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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR12D3 Gene

protein-coding   GIFtS: 49
GCID: GC06M029346

Olfactory Receptor, Family 12, Subfamily D, Member 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 12, Subfamily D, Member 31 2
Olfactory Receptor OR6-272 3
hs6M1-272
Olfactory Receptor 12D32
Hs6M1-273

External Ids:    HGNC: 139631   Entrez Gene: 817972   Ensembl: ENSG000001124627   UniProtKB: Q9UGF73   

Export aliases for OR12D3 gene to outside databases

Previous GC identifers: GC06M029399 GC06M029449 GC06M029237 GC06Mo29271


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR12D3 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR12D3 Gene: 
OR12D3 (olfactory receptor, family 12, subfamily D, member 3) is a protein-coding gene. Diseases associated with OR12D3 include systemic lupus erythematosus, and lupus erythematosus, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is ENSG00000251608.

UniProtKB/Swiss-Prot: O12D3_HUMAN, Q9UGF7
Function: Odorant receptor (Potential)

Gene Wiki entry for OR12D3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR12D3 gene promoter:
         HFH-3   TBP   FOXF2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   STAT5A   POU3F2   FOXI1   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR12D3 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR12D3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR12D3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

OR12D3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR12D3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M029346:  view genomic region     (about GC identifiers)

Start:
29,342,117 bp from pter      End:
29,343,064 bp from pter
Size:
948 bases      Orientation:
minus strand

5 alternative locations:
Chr6-,NT_167247 644,521-646,389      Chr6-,NT_113891.2 860,134-862,002      Chr6-,NT_167245 644,656-646,524     
Chr6-,NT_167246 644,333-646,201      Chr6-,NT_167249 681,846-683,714     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: O12D3_HUMAN, Q9UGF7 (See protein sequence)
Recommended Name: Olfactory receptor 12D3  
Size: 316 amino acids; 35791 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A2BDZ1 Q5SQI8 Q6IF23

Explore the universe of human proteins at neXtProt for OR12D3: NX_Q9UGF7

HORDE protein sequence for OR12D3
OR12D3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_112221.1  
ENSEMBL proteins: 
 ENSP00000380023  
Reactome Protein details: Q9UGF7
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

OR12D3 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
OR12: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q9UGF7

ProtoNet protein and cluster: Q9UGF7

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O12D3_HUMAN, Q9UGF7
Similarity: Belongs to the G-protein coupled receptor 1 family


OR12D3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: O12D3_HUMAN, Q9UGF7
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
OR12D3 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OR12D3 About                                                                                                See pathways by source

SuperPathContained pathways About
1Olfactory transduction
Olfactory Signaling Pathway0.81
Olfactory transduction0.81
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
3Class A/1 (Rhodopsin-like receptors)
GPCRs, Class A Rhodopsin-like0.41

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for OR12D3
    GPCRs, Class A Rhodopsin-like

4        Reactome Pathways for OR12D3
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR


1         Kegg Pathway  (Kegg details for OR12D3):
    Olfactory transduction


OR12D3 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR12D3

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

OR12D3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR12D3 (O12D3)

Search CenterWatch for drugs/clinical trials and news about OR12D3 / O12D3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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About This Section

REFSEQ mRNAs for OR12D3 gene: 
NM_030959.2  

Unigene Cluster for OR12D3:

Olfactory receptor, family 12, subfamily D, member 3
Hs.272280
Unigene Representative Sequence: NM_030959
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000396806(uc003nme.3)
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Additional mRNA sequence: 

AJ459858.1 BC069082.1 BC069154.1 BC103892.1 BC106898.2 

1 DOTS entry:

DT.102821253 

4 AceView cDNA sequences:

NM_030959 BC069154 BC069082 AJ459858 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR12D3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATGCTTTAGT
OR12D3 Expression
About this image


