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Aliases for OR10Z1 Gene

Aliases for OR10Z1 Gene

  • Olfactory Receptor Family 10 Subfamily Z Member 1 2 3 5
  • Olfactory Receptor, Family 10, Subfamily Z, Member 1 2 3
  • Olfactory Receptor OR1-15 3 4
  • OR1-15 3

External Ids for OR10Z1 Gene

Previous GeneCards Identifiers for OR10Z1 Gene

  • GC01U990421
  • GC01P155793
  • GC01P155389
  • GC01P156842

Summaries for OR10Z1 Gene

Entrez Gene Summary for OR10Z1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10Z1 Gene

OR10Z1 (Olfactory Receptor Family 10 Subfamily Z Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR10H1.

UniProtKB/Swiss-Prot for OR10Z1 Gene

  • Odorant receptor.

Gene Wiki entry for OR10Z1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10Z1 Gene

Genomics for OR10Z1 Gene

Regulatory Elements for OR10Z1 Gene

Genomic Location for OR10Z1 Gene

Chromosome:
1
Start:
158,606,439 bp from pter
End:
158,607,380 bp from pter
Size:
942 bases
Orientation:
Plus strand

Genomic View for OR10Z1 Gene

Genes around OR10Z1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10Z1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10Z1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10Z1 Gene

Proteins for OR10Z1 Gene

  • Protein details for OR10Z1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGY1-O10Z1_HUMAN
    Recommended name:
    Olfactory receptor 10Z1
    Protein Accession:
    Q8NGY1
    Secondary Accessions:
    • Q5VYL0
    • Q6IFR7

    Protein attributes for OR10Z1 Gene

    Size:
    313 amino acids
    Molecular mass:
    34609 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10Z1 Gene

Proteomics data for OR10Z1 Gene at MOPED

Post-translational modifications for OR10Z1 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10Z1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for OR10Z1

No data available for DME Specific Peptides for OR10Z1 Gene

Domains & Families for OR10Z1 Gene

Gene Families for OR10Z1 Gene

Protein Domains for OR10Z1 Gene

Suggested Antigen Peptide Sequences for OR10Z1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGY1

UniProtKB/Swiss-Prot:

O10Z1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10Z1: view

Function for OR10Z1 Gene

Molecular function for OR10Z1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR10Z1: view
genes like me logo Genes that share phenotypes with OR10Z1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10Z1 Gene

Localization for OR10Z1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10Z1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR10Z1 Gene COMPARTMENTS Subcellular localization image for OR10Z1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR10Z1: view

Pathways & Interactions for OR10Z1 Gene

genes like me logo Genes that share pathways with OR10Z1: view

Pathways by source for OR10Z1 Gene

Interacting Proteins for OR10Z1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354707%0d%0a9606.ENSP00000269260%0d%0a9606.ENSP00000317578%0d%0a9606.ENSP00000334051%0d%0a
Selected Interacting proteins: ENSP00000354707 for OR10Z1 Gene via STRING

Gene Ontology (GO) - Biological Process for OR10Z1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10Z1: view

No data available for SIGNOR curated interactions for OR10Z1 Gene

Drugs & Compounds for OR10Z1 Gene

No Compound Related Data Available

Transcripts for OR10Z1 Gene

mRNA/cDNA for OR10Z1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR10Z1 Gene

No ASD Table

Relevant External Links for OR10Z1 Gene

GeneLoc Exon Structure for
OR10Z1
ECgene alternative splicing isoforms for
OR10Z1

Expression for OR10Z1 Gene

mRNA expression in normal human tissues for OR10Z1 Gene

SOURCE GeneReport for Unigene cluster for OR10Z1 Gene Hs.553590

genes like me logo Genes that share expression patterns with OR10Z1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR10Z1 Gene

Orthologs for OR10Z1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10Z1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469532 35
  • 99.25 (n)
  • 99.04 (a)
OR10Z1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR10Z1 36
  • 86 (a)
OneToOne
OR10Z1 35
  • 85.3 (n)
  • 85.62 (a)
dog
(Canis familiaris)
Mammalia OR10Z1 35
  • 85.41 (n)
  • 88.82 (a)
OR10Z1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr419 16
Olfr419 36
  • 88 (a)
OneToOne
Olfr419 35
  • 83.39 (n)
  • 87.54 (a)
oppossum
(Monodelphis domestica)
Mammalia OR10Z1 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1597 35
  • 82 (n)
  • 85.94 (a)
Species with no ortholog for OR10Z1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10Z1 Gene

ENSEMBL:
Gene Tree for OR10Z1 (if available)
TreeFam:
Gene Tree for OR10Z1 (if available)

Paralogs for OR10Z1 Gene

(456) SIMAP similar genes for OR10Z1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10Z1: view

Variants for OR10Z1 Gene

Sequence variations from dbSNP and Humsavar for OR10Z1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs857685 - 158,607,319(+) AAGGA(A/C/G)TAGGG reference, missense
rs857683 -- 158,604,795(+) GGGGA(A/G)CAGCT upstream-variant-2KB
rs12129479 -- 158,606,086(+) AGTTT(C/T)GAATG upstream-variant-2KB
rs28565358 -- 158,606,922(+) CACTA(G/T)TTATT reference, missense
rs59285836 -- 158,605,770(+) TCTGT(G/T)TGACT upstream-variant-2KB

Variation tolerance for OR10Z1 Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.84; 83.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10Z1 Gene

HapMap Linkage Disequilibrium report
OR10Z1
Human Gene Mutation Database (HGMD)
OR10Z1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR10Z1 Gene

Disorders for OR10Z1 Gene

Relevant External Links for OR10Z1

Genetic Association Database (GAD)
OR10Z1
Human Genome Epidemiology (HuGE) Navigator
OR10Z1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR10Z1

No disorders were found for OR10Z1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10Z1 Gene

Publications for OR10Z1 Gene

  1. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 48 67
  2. Seventy-five genetic loci influencing the human red blood cell. (PMID: 23222517) van der Harst P. … Chambers J.C. (Nature 2012) 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3

Products for OR10Z1 Gene

Sources for OR10Z1 Gene

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