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Aliases for OR10K2 Gene

Aliases for OR10K2 Gene

  • Olfactory Receptor Family 10 Subfamily K Member 2 2 3 5
  • Olfactory Receptor, Family 10, Subfamily K, Member 2 2 3
  • Olfactory Receptor OR1-4 3 4
  • OR1-4 3

External Ids for OR10K2 Gene

Previous GeneCards Identifiers for OR10K2 Gene

  • GC01U990365
  • GC01M155606
  • GC01P155248
  • GC01M155203
  • GC01M156657

Summaries for OR10K2 Gene

Entrez Gene Summary for OR10K2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10K2 Gene

OR10K2 (Olfactory Receptor Family 10 Subfamily K Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR10H1.

UniProtKB/Swiss-Prot for OR10K2 Gene

  • Odorant receptor.

Gene Wiki entry for OR10K2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10K2 Gene

Genomics for OR10K2 Gene

Regulatory Elements for OR10K2 Gene

Genomic Location for OR10K2 Gene

Chromosome:
1
Start:
158,419,928 bp from pter
End:
158,420,866 bp from pter
Size:
939 bases
Orientation:
Minus strand

Genomic View for OR10K2 Gene

Genes around OR10K2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10K2 Gene

Proteins for OR10K2 Gene

  • Protein details for OR10K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IF99-O10K2_HUMAN
    Recommended name:
    Olfactory receptor 10K2
    Protein Accession:
    Q6IF99

    Protein attributes for OR10K2 Gene

    Size:
    312 amino acids
    Molecular mass:
    35029 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10K2 Gene

Proteomics data for OR10K2 Gene at MOPED

Post-translational modifications for OR10K2 Gene

  • Glycosylation at Asn 5 and Asn 265

Other Protein References for OR10K2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10K2 Gene

Domains & Families for OR10K2 Gene

Gene Families for OR10K2 Gene

Protein Domains for OR10K2 Gene

Suggested Antigen Peptide Sequences for OR10K2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6IF99

UniProtKB/Swiss-Prot:

O10K2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10K2: view

Function for OR10K2 Gene

Molecular function for OR10K2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR10K2: view
genes like me logo Genes that share phenotypes with OR10K2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10K2 Gene

Localization for OR10K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10K2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR10K2 Gene COMPARTMENTS Subcellular localization image for OR10K2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR10K2: view

Pathways & Interactions for OR10K2 Gene

genes like me logo Genes that share pathways with OR10K2: view

Pathways by source for OR10K2 Gene

Interacting Proteins for OR10K2 Gene

Gene Ontology (GO) - Biological Process for OR10K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10K2: view

No data available for SIGNOR curated interactions for OR10K2 Gene

Drugs & Compounds for OR10K2 Gene

No Compound Related Data Available

Transcripts for OR10K2 Gene

mRNA/cDNA for OR10K2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR10K2 Gene

No ASD Table

Relevant External Links for OR10K2 Gene

GeneLoc Exon Structure for
OR10K2
ECgene alternative splicing isoforms for
OR10K2

Expression for OR10K2 Gene

mRNA expression in normal human tissues for OR10K2 Gene

Protein differential expression in normal tissues from HIPED for OR10K2 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR10K2 Gene



SOURCE GeneReport for Unigene cluster for OR10K2 Gene Hs.626815

genes like me logo Genes that share expression patterns with OR10K2: view

Protein tissue co-expression partners for OR10K2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR10K2 Gene

Orthologs for OR10K2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10K2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100615080 35
  • 98.59 (n)
  • 98.38 (a)
OR10K2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR10K2 36
  • 85 (a)
OneToOne
OR10K2 35
  • 86.26 (n)
  • 85.06 (a)
dog
(Canis familiaris)
Mammalia OR10K2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr370 36
  • 80 (a)
OneToOne
Olfr370 16
Olfr370 35
  • 80.6 (n)
  • 81.03 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 49 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1667 35
  • 80.92 (n)
  • 81.35 (a)
Species with no ortholog for OR10K2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10K2 Gene

ENSEMBL:
Gene Tree for OR10K2 (if available)
TreeFam:
Gene Tree for OR10K2 (if available)

Paralogs for OR10K2 Gene

(441) SIMAP similar genes for OR10K2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR10K2: view

Variants for OR10K2 Gene

Sequence variations from dbSNP and Humsavar for OR10K2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12240099 - 158,420,245(+) GATAG(C/T)CAGGA reference, missense
rs4143457 -- 158,420,876(+) CATAC(A/C)tcatc upstream-variant-2KB
rs16840136 -- 158,421,046(+) AATCA(G/T)GCAAG upstream-variant-2KB
rs16840139 -- 158,422,534(+) GTACA(G/T)TTGCT upstream-variant-2KB
rs34616883 -- 158,420,711(+) GCCCT(A/G)TCCAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR10K2 Gene

Variant ID Type Subtype PubMed ID
dgv393n71 CNV Gain 21882294
nsv831692 CNV Gain 17160897

Variation tolerance for OR10K2 Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR10K2 Gene

HapMap Linkage Disequilibrium report
OR10K2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10K2 Gene

Disorders for OR10K2 Gene

Relevant External Links for OR10K2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR10K2

No disorders were found for OR10K2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10K2 Gene

Publications for OR10K2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3

Products for OR10K2 Gene

Sources for OR10K2 Gene

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