Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR11A1 Gene

Aliases for OR11A1 Gene

  • Olfactory Receptor Family 11 Subfamily A Member 1 2 3 5
  • Olfactory Receptor, Family 11, Subfamily A, Member 2 2 3
  • Olfactory Receptor OR6-30 3 4
  • Olfactory Receptor 11A2 3 4
  • Hs6M1-18 3 4
  • OR11A2 3 4
  • Olfactory Receptor, Family 11, Subfamily A, Member 1 2
  • Olfactory Receptor 11A1 3
  • DJ994E9.6 3
  • 6M1-18 3

External Ids for OR11A1 Gene

Previous HGNC Symbols for OR11A1 Gene

  • OR11A2

Previous GeneCards Identifiers for OR11A1 Gene

  • GC06M029451
  • GC06M029165
  • GC06M029501
  • GC06M029432
  • GC06M029393
  • GC06Mo29324

Summaries for OR11A1 Gene

Entrez Gene Summary for OR11A1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR11A1 Gene

OR11A1 (Olfactory Receptor Family 11 Subfamily A Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR11A1 Gene

  • Odorant receptor.

Gene Wiki entry for OR11A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR11A1 Gene

Genomics for OR11A1 Gene

Regulatory Elements for OR11A1 Gene

Enhancers for OR11A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F028586 1.2 ENCODE 16.2 +869.9 869906 1.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GPX6 GPX5 ZNF603P ZNF90P2 KRT18P1 OR2W1 OR2AD1P OR2P1P ENSG00000228364 OR2B3
GH06F030194 1.1 ENCODE 16.2 -738.3 -738257 1.6 ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF302 SP3 SP5 MXD4 ZHX2 HCG18 GTF2H4 PPP1R10 ETF1P1 DHX16 PAIP1P1 ZNRD1ASP HCG4P7 TRIM31 GNL1
GH06F029509 0.5 FANTOM5 10.8 -52.2 -52239 0.1 IKZF1 EBF1 RELA LINC01015 OR11A1 OR2H1 OR5V1 OR10C1 OR2H2 PIRC24 LOC105375009
GH06F029467 0.3 FANTOM5 11.6 -10.6 -10629 0.3 OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2 OR5V1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR11A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR11A1 Gene

29,425,504 bp from pter
29,457,071 bp from pter
31,568 bases
Minus strand

Genomic View for OR11A1 Gene

Genes around OR11A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR11A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR11A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR11A1 Gene

  • Protein details for OR11A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 11A1
    Protein Accession:
    Secondary Accessions:
    • A2BF33
    • A6NFQ3
    • B0S7T2
    • Q5ST16
    • Q9GZK8

    Protein attributes for OR11A1 Gene

    315 amino acids
    Molecular mass:
    35250 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR11A1 Gene

Post-translational modifications for OR11A1 Gene

  • Glycosylation at Asn 8
  • Modification sites at PhosphoSitePlus

Other Protein References for OR11A1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR11A1 Gene

Domains & Families for OR11A1 Gene

Gene Families for OR11A1 Gene

Protein Domains for OR11A1 Gene

Suggested Antigen Peptide Sequences for OR11A1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR11A1: view

Function for OR11A1 Gene

Molecular function for OR11A1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 11,subfamily A,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR11A1: view
genes like me logo Genes that share phenotypes with OR11A1: view

Animal Model Products

miRNA for OR11A1 Gene

miRTarBase miRNAs that target OR11A1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR11A1 Gene

Localization for OR11A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR11A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR11A1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR11A1: view

Pathways & Interactions for OR11A1 Gene

genes like me logo Genes that share pathways with OR11A1: view

Pathways by source for OR11A1 Gene

1 BioSystems pathway for OR11A1 Gene
1 KEGG pathway for OR11A1 Gene

Interacting Proteins for OR11A1 Gene

Gene Ontology (GO) - Biological Process for OR11A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR11A1: view

No data available for SIGNOR curated interactions for OR11A1 Gene

Transcripts for OR11A1 Gene

mRNA/cDNA for OR11A1 Gene

(1) REFSEQ mRNAs :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR11A1 Gene

No ASD Table

Relevant External Links for OR11A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR11A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR11A1 Gene

mRNA differential expression in normal tissues according to GTEx for OR11A1 Gene

This gene is overexpressed in Testis (x36.8).

