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OR10J5 Gene

protein-coding   GIFtS: 47
GCID: GC01M159504

Olfactory Receptor, Family 10, Subfamily J, Member 5

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 10, Subfamily J, Member 51 2
Olfactory Receptor OR1-282 3
OR1-282
Olfactory Receptor 10J52

External Ids:    HGNC: 149931   Entrez Gene: 1273852   Ensembl: ENSG000001841557   UniProtKB: Q8NHC43   

Export aliases for OR10J5 gene to outside databases

Previous GC identifers: GC01U990424 GC01M156722 GC01M156317 GC01M157771 GC01M157516


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR10J5 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR10J5 Gene:
OR10J5 (olfactory receptor, family 10, subfamily J, member 5) is a protein-coding gene. GO annotations related to this gene include serotonin receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H4.

UniProtKB/Swiss-Prot: O10J5_HUMAN, Q8NHC4
Function: Odorant receptor (Potential)

Gene Wiki entry for OR10J5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR10J5 gene promoter:
         NF-1   C/EBPbeta   AML1a   HSF1 (long)   NF-kappaB   C/EBPalpha   Pax-3   NF-kappaB2   HSF1short   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR10J5 promoter sequence
   Search Chromatin IP Primers for OR10J5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR10J5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.2   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23.2

OR10J5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10J5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M159504:  view genomic region     (about GC identifiers)

Start:
159,504,871 bp from pter      End:
159,505,797 bp from pter
Size:
927 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: O10J5_HUMAN, Q8NHC4 (See protein sequence)
Recommended Name: Olfactory receptor 10J5  
Size: 309 amino acids; 34401 Da
Secondary accessions: B9EH35 Q6IFH2

Explore the universe of human proteins at neXtProt for OR10J5: NX_Q8NHC4

Explore proteomics data for OR10J5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR10J5

    See OR10J5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004469.1  
    ENSEMBL proteins: 
     ENSP00000334441  
    Reactome Protein details: Q8NHC4

    OR10J5 Human Recombinant Protein Products:

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    antibodies-online peptides for OR10J5

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    antibodies-online antibodies for OR10J5 (26 products) 

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    antibodies-online kits for OR10J5 (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR10: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NHC4

    ProtoNet protein and cluster: Q8NHC4

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O10J5_HUMAN, Q8NHC4
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR10J5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O10J5_HUMAN, Q8NHC4
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR10J5           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Olfr16):
     craniofacial  nervous system  no phenotypic analysis  respiratory system  taste/olfaction 

    Find genes that share phenotypes with OR10J5           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR10J5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OR10J5
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    miRNA
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    GenScript: all cDNA clones in your preferred vector: OR10J5 (NM_001004469)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OR10J5
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    Addgene plasmids for OR10J5 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O10J5_HUMAN, Q8NHC4: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR10J5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR10J5 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR10J5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR10J5
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR10J5):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR10J5
    Interactions:

        Search GeneGlobe Interaction Network for OR10J5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR10J5 (ENSP000003344414) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    GNALENSP000003340514STRING: ENSP00000334051
    OR10A4ENSP000003691574STRING: ENSP00000369157
    OR10J1ENSP000003990784STRING: ENSP00000399078
    OR1D2ENSP000003275854STRING: ENSP00000327585
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    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR10J5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR10J5 (O10J5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR10J5 gene: 
    NM_001004469.1  

    Unigene Cluster for OR10J5:

    Olfactory receptor, family 10, subfamily J, member 5
    Hs.553587
    Unigene Representative Sequence: BC137026
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000334857(uc010piw.2)
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OR10J5
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    Addgene plasmids for OR10J5 
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OR10J5
      QuantiTect SYBR Green Assays in human, mouse, rat OR10J5
      QuantiFast Probe-based Assays in human, mouse, rat OR10J5

    Additional mRNA sequence: 

    BC137025.1 BC137026.1 

    1 AceView cDNA sequence:

    NM_001004469 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR10J5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTTTCTT
    OR10J5 Expression
    About this image

    OR10J5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR10J5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553587
        Custom PCR Arrays for OR10J5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR10J5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR10J5 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr161 , 5 olfactory receptor 161, 5 85.11(n)1
    87.38(a)1
      1 (80.33 cM)5
    183131  NM_008763.21  NP_032789.11 
     1729567685 


    ENSEMBL Gene Tree for OR10J5 (if available)
    TreeFam Gene Tree for OR10J5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR10J5 gene
    OR10H42  OR10K22  OR10Z12  OR10X12  OR10J42  OR10H52  OR10T22  OR10H12  
    OR10J32  OR10H22  OR10R22  OR10H32  OR10K12  OR10J12  
    Selected SIMAP similar genes for OR10J5 using alignment to 1 protein entry:     O10J5_HUMAN(see all similar genes):
    OR10J6P    OR10J1    OR10J3    OR10J4    OR10T2    OR10A7
    OR10K1    OR10R2    OR10R3P    OR10H4    OR10H1    OR10H2
    OR10H3    OR10K2    OR10X1    OR10Z1    OR5V1    OR10Q1

    Find genes that share paralogs with OR10J5           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for OR10J5
    PGOHUM00000245036


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR10J5 (see all 109)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1141070281,2
    F--159504420(+) ATATTA/TTTTGA 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs1842495611,2
    --159504609(+) AAAAGC/TTTTCA 1 -- ds50010--------
    rs1164428051,2
    C,F--159504762(+) TGACAG/CTATTC 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs782921981,2
    C,F--159504784(+) TATATT/GTGATG 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs2000404361,2
    --159504917(+) CCTCCC/TTGTTT 2 K R mis10--------
    rs1878324351,2
    C--159504919(+) TCCTTG/TTTTCT 2 K N mis10--------
    rs1932221431,2
    C--159504942(+) AACAGC/GGTTCA 2 P A mis10--------
    rs1490966561,2
    C,F--159504971(+) TGTACG/ATCACT 2 /T /M mis12Minor allele frequency- A:0.00NA EU 5875
    rs353937231,2,,4
    C,F--159505101(+) CTTCCG/AGCCCT 2 /R /W mis17Minor allele frequency- A:0.14NA CSA EU 6004
    rs567863071,2
    C,F--159505202(+) CACCAT/AAATTT 2 /Y /F mis13Minor allele frequency- A:0.03WA NA EU 5981

    HapMap Linkage Disequilibrium report for OR10J5 ( 159504871 - 159505797 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OR10J5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR10J5
    DNA2.0 Custom Variant and Variant Library Synthesis for OR10J5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR10J5           About GenesLikeMe

    Genetic Association Database (GAD): OR10J5

    Export disorders for OR10J5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR10J5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR10J5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)1, 4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    4. Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. (PubMed id 22939635)1 Reiner A.P....Tang H. (Am. J. Hum. Genet. 2012)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Natural selection on the olfactory receptor gene family in humans and chimpanzees. (PubMed id 12908129)1 Gilad Y.... Paabo S. (Am. J. Hum. Genet. 2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 127385 HGNC: 14993 AceView: OR10J5 Ensembl:ENSG00000184155 euGenes: HUgn127385
    ECgene: OR10J5 Kegg: 127385 H-InvDB: OR10J5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR10J5 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR10J5 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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