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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR11H2 Gene

protein-coding   GIFtS: 30
GCID: GC14M020180          (predicted)

Olfactory Receptor, Family 11, Subfamily H, Member 2

(Previous names: olfactory receptor, family 11, subfamily H, member 8 pseudogene)
(Previous symbols: OR11H2P, OR11H8P, C14orf15)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 11, Subfamily H, Member 21 2     Olfactory Receptor OR14-12 3
C14orf151 2 3     Olfactory Receptor 11H22
OR11H2P1 2 3     Olfactory Receptor, Family 11, Subfamily H, Member 2 Pseudogene2
OR11H8P1 2     Seven Transmembrane Helix Receptor2
Olfactory Receptor, Family 11, Subfamily H, Member 8 Pseudogene1 2     

External Ids:    HGNC: 147161   Entrez Gene: 793342   Ensembl: ENSG000002584537   UniProtKB: Q8NH073   

Export aliases for OR11H2 gene to outside databases

Previous GC identifers: GC13U900259 GC14M019252


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR11H2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR11H2 Gene: 
OR11H2 (olfactory receptor, family 11, subfamily H, member 2) is a protein-coding gene. Diseases associated with OR11H2 include neuronitis, and among its related super-pathways are Signaling by GPCR and Olfactory transduction. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11H1.

UniProtKB/Swiss-Prot: O11H2_HUMAN, Q8NH07
Function: Odorant receptor (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for OR11H2
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR11H2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

OR11H2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR11H2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M020180:  view genomic region     (about GC identifiers)

Start:
20,181,098 bp from pter      End:
20,182,042 bp from pter
Size:
945 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: O11H2_HUMAN, Q8NH07 (See protein sequence)
Recommended Name: Olfactory receptor 11H2  
Size: 326 amino acids; 36531 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (Potential)
Caution: It is uncertain whether Met-1 or Met-12 is the initiator

Explore the universe of human proteins at neXtProt for OR11H2: NX_Q8NH07

HORDE protein sequence for OR11H2
OR11H2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_001184216.1  Reactome Protein details: Q8NH07
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

OR11H2 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
OR11: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NH07

ProtoNet protein and cluster: Q8NH07

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O11H2_HUMAN, Q8NH07
Similarity: Belongs to the G-protein coupled receptor 1 family


OR11H2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: O11H2_HUMAN, Q8NH07
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
OR11H2 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OR11H2 About                                                                                                See pathways by source

SuperPathContained pathways About
1Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
2Olfactory transduction
Olfactory Signaling Pathway0.81

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


4        Reactome Pathways for OR11H2
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR



OR11H2 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR11H2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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Search CenterWatch for drugs/clinical trials and news about OR11H2 / O11H2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OR11H2 gene: 
NM_001197287.1  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000556246
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR11H2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
OR11H2 Expression
About this image

    SABiosciences Custom PCR Arrays for OR11H2
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of mammals.

Orthologs for OR11H2 gene from 1/3 species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia LOC1006860061 olfactory receptor 11H12-like 86.4(n)
80.69(a)
  100686006  XM_003431966.2  XP_003432014.2 


ENSEMBL Gene Tree for OR11H2 (if available)
TreeFam Gene Tree for OR11H2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OR11H2 gene
OR11H1  OR11H12  
18/450 SIMAP similar genes for OR11H2 using alignment to 1 protein entry:     O11H2_HUMAN(see all similar genes):
OR11H1    OR11H12    OR11H13P    OR11H6    OR11G2    OR11H4
OR11H7    FKSG35    OR2A12    OR6C70    OR6M1    OR6N1
OR2A2    OR2A5    OR5AR1    OR5F1    OR6C3    OR6F1

OR11H2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/45 SNPs in OR11H2 are shown (see all 45)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1995188001,2
F--20181174(+) GGGGAT/CTGAAG 2 /N /S mis11Minor allele frequency- C:0.01EU 589
rs2000934741,2
C,F--20181271(+) AAGAGG/AGCTAT 2 /P /S mis11Minor allele frequency- A:0.01EU 491
rs2010202811,2
C,F--20181274(+) AGGGCT/CATAGC 2 /S /G mis11Minor allele frequency- C:0.01EU 525
rs1816438441,2
--20181279(+) TATAGA/CACAGT 2 C F mis10--------
rs2003704131,2
C--20181357(+) CCAACA/CCAGCT 2 G V mis10--------
rs2010240811,2
C--20181502(+) CACAAC/TATGGT 2 I V mis10--------
rs1995861391,2
C,F--20181534(+) AGGGCT/ATCTGA 2 /K /M mis11Minor allele frequency- A:0.02EU 191
rs2016564551,2
F--20181609(+) TGGCAT/CAGAGA 2 /Y /C mis11Minor allele frequency- C:0.19EU 393
rs619796101,2
C,F--20181930(+) CATATA/GTTGTA 2 T I mis11Minor allele frequency- G:0.25EU 333
rs1467892131,2
--20183061(+) TTACTG/TTAATT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for OR11H2 ( 20181098 - 20182042 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/40 variations for OR11H2 (see all 40):    About this table     
Variant IDTypeSubtypePubMed ID
esv2748433CNV Deletion23290073
dgv6n31CNV Duplication19718026
nsv436829CNV Insertion17901297
nsv819711CNV Loss19587683
nsv901198CNV Loss21882294
dgv45e180CNV Loss20482838
nsv901192CNV Loss21882294
nsv901139CNV Loss21882294
dgv1833n71CNV Loss21882294
dgv1828n71CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for OR11H2:    About MalaCards
neuronitis    


OR11H2 for disorders           About GeneDecksing


Export disorders for OR11H2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OR11H2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR11H2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
  2. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 79334 HGNC: 14716 Ensembl:ENSG00000258453 euGenes: HUgn79334 ECgene: OR11H2
H-InvDB: OR11H2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR11H2 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR11H2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR11H2 gene:
Search GeneIP for patents involving OR11H2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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 Proteins for OR11H2
 Antibodies for OR11H2
 ELISAs for OR11H2
 CLIAs for OR11H2
 Search LifeMap BioReagents cell lines for OR11H2
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR11H2
 Browse SwitchGear 3'UTR luciferase reporter plasmids for OR11H2
 Browse SwitchGear Promoter luciferase reporter plasmids for OR11H2
 Search ThermoFisher Antibodies for OR11H2
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OR11H2
 inGenious Targeting Laboratory - Custom generated mouse model solutions for OR11H2
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OR11H2
Customized:
 lentivirus for stable overexpression of OR11H2
 lentivirus expression plasmids for stable overexpression of OR11H2
 adenovirus for overexpression of OR11H2
 Search LSBio for Antibodies for OR11H2
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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