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Aliases for OR11H4 Gene

Aliases for OR11H4 Gene

  • Olfactory Receptor Family 11 Subfamily H Member 4 2 3 5
  • Olfactory Receptor OR14-36 3 4
  • Olfactory Receptor, Family 11, Subfamily H, Member 4 2
  • Olfactory Receptor 11H4 3
  • OR14-36 3

External Ids for OR11H4 Gene

Previous GeneCards Identifiers for OR11H4 Gene

  • GC14U990446
  • GC14P018703
  • GC14P019780
  • GC14P020710

Summaries for OR11H4 Gene

Entrez Gene Summary for OR11H4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11H4 Gene

OR11H4 (Olfactory Receptor Family 11 Subfamily H Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11H6.

UniProtKB/Swiss-Prot for OR11H4 Gene

  • Odorant receptor.

Gene Wiki entry for OR11H4 Gene

Additional gene information for OR11H4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR11H4 Gene

Genomics for OR11H4 Gene

Regulatory Elements for OR11H4 Gene

Enhancers for OR11H4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H020591 0.4 FANTOM5 13.2 +352.6 352586 0 IKZF1 OR4K17 OR6S1 RNASE12 OR11H6 OR4N5 OR11H4 RNASE8 EDDM3B RNASE9 RNASE13
GH14H020071 0.3 FANTOM5 6.4 -167.5 -167518 0 OR4K17 OR4K14 OR4L1 OR4Q3 OR11H4 OR11H6 OR4N5 OR4M1 OR4K5 OR4K1
GH14H020262 0.9 ENCODE 0.3 +23.6 23603 1 HDAC1 ZEB1 ZNF766 ATF7 IKZF2 CEBPB ZEB2 ZNF398 ZNF518A NFIC ENSG00000258515 METTL17 ENSG00000258768 OR11H4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR11H4 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR11H4 Gene

Chromosome:
14
Start:
20,239,286 bp from pter
End:
20,244,349 bp from pter
Size:
5,064 bases
Orientation:
Plus strand

Genomic View for OR11H4 Gene

Genes around OR11H4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR11H4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR11H4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR11H4 Gene

Proteins for OR11H4 Gene

  • Protein details for OR11H4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGC9-O11H4_HUMAN
    Recommended name:
    Olfactory receptor 11H4
    Protein Accession:
    Q8NGC9
    Secondary Accessions:
    • B2RNQ4
    • Q6IF07

    Protein attributes for OR11H4 Gene

    Size:
    324 amino acids
    Molecular mass:
    36886 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR11H4 Gene

Post-translational modifications for OR11H4 Gene

  • Glycosylation at Asn12
  • Modification sites at PhosphoSitePlus

Other Protein References for OR11H4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR11H4 Gene

Domains & Families for OR11H4 Gene

Gene Families for OR11H4 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR11H4 Gene

Suggested Antigen Peptide Sequences for OR11H4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGC9

UniProtKB/Swiss-Prot:

O11H4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR11H4: view

Function for OR11H4 Gene

Molecular function for OR11H4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR11H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G-protein coupled serotonin receptor activity IBA --
GO:0030594 neurotransmitter receptor activity IBA --
genes like me logo Genes that share ontologies with OR11H4: view
genes like me logo Genes that share phenotypes with OR11H4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR11H4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR11H4 Gene

Localization for OR11H4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11H4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR11H4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR11H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR11H4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR11H4 Gene

Pathways & Interactions for OR11H4 Gene

genes like me logo Genes that share pathways with OR11H4: view

Pathways by source for OR11H4 Gene

Interacting Proteins for OR11H4 Gene

Gene Ontology (GO) - Biological Process for OR11H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR11H4: view

No data available for SIGNOR curated interactions for OR11H4 Gene

Drugs & Compounds for OR11H4 Gene

No Compound Related Data Available

Transcripts for OR11H4 Gene

mRNA/cDNA for OR11H4 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR11H4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR11H4 Gene

No ASD Table

Relevant External Links for OR11H4 Gene

GeneLoc Exon Structure for
OR11H4
ECgene alternative splicing isoforms for
OR11H4

Expression for OR11H4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR11H4 Gene

mRNA differential expression in normal tissues according to GTEx for OR11H4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of OR11H4 Gene:

OR11H4

SOURCE GeneReport for Unigene cluster for OR11H4 Gene:

Hs.553767
genes like me logo Genes that share expression patterns with OR11H4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR11H4 Gene

Orthologs for OR11H4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR11H4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473319 33
  • 98.77 (n)
OR11H4 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR11H4 33 34
  • 88 (n)
dog
(Canis familiaris)
Mammalia OR11H4 34
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or11h4b 52 Olfr747 34
  • 87 (a)
OneToMany
Or11h4 52 Olfr749 33 16 34
  • 86.32 (n)
rat
(Rattus norvegicus)
Mammalia Olr1635 33
  • 83.95 (n)
oppossum
(Monodelphis domestica)
Mammalia OR11H4 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
OneToMany
Species where no ortholog for OR11H4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR11H4 Gene

ENSEMBL:
Gene Tree for OR11H4 (if available)
TreeFam:
Gene Tree for OR11H4 (if available)

Paralogs for OR11H4 Gene

Paralogs for OR11H4 Gene

(453) SIMAP similar genes for OR11H4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR11H4 Gene

genes like me logo Genes that share paralogs with OR11H4: view

Variants for OR11H4 Gene

Sequence variations from dbSNP and Humsavar for OR11H4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000287315 -- 20,241,761(+) TCAGC(-/A)AAAAA upstream-variant-2KB
rs1000357180 -- 20,241,958(+) CCAAC(A/C)TGTCT upstream-variant-2KB
rs1001020534 -- 20,241,008(+) AAGTA(C/G)ATACC upstream-variant-2KB
rs1001395304 -- 20,243,166(+) TTTCT(A/G)GCAGT reference, synonymous-codon
rs1001919550 -- 20,241,597(+) TTCTG(A/G)TCTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR11H4 Gene

Variant ID Type Subtype PubMed ID
dgv1797n100 CNV loss 25217958
esv2751268 CNV gain 17911159
esv3633679 CNV loss 21293372
esv3633681 CNV loss 21293372
esv3633682 CNV loss 21293372
nsv563845 CNV gain 21841781
nsv832739 CNV gain 17160897

Variation tolerance for OR11H4 Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.24; 62.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR11H4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR11H4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR11H4 Gene

Disorders for OR11H4 Gene

Relevant External Links for OR11H4

Genetic Association Database (GAD)
OR11H4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR11H4

No disorders were found for OR11H4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR11H4 Gene

Publications for OR11H4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for OR11H4 Gene

Sources for OR11H4 Gene

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