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Aliases for OR12D3 Gene

Aliases for OR12D3 Gene

  • Olfactory Receptor Family 12 Subfamily D Member 3 2 3 5
  • Olfactory Receptor OR6-27 3 4
  • Hs6M1-27 3 4
  • Olfactory Receptor, Family 12, Subfamily D, Member 3 2
  • Olfactory Receptor 12D3 3

External Ids for OR12D3 Gene

Previous GeneCards Identifiers for OR12D3 Gene

  • GC06M029399
  • GC06M029449
  • GC06M029237
  • GC06Mo29271

Summaries for OR12D3 Gene

Entrez Gene Summary for OR12D3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR12D3 Gene

OR12D3 (Olfactory Receptor Family 12 Subfamily D Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR12D2.

UniProtKB/Swiss-Prot for OR12D3 Gene

  • Odorant receptor.

Gene Wiki entry for OR12D3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR12D3 Gene

Genomics for OR12D3 Gene

Regulatory Elements for OR12D3 Gene

Enhancers for OR12D3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F028586 0.7 ENCODE 16.2 +788.1 788126 1.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GPX6 GPX5 ZNF603P ZNF90P2 KRT18P1 OR2W1 OR2AD1P OR2P1P ENSG00000228364 OR2B3
GH06F030194 0.4 ENCODE 16.2 -820.0 -820037 1.6 ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF302 SP3 SP5 MXD4 ZHX2 HCG18 GTF2H4 PPP1R10 ETF1P1 DHX16 PAIP1P1 ZNRD1ASP HCG4P7 TRIM31 GNL1
GH06F029477 0.3 FANTOM5 10.9 -102.8 -102807 0.6 GATA2 USF2 FOXJ2 MAS1L OR12D3 OR5V1 UBD LINC01015 OR2H2 OR14J1 MAS1LP1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR12D3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR12D3 Gene

29,373,423 bp from pter
29,375,291 bp from pter
1,869 bases
Minus strand

Genomic View for OR12D3 Gene

Genes around OR12D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR12D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR12D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR12D3 Gene

  • Protein details for OR12D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 12D3
    Protein Accession:
    Secondary Accessions:
    • A2BDZ1
    • Q5SQI8
    • Q6IF23

    Protein attributes for OR12D3 Gene

    316 amino acids
    Molecular mass:
    35791 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR12D3 Gene

Post-translational modifications for OR12D3 Gene

Other Protein References for OR12D3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR12D3 Gene

Domains & Families for OR12D3 Gene

Gene Families for OR12D3 Gene

Protein Domains for OR12D3 Gene

Suggested Antigen Peptide Sequences for OR12D3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR12D3: view

Function for OR12D3 Gene

Molecular function for OR12D3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR12D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR12D3: view
genes like me logo Genes that share phenotypes with OR12D3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR12D3 Gene

Localization for OR12D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR12D3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR12D3 Gene COMPARTMENTS Subcellular localization image for OR12D3 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for OR12D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR12D3: view

Pathways & Interactions for OR12D3 Gene

genes like me logo Genes that share pathways with OR12D3: view

Pathways by source for OR12D3 Gene

1 BioSystems pathway for OR12D3 Gene
1 KEGG pathway for OR12D3 Gene

Interacting Proteins for OR12D3 Gene

Gene Ontology (GO) - Biological Process for OR12D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR12D3: view

No data available for SIGNOR curated interactions for OR12D3 Gene

Transcripts for OR12D3 Gene

mRNA/cDNA for OR12D3 Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR12D3 Gene

No ASD Table

Relevant External Links for OR12D3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR12D3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR12D3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR12D3 Gene:


SOURCE GeneReport for Unigene cluster for OR12D3 Gene:

genes like me logo Genes that share expression patterns with OR12D3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR12D3 Gene

Orthologs for OR12D3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR12D3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC471938 34
  • 99.5 (n)
(Bos Taurus)
Mammalia OR12D3 34 35
  • 83.76 (n)
(Mus musculus)
Mammalia Or12d17 55 Olfr109 34 16 35
  • 80.54 (n)
(Rattus norvegicus)
Mammalia Olr1868 34
  • 80.32 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 62 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 39 (a)
(Gallus gallus)
Aves -- 35
  • 58 (a)
Species where no ortholog for OR12D3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR12D3 Gene

Gene Tree for OR12D3 (if available)
Gene Tree for OR12D3 (if available)

Paralogs for OR12D3 Gene

Paralogs for OR12D3 Gene

(446) SIMAP similar genes for OR12D3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with OR12D3: view

Variants for OR12D3 Gene

Sequence variations from dbSNP and Humsavar for OR12D3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs545611345 A breast cancer sample 29,374,540(+) ATAGA(A/G)AAGAC intron-variant, reference, missense
rs10456372 -- 29,373,672(+) aatgt(A/G)tacat intron-variant, utr-variant-3-prime
rs10456373 -- 29,375,556(+) GGCAT(C/T)TGTTT intron-variant, upstream-variant-2KB
rs111677760 -- 29,374,346(+) TGGTG(C/T)TGCTG intron-variant, reference, synonymous-codon
rs111700609 -- 29,374,093(+) ACCGA(A/G)TTATC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OR12D3 Gene

Variant ID Type Subtype PubMed ID
dgv10338n54 CNV gain 21841781
esv3608477 CNV loss 21293372
nsv1015796 CNV gain 25217958
nsv1020683 CNV gain 25217958
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv601223 CNV loss 21841781
nsv830624 CNV loss 17160897

Variation tolerance for OR12D3 Gene

Residual Variation Intolerance Score: 44.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.37; 63.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR12D3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR12D3 Gene

Disorders for OR12D3 Gene

Relevant External Links for OR12D3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR12D3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR12D3 Gene

Publications for OR12D3 Gene

  1. Host determinants of HIV-1 control in African Americans. (PMID: 20205591) Pelak K. … . (J. Infect. Dis. 2010) 3 46 64
  2. Refining the association of MHC with multiple sclerosis in African Americans. (PMID: 20466734) McElroy J.P. … Gourraud P.A. (Hum. Mol. Genet. 2010) 3 46 64
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for OR12D3 Gene

Sources for OR12D3 Gene

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