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OR10K2 Gene

protein-coding   GIFtS: 45
GCID: GC01M158388

Olfactory Receptor, Family 10, Subfamily K, Member 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 10, Subfamily K, Member 21 2
Olfactory Receptor OR1-42 3
OR1-42
Olfactory Receptor 10K22

External Ids:    HGNC: 148261   Entrez Gene: 3911072   Ensembl: ENSG000001807087   UniProtKB: Q6IF993   

Export aliases for OR10K2 gene to outside databases

Previous GC identifers: GC01U990365 GC01M155606 GC01P155248 GC01M155203 GC01M156657


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR10K2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR10K2 Gene:
OR10K2 (olfactory receptor, family 10, subfamily K, member 2) is a protein-coding gene. Diseases associated with OR10K2 include anterograde amnesia, and peroneal neuropathy. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H4.

UniProtKB/Swiss-Prot: O10K2_HUMAN, Q6IF99
Function: Odorant receptor (Potential)

Gene Wiki entry for OR10K2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR10K2 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   AREB6   Nkx3-1 v2   S8   Cart-1   Nkx3-1 v3   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR10K2 promoter sequence
   Search Chromatin IP Primers for OR10K2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR10K2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23.1

OR10K2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10K2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M158388:  view genomic region     (about GC identifiers)

Start:
158,389,721 bp from pter      End:
158,390,656 bp from pter
Size:
936 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: O10K2_HUMAN, Q6IF99 (See protein sequence)
Recommended Name: Olfactory receptor 10K2  
Size: 312 amino acids; 35029 Da

Explore the universe of human proteins at neXtProt for OR10K2: NX_Q6IF99

Explore proteomics data for OR10K2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5, Asn265
  • HORDE protein sequence for OR10K2

    See OR10K2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004476.1  
    ENSEMBL proteins: 
     ENSP00000324251  
    Reactome Protein details: Q6IF99

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR10: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q6IF99

    ProtoNet protein and cluster: Q6IF99

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O10K2_HUMAN, Q6IF99
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR10K2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O10K2_HUMAN, Q6IF99
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR10K2 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O10K2_HUMAN, Q6IF99: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR10K2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR10K2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR10K2
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR10K2):
        Olfactory transduction


    OR10K2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR10K2
    Interactions:

        Search GeneGlobe Interaction Network for OR10K2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR10K2 (ENSP000003242514) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10K1ENSP000002894514STRING: ENSP00000289451
    OR10R2ENSP000003571344STRING: ENSP00000357134
    OR10T2ENSP000003341154STRING: ENSP00000334115
    OR2L13ENSP000003508364STRING: ENSP00000350836
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR10K2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR10K2 (O10K2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR10K2 gene: 
    NM_001004476.1  

    Unigene Cluster for OR10K2:

    Olfactory receptor, family 10, subfamily K, member 2
    Hs.626815
    Unigene Representative Sequence: NM_001004476
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000314902(uc010pii.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR10K2

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR10K2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTGTACAT
    OR10K2 Expression
    About this image

    OR10K2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR10K2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.626815
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR10K2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr3701 , 5 olfactory receptor 3701, 5 80.6(n)1
    81.03(a)1
      8 (40.22 cM)5
    2582671  NM_146270.21  NP_666382.21 
     835410935 


    ENSEMBL Gene Tree for OR10K2 (if available)
    TreeFam Gene Tree for OR10K2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR10K2 gene
    OR10H42  OR10Z12  OR10X12  OR10J42  OR10H52  OR10J52  OR10T22  OR10H12  
    OR10J32  OR10H22  OR10R22  OR10H32  OR10K12  OR10J12  
    Selected SIMAP similar genes for OR10K2 using alignment to 2 protein entries:     O10K2_HUMAN (see all proteins) (see all similar genes):
    OR10K1    OR10T2    OR10R2    OR10R3P    OR10J5    OR10H1
    OR10H2    OR10H4    OR10H5    OR10H3    OR5V1    OR10J1
    OR10J4    OR2D2    OR10X1    OR10J3    OR10V1    OR5A2

    OR10K2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR10K2 (see all 120)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922627171,2
    --158389366(+) TATAAC/GTTGTG 1 -- ds50010--------
    rs1471746011,2
    --158389377(+) GTTTAC/TGGTTT 1 -- ds50010--------
    rs1421056101,2
    C--158389401(+) AAGAT-/TTTTTT 1 -- ds50010--------
    rs1486378761,2
    --158389443(+) TCTGTC/TGCCCA 1 -- ds50010--------
    rs1412863561,2
    --158389459(+) GAGTGA/CAGTGA 1 -- ds50010--------
    rs1140827871,2
    C,F--158389529(+) CTGAGT/CAGCTG 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1507741551,2
    --158389553(+) CCACCA/GCAGCA 1 -- ds50010--------
    rs1391225811,2
    --158389554(+) CACCAC/TAGCAT 1 -- ds50010--------
    rs1837971681,2
    --158389594(+) ATAGGA/GTTTCA 1 -- ds50010--------
    rs575255981,2
    C,F--158389630(+) GTCCTG/CACCTC 1 -- ds50013Minor allele frequency- C:0.50NA CSA 6

    HapMap Linkage Disequilibrium report for OR10K2 ( 158389721 - 158390656 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OR10K2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv393n71CNV Gain21882294
    nsv831692CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for OR10K2:    About MalaCards
    anterograde amnesia    peroneal neuropathy    neuropathy    neuronitis

    1 disease from the University of Copenhagen DISEASES database for OR10K2:
    Peroneal neuropathy

    OR10K2 for disorders           About GeneDecksing


    Export disorders for OR10K2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR10K2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR10K2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 391107 HGNC: 14826 Ensembl:ENSG00000180708 euGenes: HUgn391107 ECgene: OR10K2 Kegg: 391107
    H-InvDB: OR10K2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR10K2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR10K2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR10K2 gene:
    Search GeneIP for patents involving OR10K2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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