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Aliases for OR10R2 Gene

Aliases for OR10R2 Gene

  • Olfactory Receptor, Family 10, Subfamily R, Member 2 2 3
  • Olfactory Receptor OR1-8 3 4
  • Olfactory Receptor 10R2 3
  • OR10R2Q 3
  • OR1-8 3

External Ids for OR10R2 Gene

Previous GeneCards Identifiers for OR10R2 Gene

  • GC01U990367
  • GC01P155659
  • GC01P155250
  • GC01P156716

Summaries for OR10R2 Gene

Entrez Gene Summary for OR10R2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10R2 Gene

OR10R2 (Olfactory Receptor, Family 10, Subfamily R, Member 2) is a Protein Coding gene. Diseases associated with OR10R2 include verrucous papilloma and tinea unguium. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10X1.

UniProtKB/Swiss-Prot for OR10R2 Gene

  • Odorant receptor.

Gene Wiki entry for OR10R2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10R2 Gene

Genomics for OR10R2 Gene

Regulatory Elements for OR10R2 Gene

Genomic Location for OR10R2 Gene

Start:
158,479,878 bp from pter
End:
158,480,885 bp from pter
Size:
1,008 bases
Orientation:
Plus strand

Genomic View for OR10R2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR10R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10R2 Gene

Proteins for OR10R2 Gene

  • Protein details for OR10R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGX6-O10R2_HUMAN
    Recommended name:
    Olfactory receptor 10R2
    Protein Accession:
    Q8NGX6
    Secondary Accessions:
    • Q5VWM8
    • Q6IFS1
    • Q96R61

    Protein attributes for OR10R2 Gene

    Size:
    335 amino acids
    Molecular mass:
    37486 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH70559.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR10R2 Gene

Proteomics data for OR10R2 Gene at MOPED

Post-translational modifications for OR10R2 Gene

  • Glycosylation at Asn25
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10R2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10R2 Gene

Domains for OR10R2 Gene

Gene Families for OR10R2 Gene

HGNC:
  • OR10 :GPCR / Class A : Olfactory receptors

Protein Domains for OR10R2 Gene

Suggested Antigen Peptide Sequences for OR10R2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGX6

UniProtKB/Swiss-Prot:

O10R2_HUMAN :
  • Q8NGX6
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10R2: view

Function for OR10R2 Gene

Molecular function for OR10R2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR10R2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR10R2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR10R2 Gene

Localization for OR10R2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10R2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR10R2 Gene COMPARTMENTS Subcellular localization image for OR10R2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10R2: view

Pathways for OR10R2 Gene

genes like me logo Genes that share pathways with OR10R2: view

Pathways by source for OR10R2 Gene

Interacting Proteins for OR10R2 Gene

Gene Ontology (GO) - Biological Process for OR10R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10R2: view

Transcripts for OR10R2 Gene

mRNA/cDNA for OR10R2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10R2 Gene

Olfactory receptor, family 10, subfamily R, member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR10R2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10R2 Gene

No ASD Table

Relevant External Links for OR10R2 Gene

GeneLoc Exon Structure for
OR10R2
ECgene alternative splicing isoforms for
OR10R2

Expression for OR10R2 Gene

mRNA expression in normal human tissues for OR10R2 Gene

Protein differential expression in normal tissues for OR10R2 Gene

This gene is overexpressed in Esophagus (46.6) and Kidney (22.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR10R2 Gene

SOURCE GeneReport for Unigene cluster for OR10R2 Gene Hs.451913

genes like me logo Genes that share expressions with OR10R2: view

Expression partners for OR10R2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR10R2 Gene

Orthologs for OR10R2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10R2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR10R2 35
  • 86.6 (n)
  • 90.51 (a)
OR10R2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC469527 35
  • 99.6 (n)
  • 99.4 (a)
OR10R2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1406 16
Olfr1406 36
  • 55 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 74 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia OR10R2 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734876 35
  • 56.49 (n)
  • 53.44 (a)
Species with no ortholog for OR10R2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10R2 Gene

ENSEMBL:
Gene Tree for OR10R2 (if available)
TreeFam:
Gene Tree for OR10R2 (if available)

Paralogs for OR10R2 Gene

Selected SIMAP similar genes for OR10R2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR10R2 Gene

genes like me logo Genes that share paralogs with OR10R2: view

Variants for OR10R2 Gene

Sequence variations from dbSNP and Humsavar for OR10R2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1418843 - 158,480,592(+) CTTAT(C/T)TCTGC reference, missense
rs3820678 - 158,480,448(+) GTAGC(A/G)CCAAC missense, reference
rs6666585 -- 158,480,622(+) AGATT(C/T)CCTCA reference, missense
rs6679056 - 158,480,524(+) TAACG(A/G)ATTTG reference, missense
rs11264977 -- 158,478,062(+) AGGAC(G/T)CCCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10R2 Gene

Variant ID Type Subtype PubMed ID
dgv393n71 CNV Gain 21882294

Relevant External Links for OR10R2 Gene

HapMap Linkage Disequilibrium report
OR10R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10R2 Gene

Disorders for OR10R2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for OR10R2 Gene in MalaCards »

(2) Diseases for OR10R2 Gene including...

(2) University of Copenhagen DISEASES for OR10R2 Gene

Relevant External Links for OR10R2

Genetic Association Database (GAD)
OR10R2
genes like me logo Genes that share disorders with OR10R2: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for OR10R2 Gene

Publications for OR10R2 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Genome-wide association of sleep and circadian phenotypes. (PMID: 17903308) Gottlieb D.J. … Wilk J.B. (BMC Med. Genet. 2007) 48

Products for OR10R2 Gene

Sources for OR10R2 Gene

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