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Aliases for OR10K2 Gene

Aliases for OR10K2 Gene

  • Olfactory Receptor Family 10 Subfamily K Member 2 2 3 5
  • Olfactory Receptor OR1-4 3 4
  • Olfactory Receptor, Family 10, Subfamily K, Member 2 2
  • Olfactory Receptor 10K2 3
  • OR1-4 3

External Ids for OR10K2 Gene

Previous GeneCards Identifiers for OR10K2 Gene

  • GC01U990365
  • GC01M155606
  • GC01P155248
  • GC01M155203
  • GC01M156657

Summaries for OR10K2 Gene

Entrez Gene Summary for OR10K2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10K2 Gene

OR10K2 (Olfactory Receptor Family 10 Subfamily K Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR10K1.

UniProtKB/Swiss-Prot for OR10K2 Gene

  • Odorant receptor.

Gene Wiki entry for OR10K2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10K2 Gene

Genomics for OR10K2 Gene

Regulatory Elements for OR10K2 Gene

Enhancers for OR10K2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F158333 0.6 FANTOM5 Ensembl 2.8 +87.2 87230 0.9 CD1E CD1B OR6Y1 OR10K2 OR6K6 OR10T2 CD1C
GH01F158400 0.3 FANTOM5 0.3 +19.8 19842 0.3 CD1E CD1B OR10T2 OR10K1 OR6K3 OR6N1 OR10K2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR10K2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR10K2 Gene

Chromosome:
1
Start:
158,419,928 bp from pter
End:
158,420,866 bp from pter
Size:
939 bases
Orientation:
Minus strand

Genomic View for OR10K2 Gene

Genes around OR10K2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10K2 Gene

Proteins for OR10K2 Gene

  • Protein details for OR10K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IF99-O10K2_HUMAN
    Recommended name:
    Olfactory receptor 10K2
    Protein Accession:
    Q6IF99

    Protein attributes for OR10K2 Gene

    Size:
    312 amino acids
    Molecular mass:
    35029 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10K2 Gene

Post-translational modifications for OR10K2 Gene

  • Glycosylation at Asn 5 and Asn 265

Other Protein References for OR10K2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10K2 Gene

Domains & Families for OR10K2 Gene

Gene Families for OR10K2 Gene

Protein Domains for OR10K2 Gene

Suggested Antigen Peptide Sequences for OR10K2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6IF99

UniProtKB/Swiss-Prot:

O10K2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10K2: view

Function for OR10K2 Gene

Molecular function for OR10K2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR10K2: view
genes like me logo Genes that share phenotypes with OR10K2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10K2 Gene

Localization for OR10K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10K2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10K2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10K2: view

Pathways & Interactions for OR10K2 Gene

genes like me logo Genes that share pathways with OR10K2: view

Pathways by source for OR10K2 Gene

Interacting Proteins for OR10K2 Gene

Gene Ontology (GO) - Biological Process for OR10K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
genes like me logo Genes that share ontologies with OR10K2: view

No data available for SIGNOR curated interactions for OR10K2 Gene

Transcripts for OR10K2 Gene

mRNA/cDNA for OR10K2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10K2 Gene

No ASD Table

Relevant External Links for OR10K2 Gene

GeneLoc Exon Structure for
OR10K2
ECgene alternative splicing isoforms for
OR10K2

Expression for OR10K2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10K2 Gene

Protein differential expression in normal tissues from HIPED for OR10K2 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR10K2 Gene



Protein tissue co-expression partners for OR10K2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10K2 Gene:

OR10K2

SOURCE GeneReport for Unigene cluster for OR10K2 Gene:

Hs.626815
genes like me logo Genes that share expression patterns with OR10K2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR10K2 Gene

Orthologs for OR10K2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10K2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR10K2 35
  • 99 (a)
OneToOne
LOC100615080 34
  • 98.59 (n)
cow
(Bos Taurus)
Mammalia OR10K2 34 35
  • 86.26 (n)
dog
(Canis familiaris)
Mammalia OR10K2 35
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1667 34
  • 80.92 (n)
mouse
(Mus musculus)
Mammalia Or10k2 55 Olfr370 34 16 35
  • 80.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 59 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 49 (a)
ManyToMany
Species where no ortholog for OR10K2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10K2 Gene

ENSEMBL:
Gene Tree for OR10K2 (if available)
TreeFam:
Gene Tree for OR10K2 (if available)

Paralogs for OR10K2 Gene

(441) SIMAP similar genes for OR10K2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR10K2: view

Variants for OR10K2 Gene

Sequence variations from dbSNP and Humsavar for OR10K2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs386352340 Uncertain significance 158,420,710(-) TGGAC(A/G)GGGCC reference, missense
rs10489830 -- 158,421,044(+) AAAAT(A/C)AGGCA upstream-variant-2KB
rs111878656 -- 158,420,503(+) GTAAC(A/G)ATCAT reference, missense
rs112169513 -- 158,422,501(+) ATTCT(G/T)TGTAC upstream-variant-2KB
rs113809374 -- 158,422,794(+) AAGAC(C/G)CAGTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR10K2 Gene

Variant ID Type Subtype PubMed ID
nsv831692 CNV gain 17160897

Variation tolerance for OR10K2 Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10K2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10K2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10K2 Gene

Disorders for OR10K2 Gene

Relevant External Links for OR10K2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR10K2

No disorders were found for OR10K2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10K2 Gene

Publications for OR10K2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64

Products for OR10K2 Gene

Sources for OR10K2 Gene

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