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Aliases for OR11H4 Gene

Aliases for OR11H4 Gene

  • Olfactory Receptor, Family 11, Subfamily H, Member 4 2 3
  • Olfactory Receptor OR14-36 3 4
  • Olfactory Receptor 11H4 3
  • OR14-36 3

External Ids for OR11H4 Gene

Summaries for OR11H4 Gene

Entrez Gene Summary for OR11H4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11H4 Gene

OR11H4 (Olfactory Receptor, Family 11, Subfamily H, Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include olfactory receptor activity and serotonin receptor activity. An important paralog of this gene is OR6N1.

UniProtKB/Swiss-Prot for OR11H4 Gene

  • Odorant receptor.

Gene Wiki entry for OR11H4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR11H4 Gene

Genomics for OR11H4 Gene

Genomic Location for OR11H4 Gene

Start:
20,242,739 bp from pter
End:
20,243,820 bp from pter
Size:
1,082 bases
Orientation:
Plus strand

Genomic View for OR11H4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR11H4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR11H4 Gene

Regulatory Elements for OR11H4 Gene

Proteins for OR11H4 Gene

  • Protein details for OR11H4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGC9-O11H4_HUMAN
    Recommended name:
    Olfactory receptor 11H4
    Protein Accession:
    Q8NGC9
    Secondary Accessions:
    • B2RNQ4
    • Q6IF07

    Protein attributes for OR11H4 Gene

    Size:
    324 amino acids
    Molecular mass:
    36886 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR11H4 Gene

Proteomics data for OR11H4 Gene at MOPED

Post-translational modifications for OR11H4 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn12

Other Protein References for OR11H4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR11H4 Gene

Domains for OR11H4 Gene

Gene Families for OR11H4 Gene

HGNC:
  • OR11 :GPCR / Class A : Olfactory receptors

Protein Domains for OR11H4 Gene

Suggested Antigen Peptide Sequences for OR11H4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGC9

UniProtKB/Swiss-Prot:

O11H4_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGC9
genes like me logo Genes that share domains with OR11H4: view

Function for OR11H4 Gene

Molecular function for OR11H4 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR11H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR11H4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR11H4 Gene

Localization for OR11H4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11H4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR11H4 Gene COMPARTMENTS Subcellular localization image for OR11H4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR11H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR11H4: view

Pathways for OR11H4 Gene

genes like me logo Genes that share pathways with OR11H4: view

Pathways by source for OR11H4 Gene

Interacting Proteins for OR11H4 Gene

Gene Ontology (GO) - Biological Process for OR11H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR11H4: view

Transcripts for OR11H4 Gene

mRNA/cDNA for OR11H4 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR11H4 Gene

No ASD Table

Relevant External Links for OR11H4 Gene

GeneLoc Exon Structure for
OR11H4
ECgene alternative splicing isoforms for
OR11H4

Expression for OR11H4 Gene

mRNA expression in normal human tissues for OR11H4 Gene

mRNA differential expression in normal tissues according to GTEx for OR11H4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.3).

SOURCE GeneReport for Unigene cluster for OR11H4 Gene Hs.553767

genes like me logo Genes that share expressions with OR11H4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for OR11H4 Gene

Orthologs for OR11H4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR11H4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473319 35
  • 98.77 (n)
  • 98.15 (a)
OR11H4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR11H4 35
  • 88 (n)
  • 86.62 (a)
OR11H4 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR11H4 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr747 16
Olfr747 36
  • 87 (a)
OneToMany
Olfr749 35
  • 86.32 (n)
  • 89.1 (a)
Olfr749 36
  • 89 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia OR11H4 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr1635 35
  • 83.95 (n)
  • 85.4 (a)
Species with no ortholog for OR11H4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR11H4 Gene

ENSEMBL:
Gene Tree for OR11H4 (if available)
TreeFam:
Gene Tree for OR11H4 (if available)

Paralogs for OR11H4 Gene

Paralogs for OR11H4 Gene

Selected SIMAP similar genes for OR11H4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR11H4 Gene

genes like me logo Genes that share paralogs with OR11H4: view

Variants for OR11H4 Gene

Sequence variations from dbSNP and Humsavar for OR11H4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7148414 -- 20,241,656(+) agaaa(C/T)aacag upstream-variant-2KB
rs7156806 -- 20,241,529(+) AAATA(A/C)ATTTG upstream-variant-2KB
rs8004950 -- 20,241,786(+) gagca(C/G)ggtga upstream-variant-2KB
rs8005108 -- 20,241,834(+) agaat(C/G)tatgt upstream-variant-2KB
rs8005314 -- 20,241,954(+) actgc(A/C)aacat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR11H4 Gene

Variant ID Type Subtype PubMed ID
nsv901299 CNV Gain 21882294
esv2751268 CNV Gain 17911159
nsv832739 CNV Gain 17160897
nsv901467 CNV Gain 21882294

Relevant External Links for OR11H4 Gene

HapMap Linkage Disequilibrium report
OR11H4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR11H4 Gene

Disorders for OR11H4 Gene

Relevant External Links for OR11H4

Genetic Association Database (GAD)
OR11H4
genes like me logo Genes that share disorders with OR11H4: view

No data available for UniProtKB/Swiss-Prot for OR11H4 Gene

Publications for OR11H4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR11H4 Gene

Sources for OR11H4 Gene

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