OR12D2 Gene
protein-coding GIFtS: 51
GCID: GC06P029364
|
|
olfactory receptor, family 12, subfamily D, member 2
| |
Aliases for OR12D2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 12, Subfamily D, Member 21 2 | | HS6M1-202 | | Olfactory Receptor OR6-282 3 | | Olfactory Receptor 12D22 | | Hs6M1-203 | | Hs6M1-203 | | DJ994E9.82 | | |
Export aliases for OR12D2 gene to outside databasesPrevious GC identifers: GC06P029421 GC06P029135 GC06P029472 GC06P029172 |
Summaries for OR12D2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for OR12D2: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008) UniProtKB/Swiss-Prot: O12D2_HUMAN, P58182Function: Odorant receptor (Potential) Gene Wiki entry for OR12D2
|
Genomic Views for OR12D2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167246.1 NT_167247.1 NT_167249.1
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the OR12D2 gene promoter: GR AML1a FOXF2 Brachyury GR-beta POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 GR-alpha Other transcription factors
Search SABiosciences Chromatin IP Primers for OR12D2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR12D2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p22.2-p21.31 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p22.2-p21.31OR12D2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P029364: view genomic region
(about GC identifiers)
Start:
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29,364,477 bp from pter |
End:
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29,365,397 bp from pter |
Size:
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921 bases |
Orientation:
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plus strand |
5 alternative locations:
| Chr6+,ALT_REF_LOCI_2 29,361,002-29,401,222 | Chr6+,ALT_REF_LOCI_4 29,287,063-29,288,095 | Chr6+,ALT_REF_LOCI_5 29,279,021-29,280,053 | | Chr6+,ALT_REF_LOCI_3 29,364,252-29,376,406 | Chr6+,ALT_REF_LOCI_7 29,294,407-29,295,439 |
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Proteins for OR12D2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: O12D2_HUMAN, P58182 (See
protein sequence)Recommended Name: Olfactory receptor 12D2 Size: 307 amino acids; 34813 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B0S862 Q5SUN9 Q6IET9Explore the universe of human proteins at neXtProt for OR12D2: NX_P58182
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P58182 HORDE protein sequence for OR12D2 OR12D2 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_039224.2 ENSEMBL proteins: ENSP00000373047 Human Recombinant Protein Products for OR12D2:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR12D2 for ontologies About GeneDecksing
OR12D2 Antibody Products: Assay Products for OR12D2: |
Protein
Domains / Families for OR12D2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR12D2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P58182ProtoNet protein and cluster: P58182 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: O12D2_HUMAN, P58182Similarity: Belongs to the G-protein coupled receptor 1 family |
Function for OR12D2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: O12D2_HUMAN, P58182Function: Odorant receptor (Potential) Genatlas biochemistry entry for OR12D2:olfactory receptor,family 12,subfamily D,member 2,G protein coupled receptor superfamily
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR12D2 for ontologies About GeneDecksing
Phenotypes: 1 GenomeRNAi human phenotype for OR12D2: Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR12D2 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR12D2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR12D2 |
|
Pathways & Interactions for OR12D2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Olfactory transduction | |
Pathway sources See GeneCards unified pathways Show all pathways
1
Kegg Pathway (Kegg details for OR12D2):
OR12D2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR12D2
|
Drugs & Compounds for OR12D2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for OR12D2 Search CenterWatch for drugs/clinical trials and news about OR12D2 / O12D2 
|
Transcripts for OR12D2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for OR12D2 gene: NM_013936.3 Unigene Cluster for OR12D2: Olfactory receptor, family 12, subfamily D, member 2 Hs.247862 Unigene Representative Sequence: NM_0139361 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000383555(uc003nmf.4)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR12D2 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR12D2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OR12D2 (NM_013936) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR12D2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR12D2  |
Additional cDNA sequence: AJ459861.1 BC069123.1 BC101742.1 BC101746.1 1 DOTS entry: DT.92006718 3 AceView cDNA sequences: NM_013936 AJ459861 BC069123 GeneLoc Exon Structure
|
Expression for OR12D2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR12D2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GACCAGGACC
 About this image See OR12D2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for OR12D2
SOURCE GeneReport for Unigene cluster: Hs.247862 SABiosciences Custom PCR Arrays for OR12D2
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR12D2 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR12D2 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR12D2 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR12D2 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR12D2 |
Orthologs for OR12D2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OR12D2 gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
F1NWU8_CHICK6 |
Uncharacterized protein |
55(a) |
1 → many |
10(116078-117022) |
Species with no ortholog for OR12D2
ENSEMBL Gene Tree for OR12D2 (if available) TreeFam Gene Tree for OR12D2 (if available)  |
Paralogs for OR12D2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for OR12D2 gene
- OR12D32
18/459 SIMAP similar genes for OR12D2 using alignment to 3 protein entries: O12D2_HUMAN (see all proteins)
(see all similar genes):OR12D3 OR1L4 OR5V1 OR8U1 OR8U9 OR1L6 OR1A1 OR8U8 OR1D2 OR1E1 OR1L3 OR3A3 OR4E2 OR5M10 OR2B8P OR4D5 OR5A1 OR5AR1
OR12D2 for paralogs About GeneDecksing
|
Genomic Variants for OR12D2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 6 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for OR12D2 ( 29364477 - 29365397 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for OR12D2 1 CNV: 99478 Human Gene Mutation Database (HGMD): OR12D2
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR12D2 |
|
Disorders
/ Diseases for OR12D2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR12D2 for disorders About GeneDecksing
3 diseases for OR12D2: About MalaCardssystemic lupus erythematosus lupus erythematosus neuronitis Human Genome Epidemiology (HuGE) Navigator: OR12D2 (3 documents) Export disorders for OR12D2 gene to outside databases
|
Publications for OR12D2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR12D2 gene integrated from 9 sources: (articles sorted by number of sources associating them with OR12D2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Genome-wide association and large-scale follow up iden tifies 16 new loci influencing lung function. (PubMed id 21946350)1 Soler Artigas M....Tobin M.D. (2011)
- Sequence variations at the human leukocyte antigen-li nked olfactory receptor cluster do not influence female preferences for male od ors. (PubMed id 19833159)1 Thompson E.E....Ober C. (2010)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
- Complex transcription and splicing of odorant receptor genes. (PubMed id 12637542)1 Volz A.... Ziegler A. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Characterization of clustered MHC-linked olfactory receptor genes in human and mouse. (PubMed id 11282967)1 Younger R.M....Beck S. (2001)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for OR12D2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing OR12D2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR12D2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR12D2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for OR12D2 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR12D2 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
|
| | |
About This Section
| Patent Information for OR12D2 gene: Search GeneIP for patents involving OR12D2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for OR12D2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR12D2 |
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