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Aliases for OR11H7 Gene

Aliases for OR11H7 Gene

  • Olfactory Receptor, Family 11, Subfamily H, Member 7 (Gene/Pseudogene) 2 3
  • Olfactory Receptor, Family 11, Subfamily H, Member 7 Pseudogene 2 3
  • OR11H7P 3 4
  • Olfactory Receptor OR14-32 4
  • Olfactory Receptor 11H7 3

External Ids for OR11H7 Gene

Previous HGNC Symbols for OR11H7 Gene

  • OR11H7P

Previous GeneCards Identifiers for OR11H7 Gene

  • GC14P019768
  • GC14P020697
  • GC14P000819

Summaries for OR11H7 Gene

Entrez Gene Summary for OR11H7 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11H7 Gene

OR11H7 (Olfactory Receptor, Family 11, Subfamily H, Member 7 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include olfactory receptor activity and adrenergic receptor activity. An important paralog of this gene is OR6N1.

UniProtKB/Swiss-Prot for OR11H7 Gene

  • Odorant receptor. Activated by isovaleric acid.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR11H7 Gene

Genomics for OR11H7 Gene

Genomic Location for OR11H7 Gene

Start:
20,229,402 bp from pter
End:
20,230,344 bp from pter
Size:
943 bases
Orientation:
Plus strand

Genomic View for OR11H7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR11H7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR11H7 Gene

No data available for Regulatory Elements for OR11H7 Gene

Proteins for OR11H7 Gene

  • Protein details for OR11H7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGC8-O11H7_HUMAN
    Recommended name:
    Olfactory receptor 11H7
    Protein Accession:
    Q8NGC8
    Secondary Accessions:

    Protein attributes for OR11H7 Gene

    Size:
    314 amino acids
    Molecular mass:
    35499 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR11H7 Gene

Proteomics data for OR11H7 Gene at MOPED

Post-translational modifications for OR11H7 Gene

Other Protein References for OR11H7 Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for OR11H7 Gene

Domains for OR11H7 Gene

Gene Families for OR11H7 Gene

HGNC:
  • OR11 :GPCR / Class A : Olfactory receptors

Protein Domains for OR11H7 Gene

Suggested Antigen Peptide Sequences for OR11H7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGC8

UniProtKB/Swiss-Prot:

O11H7_HUMAN :
  • Q8NGC8
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR11H7: view

Function for OR11H7 Gene

Molecular function for OR11H7 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor. Activated by isovaleric acid.

Gene Ontology (GO) - Molecular Function for OR11H7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR11H7: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR11H7 Gene

Localization for OR11H7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11H7 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR11H7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR11H7: view

No data available for Subcellular locations from COMPARTMENTS for OR11H7 Gene

Pathways for OR11H7 Gene

genes like me logo Genes that share pathways with OR11H7: view

Pathways by source for OR11H7 Gene

Interacting Proteins for OR11H7 Gene

Gene Ontology (GO) - Biological Process for OR11H7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR11H7: view

Transcripts for OR11H7 Gene

mRNA/cDNA for OR11H7 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR11H7 Gene

No ASD Table

Relevant External Links for OR11H7 Gene

GeneLoc Exon Structure for
OR11H7
ECgene alternative splicing isoforms for
OR11H7

Expression for OR11H7 Gene

mRNA expression in normal human tissues for OR11H7 Gene

mRNA differential expression in normal tissues according to GTEx for OR11H7 Gene

This gene is overexpressed in Testis (6.0).
genes like me logo Genes that share expressions with OR11H7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for OR11H7 Gene

Orthologs for OR11H7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR11H7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR11H7 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 57 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr746 36
  • 80 (a)
OneToMany
Olfr748 36
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
OneToMany
Species with no ortholog for OR11H7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR11H7 Gene

ENSEMBL:
Gene Tree for OR11H7 (if available)
TreeFam:
Gene Tree for OR11H7 (if available)

Paralogs for OR11H7 Gene

Paralogs for OR11H7 Gene

Selected SIMAP similar genes for OR11H7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR11H7: view

Variants for OR11H7 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR11H7 Gene

Q8NGC8-O11H7_HUMAN
A stop codon in the gene coding for this protein at position Gln-227 is responsible for functional diversity thus producing a pseudogene. Hypersensitivity towards isovaleric acid is seen predominantly in individuals who carry at least one copy of the intact allele

Relevant External Links for OR11H7 Gene

HapMap Linkage Disequilibrium report
OR11H7
Human Gene Mutation Database (HGMD)
OR11H7

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for OR11H7 Gene

Disorders for OR11H7 Gene

No disorders were found for OR11H7 Gene.

No data available for UniProtKB/Swiss-Prot for OR11H7 Gene

Publications for OR11H7 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  3. Different noses for different people. (PMID: 12730696) Menashe I. … Gilad Y. (Nat. Genet. 2003) 3 4
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  5. Genetic elucidation of human hyperosmia to isovaleric acid. (PMID: 17973576) Menashe I. … Lancet D. (PLoS Biol. 2007) 3 4

Products for OR11H7 Gene

Sources for OR11H7 Gene

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