Protein differential expression in normal tissues from HIPED for OR11A1 Gene

This gene is overexpressed in Stomach (44.8) and Frontal cortex (24.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR11A1 Gene

Protein tissue co-expression partners for OR11A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR11A1 Gene:


SOURCE GeneReport for Unigene cluster for OR11A1 Gene:

genes like me logo Genes that share expression patterns with OR11A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR11A1 Gene

Orthologs for OR11A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR11A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC471941 34
  • 97.67 (n)
OR11A1 35
  • 96 (a)
(Bos Taurus)
Mammalia LOC523389 34
  • 84.55 (n)
-- 35
  • 79 (a)
-- 35
  • 76 (a)
(Mus musculus)
Mammalia Or11a4 55 Olfr96 34 16 35
  • 79.17 (n)
Or11a2-ps 55 Olfr754-ps1
  • chr17:37,250,213-37,250,888
Or11a3-ps 55 Olfr755-ps1
  • chr17:37,277,435-37,278,087
Or11a5-ps 55 Olfr759-ps1
  • chr17:37,407,837-37,408,481
Or11a6-ps 55 Olfr760-ps1
  • chr17:37,451,436-37,452,000
(Rattus norvegicus)
Mammalia Olr1743 34
  • 78.31 (n)
(Monodelphis domestica)
Mammalia OR11A1 35
  • 74 (a)
(Canis familiaris)
Mammalia OR28H03 35
  • 52 (a)
(Gallus gallus)
Aves OR11A1 35
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 46 (a)
-- 35
  • 45 (a)
-- 35
  • 45 (a)
-- 35
  • 44 (a)
-- 35
  • 44 (a)
-- 35
  • 44 (a)
-- 35
  • 43 (a)
Species where no ortholog for OR11A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR11A1 Gene

Gene Tree for OR11A1 (if available)
Gene Tree for OR11A1 (if available)

Paralogs for OR11A1 Gene

(456) SIMAP similar genes for OR11A1 Gene using alignment to 2 proteins: Pseudogenes for OR11A1 Gene

genes like me logo Genes that share paralogs with OR11A1: view

No data available for Paralogs for OR11A1 Gene

Variants for OR11A1 Gene

Sequence variations from dbSNP and Humsavar for OR11A1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10946990 -- 29,428,869(+) TGTAA(C/T)TGAGC intron-variant, upstream-variant-2KB
rs111422349 -- 29,428,165(+) TCATT(A/C)TCTCA intron-variant, upstream-variant-2KB
rs112186402 -- 29,428,904(+) TGGCT(C/T)TGTCA intron-variant, upstream-variant-2KB
rs112531151 -- 29,427,648(+) TCGAT(C/T)GTCCA intron-variant, utr-variant-5-prime
rs112976090 -- 29,427,156(+) ACCAG(A/G)GCCAC intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR11A1 Gene

Variant ID Type Subtype PubMed ID
nsv830624 CNV loss 17160897
nsv1145096 CNV deletion 24896259
nsv1122126 CNV deletion 24896259
nsv1074389 CNV deletion 25765185
esv3570836 CNV loss 25503493

Variation tolerance for OR11A1 Gene

Residual Variation Intolerance Score: 60.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.26; 76.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR11A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR11A1 Gene

Disorders for OR11A1 Gene

Relevant External Links for OR11A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR11A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR11A1 Gene

Publications for OR11A1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  4. Complex transcription and splicing of odorant receptor genes. (PMID: 12637542) Volz A. … Ziegler A. (J. Biol. Chem. 2003) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for OR11A1 Gene

Sources for OR11A1 Gene

Loading form....