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OR10J1 Gene

protein-coding   GIFtS: 52
GCID: GC01P159409

Olfactory Receptor, Family 10, Subfamily J, Member 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 10, Subfamily J, Member 11 2
Olfactory Receptor OR1-262 3
Olfactory Receptor-Like Protein HGMP07J2 3
HGMP07J2
HSHGMP07J2
Olfactory Receptor 10J12

External Ids:    HGNC: 81751   Entrez Gene: 264762   Ensembl: ENSG000001961847   UniProtKB: P309543   

Export aliases for OR10J1 gene to outside databases

Previous GC identifers: GC01P157201 GC01P155141 GC01P156187 GC01P156626 GC01P156619 GC01P156222 GC01P157669 GC01P157590 GC01P157676 GC01P159320


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR10J1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR10J1 Gene:
OR10J1 (olfactory receptor, family 10, subfamily J, member 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H4.

UniProtKB/Swiss-Prot: O10J1_HUMAN, P30954
Function: Odorant receptor (Potential)

Gene Wiki entry for OR10J1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR10J1 gene promoter:
         COUP-TF1   COUP   HNF-4alpha1   NF-AT   NF-AT4   NF-AT2   COUP-TF   Sox9   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR10J1 promoter sequence
   Search Chromatin IP Primers for OR10J1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR10J1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.2   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q23.2

OR10J1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10J1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P159409:  view genomic region     (about GC identifiers)

Start:
159,409,582 bp from pter      End:
159,410,508 bp from pter
Size:
927 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: O10J1_HUMAN, P30954 (See protein sequence)
Recommended Name: Olfactory receptor 10J1  
Size: 320 amino acids; 35925 Da
Secondary accessions: Q2M1M8 Q5VSV1 Q6IET5 Q96R56

Explore the universe of human proteins at neXtProt for OR10J1: NX_P30954

Post-translational modifications: 

  • Glycosylation2 at Asn9, Asn16
  • HORDE protein sequence for OR10J1
    REFSEQ proteins: NP_036483.2  
    ENSEMBL proteins: 
     ENSP00000399078  
    Reactome Protein details: P30954

    OR10J1 Human Recombinant Protein Products:

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    antibodies-online antibodies for OR10J1 (14 products) 

    OR10J1 Assay Products:

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    antibodies-online kits for OR10J1 (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR10: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P30954

    ProtoNet protein and cluster: P30954

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O10J1_HUMAN, P30954
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR10J1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O10J1_HUMAN, P30954
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR10J1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OR10J1:
     Decreased Hepatitis C virus re 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR10J1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O10J1_HUMAN, P30954: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1370859
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with OR10J1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR10J1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43


    Find genes that share SuperPaths with OR10J1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR10J1
        GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR10J1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR10J1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR10J1
    Interactions:

        Search GeneGlobe Interaction Network for OR10J1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR10J1 (P309543 ENSP000003990784) via UniProtKB, MINT, STRING, and/or I2D (see all 275)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF6Q9Y4K33I2D: score=1 
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10AG1ENSP000003114774STRING: ENSP00000311477
    OR10H2ENSP000003060954STRING: ENSP00000306095
    OR10J3ENSP000003317894STRING: ENSP00000331789
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS1370859
    GO:0007338single fertilization TAS1370859
    GO:0007606sensory perception of chemical stimulus TAS1370859

    Find genes that share ontologies with OR10J1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR10J1 (O10J1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR10J1 gene: 
    NM_012351.2  

    Unigene Cluster for OR10J1:

    Olfactory receptor, family 10, subfamily J, member 1
    Hs.532661  [show with all ESTs]
    Unigene Representative Sequence: BC112290
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000423932(uc010piv.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR10J1

    Additional mRNA sequence: 

    BC069150.1 BC112290.1 BC112292.1 

    1 DOTS entry:

    DT.92014820 

    2 AceView cDNA sequences:

    BC069150 NM_012351 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR10J1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCAGCTGAT
    OR10J1 Expression
    About this image

    OR10J1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.532661
        Custom PCR Arrays for OR10J1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR10J1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR10J1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr418-ps11 olfactory receptor 418, pseudogene 1 77.49(n)
    79.67(a)
      258645  NM_146651.2  NP_666862.2 


    ENSEMBL Gene Tree for OR10J1 (if available)
    TreeFam Gene Tree for OR10J1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR10J1 gene
    OR10H42  OR10K22  OR10Z12  OR10X12  OR10J42  OR10H52  OR10J52  OR10T22  
    OR10H12  OR10J32  OR10H22  OR10R22  OR10H32  OR10K12  
    Selected SIMAP similar genes for OR10J1 using alignment to 1 protein entry:     O10J1_HUMAN(see all similar genes):
    OR10J3    OR10J5    OR10J6P    OR10J4    OR10R3P    OR10T2
    OR10R2    OR10H2    OR10Q1    OR10Z1    OR10A2    OR10A5
    OR10A7    OR10H1    OR10H5    OR10K1    OR10X1    OR5A2

    Find genes that share paralogs with OR10J1           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for OR10J1
    PGOHUM00000259502 PGOHUM00000259593 PGOHUM00000259594 PGOHUM00000259595


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR10J1 (see all 130)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1839104681,2
    --159407525(+) CTTCAA/GGGAGT 1 -- us2k10--------
    rs1876085051,2
    --159407627(+) TGACTC/GTCAAA 1 -- us2k10--------
    rs1135197331,2
    C,F--159407657(+) GTGTGC/TGTTTA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1453101261,2
    --159407693(+) CTGCCA/GTAGGC 1 -- us2k10--------
    rs1843148551,2
    --159407702(+) GCACTC/TTTGGT 1 -- us2k10--------
    rs115895141,2
    C,F,H--159407727(+) TGGTCA/TCCCTA 1 -- us2k17Minor allele frequency- T:0.02EA NS NA 476
    rs1179235041,2
    C,F--159407783(+) TCCTCG/TGCCTC 1 -- us2k11Minor allele frequency- T:0.10EA 120
    rs1134126921,2
    C--159407789(+) GCCTCC/TTCCAG 1 -- us2k10--------
    rs1476030661,2
    --159407832(+) AGAGTC/TATGTG 1 -- us2k10--------
    rs1916021221,2
    --159408017(+) AAATCA/GTAATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR10J1 ( 159409582 - 159410508 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OR10J1: --
    Human Gene Mutation Database (HGMD): OR10J1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR10J1
    DNA2.0 Custom Variant and Variant Library Synthesis for OR10J1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR10J1           About GenesLikeMe

    Genetic Association Database (GAD): OR10J1
    Human Genome Epidemiology (HuGE) Navigator: OR10J1 (1 document)

    Export disorders for OR10J1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR10J1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with OR10J1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PubMed id 1370859)1, 2, 3 Parmentier M.... Vassart G. (Nature 1992)
    2. Chemerin, a novel adipokine in the regulation of angiogenesis. (PubMed id 20237162)1, 4 Bozaoglu K....Jowett J.B. (J. Clin. Endocrinol. Metab. 2010)
    3. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)1, 4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    4. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)1, 4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    7. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    9. Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women. (PubMed id 22939635)1 Reiner A.P....Tang H. (Am. J. Hum. Genet. 2012)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26476 HGNC: 8175 AceView: OR10J1 Ensembl:ENSG00000196184 euGenes: HUgn26476
    ECgene: OR10J1 Kegg: 26476 H-InvDB: OR10J1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR10J1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR10J1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
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