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Aliases for OR12D3 Gene

Aliases for OR12D3 Gene

  • Olfactory Receptor, Family 12, Subfamily D, Member 3 2 3
  • Olfactory Receptor OR6-27 3 4
  • Hs6M1-27 3 4
  • Olfactory Receptor 12D3 3

External Ids for OR12D3 Gene

Summaries for OR12D3 Gene

Entrez Gene Summary for OR12D3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR12D3 Gene

OR12D3 (Olfactory Receptor, Family 12, Subfamily D, Member 3) is a Protein Coding gene. Diseases associated with OR12D3 include colorectal cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR12D2.

UniProtKB/Swiss-Prot for OR12D3 Gene

  • Odorant receptor.

Gene Wiki entry for OR12D3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR12D3 Gene

Genomics for OR12D3 Gene

Genomic Location for OR12D3 Gene

Start:
29,373,423 bp from pter
End:
29,375,291 bp from pter
Size:
1,869 bases
Orientation:
Minus strand

Genomic View for OR12D3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR12D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR12D3 Gene

  • Protein details for OR12D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGF7-O12D3_HUMAN
    Recommended name:
    Olfactory receptor 12D3
    Protein Accession:
    Q9UGF7
    Secondary Accessions:
    • A2BDZ1
    • Q5SQI8
    • Q6IF23

    Protein attributes for OR12D3 Gene

    Size:
    316 amino acids
    Molecular mass:
    35791 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR12D3 Gene

Proteomics data for OR12D3 Gene at MOPED

Post-translational modifications for OR12D3 Gene

Other Protein References for OR12D3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR12D3 Gene

Domains for OR12D3 Gene

Gene Families for OR12D3 Gene

HGNC:
  • OR12 :GPCR / Class A : Olfactory receptors

Protein Domains for OR12D3 Gene

Suggested Antigen Peptide Sequences for OR12D3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGF7

UniProtKB/Swiss-Prot:

O12D3_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9UGF7
genes like me logo Genes that share domains with OR12D3: view

Function for OR12D3 Gene

Molecular function for OR12D3 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR12D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR12D3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR12D3 Gene

Localization for OR12D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR12D3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR12D3 Gene COMPARTMENTS Subcellular localization image for OR12D3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR12D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR12D3: view

Pathways for OR12D3 Gene

genes like me logo Genes that share pathways with OR12D3: view

Pathways by source for OR12D3 Gene

1 BioSystems pathway for OR12D3 Gene
1 KEGG pathway for OR12D3 Gene

Interacting Proteins for OR12D3 Gene

Gene Ontology (GO) - Biological Process for OR12D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR12D3: view

Transcripts for OR12D3 Gene

mRNA/cDNA for OR12D3 Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR12D3 Gene

No ASD Table

Relevant External Links for OR12D3 Gene

GeneLoc Exon Structure for
OR12D3
ECgene alternative splicing isoforms for
OR12D3

Expression for OR12D3 Gene

mRNA expression in normal human tissues for OR12D3 Gene

SOURCE GeneReport for Unigene cluster for OR12D3 Gene Hs.272280

genes like me logo Genes that share expressions with OR12D3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR12D3 Gene

Orthologs for OR12D3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR12D3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC471938 35
  • 99.5 (n)
  • 98.5 (a)
cow
(Bos Taurus)
Mammalia OR12D3 35
  • 83.76 (n)
  • 81.01 (a)
OR12D3 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr109 35
  • 80.54 (n)
  • 80.32 (a)
Olfr109 16
Olfr109 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr1868 35
  • 80.32 (n)
  • 79.37 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 58 (a)
OneToMany
Species with no ortholog for OR12D3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR12D3 Gene

ENSEMBL:
Gene Tree for OR12D3 (if available)
TreeFam:
Gene Tree for OR12D3 (if available)

Paralogs for OR12D3 Gene

Paralogs for OR12D3 Gene

Selected SIMAP similar genes for OR12D3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OR12D3: view

Variants for OR12D3 Gene

Sequence variations from dbSNP and Humsavar for OR12D3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2144425 -- 29,377,162(+) TATGA(A/G)CGACT upstream-variant-2KB
rs2144426 -- 29,377,252(+) aagaa(A/G)gacaa upstream-variant-2KB
rs3749970 -- 29,375,048(-) CTGCT(C/T)GTAAA reference, synonymous-codon
rs3749971 - 29,374,998(-) TATCA(C/T)CCAGC reference, missense
rs4576280 -- 29,376,731(+) TAGAA(A/T)AAAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR12D3 Gene

Variant ID Type Subtype PubMed ID
nsv830624 CNV Loss 17160897
nsv883527 CNV Loss 21882294

Relevant External Links for OR12D3 Gene

HapMap Linkage Disequilibrium report
OR12D3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR12D3 Gene

Disorders for OR12D3 Gene

(1) MalaCards Diseases for OR12D3 Gene

Search for OR12D3 Gene in MalaCards »

Relevant External Links for OR12D3

Genetic Association Database (GAD)
OR12D3
Human Genome Epidemiology (HuGE) Navigator
OR12D3
genes like me logo Genes that share disorders with OR12D3: view

No data available for UniProtKB/Swiss-Prot for OR12D3 Gene

Publications for OR12D3 Gene

  1. Complex transcription and splicing of odorant receptor genes. (PMID: 12637542) Volz A. … Ziegler A. (J. Biol. Chem. 2003) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48

Products for OR12D3 Gene

Sources for OR12D3 Gene

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