Genevestigator expression for OR12D3

SOURCE GeneReport for Unigene cluster: Hs.272280
    SABiosciences Custom PCR Arrays for OR12D3
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR12D3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for OR12D3 gene from 2/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr1091 , 5 olfactory receptor 1091, 5 80.54(n)1
80.32(a)1
  17 (19.16 cM)5
2588321  NM_146835.11  NP_667046.11 
 374662085 
chicken
(Gallus gallus)
Aves OR12D26
Uncharacterized protein
58(a)
1 → many
10(283204-284133)


ENSEMBL Gene Tree for OR12D3 (if available)
TreeFam Gene Tree for OR12D3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OR12D3 gene
ENSG000002516082  OR12D22  
18/448 SIMAP similar genes for OR12D3 using alignment to 3 protein entries:     O12D3_HUMAN (see all proteins) (see all similar genes):
OR12D2    OR5F1    OR1L3    OR2C1    OR2J4P    OR4B1
OR4K2    OR4Q3    OR4S2    OR5V1    OR7E86P    OR8U1
OR1J1    OR1L8    OR1M1    OR2B11    OR2B8P    OR2G3

OR12D3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/109 SNPs in OR12D3 are shown (see all 109)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0362094
A breast cancer sample4--see VAR_0362092 F L mis40--------
rs2000859071,2
--29340730(+) ACAAC-/AAAAAA 1 -- ds50010--------
rs92578001,2
C,F,H--29340743(+) TGATAC/TGAGAT 1 -- ds50017Minor allele frequency- T:0.05NS EA NA 544
rs1441324521,2
C--29340765(+) TCTCCA/GTGAAG 1 -- ds50010--------
rs1486930361,2
--29340817(+) AAAAGA/GCATTT 1 -- ds50010--------
rs92578011,2
C,F,H--29340919(+) aatgtG/Ttgaca 1 -- ds50015Minor allele frequency- T:0.04NS EA WA 536
rs1445726531,2
--29340938(+) ACAAAA/GCATGA 1 -- ds50010--------
rs77729821,2
C,F,A,H--29341007(+) tattaT/Cgtgaa 1 -- ds500126Minor allele frequency- C:0.25NS EA WA CSA NA 3349
rs1910775731,2
--29341015(+) GAAGAA/TATATT 1 -- ds50010--------
rs1478827201,2
--29341036(+) AAAATC/GTACAT 1 -- ds50010--------

HapMap Linkage Disequilibrium report for OR12D3 ( 29342117 - 29343064 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for OR12D3:    About this table     
Variant IDTypeSubtypePubMed ID
nsv883527CNV Loss21882294
nsv830624CNV Loss17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
3 diseases for OR12D3:    About MalaCards
systemic lupus erythematosus    lupus erythematosus    neuronitis


OR12D3 for disorders           About GeneDecksing

Genetic Association Database (GAD): OR12D3
Human Genome Epidemiology (HuGE) Navigator: OR12D3 (6 documents)

Export disorders for OR12D3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OR12D3 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with OR12D3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Refining the association of MHC with multiple scleros is in African Americans. (PubMed id 20466734)1, 4 McElroy J.P....Gourraud P.A. (2010)
  2. Host determinants of HIV-1 control in African America ns. (PubMed id 20205591)1, 4 Pelak K....Weintrob A.C. (2010)
  3. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (2009)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
  6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
  7. Complex transcription and splicing of odorant receptor genes. (PubMed id 12637542)1, 2 Volz A.... Ziegler A. (2003)
  8. Genome-wide association study of retinopathy in indivi duals without diabetes. (PubMed id 23393555)1 Jensen R.A....Wong T.Y. (2013)
  9. Genome-wide association and large-scale follow up iden tifies 16 new loci influencing lung function. (PubMed id 21946350)4 Soler Artigas M....Tobin M.D. (2011)
  10. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. (PubMed id 18204098)4 Hom G....Behrens T.W. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 81797 HGNC: 13963 AceView: OR12D3 Ensembl:ENSG00000112462 euGenes: HUgn81797
ECgene: OR12D3 Kegg: 81797 H-InvDB: OR12D3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR12D3 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR12D3 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR12D3 gene:
Search GeneIP for patents involving OR12D3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Proteins for OR12D3
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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