SABiosciences Custom PCR Arrays for OR13C2
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of mammals.

Orthologs for OR13C2 gene from 1/4 species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
--
--
90(a)
90(a)
many ↔ many
many ↔ many
11(60575241-60576194)
11(60587676-60588632)


ENSEMBL Gene Tree for OR13C2 (if available)
TreeFam Gene Tree for OR13C2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OR13C2 gene
OR13C82  OR13C32  OR13J12  OR2K22  OR13C42  OR13C92  OR13F12  OR13D12  
OR13C52  OR2S22  OR13H12  
18/451 SIMAP similar genes for OR13C2 using alignment to 1 protein entry:     O13C2_HUMAN(see all similar genes):
OR13C5    OR13C9    OR13C3    OR13C4    OR2S2    OR13D1
OR2K2    OR13C8    OR13F1    OR2G3    OR13J1    OR2B2
OR2G6    OR2J1    OR2J3    OR2J4P    FKSG35    OR1C1

OR13C2 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for OR13C2
PGOHUM00000236024


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/182 SNPs in OR13C2 are shown (see all 182)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1166502901,2
F--107366464(+) GTGGCT/CTAACA 1 -- ds50011Minor allele frequency- C:0.01WA 118
rs9561931,2
C,F,A,H--107366471(-) CAGATC/TCTGTT 1 -- ds500120Minor allele frequency- T:0.45NA EA NS WA CSA 1090
rs1163329311,2
C,F--107366482(+) GAGATT/GAACGT 1 -- ds50011Minor allele frequency- G:0.06WA 118
rs782081731,2
F--107366485(+) ATTAAC/TGTGAA 1 -- ds50011Minor allele frequency- T:0.02NA 120
rs1420535001,2
C--107366662(+) CCCAAC/TTCCAA 1 -- ds50010--------
rs1877520681,2
--107366747(+) TAATAA/GGTAAC 1 -- ds50010--------
rs1922212351,2
--107366761(+) TCTTTC/GTTCTT 1 -- ds50010--------
rs1463310241,2
C--107366854(+) AATATA/GTGAAA 1 -- ds50010--------
rs1842818791,2
--107366882(+) AAGTAC/TCCAAA 1 -- ds50010--------
rs78566431,2
C,F,A,H--107366884(+) GTACCC/GAAAAT 1 -- ds500110Minor allele frequency- G:0.42NS EA WA CSA NA 653

HapMap Linkage Disequilibrium report for OR13C2 ( 107366955 - 107367908 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/20 variations for OR13C2 (see all 20):    About this table     
Variant IDTypeSubtypePubMed ID
esv2664971CNV Deletion23128226
esv2738876CNV Deletion23290073
dgv1364e199CNV Deletion23128226
esv2676803CNV Deletion23128226
esv2546770CNV Deletion19546169
nsv436624CNV Deletion17901297
dgv1365e199CNV Deletion23128226
esv2738875CNV Deletion23290073
dgv120e19CNV Loss19470904
nsv471313CNV Loss18288195

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for OR13C2:    About MalaCards
neuronitis    


OR13C2 for disorders           About GeneDecksing


Export disorders for OR13C2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OR13C2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR13C2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
  2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  4. Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human. (PubMed id 12906860)1 Hoppe R....Strotmann J. (2003)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 392376 HGNC: 14701 AceView: OR13C2 Ensembl:ENSG00000257019 euGenes: HUgn392376
ECgene: OR13C2 Kegg: 392376 H-InvDB: OR13C2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR13C2 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR13C2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR13C2 gene:
Search GeneIP for patents involving OR13C2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Regulatory tfbs in OR13C2 promoter
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
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 Proteins for OR13C2
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 Browse SwitchGear 3'UTR luciferase reporter plasmids for OR13C2
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR13C2
 inGenious Targeting Laboratory - Custom generated mouse model solutions for OR13C2
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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