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Aliases for OR11H12 Gene

Aliases for OR11H12 Gene

  • Olfactory Receptor, Family 11, Subfamily H, Member 12 2 3

External Ids for OR11H12 Gene

Summaries for OR11H12 Gene

Entrez Gene Summary for OR11H12 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11H12 Gene

OR11H12 (Olfactory Receptor, Family 11, Subfamily H, Member 12) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6N1.

UniProtKB/Swiss-Prot for OR11H12 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR11H12 Gene

Genomics for OR11H12 Gene

Genomic Location for OR11H12 Gene

Start:
18,601,045 bp from pter
End:
18,602,129 bp from pter
Size:
1,085 bases
Orientation:
Plus strand

Genomic View for OR11H12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR11H12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR11H12 Gene

Regulatory Elements for OR11H12 Gene

Proteins for OR11H12 Gene

  • Protein details for OR11H12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B2RN74-O11HC_HUMAN
    Recommended name:
    Olfactory receptor 11H12
    Protein Accession:
    B2RN74
    Secondary Accessions:

    Protein attributes for OR11H12 Gene

    Size:
    326 amino acids
    Molecular mass:
    36530 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR11H12 Gene

Proteomics data for OR11H12 Gene at MOPED

Post-translational modifications for OR11H12 Gene

  • Glycosylation at Asn13, Asn18, and Asn106

Other Protein References for OR11H12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OR11H12 Gene

Domains for OR11H12 Gene

Gene Families for OR11H12 Gene

HGNC:
  • OR11 :GPCR / Class A : Olfactory receptors

Protein Domains for OR11H12 Gene

Suggested Antigen Peptide Sequences for OR11H12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B2RN74

UniProtKB/Swiss-Prot:

O11HC_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • B2RN74
genes like me logo Genes that share domains with OR11H12: view

Function for OR11H12 Gene

Molecular function for OR11H12 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR11H12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR11H12: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR11H12 Gene

Localization for OR11H12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11H12 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR11H12 Gene COMPARTMENTS Subcellular localization image for OR11H12 gene
Compartment Confidence
plasma membrane 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for OR11H12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR11H12: view

Pathways for OR11H12 Gene

genes like me logo Genes that share pathways with OR11H12: view

Pathways by source for OR11H12 Gene

1 KEGG pathway for OR11H12 Gene

Interacting Proteins for OR11H12 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000449002%0d%0a9606.ENSP00000334051%0d%0a9606.ENSP00000269260%0d%0a9606.ENSP00000317578%0d%0a
Selected Interacting proteins: ENSP00000449002 for OR11H12 Gene via STRING

Gene Ontology (GO) - Biological Process for OR11H12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR11H12: view

Transcripts for OR11H12 Gene

mRNA/cDNA for OR11H12 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR11H12 Gene

No ASD Table

Relevant External Links for OR11H12 Gene

GeneLoc Exon Structure for
OR11H12
ECgene alternative splicing isoforms for
OR11H12

Expression for OR11H12 Gene

mRNA expression in normal human tissues for OR11H12 Gene

SOURCE GeneReport for Unigene cluster for OR11H12 Gene Hs.534880

genes like me logo Genes that share expressions with OR11H12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR11H12 Gene

Orthologs for OR11H12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR11H12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
LOC740929 35
  • 98.57 (n)
  • 96.63 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 82 (a)
ManyToMany
-- 36
  • 78 (a)
ManyToMany
LOC784332 35
  • 86.29 (n)
  • 81.93 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 62 (a)
ManyToMany
LOC102153096 35
  • 87.9 (n)
  • 85.08 (a)
mouse
(Mus musculus)
Mammalia Olfr736 36
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
Species with no ortholog for OR11H12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR11H12 Gene

ENSEMBL:
Gene Tree for OR11H12 (if available)
TreeFam:
Gene Tree for OR11H12 (if available)

Paralogs for OR11H12 Gene

Paralogs for OR11H12 Gene

Selected SIMAP similar genes for OR11H12 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR11H12 Gene

genes like me logo Genes that share paralogs with OR11H12: view

Variants for OR11H12 Gene

Sequence variations from dbSNP and Humsavar for OR11H12 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2212201 -- 18,601,712(-) CAAAT(A/C)GTGGC reference, missense
rs2257456 -- 18,600,841(-) TGATT(G/T)AATAT upstream-variant-2KB
rs61969156 -- 18,601,382(+) GTATG(C/T)CTCTT missense, reference
rs61969158 -- 18,601,835(+) AGCTG(G/T)GTTGG missense, reference
rs78043369 -- 18,601,195(+) ATGAA(C/T)TTATA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for OR11H12 Gene

Variant ID Type Subtype PubMed ID
esv23873 CNV Gain+Loss 19812545
esv33527 CNV Gain+Loss 17666407
nsv819711 CNV Loss 19587683
nsv9117 CNV Gain+Loss 18304495

Relevant External Links for OR11H12 Gene

HapMap Linkage Disequilibrium report
OR11H12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR11H12 Gene

Disorders for OR11H12 Gene

No disorders were found for OR11H12 Gene.

No data available for UniProtKB/Swiss-Prot for OR11H12 Gene

Publications for OR11H12 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for OR11H12 Gene

  • antibodies-online peptides for OR11H12
  • antibodies-online antibodies for OR11H12
  • antibodies-online kits for OR11H12

Sources for OR11H12 Gene

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