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OR11H6 Gene

protein-coding   GIFtS: 42
GCID: GC14P020691

Olfactory Receptor, Family 11, Subfamily H, Member 6

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 11, Subfamily H, Member 61 2
Olfactory Receptor OR14-352 3
Olfactory Receptor 11H62

External Ids:    HGNC: 153491   Entrez Gene: 1227482   Ensembl: ENSG000001762197   UniProtKB: Q8NGC73   

Export aliases for OR11H6 gene to outside databases

Previous GC identifers: GC14U990444 GC14P018682 GC14P019761


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR11H6 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR11H6 Gene:
OR11H6 (olfactory receptor, family 11, subfamily H, member 6) is a protein-coding gene. Diseases associated with OR11H6 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6N1.

UniProtKB/Swiss-Prot: O11H6_HUMAN, Q8NGC7
Function: Odorant receptor (Potential)

Gene Wiki entry for OR11H6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR11H6 gene promoter:
         Tal-1   AML1a   HSF1 (long)   CUTL1   LCR-F1   E47   HSF1short   PPAR-gamma2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR11H6 promoter sequence
   Search Chromatin IP Primers for OR11H6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR11H6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

OR11H6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR11H6 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P020691:  view genomic region     (about GC identifiers)

Start:
20,691,938 bp from pter      End:
20,692,858 bp from pter
Size:
921 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: O11H6_HUMAN, Q8NGC7 (See protein sequence)
Recommended Name: Olfactory receptor 11H6  
Size: 330 amino acids; 36788 Da
Secondary accessions: Q6IF08

Explore the universe of human proteins at neXtProt for OR11H6: NX_Q8NGC7

Post-translational modifications: 

  • Glycosylation2 at Asn21
  • HORDE protein sequence for OR11H6
    REFSEQ proteins: NP_001004480.1  
    ENSEMBL proteins: 
     ENSP00000319071  
    Reactome Protein details: Q8NGC7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR11: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGC7

    ProtoNet protein and cluster: Q8NGC7

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O11H6_HUMAN, Q8NGC7
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR11H6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O11H6_HUMAN, Q8NGC7
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR11H6 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O11H6_HUMAN, Q8NGC7: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR11H6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR11H6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR11H6
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR11H6):
        Olfactory transduction


    OR11H6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR11H6
    Interactions:

        Search GeneGlobe Interaction Network for OR11H6

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for OR11H6 (ENSP000003190714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRBK2ENSP000003175784STRING: ENSP00000317578
    ARRB2ENSP000002692604STRING: ENSP00000269260
    GNALENSP000003340514STRING: ENSP00000334051
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR11H6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for OR11H6 (O11H6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR11H6 gene: 
    NM_001004480.1  

    Unigene Cluster for OR11H6:

    Olfactory receptor, family 11, subfamily H, member 6
    Hs.553575
    Unigene Representative Sequence: NM_001004480
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000315519(uc010tlc.2)
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      QuantiFast Probe-based Assays in human, mouse, rat OR11H6

    1 AceView cDNA sequence:

    NM_001004480 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR11H6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGATGCTC
    OR11H6 Expression
    About this image

    OR11H6 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.553575
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR11H6 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr7451 , 5 olfactory receptor 7451, 5 84.3(n)1
    82.26(a)1
      14 (26.18 cM)5
    2582961  NM_146299.21  NP_666411.21 
     506421955 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004862131 olfactory receptor 6B1-like 52.15(n)
    44.55(a)
      100486213  XM_004911377.1  XP_004911434.1 


    ENSEMBL Gene Tree for OR11H6 (if available)
    TreeFam Gene Tree for OR11H6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR11H6 gene
    OR6N12  OR6K32  OR6N22  OR11H72  OR6K22  OR11G22  OR11H122  OR6K62  
    OR11H12  OR11H42  
    Selected SIMAP similar genes for OR11H6 using alignment to 1 protein entry:     O11H6_HUMAN(see all similar genes):
    OR11H1    OR11H12    OR11H13P    OR11H2    OR11H4    OR11H7
    OR11G2    OR6N1    FKSG35    OR6N2    OR2A12    OR11A1
    OR2A5    OR6C70    OR6M1    OR2W3    OR13C2    OR13C3

    OR11H6 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for OR11H6
    PGOHUM00000248041 PGOHUM00000246631 PGOHUM00000246643 PGOHUM00000246644


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR11H6 (see all 140)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs101481931,2
    C--20690052(+) cacaaG/Tggttg 1 -- us2k10--------
    rs1866795601,2
    --20690099(+) TCCTAC/TTTCTC 1 -- us2k10--------
    rs1910865941,2
    --20690105(+) TTCTCC/TACATC 1 -- us2k10--------
    rs1840573861,2
    --20690106(+) TCTCCA/GCATCC 1 -- us2k10--------
    rs133792191,2
    C--20690108(+) TCCACC/ATCCTC 1 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs71544601,2
    C,F,A,H--20690168(+) CAACCG/ATTTTT 1 -- us2k1100Minor allele frequency- A:0.08NS EA NA PA EU CA WA CSA 6186
    rs769039891,2
    C,F--20690304(+) GATCAT/CGATAA 1 -- us2k11Minor allele frequency- C:0.08WA 118
    rs758597551,2
    C--20690374(+) TATTAG/CAGAAA 1 -- us2k14Minor allele frequency- C:0.09CSA WA NA EA 359
    rs1405331671,2
    --20690431(+) ACCTCA/GGCAAT 1 -- us2k10--------
    rs619938611,2
    C,F--20690450(+) TATGCC/TTTTGG 1 -- us2k12Minor allele frequency- T:0.50NA 4

    HapMap Linkage Disequilibrium report for OR11H6 ( 20691938 - 20692858 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for OR11H6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901466CNV Loss21882294
    nsv456144CNV Loss19166990
    nsv901299CNV Gain21882294
    nsv832739CNV Gain17160897
    nsv901467CNV Gain21882294
    esv2751268CNV Gain17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR11H6:    About MalaCards
    neuronitis


    OR11H6 for disorders           About GeneDecksing


    Export disorders for OR11H6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR11H6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR11H6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 122748 HGNC: 15349 AceView: OR11H6 Ensembl:ENSG00000176219 euGenes: HUgn122748
    ECgene: OR11H6 Kegg: 122748 H-InvDB: OR11H6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR11H6 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR11H6 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR11H6 gene:
    Search GeneIP for patents involving OR11H6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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