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Aliases for OR12D2 Gene

Aliases for OR12D2 Gene

  • Olfactory Receptor Family 12 Subfamily D Member 2 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 12, Subfamily D, Member 2 2 3
  • Olfactory Receptor OR6-28 3 4
  • HS6M1-20 3 4
  • Olfactory Receptor, Family 12, Subfamily D, Member 2 (Gene/Pseudogene) 2
  • Olfactory Receptor 12D2 3
  • DJ994E9.8 3

External Ids for OR12D2 Gene

Previous GeneCards Identifiers for OR12D2 Gene

  • GC06P029421
  • GC06P029135
  • GC06P029472
  • GC06P029364
  • GC06P029172
  • GC06P029401

Summaries for OR12D2 Gene

Entrez Gene Summary for OR12D2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR12D2 Gene

OR12D2 (Olfactory Receptor Family 12 Subfamily D Member 2 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR12D3.

UniProtKB/Swiss-Prot for OR12D2 Gene

  • Odorant receptor.

Gene Wiki entry for OR12D2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR12D2 Gene

Genomics for OR12D2 Gene

Regulatory Elements for OR12D2 Gene

Enhancers for OR12D2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F029467 0.7 FANTOM5 2.4 +71.1 71145 0.3 OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2 OR5V1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR12D2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR12D2 Gene

Chromosome:
6
Start:
29,396,555 bp from pter
End:
29,397,671 bp from pter
Size:
1,117 bases
Orientation:
Plus strand

Genomic View for OR12D2 Gene

Genes around OR12D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR12D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR12D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR12D2 Gene

  • Protein details for OR12D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58182-O12D2_HUMAN
    Recommended name:
    Olfactory receptor 12D2
    Protein Accession:
    P58182
    Secondary Accessions:
    • B0S862
    • Q5SUN9
    • Q6IET9

    Protein attributes for OR12D2 Gene

    Size:
    307 amino acids
    Molecular mass:
    34813 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR12D2 Gene

Post-translational modifications for OR12D2 Gene

  • Glycosylation at Asn 3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR12D2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR12D2 Gene

Domains & Families for OR12D2 Gene

Gene Families for OR12D2 Gene

Protein Domains for OR12D2 Gene

Suggested Antigen Peptide Sequences for OR12D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P58182

UniProtKB/Swiss-Prot:

O12D2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR12D2: view

Function for OR12D2 Gene

Molecular function for OR12D2 Gene

GENATLAS Biochemistry:
olfactory receptor,family 12,subfamily D,member 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR12D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR12D2: view
genes like me logo Genes that share phenotypes with OR12D2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR12D2 Gene

Localization for OR12D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR12D2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR12D2 Gene COMPARTMENTS Subcellular localization image for OR12D2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR12D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR12D2: view

Pathways & Interactions for OR12D2 Gene

genes like me logo Genes that share pathways with OR12D2: view

Pathways by source for OR12D2 Gene

Interacting Proteins for OR12D2 Gene

Selected Interacting proteins: P58182-O12D2_HUMAN for OR12D2 Gene via IID

Gene Ontology (GO) - Biological Process for OR12D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR12D2: view

No data available for SIGNOR curated interactions for OR12D2 Gene

Transcripts for OR12D2 Gene

mRNA/cDNA for OR12D2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR12D2 Gene

Olfactory receptor, family 12, subfamily D, member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR12D2 Gene

No ASD Table

Relevant External Links for OR12D2 Gene

GeneLoc Exon Structure for
OR12D2
ECgene alternative splicing isoforms for
OR12D2

Expression for OR12D2 Gene

mRNA expression in normal human tissues for OR12D2 Gene

mRNA differential expression in normal tissues according to GTEx for OR12D2 Gene

This gene is overexpressed in Brain - Hypothalamus (x13.9), Brain - Caudate (basal ganglia) (x10.7), Brain - Hippocampus (x8.2), Brain - Nucleus accumbens (basal ganglia) (x5.0), and Cervix - Endocervix (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of OR12D2 Gene:

OR12D2

SOURCE GeneReport for Unigene cluster for OR12D2 Gene:

Hs.247862
genes like me logo Genes that share expression patterns with OR12D2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR12D2 Gene

Orthologs for OR12D2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR12D2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC471939 34
  • 98.91 (n)
mouse
(Mus musculus)
Mammalia Or12d2 55 Olfr102 34 16
  • 80.83 (n)
Or12d12 55 Olfr101
  • chr17:37,299,497-37,300,420
Or12d13 55 Olfr103
  • chr17:37,336,292-37,337,230
Or12d14-ps 55 Olfr104-ps1
  • chr17:37,362,158-37,363,084
Or12d15 55 Olfr105
  • chr17:37,382,641-37,383,483
Or12d16-ps 55 Olfr106-ps1
  • chr17:37,394,581-37,395,507
rat
(Rattus norvegicus)
Mammalia Olr1736 34
  • 80.39 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497240 34
  • 58.97 (n)
Species where no ortholog for OR12D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR12D2 Gene

ENSEMBL:
Gene Tree for OR12D2 (if available)
TreeFam:
Gene Tree for OR12D2 (if available)

Paralogs for OR12D2 Gene

Paralogs for OR12D2 Gene

(449) SIMAP similar genes for OR12D2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR12D2: view

Variants for OR12D2 Gene

Sequence variations from dbSNP and Humsavar for OR12D2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs111677372 -- 29,396,821(+) GAATG(A/G)AGCCG intron-variant, reference, missense
rs111766836 -- 29,395,474(+) AACAG(A/G)CCTCT intron-variant, upstream-variant-2KB
rs112592732 -- 29,397,496(+) GAGCT(C/T)CATGG intron-variant, reference, missense
rs113268717 -- 29,397,300(+) CTGTC(A/G)CGGGG intron-variant, reference, missense
rs113539956 -- 29,397,484(+) TCCTG(A/C)GTTAG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR12D2 Gene

Variant ID Type Subtype PubMed ID
dgv10340n54 CNV loss 21841781
esv2639371 CNV deletion 19546169
esv2667426 CNV deletion 23128226
esv2731760 CNV deletion 23290073
esv2731763 CNV deletion 23290073
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv830624 CNV loss 17160897

Variation tolerance for OR12D2 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.44; 97.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR12D2 Gene

Human Gene Mutation Database (HGMD)
OR12D2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR12D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR12D2 Gene

Disorders for OR12D2 Gene

Relevant External Links for OR12D2

Genetic Association Database (GAD)
OR12D2
Human Genome Epidemiology (HuGE) Navigator
OR12D2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR12D2

No disorders were found for OR12D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR12D2 Gene

Publications for OR12D2 Gene

  1. Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors. (PMID: 19833159) Thompson E.E. … Ober C. (Hum. Immunol. 2010) 3 46 64
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for OR12D2 Gene

Sources for OR12D2 Gene

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