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Aliases for OR11A1 Gene

Aliases for OR11A1 Gene

  • Olfactory Receptor, Family 11, Subfamily A, Member 1 2 3
  • Olfactory Receptor, Family 11, Subfamily A, Member 2 2 3
  • Olfactory Receptor OR6-30 3 4
  • Olfactory Receptor 11A2 3 4
  • Hs6M1-18 3 4
  • OR11A2 3 4
  • Olfactory Receptor 11A1 3
  • DJ994E9.6 3
  • 6M1-18 3

External Ids for OR11A1 Gene

Previous HGNC Symbols for OR11A1 Gene

  • OR11A2

Previous GeneCards Identifiers for OR11A1 Gene

  • GC06M029451
  • GC06M029165
  • GC06M029501
  • GC06M029432
  • GC06M029393
  • GC06Mo29324

Summaries for OR11A1 Gene

Entrez Gene Summary for OR11A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11A1 Gene

OR11A1 (Olfactory Receptor, Family 11, Subfamily A, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR11A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR11A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR11A1 Gene

Genomics for OR11A1 Gene

Regulatory Elements for OR11A1 Gene

Genomic Location for OR11A1 Gene

Start:
29,425,504 bp from pter
End:
29,457,071 bp from pter
Size:
31,568 bases
Orientation:
Minus strand

Genomic View for OR11A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR11A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR11A1 Gene

  • Protein details for OR11A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZK7-O11A1_HUMAN
    Recommended name:
    Olfactory receptor 11A1
    Protein Accession:
    Q9GZK7
    Secondary Accessions:
    • A2BF33
    • A6NFQ3
    • B0S7T2
    • Q5ST16
    • Q9GZK8

    Protein attributes for OR11A1 Gene

    Size:
    315 amino acids
    Molecular mass:
    35250 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR11A1 Gene

Proteomics data for OR11A1 Gene at MOPED

Post-translational modifications for OR11A1 Gene

  • Glycosylation at Asn8
  • Modification sites at PhosphoSitePlus

Other Protein References for OR11A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR11A1 Gene

Domains for OR11A1 Gene

Gene Families for OR11A1 Gene

HGNC:
  • OR11 :GPCR / Class A : Olfactory receptors

Protein Domains for OR11A1 Gene

Suggested Antigen Peptide Sequences for OR11A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZK7

UniProtKB/Swiss-Prot:

O11A1_HUMAN :
  • Q9GZK7
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR11A1: view

Function for OR11A1 Gene

Molecular function for OR11A1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 11,subfamily A,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR11A1: view

Phenotypes for OR11A1 Gene

genes like me logo Genes that share phenotypes with OR11A1: view

Animal Model Products

CRISPR Products

miRNA for OR11A1 Gene

miRTarBase miRNAs that target OR11A1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OR11A1 Gene

Localization for OR11A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR11A1 Gene COMPARTMENTS Subcellular localization image for OR11A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR11A1: view

Pathways for OR11A1 Gene

genes like me logo Genes that share pathways with OR11A1: view

Pathways by source for OR11A1 Gene

1 BioSystems pathway for OR11A1 Gene
1 KEGG pathway for OR11A1 Gene

Interacting Proteins for OR11A1 Gene

Gene Ontology (GO) - Biological Process for OR11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR11A1: view

Transcripts for OR11A1 Gene

mRNA/cDNA for OR11A1 Gene

(9) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR11A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR11A1 Gene

No ASD Table

Relevant External Links for OR11A1 Gene

GeneLoc Exon Structure for
OR11A1
ECgene alternative splicing isoforms for
OR11A1

Expression for OR11A1 Gene

mRNA expression in normal human tissues for OR11A1 Gene

mRNA differential expression in normal tissues according to GTEx for OR11A1 Gene

This gene is overexpressed in Testis (36.8).

Protein differential expression in normal tissues for OR11A1 Gene

This gene is overexpressed in Stomach (44.8) and Frontal cortex (24.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for OR11A1 Gene

SOURCE GeneReport for Unigene cluster for OR11A1 Gene Hs.676010

genes like me logo Genes that share expressions with OR11A1: view

Expression partners for OR11A1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR11A1 Gene

Orthologs for OR11A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR11A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC523389 35
  • 84.55 (n)
  • 81.59 (a)
-- 36
  • 76 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr96 35
  • 79.17 (n)
  • 74.68 (a)
Olfr96 16
Olfr96 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC471941 35
  • 97.67 (n)
  • 96.19 (a)
OR11A1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1743 35
  • 78.31 (n)
  • 74.36 (a)
dog
(Canis familiaris)
Mammalia OR28H03 36
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR11A1 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves OR11A1 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
-- 36
  • 45 (a)
OneToMany
Species with no ortholog for OR11A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR11A1 Gene

ENSEMBL:
Gene Tree for OR11A1 (if available)
TreeFam:
Gene Tree for OR11A1 (if available)

Paralogs for OR11A1 Gene

Selected SIMAP similar genes for OR11A1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OR11A1 Gene

genes like me logo Genes that share paralogs with OR11A1: view

No data available for Paralogs for OR11A1 Gene

Variants for OR11A1 Gene

Sequence variations from dbSNP and Humsavar for OR11A1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1419647 -- 29,454,907(-) CGAGA(A/C)GCGAT intron-variant
rs1535039 -- 29,443,655(+) tgggg(C/T)aaata intron-variant
rs2021078 -- 29,445,191(-) CGTCT(C/T)TACTA intron-variant
rs2023463 -- 29,445,226(-) AGTTC(A/G)AGACC intron-variant
rs2074470 -- 29,426,650(-) CTCCA(C/T)TGGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OR11A1 Gene

Variant ID Type Subtype PubMed ID
nsv830624 CNV Loss 17160897

Relevant External Links for OR11A1 Gene

HapMap Linkage Disequilibrium report
OR11A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR11A1 Gene

Disorders for OR11A1 Gene

Relevant External Links for OR11A1

Genetic Association Database (GAD)
OR11A1
Human Genome Epidemiology (HuGE) Navigator
OR11A1

No disorders were found for OR11A1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for OR11A1 Gene

Publications for OR11A1 Gene

  1. Complex transcription and splicing of odorant receptor genes. (PMID: 12637542) Volz A. … Ziegler A. (J. Biol. Chem. 2003) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for OR11A1 Gene

Sources for OR11A1 Gene

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