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OR10J3 Gene

protein-coding   GIFtS: 44
GCID: GC01M159249

Olfactory Receptor, Family 10, Subfamily J, Member 3


(Previous symbol: OR10J3P)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 10, Subfamily J, Member 31 2
OR10J3P1 2 3
OR1-252
Olfactory Receptor 10J32
Olfactory Receptor OR1-25 Pseudogene2
Olfactory Receptor, Family 10, Subfamily J, Member 3 Pseudogene2

External Ids:    HGNC: 149921   Entrez Gene: 4419112   Ensembl: ENSG000001962667   UniProtKB: Q5JRS43   

Export aliases for OR10J3 gene to outside databases

Previous GC identifers: GC01M156500 GC01M156062 GC01M156096 GC01M157550


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR10J3 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR10J3 Gene:
OR10J3 (olfactory receptor, family 10, subfamily J, member 3) is a protein-coding gene. Diseases associated with OR10J3 include childhood leukemia, and meningioma. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H4.

UniProtKB/Swiss-Prot: O10J3_HUMAN, Q5JRS4
Function: Odorant receptor (Potential)

Gene Wiki entry for OR10J3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR10J3 gene promoter:
         Nkx3-1   HOXA9   HOXA9B   Nkx3-1 v1   LUN-1   Meis-1b   Nkx3-1 v2   AREB6   Nkx3-1 v3   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OR10J3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR10J3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.2   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23.2

OR10J3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10J3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M159249:  view genomic region     (about GC identifiers)

Start:
159,283,463 bp from pter      End:
159,284,449 bp from pter
Size:
987 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: O10J3_HUMAN, Q5JRS4 (See protein sequence)
Recommended Name: Olfactory receptor 10J3  
Size: 329 amino acids; 36549 Da

Explore the universe of human proteins at neXtProt for OR10J3: NX_Q5JRS4

Explore proteomics data for OR10J3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR10J3

    See OR10J3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004467.1  
    ENSEMBL proteins: 
     ENSP00000331789  
    Reactome Protein details: Q5JRS4

    OR10J3 Human Recombinant Protein Products:

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    OR10J3 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR10: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q5JRS4

    ProtoNet protein and cluster: Q5JRS4

    UniProtKB/Swiss-Prot: O10J3_HUMAN, Q5JRS4
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR10J3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O10J3_HUMAN, Q5JRS4
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR10J3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR10J3
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O10J3_HUMAN, Q5JRS4: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR10J3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR10J3 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR10J3
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR10J3):
        Olfactory transduction


    OR10J3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OR10J3: 
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for OR10J3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR10J3 (ENSP000003317894) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10J1ENSP000003990784STRING: ENSP00000399078
    OR10Q1ENSP000003143244STRING: ENSP00000314324
    OR1B1ENSP000003031514STRING: ENSP00000303151
    OR1N1ENSP000003069744STRING: ENSP00000306974
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR10J3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR10J3 (O10J3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR10J3 gene: 
    NM_001004467.1  

    Unigene Cluster for OR10J3:

    Olfactory receptor, family 10, subfamily J, member 3
    Hs.553833
    Unigene Representative Sequence: NM_001004467
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000332217(uc010piu.2)
    miRNA
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    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat OR10J3
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat OR10J3
      QuantiFast Probe-based Assays in human, mouse, rat OR10J3

    1 AceView cDNA sequence:

    NM_001004467 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR10J3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR10J3 Expression
    About this image

    OR10J3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR10J3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553833
        Pathway & Disease-focused RT2 Profiler PCR Arrays including OR10J3: 
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR10J3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR10J3 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr14045
    Olfr2181
    olfactory receptor 14045
    olfactory receptor 2181
    84.04(n)1
    86.97(a)1
      1 (80.33 cM)5
    2588801  NM_001001809.21  NP_001001809.21 
     1732156075 


    ENSEMBL Gene Tree for OR10J3 (if available)
    TreeFam Gene Tree for OR10J3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR10J3 gene
    OR10H42  OR10K22  OR10Z12  OR10X12  OR10J42  OR10H52  OR10J52  OR10T22  
    OR10H12  OR10H22  OR10R22  OR10H32  OR10K12  OR10J12  
    Selected SIMAP similar genes for OR10J3 using alignment to 1 protein entry:     O10J3_HUMAN(see all similar genes):
    OR10J4    OR10J1    OR10J6P    OR10J5    OR10R3P    OR10T2
    OR5A2    OR10Q1    OR10A7    OR10H4    OR10K1    OR10R2
    OR10Z1    OR8B2    OR10H1    OR10H2    OR10H3    OR10H5

    OR10J3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OR10J3
    PGOHUM00000244304


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR10J3 (see all 113)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394150951,2
    --159282980(+) CCTCCA/GCCTCC 1 -- ds50010--------
    rs772326311,2
    C--159282991(+) CAGGT-/CCACGA 1 -- ds50010--------
    rs673511741,2
    C--159282992(-) CTCGT-/GAACCT 1 -- ds50011Minor allele frequency- G:0.00NA 2
    rs1450213911,2
    --159283067(+) TTTTGC/TATTTT 1 -- ds50010--------
    rs121166251,2
    F--159283078(+) tagtaA/C/Gagatg 1 -- ds50010--------
    rs1475753071,2
    --159283171(+) ACAGAC/TGTGAG 1 -- ds50010--------
    rs1826048871,2
    --159283188(+) CACCTA/GGCCAG 1 -- ds50010--------
    rs1858462471,2
    --159283198(+) GACTTC/TATGTT 1 -- ds50010--------
    rs1422530371,2
    C--159283433(+) ACATAA/GGGGCA 1 -- ds50010--------
    rs1432760881,2
    C--159283467(+) AGTACA/GTATTT 2 T M mis11Minor allele frequency- G:0.00NA 3710

    HapMap Linkage Disequilibrium report for OR10J3 ( 159283463 - 159284449 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OR10J3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv396n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR10J3
    DNA2.0 Custom Variant and Variant Library Synthesis for OR10J3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for OR10J3:    
    About MalaCards
    childhood leukemia    meningioma    neuronitis    breast cancer
    leukemia


    OR10J3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OR10J3
    Human Genome Epidemiology (HuGE) Navigator: OR10J3 (6 documents)

    Export disorders for OR10J3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR10J3 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with OR10J3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    2. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    3. Chemerin, a novel adipokine in the regulation of angiogenesis. (PubMed id 20237162)1, 4 Bozaoglu K....Jowett J.B. (J. Clin. Endocrinol. Metab. 2010)
    4. Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women. (PubMed id 19372141)1, 4 Lee J.Y....Kang D. (Carcinogenesis 2009)
    5. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)1, 4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. (PubMed id 22939635)1 Reiner A.P....Tang H. (Am. J. Hum. Genet. 2012)
    8. A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. (PubMed id 22075330)1 Granada M....O'Connor G.T. (J. Allergy Clin. Immunol. 2012)
    9. Common variation in genes related to innate immunity and risk of adult glioma. (PubMed id 19423540)1 Rajaraman P....Chanock S.J. (amp 2009)
    10. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 441911 HGNC: 14992 AceView: OR10J3 Ensembl:ENSG00000196266 euGenes: HUgn441911
    ECgene: OR10J3 Kegg: 441911 H-InvDB: OR10J3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR10J3 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR10J3 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR10J3 gene:
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