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OR10W1 Gene

protein-coding   GIFtS: 44
GCID: GC11M058035

Olfactory Receptor, Family 10, Subfamily W, Member 1

(Previous names: olfactory receptor, family 10, subfamily W, member 1 pseudogene)
(Previous symbol: OR10W1P)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 10, Subfamily W, Member 11 2     OR10W1Q2
OR10W1P1 2 3     OR11-2362
Olfactory Receptor, Family 10, Subfamily W, Member 1 Pseudogene1 2     UNQ64692
Olfactory Receptor OR11-2362 3     Olfactory Receptor 10W12

External Ids:    HGNC: 151391   Entrez Gene: 813412   Ensembl: ENSG000001727727   UniProtKB: Q8NGF63   

Export aliases for OR10W1 gene to outside databases

Previous GC identifers: GC11U900581 GC11M057790


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR10W1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR10W1 Gene:
OR10W1 (olfactory receptor, family 10, subfamily W, member 1) is a protein-coding gene. Diseases associated with OR10W1 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10V1.

UniProtKB/Swiss-Prot: O10W1_HUMAN, Q8NGF6
Function: Odorant receptor (Potential)

Gene Wiki entry for OR10W1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR10W1 gene promoter:
         USF1   AML1a   USF2   USF-1:USF-2   Cdc5   C/EBPalpha   CHOP-10   CP2   USF-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR10W1 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR10W1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

OR10W1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10W1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M058035:  view genomic region     (about GC identifiers)

Start:
58,034,416 bp from pter      End:
58,035,330 bp from pter
Size:
915 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB/Swiss-Prot: O10W1_HUMAN, Q8NGF6 (See protein sequence)
Recommended Name: Olfactory receptor 10W1  
Size: 305 amino acids; 33376 Da
Secondary accessions: A2RUD2 A8MTE1 Q6UXQ2

Explore the universe of human proteins at neXtProt for OR10W1: NX_Q8NGF6

Explore proteomics data for OR10W1 at MOPED

HORDE protein sequence for OR10W1

See OR10W1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_997257.2  
ENSEMBL proteins: 
 ENSP00000378516  
Reactome Protein details: Q8NGF6

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
OR10: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGF6

ProtoNet protein and cluster: Q8NGF6

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O10W1_HUMAN, Q8NGF6
Similarity: Belongs to the G-protein coupled receptor 1 family


OR10W1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: O10W1_HUMAN, Q8NGF6
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
OR10W1 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
O10W1_HUMAN, Q8NGF6: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane IEA--

OR10W1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OR10W1 About    
See pathways by source

SuperPathContained pathways About
1Olfactory Signaling Pathway
Olfactory Signaling Pathway0.82
Olfactory transduction0.82
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Reactome Pathway for OR10W1
    Olfactory Signaling Pathway


1 Kegg Pathway  (Kegg details for OR10W1):
    Olfactory transduction


OR10W1 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR10W1
Interactions:

    Search GeneGlobe Interaction Network for OR10W1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for OR10W1 (ENSP000003785164) via UniProtKB, MINT, STRING, and/or I2D (see all 271)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
OR10AD1ENSP000003086894STRING: ENSP00000308689
OR10P1ENSP000003080824STRING: ENSP00000308082
OR11G2ENSP000003499304STRING: ENSP00000349930
OR2A12ENSP000003861744STRING: ENSP00000386174
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

OR10W1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for OR10W1 (O10W1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for OR10W1 gene: 
NM_207374.3  

Unigene Cluster for OR10W1:

Olfactory receptor, family 10, subfamily W, member 1
Hs.531507
Unigene Representative Sequence: AY358251
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000395079(uc001nmq.1)
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Additional mRNA sequence: 

AY358251.1 BC132848.1 BC132850.1 

1 DOTS entry:

DT.101960454 

2 AceView cDNA sequences:

AY358251 NM_207374 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR10W1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
OR10W1 Expression
About this image

OR10W1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OR10W1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.531507
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for OR10W1 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr14901 , 5 olfactory receptor 14901, 5 81.14(n)1
80.59(a)1
  19 (8.75 cM)5
2580981  NM_001011832.11  NP_001011832.11 
 136544465 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
44(a)
1 → many
1(76965362-76966327) ENSGALG00000014685
lizard
(Anolis carolinensis)
Reptilia OR10W16
olfactory receptor, family 10, subfamily W, member...
55(a)
1 ↔ 1
1(91326205-91327119)


ENSEMBL Gene Tree for OR10W1 (if available)
TreeFam Gene Tree for OR10W1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OR10W1 gene
OR10V12  OR10Q12  
Selected SIMAP similar genes for OR10W1 using alignment to 1 protein entry:     O10W1_HUMAN(see all similar genes):
OR10Q1    OR10A7    OR10R3P    OR10V1    OR10R2    OR10A3
OR10T2    OR10J1    OR10K1    OR10Z1    OR2G3    OR2T10
OR5F1    OR5V1    OR8U9    OLFR 42A    OR10A2    OR10A5

OR10W1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for OR10W1
PGOHUM00000233051


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OR10W1 (see all 109)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs49392001,2
C,F,A,H--58033781(+) CTCCCT/CTCTTG 1 -- ds500111Minor allele frequency- C:0.50NA WA CSA EA 374
rs108967321,2
C,F,A,H--58033837(+) ATTTTG/TAGCAA 1 -- ds500111Minor allele frequency- T:0.50NA WA CSA EA 374
rs560069351,2
C,F--58033849(+) GAGACG/ACTGGG 1 -- ds50013Minor allele frequency- A:0.12WA NA 240
rs1852210641,2
--58033855(+) CTGGGG/TTATTT 1 -- ds50010--------
rs1383797481,2
--58033857(+) GGGGTA/GTTTGC 1 -- ds50010--------
rs1492818041,2
--58033866(+) GCCTCC/TCTGTC 1 -- ds50010--------
rs1444996201,2
--58033961(+) TCTAAC/TTGTCA 1 -- ds50010--------
rs1484163901,2
--58034048(+) GCTAGC/TGTGTT 1 -- ds50010--------
rs112293251,2
C,F--58034120(+) ATATTT/GTTTTA 1 -- ds50015Minor allele frequency- G:0.25WA NA EA 362
rs2009300091,2
--58034127(+) TTTAG-/TTAAAA 1 -- ds50010--------

HapMap Linkage Disequilibrium report for OR10W1 ( 58034416 - 58035330 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for OR10W1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv897589CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing OR10W1
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for OR10W1:    
About MalaCards
neuronitis


OR10W1 for disorders           About GeneDecksing


Export disorders for OR10W1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OR10W1 gene integrated from 10 sources:
(articles sorted by number of sources associating them with OR10W1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 81341 HGNC: 15139 AceView: UNQ6469 Ensembl:ENSG00000172772 euGenes: HUgn81341
ECgene: OR10W1 Kegg: 81341 H-InvDB: OR10W1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OR10W1 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR10W1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OR10W1 gene:
Search GeneIP for patents involving OR10W1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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