Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR10W1 Gene

Aliases for OR10W1 Gene

  • Olfactory Receptor Family 10 Subfamily W Member 1 2 3 5
  • Olfactory Receptor, Family 10, Subfamily W, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR11-236 3 4
  • OR10W1P 3 4
  • Olfactory Receptor, Family 10, Subfamily W, Member 1 2
  • Olfactory Receptor 10W1 3
  • OR11-236 3
  • OR10W1Q 3
  • UNQ6469 3

External Ids for OR10W1 Gene

Previous HGNC Symbols for OR10W1 Gene

  • OR10W1P

Previous GeneCards Identifiers for OR10W1 Gene

  • GC11U900581
  • GC11M057790
  • GC11M058035

Summaries for OR10W1 Gene

Entrez Gene Summary for OR10W1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10W1 Gene

OR10W1 (Olfactory Receptor Family 10 Subfamily W Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR10Q1.

UniProtKB/Swiss-Prot for OR10W1 Gene

  • Odorant receptor.

Gene Wiki entry for OR10W1 Gene

Additional gene information for OR10W1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10W1 Gene

Genomics for OR10W1 Gene

GeneHancer (GH) Regulatory Elements for OR10W1 Gene

Promoters and enhancers for OR10W1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I058164 Enhancer 0.9 ENCODE 9.9 +102.9 102941 2 ELF3 FOXA2 MLX RAD21 RARA CREM THAP11 MIXL1 HMG20B SP5 OR9Q2 OR1S2 OR10W1 RNU6-899P OR9Q1 MED19 TIMM10 OR5BL1P OR9I2P GC11M058117
GH11I057946 Enhancer 0.3 FANTOM5 12.2 +321.8 321826 0 GC11M057948 OR5BD1P OR10W1 OR10Q1 OR9Q2 OR5B2 OR9Q1 OR5B12 MED19 OR5B3
GH11I058632 Enhancer 0.2 FANTOM5 8.1 -364.0 -363981 0.1 OR5B12 OR1S1 OR5B3 OR10W1 OR10Q1 OR5B2 OR9Q2 OR1S2 ENSG00000280010 GC11P058595
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR10W1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10W1 gene promoter:

Genomic Locations for OR10W1 Gene

Genomic Locations for OR10W1 Gene
chr11:58,266,792-58,268,260
(GRCh38/hg38)
Size:
1,469 bases
Orientation:
Minus strand
chr11:58,034,264-58,035,732
(GRCh37/hg19)

Genomic View for OR10W1 Gene

Genes around OR10W1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10W1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10W1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10W1 Gene

Proteins for OR10W1 Gene

  • Protein details for OR10W1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGF6-O10W1_HUMAN
    Recommended name:
    Olfactory receptor 10W1
    Protein Accession:
    Q8NGF6
    Secondary Accessions:
    • A2RUD2
    • A8MTE1
    • Q6UXQ2

    Protein attributes for OR10W1 Gene

    Size:
    305 amino acids
    Molecular mass:
    33376 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10W1 Gene

Post-translational modifications for OR10W1 Gene

No Post-translational modifications

Other Protein References for OR10W1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10W1 Gene

Domains & Families for OR10W1 Gene

Gene Families for OR10W1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10W1 Gene

Suggested Antigen Peptide Sequences for OR10W1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGF6

UniProtKB/Swiss-Prot:

O10W1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10W1: view

Function for OR10W1 Gene

Molecular function for OR10W1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR10W1: view

Phenotypes for OR10W1 Gene

genes like me logo Genes that share phenotypes with OR10W1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10W1 Gene

Localization for OR10W1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10W1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10W1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10W1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10W1 Gene

Pathways & Interactions for OR10W1 Gene

genes like me logo Genes that share pathways with OR10W1: view

Pathways by source for OR10W1 Gene

Interacting Proteins for OR10W1 Gene

Gene Ontology (GO) - Biological Process for OR10W1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10W1: view

No data available for SIGNOR curated interactions for OR10W1 Gene

Drugs & Compounds for OR10W1 Gene

No Compound Related Data Available

Transcripts for OR10W1 Gene

mRNA/cDNA for OR10W1 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10W1 Gene

No ASD Table

Relevant External Links for OR10W1 Gene

GeneLoc Exon Structure for
OR10W1
ECgene alternative splicing isoforms for
OR10W1

Expression for OR10W1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10W1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR10W1 Gene



NURSA nuclear receptor signaling pathways regulating expression of OR10W1 Gene:

OR10W1

SOURCE GeneReport for Unigene cluster for OR10W1 Gene:

Hs.531507
genes like me logo Genes that share expression patterns with OR10W1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10W1 Gene

Orthologs for OR10W1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10W1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC610022 33
  • 86.34 (n)
OR16F10 34
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC531571 33
  • 81.31 (n)
OR10W1 34
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or10w1 51 Olfr1490 33 16 34
  • 81.14 (n)
Or10w3 51 Olfr1493
  • chr19:13,726,224-13,727,210
rat
(Rattus norvegicus)
Mammalia Olr372 33
  • 80.15 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 70 (a)
OneToMany
-- 34
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 42 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 44 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia OR10W1 34
  • 55 (a)
OneToOne
Species where no ortholog for OR10W1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10W1 Gene

ENSEMBL:
Gene Tree for OR10W1 (if available)
TreeFam:
Gene Tree for OR10W1 (if available)

Paralogs for OR10W1 Gene

Paralogs for OR10W1 Gene

(432) SIMAP similar genes for OR10W1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10W1: view

Variants for OR10W1 Gene

Sequence variations from dbSNP and Humsavar for OR10W1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000281604 -- 58,269,201(-) T/C upstream_transcript_variant
rs1000487399 -- 58,269,359(-) C/T upstream_transcript_variant
rs1001635963 -- 58,268,226(-) G/A 5_prime_UTR_variant
rs1001729499 -- 58,268,544(-) G/A upstream_transcript_variant
rs1001971611 -- 58,269,584(-) C/T upstream_transcript_variant

Variation tolerance for OR10W1 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.28; 76.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10W1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10W1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR10W1 Gene

Disorders for OR10W1 Gene

Additional Disease Information for OR10W1

No disorders were found for OR10W1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10W1 Gene

Publications for OR10W1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for OR10W1 Gene

Sources for OR10W1 Gene

Content
Loading form....