OR12D3 Gene
protein-coding GIFtS: 46
GCID: GC06M029346
|
|
olfactory receptor, family 12, subfamily D, member 3
| |
Aliases
for OR12D3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 12, Subfamily D, Member 31 2 | | Hs6M1-273 | | Olfactory Receptor OR6-272 3 | | Olfactory Receptor 12D32 | | Hs6M1-273 |
Export aliases for OR12D3 gene to outside databasesPrevious GC identifers: GC06M029399 GC06M029449 GC06M029237 GC06Mo29271 |
Summaries
for OR12D3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR12D3:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: O12D3_HUMAN, Q9UGF7Function: Odorant receptor (Potential)
Gene Wiki entry for OR12D3
|
Genomic Views
for OR12D3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167246.1 NT_167247.1 NT_167249.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR12D3 gene promoter:
HFH-3 TBP FOXF2 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) STAT5A POU3F2 FOXI1 FOXJ2 (long isoform) FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR12D3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR12D3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p22.1 Ensembl cytogenetic band: 6p22.1 HGNC chromosome: 6OR12D3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M029346: view genomic region
(about GC identifiers)
Start:
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29,342,117 bp from pter |
End:
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29,343,064 bp from pter |
Size:
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948 bases |
Orientation:
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minus strand |
5 alternative locations:
| Chr6-,ALT_REF_LOCI_5 29,255,944-29,257,812 | Chr6-,ALT_REF_LOCI_4 29,263,992-29,265,860 | Chr6-,ALT_REF_LOCI_3 29,341,259-29,417,808 | | Chr6-,ALT_REF_LOCI_2 29,337,930-29,414,451 | Chr6-,ALT_REF_LOCI_7 29,271,311-29,273,179 |
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Proteins
for OR12D3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: O12D3_HUMAN, Q9UGF7 (See
protein sequence)Recommended Name: Olfactory receptor 12D3 Size: 316 amino acids; 35791 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A2BDZ1 Q5SQI8 Q6IF23Explore the universe of human proteins at neXtProt for OR12D3: NX_Q9UGF7
HORDE protein sequence for OR12D3
OR12D3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_112221.1
ENSEMBL proteins: ENSP00000366348 ENSP00000380023
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR12D3 for ontologies About GeneDecksing
OR12D3 Antibody Products:
Assay Products for OR12D3: |
Protein
Domains /
Families
for OR12D3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR12D3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UGF7ProtoNet protein and cluster: Q9UGF7 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: O12D3_HUMAN, Q9UGF7Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR12D3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: O12D3_HUMAN, Q9UGF7Function: Odorant receptor (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR12D3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR12D3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OR12D3 (NM_030959) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR12D3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR12D3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR12D3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR12D3 for ontologies About GeneDecksing
|
Pathways & Interactions
for OR12D3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Olfactory transduction | | | 2 | Class A/1 (Rhodopsin-like receptors) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for OR12D3
1 
Kegg Pathway (Kegg details for OR12D3):
OR12D3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR12D3
|
Drugs & Compounds
for OR12D3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR12D3
Search CenterWatch for drugs/clinical trials and news about OR12D3 / O12D3
|
Transcripts
for OR12D3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR12D3 gene: NM_030959.2 Unigene Cluster for OR12D3: Olfactory receptor, family 12, subfamily D, member 3 Hs.272280 Unigene Representative Sequence: NM_0309592 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377143 ENST00000396806(uc003nme.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR12D3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR12D3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR12D3 (NM_030959) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR12D3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR12D3 |
Additional cDNA sequence: AJ459858.1 BC069082.1 BC069154.1 BC103892.1 BC106898.2 1 DOTS entry: DT.102821253 4 AceView cDNA sequences: BC069154 BC069082 NM_030959 AJ459858
GeneLoc Exon Structure
|
Expression
for OR12D3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR12D3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGCTTTAGT
About this image
See OR12D3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR12D3
SOURCE GeneReport for Unigene cluster: Hs.272280
SABiosciences Custom PCR Arrays for OR12D3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR12D3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR12D3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR12D3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR12D3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR12D3 |
Orthologs
for OR12D3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OR12D3 gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
F1NWU8_CHICK6 |
Uncharacterized protein |
57(a) |
1 → many |
10(116078-117022) |
ENSEMBL Gene Tree for OR12D3 (if available)
TreeFam Gene Tree for OR12D3 (if available) |
Paralogs
for OR12D3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR12D3 gene
- OR12D22
18/456 SIMAP similar genes for OR12D3 using alignment to 4 protein entries: O12D3_HUMAN (see all proteins)
(see all similar genes):OR12D2 FKSG35 OR5F1 OR2C1 OR2J4P OR4K2
OR4S2 OR5V1 OR1L3 OR4B1 OR4Q3 OR7E86P
OR8U1 OR1L8 OR1M1 OR2B11 OR2B8P OR2G3
OR12D3 for paralogs About GeneDecksing
|
Genomic Variants
for OR12D3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR12D3 ( 29342117 - 29343064 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR12D3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR12D3 |
|
Disorders
/ Diseases
for OR12D3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR12D3 for disorders About GeneDecksing
3  diseases for OR12D3: About MalaCardssystemic lupus erythematosus lupus erythematosus neuronitis
Human Genome Epidemiology (HuGE) Navigator: OR12D3 (6 documents)
Export disorders for OR12D3 gene to outside databases
|
Publications
for OR12D3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR12D3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR12D3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Complex transcription and splicing of odorant receptor genes. (PubMed id 12637542)1, 2 Volz A.... Ziegler A. (2003)
- Refining the association of MHC with multiple scleros is in African Americans. (PubMed id 20466734)1 McElroy J.P....Gourraud P.A. (2010)
- Host determinants of HIV-1 control in African America ns. (PubMed id 20205591)1 Pelak K....Weintrob A.C. (2010)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for OR12D3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OR12D3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR12D3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR12D3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR12D3 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR12D3 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
|
| | |
About This Section
| Patent Information for OR12D3 gene:
Search GeneIP for patents involving OR12D3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR12D3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR12D3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR12D3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR12D3 | | | OriGene Protein Over-expression Lysate for OR12D3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR12D3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR12D3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR12D3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OR12D3 | | OriGene Custom Protein Services for OR12D3 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR12D3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR12D3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR12D3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR12D3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR12D3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR12D3 |
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 | | | OR12D3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR12D3 |
|  |  |  | | | | Search ThermoFisher Antibodies for OR12D3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR12D3 |
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