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Aliases for OR11G2 Gene

Aliases for OR11G2 Gene

  • Olfactory Receptor Family 11 Subfamily G Member 2 2 3 5
  • Olfactory Receptor OR14-34 3 4
  • Olfactory Receptor, Family 11, Subfamily G, Member 2 2
  • Olfactory Receptor 11G2 3
  • OR14-34 3

External Ids for OR11G2 Gene

Previous GeneCards Identifiers for OR11G2 Gene

  • GC14U990447
  • GC14P018646
  • GC14P019737
  • GC14P020666

Summaries for OR11G2 Gene

Entrez Gene Summary for OR11G2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11G2 Gene

OR11G2 (Olfactory Receptor Family 11 Subfamily G Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11H6.

UniProtKB/Swiss-Prot for OR11G2 Gene

  • Odorant receptor.

Gene Wiki entry for OR11G2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR11G2 Gene

Genomics for OR11G2 Gene

Regulatory Elements for OR11G2 Gene

Enhancers for OR11G2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F020453 1.2 ENCODE 16.2 +258.2 258207 3.9 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 OSGEP SUPT16H ENSG00000258515 APEX1 TMEM55B TEP1 RNASE9 RNASE12 LOC105370394 OR11G2
GH14F020530 1.1 Ensembl ENCODE 16.2 +333.8 333765 0.6 NFXL1 YBX1 ZNF2 RAD21 ZNF366 GATA2 ETV6 FOS ZNF654 SP3 RNASE9 RNASE12 LOC105370394 OR11G2 CKAP2P1 OR11K2P OR4H12P OR4N2 OR4K6P OR4Q3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR11G2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR11G2 Gene

Chromosome:
14
Start:
20,197,336 bp from pter
End:
20,198,446 bp from pter
Size:
1,111 bases
Orientation:
Plus strand

Genomic View for OR11G2 Gene

Genes around OR11G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR11G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR11G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR11G2 Gene

Proteins for OR11G2 Gene

  • Protein details for OR11G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGC1-O11G2_HUMAN
    Recommended name:
    Olfactory receptor 11G2
    Protein Accession:
    Q8NGC1
    Secondary Accessions:
    • Q6IF09
    • Q96R33

    Protein attributes for OR11G2 Gene

    Size:
    345 amino acids
    Molecular mass:
    38871 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC06113.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR11G2 Gene

Post-translational modifications for OR11G2 Gene

  • Glycosylation at Asn 43
  • Modification sites at PhosphoSitePlus

Other Protein References for OR11G2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR11G2 Gene

Domains & Families for OR11G2 Gene

Gene Families for OR11G2 Gene

Protein Domains for OR11G2 Gene

Suggested Antigen Peptide Sequences for OR11G2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGC1

UniProtKB/Swiss-Prot:

O11G2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR11G2: view

Function for OR11G2 Gene

Molecular function for OR11G2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR11G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR11G2: view

Phenotypes for OR11G2 Gene

genes like me logo Genes that share phenotypes with OR11G2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR11G2 Gene

Localization for OR11G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11G2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR11G2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR11G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR11G2: view

Pathways & Interactions for OR11G2 Gene

genes like me logo Genes that share pathways with OR11G2: view

Pathways by source for OR11G2 Gene

Gene Ontology (GO) - Biological Process for OR11G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR11G2: view

No data available for SIGNOR curated interactions for OR11G2 Gene

Transcripts for OR11G2 Gene

mRNA/cDNA for OR11G2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR11G2 Gene

No ASD Table

Relevant External Links for OR11G2 Gene

GeneLoc Exon Structure for
OR11G2
ECgene alternative splicing isoforms for
OR11G2

Expression for OR11G2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR11G2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR11G2 Gene:

OR11G2

SOURCE GeneReport for Unigene cluster for OR11G2 Gene:

Hs.554582
genes like me logo Genes that share expression patterns with OR11G2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR11G2 Gene

Orthologs for OR11G2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR11G2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC473316 34
  • 98.82 (n)
cow
(Bos Taurus)
Mammalia OR11G2 34
  • 87.99 (n)
-- 35
  • 83 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC482549 34
  • 86.13 (n)
OR11G2 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or11g2 55 Olfr744 34 16
  • 85.12 (n)
Or11g26 55 Olfr742 35
  • 74 (a)
OneToMany
Or11g1 55 Olfr738
  • chr14:50,413,546-50,414,478
Or11g25 55 Olfr741
  • chr14:50,485,460-50,486,392
rat
(Rattus norvegicus)
Mammalia Olr1620 34
  • 84 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 77 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 62 (a)
OneToMany
Species where no ortholog for OR11G2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR11G2 Gene

ENSEMBL:
Gene Tree for OR11G2 (if available)
TreeFam:
Gene Tree for OR11G2 (if available)

Paralogs for OR11G2 Gene

(456) SIMAP similar genes for OR11G2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR11G2 Gene

genes like me logo Genes that share paralogs with OR11G2: view

Variants for OR11G2 Gene

Sequence variations from dbSNP and Humsavar for OR11G2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs112339930 -- 20,197,156(+) ACCTA(A/G)TAAAA upstream-variant-2KB
rs112959092 -- 20,198,117(+) CGTGA(A/G)AGCTG reference, missense
rs113533026 -- 20,196,514(+) AAGGC(A/G)TCATG upstream-variant-2KB
rs113709506 -- 20,198,677(+) TGAGC(C/T)GAGAT downstream-variant-500B
rs113796851 -- 20,198,684(+) AGATC(C/G)CGCCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR11G2 Gene

Variant ID Type Subtype PubMed ID
dgv3532n54 CNV loss 21841781
esv2751268 CNV gain 17911159
nsv832739 CNV gain 17160897
nsv1037890 CNV gain 25217958
esv3580929 CNV loss 25503493
esv2761819 CNV loss 21179565

Variation tolerance for OR11G2 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.07; 99.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR11G2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR11G2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR11G2 Gene

Disorders for OR11G2 Gene

Relevant External Links for OR11G2

Genetic Association Database (GAD)
OR11G2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR11G2

No disorders were found for OR11G2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR11G2 Gene

Publications for OR11G2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4 64

Products for OR11G2 Gene

Sources for OR11G2 Gene

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