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OR11H4 Gene

protein-coding   GIFtS: 49
GCID: GC14P020710

Olfactory Receptor, Family 11, Subfamily H, Member 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 11, Subfamily H, Member 41 2
Olfactory Receptor OR14-362 3
OR14-362
Olfactory Receptor 11H42

External Ids:    HGNC: 153471   Entrez Gene: 3904422   Ensembl: ENSG000001761987   UniProtKB: Q8NGC93   

Export aliases for OR11H4 gene to outside databases

Previous GC identifers: GC14U990446 GC14P018703 GC14P019780


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR11H4 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR11H4 Gene:
OR11H4 (olfactory receptor, family 11, subfamily H, member 4) is a protein-coding gene. GO annotations related to this gene include serotonin receptor activity and olfactory receptor activity. An important paralog of this gene is OR6N1.

UniProtKB/Swiss-Prot: O11H4_HUMAN, Q8NGC9
Function: Odorant receptor (Potential)

Gene Wiki entry for OR11H4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR11H4 gene promoter:
         Tal-1   AML1a   POU3F1   HSF1 (long)   HSF1short   CUTL1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR11H4 promoter sequence
   Search Chromatin IP Primers for OR11H4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR11H4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

OR11H4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR11H4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P020710:  view genomic region     (about GC identifiers)

Start:
20,710,981 bp from pter      End:
20,711,922 bp from pter
Size:
942 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: O11H4_HUMAN, Q8NGC9 (See protein sequence)
Recommended Name: Olfactory receptor 11H4  
Size: 324 amino acids; 36886 Da
Secondary accessions: B2RNQ4 Q6IF07

Explore the universe of human proteins at neXtProt for OR11H4: NX_Q8NGC9

Explore proteomics data for OR11H4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn12
  • Modification sites at PhosphoSitePlus
  • HORDE protein sequence for OR11H4

    See OR11H4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004479.1  
    ENSEMBL proteins: 
     ENSP00000318997  
    Reactome Protein details: Q8NGC9

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR11: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGC9

    ProtoNet protein and cluster: Q8NGC9

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O11H4_HUMAN, Q8NGC9
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR11H4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O11H4_HUMAN, Q8NGC9
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR11H4           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O11H4_HUMAN, Q8NGC9: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR11H4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR11H4 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR11H4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR11H4
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR11H4):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR11H4
    Interactions:

        Search GeneGlobe Interaction Network for OR11H4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for OR11H4 (ENSP000003189974) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADRBK2ENSP000003175784STRING: ENSP00000317578
    ARRB2ENSP000002692604STRING: ENSP00000269260
    GNALENSP000003340514STRING: ENSP00000334051
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR11H4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for OR11H4 (O11H4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR11H4 gene: 
    NM_001004479.1  

    Unigene Cluster for OR11H4:

    Olfactory receptor, family 11, subfamily H, member 4
    Hs.553767
    Unigene Representative Sequence: BC137055
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000315409(uc010tld.2)
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    Additional mRNA sequence: 

    BC137054.1 BC137055.1 

    1 AceView cDNA sequence:

    NM_001004479 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR11H4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTCGCTC
    OR11H4 Expression
    About this image

    OR11H4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR11H4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553767
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR11H4 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr7475
    Olfr7491
    olfactory receptor 7475
    olfactory receptor 7491
    86.32(n)1
    89.1(a)1
      14 (26.20 cM)5
    568581  NM_020288.21  NP_064684.21 
     506806915 


    ENSEMBL Gene Tree for OR11H4 (if available)
    TreeFam Gene Tree for OR11H4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR11H4 gene
    OR6N12  OR6K32  OR6N22  OR11H72  OR6K22  OR11G22  OR11H122  OR11H62  
    OR6K62  OR11H12  
    Selected SIMAP similar genes for OR11H4 using alignment to 1 protein entry:     O11H4_HUMAN(see all similar genes):
    OR11H7    OR11H6    OR11H1    OR11H12    OR11H13P    OR11H2
    OR11G2    FKSG35    OR1F12    OR6N1    OR10R3P    OR11A1
    OR11L1    OR1D2    OR2A12    OR6N2    OR10R2    OR13C2

    Find genes that share paralogs with OR11H4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for OR11H4
    PGOHUM00000241542


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR11H4 (see all 190)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs619939101,2
    C,F--20708973(+) TCAGCG/AATCTA 1 -- us2k18Minor allele frequency- A:0.24NA WA CSA 249
    rs118469951,2
    C,F,H--20709015(+) TAGGCA/CTAAGA 1 -- us2k118Minor allele frequency- C:0.13NS EA NA WA CSA 2106
    rs1913898281,2
    --20709088(+) CAAGTA/GTAAGA 1 -- us2k10--------
    rs80140601,2
    C,F,A,H--20709118(+) TTTGTG/ATATTT 1 -- us2k118Minor allele frequency- A:0.17NS EA NA WA CSA 1935
    rs1841261601,2
    --20709158(+) GCTACG/TGAAAA 1 -- us2k10--------
    rs1146911411,2
    F--20709204(+) CCTTCC/TTTTCA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1488263251,2
    --20709208(+) CCTTTC/TAGTAA 1 -- us2k10--------
    rs80144131,2
    C,F,H--20709331(+) GTATAG/CAAAAC 1 -- us2k17Minor allele frequency- C:0.05NS EA NA WA 540
    rs1434792371,2
    --20709385(+) GTAAGA/GTAGTT 1 -- us2k10--------
    rs1480131351,2
    --20709405(+) ATAGTA/GTGTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR11H4 ( 20710981 - 20711922 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for OR11H4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901299CNV Gain21882294
    nsv832739CNV Gain17160897
    nsv901467CNV Gain21882294
    esv2751268CNV Gain17911159

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR11H4           About GenesLikeMe

    Genetic Association Database (GAD): OR11H4

    Export disorders for OR11H4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR11H4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR11H4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390442 HGNC: 15347 AceView: OR11H4 Ensembl:ENSG00000176198 euGenes: HUgn390442
    ECgene: OR11H4 Kegg: 390442 H-InvDB: OR11H4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR11H4 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR11H4 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR11H4 gene:
    Search GeneIP for patents involving OR11H4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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